Article
Cell Biology
Sathish K. Murali, Robert Little, Soren B. Poulsen, Mohammed Z. Ferdaus, David H. Ellison, James A. McCormick, Robert A. Fenton
Summary: In addition to Cul3, other members of the cullin family are involved in mediating the effects of K+ on NCC phosphorylation and abundance.
Article
Zoology
A. Kasler, J. Ujszegi, D. Holly, B. Uveges, A. M. Moricz, D. Herczeg, A. Hettyey
Summary: Common toads exhibit low resistance and high tolerance to Bd infection. Although young toadlets may not be able to clear the infection, they can control the infection intensity. However, the costs of chronic infection may compromise their fitness.
JOURNAL OF ZOOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jorg Hoehfeld, Thomas Benzing, Wilhelm Bloch, Dieter O. Fuerst, Sebastian Gehlert, Michael Hesse, Bernd Hoffmann, Thorsten Hoppe, Pitter F. Huesgen, Maja Koehn, Waldemar Kolanus, Rudolf Merkel, Carien M. Niessen, Wojciech Pokrzywa, Markus M. Rinschen, Dagmar Wachten, Bettina Warscheid
Summary: Mechanical stress can threaten protein structure and proteome integrity, but cells have folding and degradation systems to combat this stress. These systems play crucial roles in cell differentiation, adhesion, and migration, and are essential for maintaining the integrity of various tissues.
Article
Genetics & Heredity
Jordan Guillon, Hugo Coquelet, Raldine Leman, Bertrand Toutain, Coralie Petit, Cecile Henry, Alice Boissard, Catherine Guette, Olivier Coqueret
Summary: Oncogenes or chemotherapy induce suppressive pathways such as apoptosis or senescence, which are associated with cancer progression and resistance to treatment. Senescence escape is regulated by specific tRNAs and ligases, highlighting the complexity and heterogeneity of this tumor suppressive pathway. Further research into tRNA biology during senescence may provide insights into controlling the strength and variability of this process.
Article
Cell Biology
Jinfa Ma, Lei Liu, Lu Song, Jianghong Liu, Lingyao Yang, Quan Chen, Jane Y. Wu, Li Zhu
Summary: This study reveals the mechanism of mitochondrial import of TDP-43 and the active role played by mitochondria in regulating TDP-43 homeostasis. FUNDC1 gene, a mitophagy receptor, is found to be co-expressed with TDP-43 and promotes mitochondrial translocation of TDP-43. Overexpressing FUNDC1 enhances TDP-43 induced mitochondrial damage, while down-regulating FUNDC1 reverses it, suggesting FUNDC1's involvement in regulating mitochondrial TDP-43 import and degradation.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Mariasole Perrone, Simone Patergnani, Tommaso Di Mambro, Laura Palumbo, Mariusz R. Wieckowski, Carlotta Giorgi, Paolo Pinton
Summary: Maintenance of mitochondrial quality is crucial for cellular homeostasis. Mitophagy, the selective elimination of dysfunctional mitochondria, plays a significant role in various diseases, including carcinogenesis, neurodegenerative disorders, and cardiovascular pathologies. The relationship between calcium homeostasis and mitophagy is still a topic of debate.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Cell Biology
Yalan Jiang, Zehua Tao, Hua Chen, Sheng Xia
Summary: The endoplasmic reticulum quality control system plays a crucial role in immune cells, maintaining protein homeostasis and ensuring normal development and function of immune cells. Imbalance in ER homeostasis may impact immune responses, suggesting new therapeutic targets for immunotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Nutrition & Dietetics
Kazuhito Sekiguchi, Hiroaki Miyahara, Masanori Inoue, Kyoko Kiyota, Kumiko Sakai, Toshikatsu Hanada, Kenji Ihara
Summary: The study found that liver autophagy is not essential for the survival of neonatal mice under starvation conditions, as they can adapt to changes in metabolic pathways, such as the malate-aspartate shuttle, aspartate metabolism, urea cycle, and glycine and serine metabolism. This adaptation may involve a change in mitochondrial function to maintain ketone production and avoid fatal starvation.
Article
Environmental Sciences
Bing Xie, Chuan-yue Chen, Xiaolin Zhang, Si-yuan Li, Zhong-qi Gu, Ji Huang, Jian-yu He, Peng-zhi Qi, Bao-ying Guo, Zhi Liao, Xiaojun Yan
Summary: This study conducted gill transcriptome analysis of Mytilus before and after starvation, revealing significant up- and down-regulation of many genes and suggesting that mussels may use autophagy to cope with damage after starvation.
FRONTIERS IN MARINE SCIENCE
(2022)
Editorial Material
Medicine, General & Internal
Alexis Drutchas
Summary: After her grandmother attempts suicide, a physician realizes that the medical team's avoidance of honest conversations about the grandmother's reality and desires leads to counterproductivity and pain in the relationship between clinicians and family.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Engineering, Aerospace
Yaroslav Mashtakov, Mikhail Ovchinnikov, Stepan Tkachev, Sergey Shestakov
Summary: This paper examines the problem of large angle slew maneuvers under attitude restrictions and proposes a modification to the single axis Lyapunov feedback attitude control to accommodate these restrictions. It thoroughly investigates the issue of unwanted equilibria appearance and considers different cases of keep-out zones intersections.
Article
Multidisciplinary Sciences
Angeles Aroca, Inmaculada Yruela, Cecilia Gotor, Diane C. Bassham
Summary: This research demonstrates that sulfide can regulate plant autophagy, particularly during ER stress, by reversible persulfidation of ATG18a. This regulation is achieved by affecting ATG18a's phospholipid-binding activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Plant Sciences
Pengwei Wang, Patrick Duckney, Erlin Gao, Patrick J. J. Hussey, Verena Kriechbaumer, Chengyang Li, Jingze Zang, Tong Zhang
Summary: Functional regulation and structural maintenance of organelles in plants are crucial for plant development, reproduction, and stress responses. Recent studies have identified proteins that regulate membrane connections in plants, providing insights into the mechanism and function of these connections. The endoplasmic reticulum plays a key role in linking different subcellular compartments in plants, and its membrane contact sites (MCS) and ER-plasma membrane contact sites (EPCS) have been extensively studied. However, plant MCS are different from those in other eukaryotic systems. In this article, we summarize the recent advances in understanding these essential links in plants and discuss their mechanisms and biological relevance.
Article
Microbiology
Chaitanya Kurhade, Soowon Kang, Scott B. Biering, Seungmin Hwang, Glenn Randall
Summary: This study reveals the collaborative action of autophagy and interferon in inhibiting viral replication. It also uncovers the mechanism by which autophagy proteins target viral replication complexes and the role of interferon-inducible GTPases in disrupting these complexes. This research provides a new understanding of the recognition and inhibition of viral replication complexes by the autophagy machinery.
Editorial Material
Immunology
Guillem Sanchez Sanchez, David Vermijlen
Summary: The control of different subsets of gamma delta IL17 cells during homeostasis and cancer is reported in this study.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Review
Behavioral Sciences
Desmond McEwan, Ryan E. Rhodes, Mark R. Beauchamp
Summary: Although behavior change interventions can improve physical activity during the intervention, these improvements are generally not sustained after the intervention concludes.
BEHAVIORAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Valentin J. A. Barthet, Michaela Mrschtik, Elzbieta Kania, David G. McEwan, Dan Croft, James O'Prey, Jaclyn S. Long, Kevin M. Ryan
Summary: DRAM-4 and DRAM-5 are nutrient-responsive members of the DRAM family that exhibit interconnected roles in the regulation of autophagy and cell survival under nutrient-deprived conditions.
Review
Cell Biology
Ivan Dikic, Brenda A. Schulman
Summary: Recent studies have advanced our understanding of ubiquitylation, revealing unconventional ubiquitylation mechanisms used by pathogens to promote infection. Structural studies have shown that ubiquitin functions involve complex multivalent interactions that regulate transcription or protein degradation. Furthermore, these interactions can induce conformational changes and regulate protein degradation or transcription. These newly discovered mechanisms provide potential opportunities for innovative therapeutic interventions for diseases such as cancer and infectious diseases.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Daniela S. Krause, Ivan Dikic
Article
Sport Sciences
Miguel A. Lopez-Gajardo, Desmond McEwan, Juan J. Pulido, Jesus Diaz-Garcia, Francisco M. Leo
Summary: A team's ability to respond positively to adversities, problems, and obstacles is crucial for success in collective sports. This study examined the relationship between resilience, vulnerability under pressure, and individual and team performance. The results showed that resilience was positively associated with subjective individual and team performance, while vulnerability under pressure was negatively related to team performance. These findings highlight the importance of developing strategies to improve team resilience for achieving positive outcomes.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Cell Biology
Alexandra Hertel, Ludovico Martins Alves, Henrik Dutz, Georg Tascher, Florian Bonn, Manuel Kaulich, Ivan Dikic, Stefan Eimer, Florian Steinberg, Anja Bremm
Summary: This study revealed a mechanism of controlling mTORC1 activation cascade at lysosomes through USP32-regulated LAMTOR1 ubiquitination.
Article
Hospitality, Leisure, Sport & Tourism
Miguel A. A. Lopez-Gajardo, Francisco M. M. Leo, Patricia C. C. Jackman, Desmond McEwan
Summary: This multistudy article examines the relationships between variables in an input-mediator-outcome (IMO) framework of team effectiveness in sport over a season. The findings show the significant and reciprocal relationships between teamwork execution and characteristics of resilience, as well as the associations between athlete leadership quality and these mediators and team performance.
SPORT EXERCISE AND PERFORMANCE PSYCHOLOGY
(2023)
Article
Chemistry, Multidisciplinary
David A. Perez A. Berrocal, Thimmalapura M. Vishwanatha, Daniel Horn-Ghetko, J. Josephine Botsch, Laura A. Hehl, Sebastian Kostrhon, Mohit Misra, Ivan Dikic, Paul P. Geurink, Hans van Dam, Brenda A. Schulman, Monique P. C. Mulder
Summary: Protein post-translational modification with ubiquitin (Ub) is a versatile signal regulating cell biology, and diseases associated with impaired Ub modification present opportunities for novel targeted treatments. The final components of the ubiquitination cascade, E3 ligases, have potential as small molecule targets. UbSRhodol, an autoimmolative Ub-based probe, enables detection of changes in E3 transthiolation activity, making it suitable for high-throughput screening and identification of small molecules modulating E3 activity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Editorial Material
Biochemistry & Molecular Biology
Angus I. Lamond, Ivan Dikic, Andre Nussenzweig, Christoph W. Mueller, Janet M. Thornton, Michael B. Yaffe
Article
Cell Biology
Anshu Bhattacharya, Rukmini Mukherjee, Santosh Kumar Kuncha, Melinda Elaine Brunstein, Rajeshwari Rathore, Stephan Junek, Christian Muench, Ivan Dikic
Summary: Acute lysosomal membrane damage reduces functional lysosomes, but they have a recovery potential independent of lysosomal biogenesis and remain unaffected in cells depleted in TFEB and TFE3. A lysosomal membrane regeneration pathway was discovered that depends on ATG8, LIMP2, TBC1D15, dynamin-2, kinesin-5B, and clathrin. LIMP2 acts as a lysophagy receptor, binding ATG8, which recruits TBC1D15 to damaged lysosomal membranes. TBC1D15 interacts with ATG8 proteins and stabilizes the autophagic lysosomal reformation machinery, promoting lysosomal tubule formation and dynamin-2-dependent scission.
NATURE CELL BIOLOGY
(2023)
Review
Immunology
Joao Mello-Vieira, Tobias Bopp, Ivan Dikic
Summary: Cell-autonomous immunity is the first line of defense for cells to recognize and eliminate invasive pathogens. Ubiquitination plays a crucial role in orchestrating immune signaling networks and stimulating the appropriate immune response. This review focuses on how ubiquitin connects pathogen sensing pathways to cellular responses and discusses therapeutic options for enhancing cell-autonomous immune responses.
CURRENT OPINION IN IMMUNOLOGY
(2023)
Article
Cell Biology
Jake Cross, Joanne Durgan, David G. McEwan, Matthew Tayler, Kevin M. Ryan, Oliver Florey
Summary: Cross et al. demonstrate that non-canonical autophagy activation is responsible for the majority of ATG8 lipidation in response to lysosome damage, rather than lysophagy. They show that ATG8 proteins directly conjugate to lysosomal membranes and interact with the lipid transfer protein ATG2. This study reveals a parallel ATG8 response to lysosome damage that is mechanistically distinct from lysophagy and involves important links to lipid transfer and dynamics.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Cell Biology
Alexis Gonzalez, Ivan Dikic
Article
Hospitality, Leisure, Sport & Tourism
Miguel A. Lopez-Gajardo, Francisco M. Leo, Patricia C. Jackman, Desmond McEwan
Summary: The purpose of this multistudy article was to investigate the relationships between variables in the input-mediator-outcome framework of team effectiveness in sports. The findings revealed significant and reciprocal positive relationships between teamwork execution and characteristics of resilience, as well as significant and reciprocal negative relationships between teamwork execution and vulnerability under pressure. The study also found that perceived athlete leadership quality had positive associations with teamwork execution and characteristics of resilience, and negative associations with player-level vulnerability under pressure. Overall, the study highlights the importance of teamwork execution, team resilience, and athlete leadership in determining team performance in sports.
SPORT EXERCISE AND PERFORMANCE PSYCHOLOGY
(2023)
Meeting Abstract
Oncology
Alicia Haydo, Johanna Ertl, Jennifer Schmidt, Marina E. Hoffmann, Stephanie Hehlgans, Alisha Crider, Rajeshwari Rathore, Christel Herold-Mende, Ivan Dikic, Mingji Dai, Alexander Adibekian, Franz Roedel, Donat Koegel, Benedikt Linder
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
