Article
Multidisciplinary Sciences
Naihua N. Gong, Leela Chakravarti Dilley, Charlette E. Williams, Emilia H. Moscato, Milan Szuperak, Qin Wang, Matthew Jensen, Santhosh Girirajan, Tiong Yang Tan, Matthew A. Deardorff, Dong Li, Yuanquan Song, Matthew S. Kayser
Summary: The chromatin remodeler ISWI is essential for adult fly sleep and its loss leads to disrupted circadian rhythms, memory, and social behavior. Expressing human ISWI homologs in flies can rescue adult phenotypes to different extents, highlighting the importance of chromatin remodeling machinery for sleep circuit formation in neurodevelopmental disorders.
Article
Multidisciplinary Sciences
Yi Sun, Zujie Yao, Yiting Ye, Jun Fang, Honglin Chen, Yuping Lyu, William Broad, Marjorie Fournier, Genyun Chen, Yonghong Hu, Shabaz Mohammed, Qihua Ling, R. Paul Jarvis
Summary: This study demonstrates the role of the nucleocytosolic ubiquitin-proteasome system (UPS) in regulating photosynthesis within endosymbiotically derived chloroplasts, through protein degradation.
Article
Biology
Yongjun Li, Paula Haynes, Shirley L. Zhang, Zhifeng Yue, Amita Sehgal
Summary: Steroid hormones, specifically ecdysone, act as long-range signals that enter the brain more at night through nuclear hormone receptors (NHRs) and regulate sleep in Drosophila. The ecdysone receptor (EcR) and its downstream NHR Eip75B (E75) were found to function in glia to affect the rhythm and amount of sleep. This suggests that ecdysone acts as a systemic secreted factor that modulates sleep by stimulating lipid metabolism in cortex glia.
Article
Cell Biology
Jinping Huang, Xiao Sheng, Zhangpeng Zhuo, Danqing Xiao, Kun Wu, Gang Wan, Haiyang Chen
Summary: This study identifies ClC-c as a regulator of intestinal stem cell proliferation in Drosophila, providing new insights into the functional relationship between chloride channels, stem cell maintenance, and tissue homeostasis.
CELL PROLIFERATION
(2022)
Article
Cell Biology
Justine Creff, Ada Nowosad, Anne Prel, Anne Pizzoccaro, Marion Aguirrebengoa, Nicolas Duquesnes, Caroline Callot, Thomas Jungas, Christine Dozier, Arnaud Besson
Summary: p57Kip2 is a cyclin/CDK inhibitor that regulates intestinal stem cell (ISC) fate and proliferation in a CDK-independent manner. In the absence of p57, there is increased proliferation of intestinal crypts and amplification of transit-amplifying cells and Hopx+ ISCs. RNA sequencing analyses reveal significant gene expression changes in Hopx+ ISCs upon p57 depletion. Furthermore, p57 binds to and inhibits the activity of Ascl2, a transcription factor critical for ISC specification and maintenance, by recruiting a corepressor complex. Hence, p57 plays a key role in maintaining Hopx+ ISC quiescence and repressing the ISC phenotype by inhibiting Ascl2 in a CDK-independent manner during intestinal development.
Article
Endocrinology & Metabolism
Ayaka Sasaki, Takashi Nishimura, Tomomi Takano, Saki Naito, Sa Kan Yoo
Summary: The study demonstrates that the white gene plays a crucial role in regulating intestinal stem cell proliferation during ageing through folate metabolism. Inhibition of white gene expression suppresses over-proliferation of stem cells and extends lifespan, indicating its potential as a therapeutic target for age-related tissue dysregulation. Metabolomics analyses further reveal the profound metabolic impacts of white gene inhibition on organismal metabolism, providing valuable insights into the regulation of stem cells by this classic gene.
Article
Oncology
Youfang Zhou, Jingnan Liu, Yuanbing Zhang, Ji-Long Liu
Summary: CTPS forms filamentous structures called cytoophidia in a subset of cells in the Drosophila midgut, including intestinal stem cells and enteroblasts, and disruption of these structures inhibits DSS-induced ISC proliferation, suggesting a crucial role for CTPS in intestinal homeostasis in Drosophila.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Hang Zhao, Lin Shi, Zhengran Li, Ruiyan Kong, Xuejing Ren, Rui Ma, Lemei Jia, Meifang Ma, Shan Lu, Ran Xu, Richard Binari, Jian-Hua Wang, Meng-qiu Dong, Norbert Perrimon, Zhouhua Li
Summary: This study identifies Yun as a factor required for the proliferation of normal and transformed intestinal stem cells in adult Drosophila. Yun acts as a scaffold to stabilize the PHB complex and is regulated by EGFR/MAPK signaling. The Yun/PHB complex interacts with and positively affects the levels of E2F1 to regulate stem cell proliferation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Microbiology
Ping-Ping Liu, Zhe Wei, Zi-Hua Cheng, Xian-Wei Wang
Summary: The study demonstrates the coordination of small immune effectors in regulating intestinal immunity in shrimp. A lysozyme digests peptidoglycan into muropeptides, inducing the expression of a bactericidal peptide and a lectin. The bactericidal peptide and lysozyme restrict intestinal bacteria, while the lectin counteracts their functions. By controlling rather than eliminating intestinal bacteria, these small effectors achieve a dynamic balance in the shrimp gut.
Article
Cell Biology
Han Han, Hiroki J. Nakaoka, Line Hofmann, Jeff Jiajing Zhou, Clinton Yu, Lisha Zeng, Junyu Nan, Gayoung Seo, Rebecca Elizabeth Vargas, Bing Yang, Ruxi Qi, Lee Bardwell, Dmitry A. Fishman, Ken W. Y. Cho, Lan Huang, Ray Luo, Rahul Warrior, Wenqi Wang
Summary: The Hippo pathway was found to regulate heavy metal homeostasis by phosphorylating and inhibiting MTF1, thus attenuating the transcription of heavy metal response genes and protecting cells from heavy metal-induced toxicity. The activity of the Hippo pathway kinase LATS is also inhibited by heavy metal treatment, suggesting an interplay between heavy metals and the Hippo pathway.
NATURE CELL BIOLOGY
(2022)
Article
Entomology
Bryon N. Hughson
Summary: This study reveals a crucial role of dg2 in regulating AKH during adulthood in Drosophila. Transcriptional silencing of dg2 decreases starvation resistance, increases sucrose responsiveness, and reduces whole body lipid content in adult flies. Additionally, dg2 is localized to CC cell membranes, and starvation leads to a significant decrease in CC intracellular AKH content. Reduced CC-dg2 expression causes a significant decrease in intracellular AKH content in adults fed ad libitum.
JOURNAL OF INSECT PHYSIOLOGY
(2022)
Article
Developmental Biology
Hongsu Wang, Carolyn A. Morrison, Neha Ghosh, Joy S. Tea, Gerald B. Call, Jessica E. Treisman
Summary: This study investigates the role of the zinc-finger transcription factor Blimp-1 in the formation of functional organ, specifically the eye. It reveals insights into the transcriptional networks and cellular interactions that are involved in the differentiation and formation of structures necessary for visual function.
Article
Pharmacology & Pharmacy
Xue Lei, Ziqian Zhou, Sihong Wang, Li Hua Jin
Summary: This study found that safranal can protect the intestines of Drosophila from damage and maintain intestinal homeostasis. This protective effect is mainly achieved by inhibiting the JNK, EGFR, and JAK/STAT pathways. In addition, safranal can also reduce the production of antimicrobial peptides and reactive oxygen species, protecting intestinal epithelial cells from damage.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Developmental Biology
Lesley N. Weaver, Daniela Drummond-Barbosa
Summary: The study reveals the crucial roles of nuclear receptor signaling in controlling reproduction, with Hormone receptor 4 (Hr4) identified as an oogenesis regulator required in the ovary and muscles. Hr4 is essential for germline stem cell maintenance, follicle growth, and early germline cyst survival, highlighting the complexity of nuclear receptor regulation in oogenesis.
Article
Pharmacology & Pharmacy
La Yan, Juanyu Zhou, Lu Yuan, Jinbao Ye, Xudong Zhao, Gang Ren, Haiyang Chen
Summary: Silibinin effectively relieves intestinal inflammation and inhibits the overproliferation of intestinal stem cells in Drosophila via modulating the JNK signaling pathway. It also protects intestinal barrier function, reduces reactive oxygen species levels and inflammatory stress, and extends lifespan.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Xiangfan Liu, Huapeng Li, Mihir Rajurkar, Qi Li, Jennifer L. Cotton, Jianhong Ou, Lihua J. Zhu, Hira L. Goel, Arthur M. Mercurio, Joo-Seop Park, Roger J. Davis, Junhao Mao
Article
Biochemistry & Molecular Biology
He Huang, Jennifer L. Cotton, Yang Wang, Mihir Rajurkar, Lihua J. Zhu, Brian C. Lewis, Junhao Mao
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Jiayi Wang, Joo-Seop Park, Yingying Wei, Mihir Rajurkar, Jennifer L. Cotton, Qishi Fan, Brian C. Lewis, Hongkai Ji, Junhao Mao
Article
Biochemistry & Molecular Biology
M. Rajurkar, H. Huang, J. L. Cotton, J. K. Brooks, J. Sicklick, A. P. McMahon, J. Mao
Article
Multidisciplinary Sciences
Mihir Rajurkar, Wilfredo E. De Jesus-Monge, David R. Driscoll, Victoria A. Appleman, He Huang, Jennifer L. Cotton, David S. Klimstra, Lihua J. Zhu, Karl Simin, Lan Xu, Andrew P. McMahon, Brian C. Lewis, Junhao Mao
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2012)
Article
Biology
Zoe Vincent-Mistiaen, Ahmed Elbediwy, Hannah Vanyai, Jennifer Cotton, Gordon Stamp, Emma Nye, Bradley Spencer-Dene, Gareth J. Thomas, Junhao Mao, Barry Thompson
Article
Cell Biology
Huapeng Li, Qi Li, Kyvan Dang, Shan Ma, Jennifer L. Cotton, Sun Yang, Lihua J. Zhu, April C. Deng, Y. Tony Ip, Randy L. Johnson, Xu Wu, Claudio Punzo, Junhao Mao
Article
Cell & Tissue Engineering
Qi Li, Yang Sun, Gopala K. Jarugumilli, Shun Liu, Kyvan Dang, Jennifer L. Cotton, Jordi Xiol, Pui Yee Chan, Michael DeRan, Lifang Ma, Rui Li, Lihua J. Zhu, Joyce H. Li, Andrew B. Leiter, Y. Tony Ip, Fernando D. Camargo, Xuelian Luo, Randy L. Johnson, Xu Wu, Junhao Mao
Letter
Hematology
Roy Jung, Harish P. Janardhan, Karen Dresser, Jennifer L. Cotton, Lloyd Hutchinson, Junhao Mao, Chinmay M. Trivedi
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Letter
Hematology
Roy Jung, Harish P. Janardhan, Karen Dresser, Jennifer L. Cotton, Lloyd Hutchinson, Junhao Mao, Chinmay M. Trivedi
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cell Biology
Jennifer L. Cotton, Kyvan Dang, Lu Hu, Yang Sun, Alka Singh, Mihir S. Rajurkar, Qi Li, Xu Wu, Junhao Mao
Summary: PTEN and LKB1 deficiency in Gli1-expressing gut mesenchymal cells, but not intestinal epithelium, drives polyp formation resembling human polyposis. Additionally, the study reveals the differential roles of PTEN and LKB1 in regulating the mTOR signaling pathway.
Article
Multidisciplinary Sciences
Yang Sun, Lu Hu, Zhipeng Tao, Gopala K. Jarugumilli, Hannah Erb, Alka Singh, Qi Li, Jennifer L. Cotton, Patricia Greninger, Regina K. Egan, Y. Tony Ip, Cyril H. Benes, Jianwei Che, Junhao Mao, Xu Wu
Summary: The study demonstrates the potential of MGH-CP1 in cancer therapy by activating the Akt pathway via TEAD-Vgll3. Furthermore, TEAD inhibitors are shown to effectively block cancer cell stemness, organ overgrowth, and tumor initiation, with sensitivity correlating significantly with YAP-dependency in a wide range of cancer cell lines.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Phoebe Carter, Ulrike Schnell, Christopher Chaney, Betty Tong, Xinchao Pan, Jianhua Ye, Glenda Mernaugh, Jennifer L. Cotton, Vitaly Margulis, Junhao Mao, Roy Zent, Bret M. Evers, Payal Kapur, Thomas J. Carroll
Summary: Misregulation of the Warts pathway can drive renal tumor formation in mice, and human tumors with active YAP may represent a unique subset of RCCs that can be therapeutically targeted.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cell Biology
Jennifer L. Cotton, Qi Li, Lifang Ma, Joo-Seop Park, Jiayi Wang, Jianhong Ou, Lihua J. Zhu, Y. Tony Ip, Randy L. Johnson, Junhao Mao
DEVELOPMENTAL CELL
(2017)
