期刊
DEVELOPMENTAL CELL
卷 21, 期 2, 页码 273-287出版社
CELL PRESS
DOI: 10.1016/j.devcel.2011.06.019
关键词
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资金
- EMBO long-term fellowship
- INSERM
- Association Francaise contre lea Myopathies (AFM)
- Ligne Nationale Contre le Cancer (LNCC)
- Association pour la Recherche contre le Cancer (ARC)
- Decrypthon
- Institut National du Cancer (INCa)
- European Union [241440]
Coordinating the balance between progenitor self-renewal and myogenic differentiation is required for a regulated expansion of the developing muscles. Previous observation that neural crest cells (NCCs) migrate throughout the somite regions, where trunk skeletal muscles first emerge, suggests a potential role for these cells in influencing early muscle formation. However, specific signaling interactions between NCCs and skeletal muscle cells remain unknown. Here we show that mice with specific NCC and peripheral nervous system defects display impaired survival of skeletal muscle and show skeletal muscle progenitor cell (MPC) depletion due to precocious commitment to differentiation. We show that reduced NCC-derived Neuregulin1 (Nrg1) in the somite region perturbs ErbB3 signaling in uncommitted MPCs. Using a combination of explant culture experiments and genetic ablation in the mouse, we demonstrate that Nrg1 signals provided by the NCC lineage play a critical role in sustainable myogenesis, by restraining MPCs from precocious differentiation.
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