期刊
DEVELOPMENTAL CELL
卷 18, 期 4, 页码 655-661出版社
CELL PRESS
DOI: 10.1016/j.devcel.2010.02.011
关键词
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资金
- Centro de Biologia do Desenvolvimento [POCTI-ISFL-4-664]
- [PTDC/BIA-BCM/71619/2006]
- [SFRH/BD/27306/2006]
- [SFRH/BPD/26668/2006]
- Fundação para a Ciência e a Tecnologia [SFRH/BPD/26668/2006] Funding Source: FCT
Hox genes are essential for the patterning of the axial skeleton. Hox group 10 has been shown to specify the lumbar domain by setting a rib-inhibiting program in the presomitic mesoderm (PSM). We have now produced mice with ribs in every vertebra by ectopically expressing Hox group 6 in the PSM, indicating that Hox genes are also able to specify the thoracic domain. We show that the information provided by Hox genes to specify rib-containing and rib-less areas is first interpreted in the myotome through the regional-specific control of Myf5 and Myf6 expression. This information is then transmitted to the sclerotome by a system that includes FGF and PDGF signaling to produce vertebrae with or without ribs at different axial levels. Our findings offer a new perspective of how Hox genes produce global patterns in the axial skeleton and support a redundant nonmyogenic role of Myf5 and Myf6 in rib formation.
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