期刊
DEVELOPMENTAL CELL
卷 16, 期 1, 页码 9-11出版社
CELL PRESS
DOI: 10.1016/j.devcel.2008.12.010
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资金
- Medical Research Council [MC_U120061476] Funding Source: researchfish
- Medical Research Council [MC_U120061476] Funding Source: Medline
- MRC [MC_U120061476] Funding Source: UKRI
Understanding the mechanisms that regulate gene expression during development is a major challenge in science. In this issue of Developmental Cell, Amano and colleagues report that expression of Sonic hedgehog (Shh) protein in the posterior mesenchyme of the mouse limb bud correlates with a long-range chromatin interaction with enhancer MFCS1 and looping of the Shh locus from its chromosome territory (CT).
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