期刊
DEVELOPMENTAL BIOLOGY
卷 392, 期 1, 页码 108-116出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2014.04.018
关键词
p39(cdk2)/p-CDK2; SUN1; Meiosis; Telomere clustering; Synapsis; Recombination; Mouse; MLH1
资金
- National Natural Science Foundation of China [81125005]
- National Basic Research Program of China [2014CB943100]
Telomere clustering is a widespread phenomenon among eukaryotes. However, the molecular mechanisms that regulate formation of telomere clustering in mammalian meiotic prophase I, are still largely unknown. Here, we show that CDK2, especially p39(cdk2), as a potential meiosis-specific connector interaction with SUN1 mediates formation of telomere clustering during mouse meiosis. The transition from CDK2 to p-CDK2 also regulates the progression from homologous recombination to desynapsis by interacting with MLH1. In addition, disappearance of CDK2 on the telomeres and of p-CDK2 on recombination sites, were observed in Sun l(-/-) mice and in pachytene-arrested hybrid sterile mice (pwk x C57BL/6 F1), respectively. These results suggest that transition from CDK2 to p-CDK2 plays a critical role for regulating meiosis progression. (C) 2014 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据