期刊
DEVELOPMENTAL BIOLOGY
卷 385, 期 2, 页码 168-178出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2013.09.031
关键词
Drosophila retina; Photoreceptor; Cell shape changes; Organogenesis; Myosin-II; Crumbs
资金
- Medical Research Council
- MRC [MC_UU_12018/3] Funding Source: UKRI
- Medical Research Council [MC_UU_12018/3] Funding Source: researchfish
Understanding how a functional organ can be produced from a small group of cells remains an outstanding question in cell and developmental biology. The developing compound eye of Drosophila has long been a model of choice for addressing this question by dissecting the cellular, genetic and molecular pathways that govern cell specification, differentiation, and multicellular patterning during organogenesis. In this review, the author focussed on cell and tissue morphogenesis during fly retinal development, including the regulated changes in cell shape and cell packing that ultimately determine the shape and architecture of the compound eye. In particular, the author reviewed recent studies that highlight the prominent roles of transcriptional and hormonal controls that orchestrate the cell shape changes, cell cell junction remodeling and polarized membrane growth that underlie photoreceptor morphogenesis and retinal patterning. (C) 2013 Elsevier Inc. All rights reserved.
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