Article
Developmental Biology
Guojun Sheng
Summary: The concept of epithelial-mesenchymal transition (EMT) has been widely applied to morphogenetic studies in both physiological and pathological contexts over the past 50 years. Recent exponential growth in the EMT field has been primarily driven by cancer-oriented EMT research. Dynamic epithelialization and de-epithelialization events play crucial roles in many developmental processes, providing a broader perspective on EMT.
Review
Immunology
Kieran D. James, William E. Jenkinson, Graham Anderson
Summary: The thymus supports T-cell development through specialized microenvironments consisting of stromal cells, including thymic epithelial cells and non-epithelial stromal cells. While the roles of thymic epithelial cells in T-cell development have been extensively studied, the developmental origins and functional properties of non-epithelial stromal cells remain poorly understood. Experimental evidence suggests that these non-epithelial stromal cells play important roles in thymus function by influencing T-cell development directly or regulating thymic epithelial cell development and function indirectly.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Navin Gupta, Ryuji Morizane
Summary: The development of kidney organoid technology has revitalized the field of kidney developmental biology, allowing for the generation of nephron and collecting duct kidney organoids through directed differentiation protocols. However, there are limitations to current methods that need to be addressed for future improvements.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Vanja Krneta-Stankic, Mark E. Corkins, Adriana Paulucci-Holthauzen, Malgorzata Kloc, Andrew B. Gladden, Rachel K. Miller
Summary: The study reveals that Daam1 plays a critical role in regulating E-cadherin-based intercellular adhesion, affecting the assembly and disassembly of cell contacts, and thus impacting the development and homeostasis of epithelial tissues.
Article
Biology
Hiroko Katsuno-Kambe, Jessica L. Teo, Robert J. Ju, James Hudson, Samantha J. Stehbens, Alpha S. Yap
Summary: The study found that collagen 1 polarization can stimulate regional cell proliferation, leading to symmetry breaking and elongation. This process requires the involvement of beta 1-integrin and ERK signaling. Collagen polarization supports elongation of epithelial anlage and may provide a lasting structural memory.
Article
Cell Biology
Jinshu Xu, Xianxiao Zhou, Ting Zhang, Bin Zhang, Pin-Xian Xu
Summary: This study investigates the role of chromatin remodeling factor Smarca4 in kidney development and disease. The results demonstrate that deficiency of Smarca4 leads to tubular defects, medulla shortening, altered cell characteristics, and dysregulated gene expression, which eventually result in fibrosis. Furthermore, Smarca4 loss upregulates the oncogene Pttg1 and promotes hyperproliferation of Wnt4(Cre) labeled cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Fernanda C. A. dos Santos, Ana F. P. Negre, Daniel A. O. Rodriguez, Gessica C. de Sousa, Giovanna A. Rodrigues, Bruno D. A. Sanches, Hernandes F. Carvalho, Sebastiao R. Taboga, Manoel F. Biancardi
Summary: This study investigated the development of the female prostate in gerbils. The results showed that the development of the female gerbil prostate exhibits a distinct budding pattern compared to the male prostate development.
MICROSCOPY AND MICROANALYSIS
(2022)
Review
Pediatrics
Ihor Yosypiv
Summary: Mutations in genes of the renin-angiotensin system can lead to congenital anomalies of the kidney and urinary tract (CAKUT), the main cause of end-stage renal disease in children. Understanding the underlying mechanisms of CAKUT is crucial for improving the care of affected children. Recent advances have shed light on how disruption of the renin-angiotensin system during kidney development contributes to CAKUT.
PEDIATRIC NEPHROLOGY
(2021)
Article
Cell & Tissue Engineering
Isaac W. Shaw, Eoin D. O'Sullivan, Angela O. Pisco, Gary Borthwick, Kevin M. Gallagher, Bruno Peault, Jeremy Hughes, David A. Ferenbach
Summary: This study characterized the heterogeneity of renal mesenchymal cells in young vs old animals and after injury, demonstrating that age and injury impact the expression patterns and transcriptomes of these cells. The findings reveal distinct subtypes of mesenchymal cells with different expression patterns with aging and following injury, offering new insights into the classification and identification of age-specific pathways and targets in renal mesenchymal cells.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Review
Cell Biology
Amel Nasri, Florent Foisset, Engi Ahmed, Zakaria Lahmar, Isabelle Vachier, Christian Jorgensen, Said Assou, Arnaud Bourdin, John De Vos
Summary: Mesenchymal cells play crucial roles in lung development, regeneration, and diseases, especially in chronic obstructive pulmonary disease.
Article
Developmental Biology
Lila Gannoun, Catalina De Schrevel, Morgane Belle, Nicolas Dauguet, Younes Achouri, Axelle Loriot, Christophe Vanderaa, Sabine Cordi, Alexandra Dili, Yves Heremans, Ilse Rooman, Isabelle A. Leclercq, Patrick Jacquemin, Laurent Gatto, Frederic P. Lemaigre
Summary: This study identifies new regulators in liver development and explores their functions in both health and liver regeneration. Experimental evidence demonstrates the significance of specific signaling pathways in portal area development and maturation of vascular smooth muscle cells in the hepatic artery.
Review
Developmental Biology
Keishi Kishimoto, Mitsuru Morimoto
Summary: Anomalies in tracheal development can lead to life-threatening malformations, necessitating the development of technologies for reconstructing the trachea from stem cells. Recent studies have utilized single-cell sequencing technologies and quantitative analyses to understand the cellular basis of tracheal morphogenesis.
Article
Medicine, Research & Experimental
Sudhir Kumar, Xueping Fan, Hila Milo Rasouly, Richa Sharma, David J. Salant, Weining Lu
Summary: This study identifies the key role of ZEB2 in maintaining the cell fate of FOXD1(+) stromal progenitors during kidney development. Loss of ZEB2 leads to differentiation of FOXD1(+) stromal progenitors into myofibroblasts and kidney fibrosis.
Review
Developmental Biology
Natalie J. Milmoe, Abigail S. Tucker
Summary: During head development, tissues undergo cell fate transitions to form structures, where neural crest cells play a crucial role in shaping skeletal tissues. These cells exhibit flexibility in transitioning back and forth between epithelial and mesenchymal states in the eye and ear. Understanding the factors triggering these transitions and the consequences of aberrant transitions is important for studying craniofacial development.
Review
Biochemistry & Molecular Biology
Zahra Ghezelayagh, Mahsa Zabihi, Mohammad Kazemi Ashtiani, Zeinab Ghezelayagh, Francis C. Lynn, Yaser Tahamtani
Summary: This review discusses the role of different non-epithelial cells in pancreatic development, and their effects on pancreatic epithelium through signaling pathways, factors or cell interactions. It also considers the impact of N-Epi cells on pancreatic endocrine development, as well as new approaches using stem cell technology and three-dimensional organoids to generate pancreatic micro-tissues.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Developmental Biology
Cheng Shi, Pengfei Jiao, Zhiyi Chen, Lan Ma, Siyue Yao
Summary: This review discusses the molecular etiology of congenital craniofacial abnormalities, with a focus on the role and mechanism of noncoding RNAs in regulating craniofacial development. Aberrant expression of noncoding RNAs has been implicated in the pathogenesis of craniofacial abnormalities, providing potential therapeutic targets.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Hideru Togashi, Steven Ray Davis, Makoto Sato
Summary: Tile patterns, regulated by cell adhesion molecules, are regular arrangements of cells that play important functional roles in multicellular organisms. The physical constraints and cell adhesion regulate both cell shape and tissue morphogenesis.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Armen Khanbabei, Lina Segura, Cynthia Petrossian, Aaron Lemus, Ithan Cano, Courtney Frazier, Armen Halajyan, Donnie Ca, Mariano Loza-Coll
Summary: This article investigates the genetic regulatory mechanisms of Drosophila intestinal stem cells. The study found that most target genes co-regulated by Esg and STAT show a consistent gene expression pattern. However, manipulating these validated targets in vivo rarely replicated the effects of manipulating Esg and STAT, suggesting the presence of complex genetic interactions among the downstream targets of these two master regulator genes.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Bayley J. Waters, Zoe R. Birman, Matthew R. Wagner, Julia Lemanski, Barak Blum
Summary: Researchers found that conditional deletion of Robo2 in adult mice led to a significant loss of islet architecture without affecting beta cell identity or function, suggesting that Robo2 plays a role in actively maintaining adult islet architecture. Understanding the factors required for islet architecture maintenance is crucial for developing future diabetes therapies.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Rhiannon Clements, Tyler Smith, Luke Cowart, Jennifer Zhumi, Alan Sherrod, Aidan Cahill, Ginger L. Hunter
Summary: Cell protrusions play a crucial role in regulating cell activities during development. By studying the regulation mechanism in fruit fly sensory bristle patterning, it was found that Myosin XV is essential for the dynamics of signaling filopodia and promotes long-range Notch signaling.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Margaret Keating, Ryan Hagle, Daniel Osorio-Mendez, Anjelica Rodriguez-Parks, Sarah I. Almutawa, Junsu Kang
Summary: Knock-in reporter (KI) animals are essential for studying gene expression in biomedical research. This study developed a new strategy using minicircle technology and a minimal promoter to enhance knock-in events and establish stable KI transgenic reporter lines. The study also highlighted the importance of selecting the proper KI line due to potential inappropriate influence of genome editing on reporter gene expression.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Christian Altbuerger, Meta Rath, Daniel Armbruster, Wolfgang Driever
Summary: This study reveals that Neurog1 and Olig2 transcription factors have differential requirements for the development of dopaminergic neurons, and they integrate local patterning signals and Notch neurogenic selection signaling to specify the progenitor population and initiate neurogenesis and differentiation.
DEVELOPMENTAL BIOLOGY
(2024)