Article
Chemistry, Multidisciplinary
Xinran Shen, Yudi Deng, Liqiang Chen, Chendong Liu, Lian Li, Yuan Huang
Summary: In this study, a targeted nanosystem was developed to efficiently deliver anticancer therapeutics into the endoplasmic reticulum (ER), triggering ER stress and autophagy. The effects of an autophagy enhancer and inhibitor on ER-related activities were compared, and it was found that the autophagy enhancer increased the antimetastasis effect of ER-targeting therapy, while the autophagy inhibitor had little effect. Mechanistic studies revealed that the autophagy enhancer accelerated the degradation of the protein SNAI1 and suppressed epithelial-mesenchymal transition, while inhibiting autophagy had the opposite effect. Furthermore, ER-targeting therapy combined with the autophagy enhancer induced a stronger immune response and tumor inhibition compared to the autophagy inhibitor. Mechanistic studies showed that the autophagy enhancer increased calcium release from the ER, leading to immunogenic cell death and triggering immune responses. Overall, the autophagy-enhancing strategy is more beneficial for ER-targeting therapy in antitumor and antimetastasis treatment.
Article
Biochemistry & Molecular Biology
Masuelli Sofia, Real Sebastian, Campoy Emanuel, Maria Teresita Branham, Diego Matias Marzese, Salomon Matthew, Gerardo De Blas, Arias Rodolfo, Levin Michael, Roque Maria
Summary: This study discovered differential DNA methylation and bioelectric differences between left-sided and right-sided breast tumors, which were associated with tumor proliferation. These findings provide new targets for future breast cancer therapeutic approaches.
MOLECULAR MEDICINE
(2022)
Article
Neurosciences
Leah T. Johnstone, Emma M. Karlsson, David P. Carey
Summary: Neuroscientific techniques show that left-handers have more unusual cerebral asymmetries for language compared to right-handers, with left-handers demonstrating less lateralization for language, faces, and bodies when they have typical cerebral asymmetries.
Article
Biochemistry & Molecular Biology
Jianguo Wang, Sidi Ma, Peijie Yu, Xionglei He
Summary: The human brain exhibits anatomical symmetry, but also possesses fine-scale structural asymmetries that contribute to distinct functional divisions. Previous studies suggested that these asymmetric structures are primate specific or unique to humans, indicating recent evolution of genes responsible for human brain asymmetry. In our study, we identified over 1,500 traits associated with human brain asymmetry and discovered approximately 200 genes that are predominantly upregulated in brain tissues. Surprisingly, these genes are evolutionarily ancient and show brain-specific upregulation in humans, indicating the role of ancient genes in shaping the structural asymmetry of the human brain over time.
MOLECULAR BIOLOGY AND EVOLUTION
(2023)
Article
Multidisciplinary Sciences
Xin-Xin Fu, Ding-Hao Zhuo, Ying-Jie Zhang, Yun-Fei Li, Xiang Liu, Yan-Yi Xing, Ying Huang, Yi-Fan Wang, Tao Cheng, Dan Wang, Si-Han Chen, Yi-Jian Chen, Guan-Nan Jiang, Fu- Lu, Yu Feng, Xiao Huang, Jun Ma, Wei Liu, Ge Bai, Peng-Fei Xu
Summary: The emergence of left-right (LR) asymmetry in a patterning field along the anterior-posterior axis is still an unresolved problem in developmental biology. This study identifies Follistatin (Fst) as a regulator that restricts the propagation of Nodal ortholog Southpaw (Spaw) in the right lateral plate mesoderm (LPM) and facilitates the establishment of a robust LR asymmetric Nodal patterning. Furthermore, Fst inhibits the Activin-Nodal signaling pathway in the forebrain, contributing to the orderly propagation of asymmetric Nodal activation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Cell Biology
Ulises Ahumada-Castro, Galdo Bustos, Eduardo Silva-Pavez, Andrea Puebla-Huerta, Alenka Lovy, Cesar Cardenas
Summary: Recent studies have shown that cross-organelle communication plays a significant role in metabolism, with calcium ions playing a crucial role in this process, especially in cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Applied
Shane M. Hickey, Ian R. D. Johnson, Elena Dallerba, Mark J. Hackett, Massimiliano Massi, Joanna Lazniewska, Lauren A. Thurgood, Frederick M. Pfeffer, Douglas A. Brooks, Trent D. Ashton
Summary: We introduce a highly fluorescent, solvatochromic, 1,8-naphthalimide probe that enables the simultaneous imaging of lipid droplets and endoplasmic reticulum, with distinguishable emission maxima. By delineating organelles based on their emission profiles, we are able to visualize lipid droplet biogenesis and intercellular trafficking events. Furthermore, this probe demonstrates potential histochemical applications by staining myelin lipids in ex vivo brain tissue.
Article
Psychology, Biological
Zhiqiang Sha, Dick Schijven, Amaia Carrion-Castillo, Marc Joliot, Bernard Mazoyer, Simon E. Fisher, Fabrice Crivello, Clyde Francks
Summary: Genes associated with brain asymmetry are linked to microtubule-related genes and embryonic brain expression, and have overlap with genetic variants related to autism, educational attainment, and schizophrenia. Left-right hemispheric asymmetry is crucial for healthy brain organization and language functions, but the mechanism behind establishing the human brain's left-right axis remains unidentified.
NATURE HUMAN BEHAVIOUR
(2021)
Review
Immunology
Jana Messias Sandes, Regina Celia Bressan Queiroz de Figueiredo
Summary: The endoplasmic reticulum (ER) is an important organelle in higher eukaryotic cells responsible for protein folding and assembly. It undergoes strict quality control to ensure proper processing of proteins, with unfolded proteins being targeted for degradation through the ER-associated degradation (ERAD) complex. Additionally, the ER responds to stress through the unfolded protein response (UPR) to restore homeostasis or induce cell death. Protozoan parasites such as Trypanosoma cruzi, Trypanosoma brucei, and Leishmania spp. also have similar ER structures and stress response mechanisms, making them attractive targets for chemotherapy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Developmental Biology
Brent H. Wyatt, Nirav M. Amin, Kristen Bagley, Dustin Wcisel, Michael K. Dush, Jeffrey A. Yoder, Nanette M. Nascone-Yoder
Summary: This study reveals the role of single-minded 2 gene in regulating left-right symmetry in the development of frog embryo stomach, further illustrating the importance of laterality factors in morphogenesis.
Article
Cell Biology
Eriko Kajikawa, Toru Miki, Masayoshi Takeda, Hiroshi Kiyonari, Hiroshi Hamada
Summary: The evolutionary diversity of brain left-right asymmetry was examined by studying reptile embryos. The Chinese softshell turtle and the red-eared slider turtle showed left-sided expression of certain genes in the developing forebrain, while this asymmetry was not detected in the Madagascar ground gecko. These findings suggest that brain left-right asymmetry varies even among reptiles.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Teije C. Middelkoop, Julia Garcia-Baucells, Porfirio Quintero-Cadena, Lokesh G. Pimpale, Shahrzad Yazdi, Paul W. Sternberg, Peter Gross, Stephan W. Grill
Summary: This study demonstrates that the active torque generation dependent on CYK-1/Formin plays a crucial role in chiral symmetry breaking of actomyosin flows, driving left-right symmetry breaking in the nematode worm. The activity of Non-Muscle Myosin II, on the other hand, promotes cortical actomyosin flows but is not essential for chiral symmetry breaking.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Naiara Demnitz, Kathrine Skak Madsen, Line K. Johnsen, Michael Kjaer, Carl-Johan Boraxbekk, Hartwig R. Siebner
Summary: The study found that older adults show similar trends of asymmetry in the white matter microstructure of the corticospinal tract and dexterity as adolescents, but to a lesser degree. However, unlike adolescents, there was no evidence of a linear relationship between CST microstructure asymmetry and dexterity in older adults.
Article
Management
Laszlo Csato
Summary: This paper compares the performance of the eigenvalue method and the row geometric mean as two weighting procedures. Through numerical experiments, it is found that the priorities derived from the two eigenvectors in the eigenvalue method do not always agree, while the row geometric mean serves as a compromise between them.
EUROPEAN JOURNAL OF OPERATIONAL RESEARCH
(2024)
Article
Neurosciences
Helena Verhelst, Thijs Dhollander, Robin Gerrits, Guy Vingerhoets
Summary: Language is predominantly lateralised to the left hemisphere in over 90% of the population. Research using fixel-based analysis found a consistent pattern of white matter lateralisation, with the arcuate fasciculus showing leftward lateralisation regardless of functional language dominance. In addition, a significant group difference in lateralisation was observed in the forceps minor, with leftward lateralisation in the LLD group and rightward lateralisation in the RLD group.
Article
Cardiac & Cardiovascular Systems
Kyle D. Hope, Yan Wang, Maalika M. Banerjee, Andrea E. Montero, Natesa G. Pandian, Anirban Banerjee
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2019)
Review
Peripheral Vascular Disease
Kyle D. Hope, Justin P. Zachariah
CURRENT HYPERTENSION REPORTS
(2019)
Article
Neurosciences
Caleb A. Doll, Katie M. Yergert, Bruce H. Appel
Editorial Material
Cardiac & Cardiovascular Systems
Kyle Hope, Iki Adachi
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2020)
Article
Cardiac & Cardiovascular Systems
Kyle D. Hope, Subhrajit Lahiri, Athar M. Qureshi
CARDIOLOGY IN THE YOUNG
(2020)
Review
Cardiac & Cardiovascular Systems
Devyani Chowdhury, Kyle D. Hope, Lindsay C. Arthur, Sharon M. Weinberger, Christina Ronai, Jonathan N. Johnson, Christopher S. Snyder
PEDIATRIC CARDIOLOGY
(2020)
Review
Cardiac & Cardiovascular Systems
Talha Niaz, Kyle Hope, Michael Fremed, Nilanjana Misra, Carrie Altman, Julie Glickstein, Joan Sanchez-de-Toledo, Alain Fraisse, Jacob Miller, Christopher Snyder, Jonathan N. Johnson, Devyani Chowdhury
Summary: COVID-19 affects patients of all ages, including children, who may develop MIS-C with similarities to Kawasaki disease but also distinct differences, such as more severe gastrointestinal symptoms and cardiovascular involvement.
PEDIATRIC CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Katie M. Yergert, Caleb A. Doll, Rebecca O'Rouke, Jacob H. Hines, Bruce Appel
Summary: The text discusses the formation and growth process of myelin sheaths, as well as the impact of local mechanisms and mRNA localization on the maturation of myelin sheaths. The study found that consensus sequences in the 3'UTR can determine the enrichment of mRNA in myelin sheaths.
Editorial Material
Cardiac & Cardiovascular Systems
Kyle D. Hope, Mohan M. John, Iki Adachi
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Neurosciences
Caleb A. Doll, Kayt Scott, Bruce Appel
Summary: Research has found that Fmrp regulates cell specification in pMN progenitor cells, leading to fewer motor neurons and excess OPCs in fmr1 mutant zebrafish, while also promoting the differentiation of OPCs. The results suggest that Fmrp has cell stage-specific requirements for the specification and differentiation of oligodendrocyte lineage cells.
Article
Pediatrics
Swati Choudhry, William J. Dreyer, Kyle D. Hope, Yunfei Wang, Joseph A. Spinner, Hari P. Tunuguntla, Antonio G. Cabrera, Jack F. Price, Susan W. Denfield
Summary: Pediatric HLT is a rare but acceptable option for recipients with combined end-organ failure, with intermediate survival outcomes comparable to those of single-organ recipients.
PEDIATRIC TRANSPLANTATION
(2021)
Review
Pediatrics
Natasha S. Afonso, Margaret R. Ninemire, Sharada H. Gowda, Jaime L. Jump, Regina L. Lantin-Hermoso, Karen E. Johnson, Kriti Puri, Kyle D. Hope, Erin Kritz, Barbara-Jo Achuff, Lindsey Gurganious, Priya N. Bhat
Summary: Patients with perinatal and neonatal congenital heart disease have higher morbidity and mortality, often requiring chronic care and placing a burden on their families. The COVID-19 pandemic has added significant stressors, highlighting the need for early pediatric palliative care consultation for improved communication and coping. Despite barriers, integrating pediatric palliative care earlier is essential for providing high-quality interdisciplinary care to patients and families.
Review
Pediatrics
Kyle D. Hope, Priya N. Bhat, William J. Dreyer, Barbara A. Elias, Jaime L. Jump, Gina Santucci, Natasha S. Afonso, Margaret R. Ninemire, Barbara-Jo Achuff, Erin M. Kritz, Sharada H. Gowda, Kriti Puri
Summary: Pediatric heart failure is a life-changing diagnosis for children and their families, with pediatric palliative care playing a crucial role in providing support throughout the journey, including grief support, discussions on goals of care, and psychosocial support.
Article
Cardiac & Cardiovascular Systems
Michael A. Fremed, Talha Niaz, Kyle D. Hope, Carolyn A. Altman, Victor Y. Levy, Julie S. Glickstein, Jonathan N. Johnson
Summary: During the initial surge of the COVID-19 pandemic, paediatric heart centres in the United States made changes such as decreasing procedures, limiting visitors, and transitioning to telemedicine encounters to minimize interruption to patient care and exposure to the virus. The information from this study can be helpful in guiding and standardizing responses to future public health crises.
CARDIOLOGY IN THE YOUNG
(2022)
Article
Pharmacology & Pharmacy
Joseph E. Rower, Autumn McKnite, Borah Hong, Kevin P. Daly, Kyle D. Hope, Antonio G. Cabrera, Kimberly M. Molina
Summary: This study validated a population pharmacokinetic model for personalized dosing of the immunosuppressant tacrolimus in pediatric heart transplant patients. The model identified weight as a significant covariate and successfully predicted future tacrolimus concentrations using as few as three concentrations. These findings support the potential clinical utility of the population PK model for personalized dosing guidance.
Review
Developmental Biology
Cheng Shi, Pengfei Jiao, Zhiyi Chen, Lan Ma, Siyue Yao
Summary: This review discusses the molecular etiology of congenital craniofacial abnormalities, with a focus on the role and mechanism of noncoding RNAs in regulating craniofacial development. Aberrant expression of noncoding RNAs has been implicated in the pathogenesis of craniofacial abnormalities, providing potential therapeutic targets.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Hideru Togashi, Steven Ray Davis, Makoto Sato
Summary: Tile patterns, regulated by cell adhesion molecules, are regular arrangements of cells that play important functional roles in multicellular organisms. The physical constraints and cell adhesion regulate both cell shape and tissue morphogenesis.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Armen Khanbabei, Lina Segura, Cynthia Petrossian, Aaron Lemus, Ithan Cano, Courtney Frazier, Armen Halajyan, Donnie Ca, Mariano Loza-Coll
Summary: This article investigates the genetic regulatory mechanisms of Drosophila intestinal stem cells. The study found that most target genes co-regulated by Esg and STAT show a consistent gene expression pattern. However, manipulating these validated targets in vivo rarely replicated the effects of manipulating Esg and STAT, suggesting the presence of complex genetic interactions among the downstream targets of these two master regulator genes.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Bayley J. Waters, Zoe R. Birman, Matthew R. Wagner, Julia Lemanski, Barak Blum
Summary: Researchers found that conditional deletion of Robo2 in adult mice led to a significant loss of islet architecture without affecting beta cell identity or function, suggesting that Robo2 plays a role in actively maintaining adult islet architecture. Understanding the factors required for islet architecture maintenance is crucial for developing future diabetes therapies.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Rhiannon Clements, Tyler Smith, Luke Cowart, Jennifer Zhumi, Alan Sherrod, Aidan Cahill, Ginger L. Hunter
Summary: Cell protrusions play a crucial role in regulating cell activities during development. By studying the regulation mechanism in fruit fly sensory bristle patterning, it was found that Myosin XV is essential for the dynamics of signaling filopodia and promotes long-range Notch signaling.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Margaret Keating, Ryan Hagle, Daniel Osorio-Mendez, Anjelica Rodriguez-Parks, Sarah I. Almutawa, Junsu Kang
Summary: Knock-in reporter (KI) animals are essential for studying gene expression in biomedical research. This study developed a new strategy using minicircle technology and a minimal promoter to enhance knock-in events and establish stable KI transgenic reporter lines. The study also highlighted the importance of selecting the proper KI line due to potential inappropriate influence of genome editing on reporter gene expression.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Christian Altbuerger, Meta Rath, Daniel Armbruster, Wolfgang Driever
Summary: This study reveals that Neurog1 and Olig2 transcription factors have differential requirements for the development of dopaminergic neurons, and they integrate local patterning signals and Notch neurogenic selection signaling to specify the progenitor population and initiate neurogenesis and differentiation.
DEVELOPMENTAL BIOLOGY
(2024)