Article
Cell Biology
Kira Mitchel, Jenna M. Bergmann, Ava E. Brent, Tova M. Finkelstein, Kyra A. Schindler, Miriam A. Holzman, Lucie Jeannotte, Jennifer H. Mansfield
Summary: The skeletal system originates from multiple embryonic sources and must develop in coordination, particularly across the lateral somitic frontier. Hox genes play a regulatory role in skeletal pattern, but there are still questions about the genetic control of this coordination, especially in structures like the sternum. The embryology of the presternum, a recently identified structure, is not well described in mouse models.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Amit Walia, Joshua Mendoza, Craig A. Bollig, Ethan J. Craig, Ryan S. Jackson, Jason T. Rich, Sidharth Puram, Sean T. Massa, Patrik Pipkorn
Summary: Short- and long-term complications are common after oromandibular reconstruction, with early complications and prior radiation being important predictive factors for late complications. There was no difference in plate complications among different free flap types, and dental implantation and use of VSP were not associated with hardware complications.
Article
Developmental Biology
Lindsey M. F. Mao, Erin A. T. Boyle Anderson, Robert K. Ho
Summary: This study elucidates asymmetrical contributions of aLPM-derived heart precursors in zebrafish, with twice as many heart precursors arising from the right side versus the left side of the embryo, dependent upon Tbx5a expression. Tbx5a is also implicated in cell specification, establishment, and maintenance of cardiac left-right asymmetry.
DEVELOPMENTAL BIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
G. Muftuoglu, B. Bayram, P. Aydin
Summary: This study aims to analyze and compare the stress distribution on bone screws and plate systems in locking and non-locking screw-plate designs in lateral mandibular defects. The results show that the locking system exhibits lower and more uniform stress values on the bone and hardware systems compared to the conventional plate model.
JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY
(2021)
Article
Dentistry, Oral Surgery & Medicine
C. Bowe, D. Butler, J. Dhanda, A. Gulati, P. Norris, B. Bisase
Summary: Reconstructing a lateral posterior segmental mandibular defect with a bridging MRP and ALT free flap provides a robust alternative option for patients not suitable for osseous reconstruction. Most patients had oral cavity squamous cell carcinoma, with a high success rate but also some complications.
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2021)
Article
Orthopedics
Patrick Hickland, Christopher Goodland, Sunil Zachariah, Lynn E. Murphy, Martyn Neil
Summary: The study evaluated different methods of internal fixation for lateral clavicle fractures and found no clear favored method in their regional trauma unit. They suggested considering concomitant coracoclavicular ligament reconstruction when using locking plate fixation, and highlighted the high re-operation rate after hook plate fixation.
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2023)
Article
Medicine, General & Internal
Vikas Vikas, Naval Bhatia, Divesh Jalan, Jatin Prakash, Jujhar Singh, Shailendra Khare
Summary: Surgical treatment of Neer type II lateral end clavicle fractures using pre-contoured locking distal clavicle plate along with coracoclavicular reconstruction with endobutton and No. 2 fiberwire resulted in excellent clinical outcomes with no major complications, and good functional and radiological assessments at one-year follow-up.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Orthopedics
Temi D. Ogunleye, Anthony J. Dugarte, Jeffrey A. Gilbertson, Peter A. Cole
Summary: This study retrospectively assessed the surgical and functional outcomes of patients who underwent surgical repair using a variable angle, locking mesh plate for complex acromion nonunions and severely comminuted fracture patterns. The results showed that most patients achieved union after surgery and had acceptable functional and health scores.
TECHNIQUES IN ORTHOPAEDICS
(2022)
Article
Biology
Moya M. Smith, Zerina Johanson, Thomas Butts, Rolf Ericsson, Melinda Modrell, Frank J. Tulenko, Marcus C. Davis, Gareth J. Fraser
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2015)
Article
Biology
Frank J. Tulenko, James L. Massey, Elishka Holmquist, Gabriel Kigundu, Sarah Thomas, Susan M. E. Smith, Sylvie Mazan, Marcus C. Davis
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2017)
Article
Evolutionary Biology
Christopher A. Sheil, Michael Jorgensen, Frank Tulenko, Sean Harrington
EVOLUTION & DEVELOPMENT
(2014)
Article
Multidisciplinary Sciences
Frank J. Tulenko, David W. McCauley, Ethan L. MacKenzie, Sylvie Mazan, Shigeru Kuratani, Fumiaki Sugaharad, Rie Kusakabe, Ann C. Burke
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
Article
Multidisciplinary Sciences
Frank J. Tulenko, Gaius J. Augustus, James L. Massey, Seth E. Sims, Sylvie Mazan, Marcus C. Davis
SCIENTIFIC REPORTS
(2016)
Article
Anatomy & Morphology
Frank J. Tulenko, Christopher A. Sheil
JOURNAL OF MORPHOLOGY
(2007)
Review
Developmental Biology
Cheng Shi, Pengfei Jiao, Zhiyi Chen, Lan Ma, Siyue Yao
Summary: This review discusses the molecular etiology of congenital craniofacial abnormalities, with a focus on the role and mechanism of noncoding RNAs in regulating craniofacial development. Aberrant expression of noncoding RNAs has been implicated in the pathogenesis of craniofacial abnormalities, providing potential therapeutic targets.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Hideru Togashi, Steven Ray Davis, Makoto Sato
Summary: Tile patterns, regulated by cell adhesion molecules, are regular arrangements of cells that play important functional roles in multicellular organisms. The physical constraints and cell adhesion regulate both cell shape and tissue morphogenesis.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Armen Khanbabei, Lina Segura, Cynthia Petrossian, Aaron Lemus, Ithan Cano, Courtney Frazier, Armen Halajyan, Donnie Ca, Mariano Loza-Coll
Summary: This article investigates the genetic regulatory mechanisms of Drosophila intestinal stem cells. The study found that most target genes co-regulated by Esg and STAT show a consistent gene expression pattern. However, manipulating these validated targets in vivo rarely replicated the effects of manipulating Esg and STAT, suggesting the presence of complex genetic interactions among the downstream targets of these two master regulator genes.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Bayley J. Waters, Zoe R. Birman, Matthew R. Wagner, Julia Lemanski, Barak Blum
Summary: Researchers found that conditional deletion of Robo2 in adult mice led to a significant loss of islet architecture without affecting beta cell identity or function, suggesting that Robo2 plays a role in actively maintaining adult islet architecture. Understanding the factors required for islet architecture maintenance is crucial for developing future diabetes therapies.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Rhiannon Clements, Tyler Smith, Luke Cowart, Jennifer Zhumi, Alan Sherrod, Aidan Cahill, Ginger L. Hunter
Summary: Cell protrusions play a crucial role in regulating cell activities during development. By studying the regulation mechanism in fruit fly sensory bristle patterning, it was found that Myosin XV is essential for the dynamics of signaling filopodia and promotes long-range Notch signaling.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Margaret Keating, Ryan Hagle, Daniel Osorio-Mendez, Anjelica Rodriguez-Parks, Sarah I. Almutawa, Junsu Kang
Summary: Knock-in reporter (KI) animals are essential for studying gene expression in biomedical research. This study developed a new strategy using minicircle technology and a minimal promoter to enhance knock-in events and establish stable KI transgenic reporter lines. The study also highlighted the importance of selecting the proper KI line due to potential inappropriate influence of genome editing on reporter gene expression.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Christian Altbuerger, Meta Rath, Daniel Armbruster, Wolfgang Driever
Summary: This study reveals that Neurog1 and Olig2 transcription factors have differential requirements for the development of dopaminergic neurons, and they integrate local patterning signals and Notch neurogenic selection signaling to specify the progenitor population and initiate neurogenesis and differentiation.
DEVELOPMENTAL BIOLOGY
(2024)