期刊
DEVELOPMENTAL BIOLOGY
卷 348, 期 2, 页码 231-243出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2010.09.014
关键词
Atonal; Senseless; Proneural; Abdominal A; Hox; EGF; Sensory organ precursor; Rhomboid; Oenocyte
资金
- Neurofibroma pilot award
- NIH [R01GM079428, R01EY017907]
The atonal (ato) proneural gene specifies a stereotypic number of sensory organ precursors (SOP) within each body segment of the Drosophila ectoderm Surprisingly the broad expression of Ato within the ectoderm results in only a modest increase in SOP formation suggesting many cells are incompetent to become SOPs Here we show that the SOP promoting activity of Ato can be greatly enhanced by three factors the Sens( less (Sens) zinc finger protein the Abdominal-A (Abd-A) Hox factor and the epidermal growth factor (I G F) pathway First we show that expression of either Ato alone or with Sens induces twice as many SOPs in the abdomen as in the thorax and do so at the expense of an abdomen-specific cell fate the larval oenocytes Second we demonstrate that Ato stimulates abdominal SOP formation by synergizing with Abd A to promote EGF ligand (Spitz) secretion and secondary SOP recruitment However we also found that Ato and Sens selectively enhance abdominal SOP development in a Spitz-independent manner suggesting additional genetic interactions between this proneural pathway and Abd-A Altogether these experiments reveal that genetic interactions between EGF-signaling Abd-A and Sens enhance the SOP promoting activity of Ato to stimulate region-specific neurogenesis in the Drosophila abdomen (C) 2010 Elsevier Inc All rights reserved
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据