Article
Ophthalmology
Sandeep Kumar, Pascal Dolle, Norbert B. Ghyselinck, Gregg Duester
EXPERIMENTAL EYE RESEARCH
(2017)
Article
Cell Biology
Thomas J. Cunningham, Michael S. Yu, Wesley L. McKeithan, Sean Spiering, Florent Carrette, Chun-Teng Huang, Paul J. Bushway, Matthew Tierney, Sonia Albini, Mauro Giacca, Miguel Mano, Pier Lorenzo Puri, Alessandra Sacco, Pilar Ruiz-Lozano, Jean-Francois Riou, Muriel Umbhauer, Gregg Duester, Mark Mercola, Alexandre R. Colas
GENES & DEVELOPMENT
(2017)
Article
Developmental Biology
Marie Berenguer, Joseph J. Lancman, Thomas J. Cunningham, P. Duc Si Dong, Gregg Duester
DEVELOPMENTAL BIOLOGY
(2018)
Correction
Neurosciences
Yang Wang, Yue Li, Minghui Yue, Jun Wang, Sandeep Kumar, Robert J. Wechsler-Reya, Zhaolei Zhang, Yuya Ogawa, Manolis Kellis, Gregg Duester, Jing Crystal Zhao
NATURE NEUROSCIENCE
(2018)
Article
Neurosciences
Yang Wang, Yue Li, Minghui Yue, Jun Wang, Sandeep Kumar, Robert J. Wechsler-Reya, Zhaolei Zhang, Yuya Ogawa, Manolis Kellis, Gregg Duester, Jing Crystal Zhao
NATURE NEUROSCIENCE
(2018)
Article
Cell Biology
Thomas J. Cunningham, Joseph J. Lancman, Marie Berenguer, P. Duc Si Dong, Gregg Duester
Letter
Genetics & Heredity
Gregg Duester
TRENDS IN GENETICS
(2019)
Article
Developmental Biology
Norbert B. Ghyselinck, Gregg Duester
Article
Multidisciplinary Sciences
David Sala, Thomas J. Cunningham, Michael J. Stec, Usue Etxaniz, Chiara Nicoletti, Alessandra Dall'Agnese, Pier Lorenzo Puri, Gregg Duester, Lucia Latella, Alessandra Sacco
NATURE COMMUNICATIONS
(2019)
Article
Multidisciplinary Sciences
Kazuya Ono, James Keller, Omar Lopez Ramirez, Antonia Gonzalez Garrido, Omid A. Zobeiri, Hui Ho Vanessa Chang, Sarath Vijayakumar, Andrianna Ayiotis, Gregg Duester, Charles C. Della Santina, Sherri M. Jones, Kathleen E. Cullen, Ruth Anne Eatock, Doris K. Wu
NATURE COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Marie Berenguer, Karolin F. Meyer, Jun Yin, Gregg Duester
Review
Biochemistry & Molecular Biology
Marie Berenguer, Gregg Duester
Summary: The role of retinoic acid (RA) and Meis1/2 in limb development is complex, with RA activating Meis1/2 in the proximal limb bud mesoderm while FGF8 represses Meis1/2 in the distal limb to generate proximodistal patterning.
Review
Cell Biology
Gregg Duester
Summary: Retinoic acid (RA) plays a crucial role in vertebrate eye development by controlling the transcriptional activity of RA receptors (RARs). It stimulates the folding of the optic vesicle to form the optic cup and is required for further morphogenesis of the optic cup and surrounding mesenchyme.
Review
Endocrinology & Metabolism
Marie Berenguer, Gregg Duester
Summary: Vitamin A (retinol) is a crucial nutrient for embryonic development and adult health. Retinoic acid (RA), a metabolite of retinol, controls gene expression directly through nuclear RA receptors (RARs) and is required for the normal development of various organs and tissues in early stages. Genetic loss-of-function studies have played an instrumental role in understanding the importance of RA signaling in normal early development.
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2022)
Editorial Material
Cell & Tissue Engineering
Gregg Duester
REGENERATIVE MEDICINE
(2022)
Review
Developmental Biology
Cheng Shi, Pengfei Jiao, Zhiyi Chen, Lan Ma, Siyue Yao
Summary: This review discusses the molecular etiology of congenital craniofacial abnormalities, with a focus on the role and mechanism of noncoding RNAs in regulating craniofacial development. Aberrant expression of noncoding RNAs has been implicated in the pathogenesis of craniofacial abnormalities, providing potential therapeutic targets.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Hideru Togashi, Steven Ray Davis, Makoto Sato
Summary: Tile patterns, regulated by cell adhesion molecules, are regular arrangements of cells that play important functional roles in multicellular organisms. The physical constraints and cell adhesion regulate both cell shape and tissue morphogenesis.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Armen Khanbabei, Lina Segura, Cynthia Petrossian, Aaron Lemus, Ithan Cano, Courtney Frazier, Armen Halajyan, Donnie Ca, Mariano Loza-Coll
Summary: This article investigates the genetic regulatory mechanisms of Drosophila intestinal stem cells. The study found that most target genes co-regulated by Esg and STAT show a consistent gene expression pattern. However, manipulating these validated targets in vivo rarely replicated the effects of manipulating Esg and STAT, suggesting the presence of complex genetic interactions among the downstream targets of these two master regulator genes.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Bayley J. Waters, Zoe R. Birman, Matthew R. Wagner, Julia Lemanski, Barak Blum
Summary: Researchers found that conditional deletion of Robo2 in adult mice led to a significant loss of islet architecture without affecting beta cell identity or function, suggesting that Robo2 plays a role in actively maintaining adult islet architecture. Understanding the factors required for islet architecture maintenance is crucial for developing future diabetes therapies.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Rhiannon Clements, Tyler Smith, Luke Cowart, Jennifer Zhumi, Alan Sherrod, Aidan Cahill, Ginger L. Hunter
Summary: Cell protrusions play a crucial role in regulating cell activities during development. By studying the regulation mechanism in fruit fly sensory bristle patterning, it was found that Myosin XV is essential for the dynamics of signaling filopodia and promotes long-range Notch signaling.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Margaret Keating, Ryan Hagle, Daniel Osorio-Mendez, Anjelica Rodriguez-Parks, Sarah I. Almutawa, Junsu Kang
Summary: Knock-in reporter (KI) animals are essential for studying gene expression in biomedical research. This study developed a new strategy using minicircle technology and a minimal promoter to enhance knock-in events and establish stable KI transgenic reporter lines. The study also highlighted the importance of selecting the proper KI line due to potential inappropriate influence of genome editing on reporter gene expression.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Christian Altbuerger, Meta Rath, Daniel Armbruster, Wolfgang Driever
Summary: This study reveals that Neurog1 and Olig2 transcription factors have differential requirements for the development of dopaminergic neurons, and they integrate local patterning signals and Notch neurogenic selection signaling to specify the progenitor population and initiate neurogenesis and differentiation.
DEVELOPMENTAL BIOLOGY
(2024)