Article
Cell Biology
Maria-Bernadette Madel, He Fu, Dominique D. Pierroz, Mariano Schiffrin, Carine Winkler, Anne Wilson, Cecile Pochon, Barbara Toffoli, Mahdia Taieb, Jean-Yves Jouzeau, Federica Gilardi, Serge Ferrari, Nicolas Bonnet, Claudine Blin-Wakkach, Beatrice Desvergne, David Moulin
Summary: The study investigated the impact of adipocyte deficiency on bone homeostasis in mice, revealing that adiponectin can inhibit osteoclastogenesis and block mature osteoclast activity by activating AMPK. This research provides potential new approaches to treat osteoporosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Yurie Sato, Masahiro Hosonuma, Daiki Sugawara, Yuki Azetsu, Akiko Karakawa, Masahiro Chatani, Takahiro Funatsu, Masamichi Takami, Nobuhiro Sakai
Summary: The study found that a diet high in both fat and cholesterol can induce bone loss, while diets high in fat or cholesterol alone do not affect bone mass.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Endocrinology & Metabolism
Xiangjiao Yi, Xin Liu, H. Mark Kenney, Rong Duan, Xi Lin, Edward Schwarz, Zhenqiang Yao
Summary: The study evaluated the effects of anti-TNF therapy on osteoporosis in an animal model of RA and found that while it can block the development of erosive arthritis, it only slightly increases vertebral and trabecular bone mass, which may be related to the mechanisms of osteoblast stimulation.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hye Jung Ihn, Jiwon Lim, Kiryeong Kim, Sang-Hyeon Nam, Soomin Lim, Su Jeong Lee, Jong-Sup Bae, Tae Hoon Kim, Jung-Eun Kim, Moon-Chang Baek, Yong Chul Bae, Eui Kyun Park
Summary: Ciclopirox effectively inhibits osteoclast differentiation and bone resorption both in vitro and in vivo, making it a potential candidate for preventing osteoporosis and other osteoclast-related bone diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Multidisciplinary
Qi Zhuang, Shuangshuang Chen, Wei Zhang, Minhui Gu, Long Xiao, Yajun Li, Yunshang Yang, Chengcheng Feng, Hong Li, Dechun Geng, Zhirong Wang
Summary: Osteoporosis is characterized by bone loss and degeneration, leading to an increased risk of fractures and impacting the health of middle-aged and elderly individuals. Drug therapy, the main treatment for osteoporosis, is limited in efficacy and often associated with side effects. Therefore, developing new, effective, and safe treatment methods is crucial. Avicularin, a flavonoid derivative, was shown to disrupt osteoclast activation and resorptive function, preventing their activity. It achieved this by inhibiting the NF-kappa B pathway and downregulating osteoclast-related genes. Treatment with Avicularin also improved bone mineral density in an osteoporosis mouse model.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Parichart Toejing, Nithidol Sakunrangsit, Pinyada Pho-on, Chinnatam Phetkong, Asada Leelahavanichkul, Somyoth Sridurongrit, Matthew B. Greenblatt, Sutada Lotinun
Summary: In this study, transgenic mice expressing constitutively active TGF-beta receptor type I were found to have osteopenia due to increased osteoclast number and decreased osteoblast number, possibly by suppressing Hedgehog signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Lieve Verlinden, Stefanie Doms, Iris Janssens, Mark B. B. Meyer, J. Wesley Pike, Geert Carmeliet, Annemieke Verstuyf
Summary: Neuropilin 2 (NRP2) plays a role in bone homeostasis by regulating osteoblasts and osteoclasts. The expression of NRP2 in osteoblasts is induced by 1,25-dihydroxyvitamin D-3. Deletion of NRP2 in osteoblasts results in reduced bone mass, while deletion in osteoclasts does not have a bone phenotype.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Letizia Pelusi, Domitilla Mandatori, Nadia Di Pietrantonio, Francesco Del Pizzo, Pamela Di Tomo, Natalia Di Pietro, Roberto Buda, Salvatore Genovese, Francesco Epifano, Assunta Pandolfi, Serena Fiorito, Caterina Pipino
Summary: Bone physiology is regulated by osteoblast and osteoclast activities. This study demonstrates that the coumarin derivative umbelliferon (UF) enhances the activity of osteoblasts from osteoporotic patients through estrogen receptor 1 (ESR1) and the activation of the beta-catenin pathway. UF also reduces the multinucleated cells involved in bone resorption. These findings suggest that UF may be a potential natural compound for the prevention and treatment of bone loss diseases.
Article
Multidisciplinary Sciences
Susan MacLauchlan, Priyanka Kushwaha, Albert Tai, Sijia Chen, Catherine Manning, Gaurav Swarnkar, Yousef Abu-Amer, Katherine A. Fitzgerald, Shruti Sharma, Ellen M. Gravallese
Summary: Stimulator of interferon genes (STING) mediates interferon signaling and plays a crucial role in regulating homeostatic processes, including osteoclast differentiation and bone homeostasis. STING prevents trabecular bone loss in mice and influences osteoclast precursor differentiation through the regulation of interferon-stimulated genes (ISGs). These findings provide evidence for the important role of STING pathway in bone homeostasis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Kimberly K. Richardson, Wen Ling, Kimberly Krager, Qiang Fu, Stephanie D. Byrum, Rupak Pathak, Nukhet Aykin-Burns, Ha-Neui Kim
Summary: This study found that exposure to multiple fractions of low-dose radiation or a single exposure to the same total dose of radiation can cause a decrease in trabecular bone mass in male mice. The damaging effect is associated with highly activated bone resorption and increased expression and activity of Sirt3, a protein essential for osteoclast mitochondrial activity. Osteoclast progenitors lacking Sirt3 exhibit impaired resorptive activity when exposed to radiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Bhaba K. Das, Lei Wang, Toshifumi Fujiwara, Jian Zhou, Nukhet Aykin-Burns, Kimberly J. Krager, Renny Lan, Samuel G. Mackintosh, Ricky Edmondson, Michael L. Jennings, Xiaofang Wang, Jian Q. Feng, Tomasa Barrientos, Jyoti Gogoi, Aarthi Kannan, Ling Gao, Weirong Xing, Subburaman Mohan, Haibo Zhao
Summary: Increased intracellular iron through Tfr1-mediated iron uptake is essential for mitochondrial metabolism and cytoskeletal organization in osteoclasts, leading to proper bone resorption and skeletal homeostasis.
Article
Physiology
Priyanka Kushwaha, Nathalie S. Alekos, Soohyun P. Kim, Zhu Li, Michael J. Wolfgang, Ryan C. Riddle
Summary: Mitochondrial long chain fatty acid oxidation plays a crucial role in normal bone resorption by osteoclasts.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Rachel Freid, Amira Hussein, Jennifer J. Schlezinger
Summary: The study investigated the effects of diet, ovariectomy, and TBT exposure on bone structure in mice, finding that TBT can protect against trabecular bone loss to some extent, especially under a low-fat diet.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
H. Yoon, H. J. Kim, H. R. Shin, B. S. Kim, W. J. Kim, Y. D. Cho, H. M. Ryoo
Summary: The study demonstrates that nicotinamide improves delayed tooth eruption in Runx2(+/-) mice through the restoration of decreased osteoclastogenesis, suggesting it as a potential therapeutic drug for dental abnormalities in patients with CCD.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Engineering, Biomedical
Zhen Geng, Luli Ji, Zhaoyang Li, Jing Wang, Hongyan He, Zhenduo Cui, Xianjin Yang, Changsheng Liu
Summary: This study fabricated a series of apatite and Sr-substituted apatite coatings using electrochemical deposition, showing that the coatings with Sr at high pH conditions promoted MSCs adhesion, proliferation, and osteogenic differentiation, while inhibiting osteoclast activity. In vivo experiments demonstrated that nano-needle-like Sr-substituted apatite coatings significantly improved new bone formation and bone-implant integration.
BIOACTIVE MATERIALS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Seiji Kobuke, Shigeki Suzuki, Hiroaki Hoshino, Naoto Haruyama, Fusanori Nishimura, Hideki Shiba
ARCHIVES OF ORAL BIOLOGY
(2015)
Article
Multidisciplinary Sciences
Kanako Miyazaki, Keigo Yoshizaki, Chieko Arai, Aya Yamada, Kan Saito, Masaki Ishikawa, Han Xue, Keita Funada, Naoto Haruyama, Yoshihiko Yamada, Satoshi Fukumoto, Ichiro Takahashi
Article
Dentistry, Oral Surgery & Medicine
Y. Furukawa, N. Haruyama, M. Nikaido, M. Nakanishi, N. Ryu, M. Oh-Hora, K. Kuremoto, K. Yoshizaki, Y. Takano, I. Takahashi
JOURNAL OF DENTAL RESEARCH
(2017)
Article
Dentistry, Oral Surgery & Medicine
Akira Suzuki, Masayuki Nakano, Keigo Yoshizaki, Atsushi Yasunaga, Naoto Haruyama, Ichiro Takahashi
CLEFT PALATE-CRANIOFACIAL JOURNAL
(2017)
Article
Multidisciplinary Sciences
Chieko Arai, Keigo Yoshizaki, Kanako Miyazaki, Kan Saito, Aya Yamada, Xue Han, Keita Funada, Emiko Fukumoto, Naoto Haruyama, Tsutomu Iwamoto, Ichiro Takahashi, Satoshi Fukumoto
SCIENTIFIC REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Shigeki Suzuki, Hiroaki Hoshino, Kazuma Yoshida, Jun Nakanishi, Shizu Tsuchiya-Hirata, Seiji Kobuke, Naoto Haruyama, Fusanori Nishimura, Hideki Shiba
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Dentistry, Oral Surgery & Medicine
K. Mitani, N. Haruyama, J. Hatakeyama, K. Igarashi
Article
Multidisciplinary Sciences
Andrew Cho, Naoto Haruyama, Bradford Hall, Mary Jo S. Danton, Lu Zhang, Praveen Arany, David J. Mooney, Yassine Harichane, Michel Goldberg, Carolyn W. Gibson, Ashok B. Kulkarni
Article
Multidisciplinary Sciences
Shigeki Suzuki, Seiji Kobuke, Naoto Haruyama, Hiroaki Hoshino, Ashok B. Kulkarni, Fusanori Nishimura
Article
Dentistry, Oral Surgery & Medicine
Jun Nakanishi, Shigeki Suzuki, Kazuma Yoshida, Shizu Hirata-Tsuchiya, Naoto Haruyama, Satoru Yamada, Hideki Shiba
ARCHIVES OF ORAL BIOLOGY
(2020)
Article
Health Care Sciences & Services
Takao Minamidate, Naoto Haruyama, Ichiro Takahashi
HEALTH AND QUALITY OF LIFE OUTCOMES
(2020)
Article
Multidisciplinary Sciences
Kyoko Tsuji, Naoto Haruyama, Shunsuke Nomura, Naohisa Murata, Keigo Yoshizaki, Takeshi Mitsuyasu, Hiroyuki Nakano, Seiji Nakamura, Yoshihide Mori, Ichiro Takahashi
Summary: This study categorized and analyzed craniofacial morphology in patients with isolated cleft palate (ICP), identifying three characteristic morphological patterns. Understanding these typical characteristics can improve diagnostic categorization and orthodontic treatment planning for patients with ICP.
Article
Multidisciplinary Sciences
Naoto Haruyama, Takayoshi Yamaza, Shigeki Suzuki, Bradford Hall, Andrew Cho, Carolyn W. Gibson, Ashok B. Kulkarni
Summary: Amelogenins, particularly LRAP, play important roles in bone turnover by regulating bone formation and osteoclastogenesis. Transgenic mice overexpressing LRAP showed enhanced bone formation, inhibited osteoclastogenesis, and resistance to bone loss, highlighting the potential therapeutic implications of LRAP in treating osteoporosis.
Article
Dentistry, Oral Surgery & Medicine
Takao Minamidate, Naoto Haruyama, Ayako Inoue, Shunsuke Nomura, Kenshi Noguchi, Keigo Yoshizaki, Ichiro Takahashi
Summary: This study evaluated the effects of secondary bone grafting (SBG) on oral health-related and generic health-related quality of life (OHRQOL and HRQOL) in preadolescent orthodontic patients with alveolar bone defects. The results showed that SBG and orthodontic treatment had a relatively small impact on the quality of life of the preadolescent children. Understanding the influence of SBG and patient factors on quality of life would enable better treatment and care for these patients.
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Mao Sato, Yoshiyuki Baba, Naoto Haruyama, Norihisa Higashihori, Michiko Tsuji, Shoichi Suzuki, Keiji Moriyama
Review
Developmental Biology
Cheng Shi, Pengfei Jiao, Zhiyi Chen, Lan Ma, Siyue Yao
Summary: This review discusses the molecular etiology of congenital craniofacial abnormalities, with a focus on the role and mechanism of noncoding RNAs in regulating craniofacial development. Aberrant expression of noncoding RNAs has been implicated in the pathogenesis of craniofacial abnormalities, providing potential therapeutic targets.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Hideru Togashi, Steven Ray Davis, Makoto Sato
Summary: Tile patterns, regulated by cell adhesion molecules, are regular arrangements of cells that play important functional roles in multicellular organisms. The physical constraints and cell adhesion regulate both cell shape and tissue morphogenesis.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Armen Khanbabei, Lina Segura, Cynthia Petrossian, Aaron Lemus, Ithan Cano, Courtney Frazier, Armen Halajyan, Donnie Ca, Mariano Loza-Coll
Summary: This article investigates the genetic regulatory mechanisms of Drosophila intestinal stem cells. The study found that most target genes co-regulated by Esg and STAT show a consistent gene expression pattern. However, manipulating these validated targets in vivo rarely replicated the effects of manipulating Esg and STAT, suggesting the presence of complex genetic interactions among the downstream targets of these two master regulator genes.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Bayley J. Waters, Zoe R. Birman, Matthew R. Wagner, Julia Lemanski, Barak Blum
Summary: Researchers found that conditional deletion of Robo2 in adult mice led to a significant loss of islet architecture without affecting beta cell identity or function, suggesting that Robo2 plays a role in actively maintaining adult islet architecture. Understanding the factors required for islet architecture maintenance is crucial for developing future diabetes therapies.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Rhiannon Clements, Tyler Smith, Luke Cowart, Jennifer Zhumi, Alan Sherrod, Aidan Cahill, Ginger L. Hunter
Summary: Cell protrusions play a crucial role in regulating cell activities during development. By studying the regulation mechanism in fruit fly sensory bristle patterning, it was found that Myosin XV is essential for the dynamics of signaling filopodia and promotes long-range Notch signaling.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Margaret Keating, Ryan Hagle, Daniel Osorio-Mendez, Anjelica Rodriguez-Parks, Sarah I. Almutawa, Junsu Kang
Summary: Knock-in reporter (KI) animals are essential for studying gene expression in biomedical research. This study developed a new strategy using minicircle technology and a minimal promoter to enhance knock-in events and establish stable KI transgenic reporter lines. The study also highlighted the importance of selecting the proper KI line due to potential inappropriate influence of genome editing on reporter gene expression.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Christian Altbuerger, Meta Rath, Daniel Armbruster, Wolfgang Driever
Summary: This study reveals that Neurog1 and Olig2 transcription factors have differential requirements for the development of dopaminergic neurons, and they integrate local patterning signals and Notch neurogenic selection signaling to specify the progenitor population and initiate neurogenesis and differentiation.
DEVELOPMENTAL BIOLOGY
(2024)