期刊
DEVELOPMENTAL BIOLOGY
卷 327, 期 1, 页码 97-105出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2008.11.019
关键词
DAF-2; DAF-16; FOXO; HLH-13; Ptf1a; Dauer; Development; Caenorhabditis elegans; Insulin signaling
资金
- Ellison Medical Foundation [R01]
- NIA [AG024425-01]
- PCCW Affinito/Stewart Grant
- GAANN
- CVG Scholar Award
Insulin/IGF-signaling (IIS) affects longevity, stress resistance and metabolism in worms, flies, and mammals. The Forkhead transcription factor DAF-16/FOXO is the major downstream effector of [IS and is responsible for the activation and repression of genes that mediate the diverse effects of IIS. We surveyed a set of informatically predicted conserved DAF-16/FOXO target genes and identified the novel DAF-16 direct target hlh-13. hlh-13 is the predicted homolog of the mammalian transcription factor Ptf1a, a critical determinant of pancreatic development. We found that an hlh-13 Mutant exits L1 arrest and IIS-dependent dauer diapause faster than control worms, but is not involved in lifespan or resistance to a variety of stresses. Our results have identified a novel DAF-16 target gene and linked its function to known outputs of IIS. Considering the high conservation of IIS in diverse species, our results also hint at an intriguing connection of IIS and Ptf1a in mammals. (C) 2008 Elsevier Inc. All rights reserved.
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