Review
Cell Biology
Lucas A. B. Fisher, Frieder Schock
Summary: The ability of multicellular animals to move is achieved through rearrangement of cytoskeleton. ALP/Enigma family proteins, characterized by PDZ and LIM domains, play a crucial role in facilitating this process in various cellular environments, and have implications in muscle-related diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Nicanor Gonzalez Morales, Oceane Marescal, Szilard Szikora, Anja Katzemich, Tuana Correia-Mesquita, Peter Biro, Miklos Erdelyi, Jozsef Mihaly, Frieder Schock
Summary: Myofibrils are intracellular cables specific to muscles composed of actin and myosin filaments. Sarcomeres, repeated units of actin and myosin filaments, form myofibrils. Zasp proteins control the diameter of myofibrils and the E1 subunit of the oxoglutarate dehydrogenase complex is recruited to the Z-disc by Zasp52. The three subunits of the oxoglutarate dehydrogenase complex are necessary for myofibril formation and an amino acid imbalance affecting protein synthesis may cause myofibril defects.
JOURNAL OF CELL SCIENCE
(2023)
Article
Developmental Biology
Lesley N. Weaver, Daniela Drummond-Barbosa
Summary: The study reveals the crucial roles of nuclear receptor signaling in controlling reproduction, with Hormone receptor 4 (Hr4) identified as an oogenesis regulator required in the ovary and muscles. Hr4 is essential for germline stem cell maintenance, follicle growth, and early germline cyst survival, highlighting the complexity of nuclear receptor regulation in oogenesis.
Review
Biochemistry & Molecular Biology
Kirsty Wadmore, Amar J. Azad, Katja Gehmlich
Summary: The Z-disc is crucial for maintaining the structure and signaling function of the sarcomere in muscle cells. Six key Z-disc proteins, associated with myopathies and cardiomyopathies, play a significant role in force transduction and intracellular signaling. Evaluating the pathogenic variants and minor allele frequency of these proteins in population cohorts can help in re-evaluating their pathogenicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Yotam Blech-Hermoni, Kalpana Subedi, Maya Silver, Leah Jensen, Stephen Coscia, Malcolm M. Kates, Yongmei Zhao, Castle Raley, Nancy Edwards, Bao Tran, Abhik Ray-Chaudhary, Pankaj Pathak, Ami Mankodi
Summary: LDB3, a member of the Enigma family of PDZ-LIM proteins, is widely expressed in the central and peripheral nervous system and plays important roles in actin cytoskeleton remodeling and neural development. Alternative splicing of LDB3 in neurons suggests splicing-dependent regulation of its expression. The expression of LDB3 in various regions of the brain and its interaction with other proteins indicate its relevance in motor planning, execution, and neurogenic manifestations in muscle diseases.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Fritz G. Rathjen, Rene Juettner
Summary: The immunoglobulin-like cell adhesion molecule CLMP, a member of the CAR family of cell adhesion proteins, is involved in the development of human congenital short-bowel syndrome (CSBS), which is characterized by defective intestinal elongation and impaired peristalsis. This review compares data from CSBS patients and a mouse knockout model, revealing the role of CLMP in the coordination of calcium signaling via gap junctions and the reduction of connexin43 levels in the intestine. Additionally, the mutations in the CLMP gene also affect other organs and tissues, including the ureter, leading to severe bilateral hydronephrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Jolanta Korczak, Marcin Mardas, Maria Litwiniuk, Pawel Bogdanski, Marta Stelmach-Mardas
Summary: This study aimed to assess the nutritional status, including sarcopenia development based on CT scans, in prostate cancer patients and its association with progression-free survival (PFS). The results showed that nutritional status was significantly related to PFS. There was a significant reduction in muscle tissue and increase in fat tissue in patients, but it had no impact on PFS. The study recommends assessing nutritional status and body composition using CT after castration therapy.
Article
Oncology
Shashipavan Chillappagari, Julian Schwarz, Vidyasagar Kesireddy, Jessica Knoell, Martina Korfei, Konrad Hoetzenecker, M. Lienhard Schmitz, Christian Behl, Saverio Bellusci, Andreas Guenther, Poornima Mahavadi
Summary: This study found that modulation of autophagy regulating proteins can be used as a therapeutic strategy for idiopathic pulmonary fibrosis (IPF). By improving autophagy and reducing fibroblast proliferation, fine tuning of this pathway may improve antifibrotic properties and enhance the efficacy of current IPF therapy.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Soon-Young Jung, Tae-Ryong Riew, Hye Hyeon Yun, Ji Hee Lim, Ji-Won Hwang, Sung Won Jung, Hong Lim Kim, Jae-Seon Lee, Mun-Yong Lee, Jeong-Hwa Lee
Summary: BIS is involved in physiological functions such as anti-apoptosis, cell proliferation, autophagy, and senescence. Bis-SMKO mice exhibit growth retardation, kyphosis, a lack of peripheral fat, and respiratory failure, ultimately leading to early death. BIS plays a critical role in protein homeostasis and energy metabolism in skeletal muscles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Peripheral Vascular Disease
Ben Ma, Elaina Melton, Robert Wiener, Ning Zhou, Wenqian Wu, Lo Lai, Charles Wang, Kevin D. Costa, Hongyu Qiu
Summary: The study found that aging-induced aortic stiffening is more prominent in hypertensive rats compared to normotensive rats. Hypertension-induced high blood pressure leads to more significant aortic stiffening in older normotensive rats. The combination of aging and hypertension has additive effects on aortic stiffness.
Article
Endocrinology & Metabolism
Ching-Ti Liu, Timothy Tsai, Brett T. Allaire, Mary L. Bouxsein, Marian T. Hannan, Thomas G. Travison, Douglas P. Kiel
Summary: This study examines the association between changes in visceral adipose tissue (VAT) over 6 years and paraspinal muscle density, finding that greater accumulation of VAT is associated with lower muscle density.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Yuxuan Li, Juan Hou, Rongfeng Chen
Summary: Although TACE is a recommended treatment for HCC, there is debate over selecting the best candidate for treatment. We studied the prognostic value of nutritional markers, obesity, visceral obesity, and sarcopenia on survival outcomes. By combining multiple factors, including SMI, VFI, A/G ratio, and BMI, we obtained more accurate comprehensive prognostic factors. Sarcopenic visceral obesity, defined by SMI and VFI, was found to be the most effective prognostic indicator for HCC compared to other single or combined assessments. It provides a more objective and accurate prediction of survival.
Article
Plant Sciences
Tamara Mendez, Yazmina Stappung, Maria A. Moya-Leon, Raul Herrera
Summary: Arabinogalactan proteins (AGPs) are a family of proteins that play important roles in cell wall dynamics. The study of inclined pines suggests that AGPs have a higher concentration on one side of the stem and their accumulation in xylem and cell wall tissues is enhanced when the tree stem loses verticality. Differential gene expression of AGPs indicates their involvement in the early response to inclination and their ability to trigger signals for lignin accumulation and cell wall thickening to restore vertical growth of the stem.
Article
Gastroenterology & Hepatology
Xiangqin He, Kunzhe Dong, Jian Shen, Guoqing Hu, James D. Mintz, Reem T. Atawia, Juanjuan Zhao, Xiuxu Chen, Robert W. Caldwell, Meixiang Xiang, David W. Stepp, David J. Fulton, Jiliang Zhou
Summary: This study reveals the critical role of Carmn, a specific long noncoding RNA (lncRNA), in regulating the contractility and phenotype of gastrointestinal smooth muscle cells (SMCs). Loss of Carmn function leads to impaired gastrointestinal motility and disease, indicating the essential role of Carmn in maintaining the function of SMCs in the gut.
Editorial Material
Critical Care Medicine
Victor Valentin, Jean-Francois Bervar, Catherine Vincent-Delorme, Thomas Smol, Lidwine Wemeau, Martine Remy, Olivier Le Rouzic, Cecile Chenivesse
Summary: Emphysema is a chronic respiratory disorder characterized by destruction of alveoli, usually caused by smoking or exposure to noxious particles or gases. Dysfunctions in proteins related to lung development and maintenance can also contribute to emphysema. Identifying new risk factors for emphysema can lead to screening, prevention, and monitoring efforts, as well as genetic testing in early-onset emphysema cases.
Article
Developmental Biology
K. Mahala Burn, Yuko Shimada, Kathleen Ayers, Feiyue Lu, Andrew M. Hudson, Lynn Cooley
DEVELOPMENTAL BIOLOGY
(2015)
Article
Genetics & Heredity
Andrew M. Hudson, Katelynn M. Mannix, Lynn Cooley
Article
Cell Biology
Andrew M. Hudson, Lynn Cooley
JOURNAL OF CELL BIOLOGY
(2010)
Article
Biochemical Research Methods
Andrew M. Hudson, Lynn Cooley
Article
Multidisciplinary Sciences
Girish Neelakanta, Andrew M. Hudson, Hameeda Sultana, Lynn Cooley, Erol Fikrig
Article
Developmental Biology
Andrew M. Hudson, Katelynn M. Mannix, Julianne A. Gerdes, Molly C. Kottemann, Lynn Cooley
Article
Developmental Biology
Ronit S. Kaufman, Kari L. Price, Katelynn M. Mannix, Kathleen M. Ayers, Andrew M. Hudson, Lynn Cooley
Article
Genetics & Heredity
Ana T. Quinones-Coello, Lisa N. Petrella, Kathleen Ayers, Anthony Melillo, Stacy Mazzalupo, Andrew M. Hudson, Shu Wang, Claudia Castiblanco, Michael Buszczak, Roger A. Hoskins, Lynn Cooley
Article
Biochemistry & Molecular Biology
V Stevenson, A Hudson, L Cooley, WE Theurkauf
Article
Cell Biology
AM Hudson, L Cooley
JOURNAL OF CELL BIOLOGY
(2002)
Article
Cell Biology
RJ Kelso, AM Hudson, L Cooley
JOURNAL OF CELL BIOLOGY
(2002)
Article
Cell Biology
JA Zallen, Y Cohen, AM Hudson, L Cooley, E Wieschaus, ED Schejter
JOURNAL OF CELL BIOLOGY
(2002)
Article
Developmental Biology
W Bender, A Hudson
Review
Developmental Biology
Cheng Shi, Pengfei Jiao, Zhiyi Chen, Lan Ma, Siyue Yao
Summary: This review discusses the molecular etiology of congenital craniofacial abnormalities, with a focus on the role and mechanism of noncoding RNAs in regulating craniofacial development. Aberrant expression of noncoding RNAs has been implicated in the pathogenesis of craniofacial abnormalities, providing potential therapeutic targets.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Hideru Togashi, Steven Ray Davis, Makoto Sato
Summary: Tile patterns, regulated by cell adhesion molecules, are regular arrangements of cells that play important functional roles in multicellular organisms. The physical constraints and cell adhesion regulate both cell shape and tissue morphogenesis.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Armen Khanbabei, Lina Segura, Cynthia Petrossian, Aaron Lemus, Ithan Cano, Courtney Frazier, Armen Halajyan, Donnie Ca, Mariano Loza-Coll
Summary: This article investigates the genetic regulatory mechanisms of Drosophila intestinal stem cells. The study found that most target genes co-regulated by Esg and STAT show a consistent gene expression pattern. However, manipulating these validated targets in vivo rarely replicated the effects of manipulating Esg and STAT, suggesting the presence of complex genetic interactions among the downstream targets of these two master regulator genes.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Bayley J. Waters, Zoe R. Birman, Matthew R. Wagner, Julia Lemanski, Barak Blum
Summary: Researchers found that conditional deletion of Robo2 in adult mice led to a significant loss of islet architecture without affecting beta cell identity or function, suggesting that Robo2 plays a role in actively maintaining adult islet architecture. Understanding the factors required for islet architecture maintenance is crucial for developing future diabetes therapies.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Rhiannon Clements, Tyler Smith, Luke Cowart, Jennifer Zhumi, Alan Sherrod, Aidan Cahill, Ginger L. Hunter
Summary: Cell protrusions play a crucial role in regulating cell activities during development. By studying the regulation mechanism in fruit fly sensory bristle patterning, it was found that Myosin XV is essential for the dynamics of signaling filopodia and promotes long-range Notch signaling.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Margaret Keating, Ryan Hagle, Daniel Osorio-Mendez, Anjelica Rodriguez-Parks, Sarah I. Almutawa, Junsu Kang
Summary: Knock-in reporter (KI) animals are essential for studying gene expression in biomedical research. This study developed a new strategy using minicircle technology and a minimal promoter to enhance knock-in events and establish stable KI transgenic reporter lines. The study also highlighted the importance of selecting the proper KI line due to potential inappropriate influence of genome editing on reporter gene expression.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Christian Altbuerger, Meta Rath, Daniel Armbruster, Wolfgang Driever
Summary: This study reveals that Neurog1 and Olig2 transcription factors have differential requirements for the development of dopaminergic neurons, and they integrate local patterning signals and Notch neurogenic selection signaling to specify the progenitor population and initiate neurogenesis and differentiation.
DEVELOPMENTAL BIOLOGY
(2024)