Review
Clinical Neurology
M. Scarabello, A. Righini, M. Severino, L. Pinelli, C. Parazzini, E. Scola, G. Palumbo, M. Di Maurizio, I D'Errico, A. Rossi, F. Triulzi, P. D. Griffiths
Summary: Ganglionic eminence anomalies are associated with specific neurodevelopmental anomalies, with cavitations and increased volume showing different associated abnormalities.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Article
Neurosciences
Kseniia Prokofeva, Yuki C. Saito, Yasutaka Niwa, Seiya Mizuno, Satoru Takahashi, Arisa Hirano, Takeshi Sakurai
Summary: To understand the regulation of sleep-wakefulness cycles, it is important to study the relationship between the preoptic area (POA) and lateral hypothalamic area (LHA), which have opposing roles in sleep-wakefulness regulation. This study revealed the direct connection between GABA- and galanin-producing neurons in the ventrolateral preoptic nucleus (VLPO) and orexin-producing neurons in the LHA. It also discovered that the VLPOGABA-LHA pathway plays a previously unknown role in the regulation of sleep and wakefulness.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Kevin R. Coffey, Vaishnavi Venkat, Mark O. West, David J. Barker
Summary: Neurons in the lateral preoptic area show varied responses to different components of drug self-administration. The majority of these neurons signal the operant response with increases in spiking activity.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Review
Neurosciences
Sarah L. Reitz, Max B. Kelz
Summary: The hypothalamic preoptic area (POA) plays a crucial role in regulating arousal states in both natural and drug-induced forms of unconsciousness. While known for promoting sleep and wake, the complexity and molecular heterogeneity of the POA make it challenging to distinguish between different populations of neurons involved in these processes.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Lindsay A. Pickett, Jonathan W. VanRyzin, Ashley E. Marquardt, Margaret M. McCarthy
Summary: The SDN-POA is a sexually dimorphic brain structure that is larger in males and is associated with mating preference. Microglia play a crucial role in reducing the size of the SDN in females by engulfing more neurons. Inhibiting microglia phagocytosis increases the SDN volume in females and affects their preference for male odors in adulthood.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Physiology
Nicolas M. Diaz, Shannon A. Gordon, Richard A. Lang, Ethan D. Buhr
Summary: Mammals regulate their body temperature by utilizing internal circadian clocks and thermosensitivity. The preoptic area of the hypothalamus houses temperature-sensitive circadian clocks that are influenced by temperature changes but not by light cues.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Neurosciences
Rebecca Rothhaas, Shinjae Chung
Summary: Sleep and body temperature are tightly interconnected in mammals, with the preoptic area of the hypothalamus playing a crucial role in regulating these behaviors. Recent research on sleep- and thermo-regulatory POA neurons has raised new questions about the overlap and pathways of these neurons and the role of signaling molecules in coordinating sleep and body temperature regulation.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Santosh Rijal, Seon Hui Jang, Soo Joung Park, Seong Kyu Han
Summary: Lithium salt can disrupt the neuroendocrine axis by modulating GABAergic synaptic activities in hypothalamic neurons, although the precise mechanisms involved are not fully understood yet.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Krystyna Bogus-Nowakowska, Anna Robak, Daniel Kalinowski, Anna Kozlowska, Maciej Rowniak
Summary: In the guinea pig preoptic area (POA), most CB+ and CR+ neurons are GABAergic and express VGAT, while a fraction of them also express VGLUT. The majority of PV+ neurons express VGAT, and a similar proportion of them express VGLUT. This indicates that these neurons may have a dual GABA/glutamate phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Jianhui Xu, Wenmin Gao, Tianhui He, Lan Yao, Hanghong Wu, Zhenwei Chen, Yupei Lai, Yajun Chen, Jie Zhang
Summary: This study found that injection of agmatine into the preoptic area (POA) of male rats induced hyperthermic responses associated with increased heat production and locomotor activity. The most effective injection sites were located in the medial preoptic area (MPA). Results suggest that agmatine injection can cause thermogenic, shivering, and locomotor responses by inhibiting warm-sensitive neurons in the POA.
JOURNAL OF THERMAL BIOLOGY
(2023)
Article
Computer Science, Information Systems
Tiao Kang, Hui Peng, Wenquan Xu, Yapeng Sun, Xiaoyan Peng
Summary: In this paper, a deep learning network combined with the SD-ARX model framework is proposed to build a nonlinear system model. Different hybrid models, including RNN-ARX, CNN-ARX, and RNN-CNN-ARX, are built to extract the dynamic characteristics of nonlinear systems. Based on these models, three model-based predictive control strategies are designed, and the feasibility and effectiveness are validated through real-time control experiments.
Article
Neurosciences
Yunyun Zhang, Huiming Li, Xinxin Zhang, Sa Wang, Dan Wang, Jiajia Wang, Tingting Tong, Zhen Zhang, Qianzi Yang, Hailong Dong
Summary: A recent study has found that there are sex differences in response to general anesthesia, but the neural mechanisms behind this are unclear. This study showed that male mice were more sensitive to sevoflurane anesthesia and that estrogen receptor alpha in the medial preoptic area played a critical role in regulating sleep in males. Furthermore, pharmacological inhibition of estrogen receptor alpha eliminated sex differences in sevoflurane anesthesia.
NEUROSCIENCE BULLETIN
(2022)
Article
Neurosciences
Marcos Garcia-Juarez, Ailyn Luna-Hernandez, Sandra Tapia-Hernandez, Omar Montes-Narvaez, Raymundo Dominguez-Ordonez, Miriam B. Tecamachaltzi-Silvaran, James G. Pfaus, Oscar Gonzalez-Flores
Summary: This study investigated the effect of apelin-13 on different brain areas at varying doses, and found that it can induce lordosis behavior, with a more pronounced effect in the VMH of EB-primed rats, and only the 0.75 μg infusion of apelin in the POA induced significant lordosis at 120 and 240 min.
NEUROSCIENCE LETTERS
(2022)
Review
Neurosciences
Sneha Sagarkar, Amit G. Choudhary, Nagalakshmi Balasubramanian, Sanjay N. Awathale, Amita R. Somalwar, Namrata Pawar, Dadasaheb M. Kokare, Nishikant K. Subhedar, Amul J. Sakharkar
Summary: This study focuses on the role of LSD1 in modulating BDNF expression during positive reinforcement, with LSD1 driving BDNF expression in the lateral hypothalamus through histone demethylation to promote synaptic plasticity.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Neurosciences
Rashmi Joglekar, Marty Cauley, Taylor Lipsich, David L. Corcoran, Heather B. Patisaul, Edward D. Levin, Joel N. Meyer, Margaret M. McCarthy, Susan K. Murphy
Summary: Nicotine exposure during development may affect the sexual differentiation of the developing brain, potentially influencing adult sexual behavior in rodents. This study found that developmental nicotine exposure had an impact on the sexual differentiation of the preoptic area (POA) in rats, with the normal sex differences in male sexual behavior and POA area eliminated in nicotine-treated animals. In neonates, nicotine exposure also induced changes in gene expression and DNA methylation levels at sexually-dimorphic regions, suggesting the involvement of epigenetic mechanisms in the masculinization of the rat POA.
Review
Developmental Biology
Cheng Shi, Pengfei Jiao, Zhiyi Chen, Lan Ma, Siyue Yao
Summary: This review discusses the molecular etiology of congenital craniofacial abnormalities, with a focus on the role and mechanism of noncoding RNAs in regulating craniofacial development. Aberrant expression of noncoding RNAs has been implicated in the pathogenesis of craniofacial abnormalities, providing potential therapeutic targets.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Hideru Togashi, Steven Ray Davis, Makoto Sato
Summary: Tile patterns, regulated by cell adhesion molecules, are regular arrangements of cells that play important functional roles in multicellular organisms. The physical constraints and cell adhesion regulate both cell shape and tissue morphogenesis.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Armen Khanbabei, Lina Segura, Cynthia Petrossian, Aaron Lemus, Ithan Cano, Courtney Frazier, Armen Halajyan, Donnie Ca, Mariano Loza-Coll
Summary: This article investigates the genetic regulatory mechanisms of Drosophila intestinal stem cells. The study found that most target genes co-regulated by Esg and STAT show a consistent gene expression pattern. However, manipulating these validated targets in vivo rarely replicated the effects of manipulating Esg and STAT, suggesting the presence of complex genetic interactions among the downstream targets of these two master regulator genes.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Bayley J. Waters, Zoe R. Birman, Matthew R. Wagner, Julia Lemanski, Barak Blum
Summary: Researchers found that conditional deletion of Robo2 in adult mice led to a significant loss of islet architecture without affecting beta cell identity or function, suggesting that Robo2 plays a role in actively maintaining adult islet architecture. Understanding the factors required for islet architecture maintenance is crucial for developing future diabetes therapies.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Rhiannon Clements, Tyler Smith, Luke Cowart, Jennifer Zhumi, Alan Sherrod, Aidan Cahill, Ginger L. Hunter
Summary: Cell protrusions play a crucial role in regulating cell activities during development. By studying the regulation mechanism in fruit fly sensory bristle patterning, it was found that Myosin XV is essential for the dynamics of signaling filopodia and promotes long-range Notch signaling.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Margaret Keating, Ryan Hagle, Daniel Osorio-Mendez, Anjelica Rodriguez-Parks, Sarah I. Almutawa, Junsu Kang
Summary: Knock-in reporter (KI) animals are essential for studying gene expression in biomedical research. This study developed a new strategy using minicircle technology and a minimal promoter to enhance knock-in events and establish stable KI transgenic reporter lines. The study also highlighted the importance of selecting the proper KI line due to potential inappropriate influence of genome editing on reporter gene expression.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Christian Altbuerger, Meta Rath, Daniel Armbruster, Wolfgang Driever
Summary: This study reveals that Neurog1 and Olig2 transcription factors have differential requirements for the development of dopaminergic neurons, and they integrate local patterning signals and Notch neurogenic selection signaling to specify the progenitor population and initiate neurogenesis and differentiation.
DEVELOPMENTAL BIOLOGY
(2024)
