期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 44, 期 1, 页码 235-244出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2013.12.012
关键词
Pre- and post-natal period; Mucosal immunity; IgA; Gut; flora; Milk; Pig
The current review focuses on pre- and post-natal development of intestinal immunoglobulin A (IgA) production in pig. IgA production is influenced by intrinsic genetic factors in the foetus as well as extrinsic environmental factors during the post-natal period. At birth, piglets are exposed to new antigens through maternal colostrums/milk as well as exogenous microbiota. This exposure to new antigens is critical for the proper development of the gut mucosal immune system and is characterized mainly by the establishment of IgA response. A second critical period for neonatal intestinal immune system development occurs at weaning time when the gut environment is exposed to new dietary antigens. Neonate needs to establish oral tolerance and in the absence of protective milk need to fight potential new pathogens. To improve knowledge about the immune response in the neonates, it is important to identify intrinsic and extrinsic factors which influence the intestinal immune system development and to elucidate their mechanism of action. (C) 2014 Elsevier Ltd. All rights reserved.
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