期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 41, 期 4, 页码 491-497出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2013.07.015
关键词
Innate immunity; Phagocytosis; Ran; S2 cells
资金
- National Basic Research Program of China [2012CB114403]
- Hi-Tech Research and Development Program of China (863 program of China) [2012AA092205-2]
- Ministry of Agriculture, China [201103034]
Phagocytosis plays important roles in innate and adaptive immunity in animals. Some small G proteins are found to be related to phagocytosis. However, the Ran GTPase has not been intensively characterized in immunity. In this paper, the sequence analysis showed that the Ran was highly conserved in animals, suggesting that its function was preserved during animal evolution. The results showed that Ran was upregulated in S2 cells in response to DCV infection. It was further revealed that the antiviral phagocytosis could be mediated by Ran in S2 cells. By comparison with the early marker and late marker of phagosomes, the results showed that the Ran protein played an essential role at the early stage of phagocytosis or throughout the entire phagocytic process. Therefore our findings enlarged our limited knowledge about the phagocytosis regulation by small G proteins concerning to the nucleus. (C) 2013 Elsevier Ltd. All rights reserved.
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