期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 39, 期 3, 页码 198-206出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2012.10.011
关键词
Influenza A virus; Dendritic cell; Innate immunity; Pathogenicity; Cytokine
资金
- Dutch Ministry of Agriculture, Nature and Food Quality
- EU [04220]
- Netherlands Organization for Scientific Research (NWO) [016.096.049]
Infection with highly pathogenic avian influenza (HPAI) in birds and mammals is associated with severe pathology and increased mortality. We hypothesize that in contrast to low pathogenicity avian influenza (LPAI) infection, HPAI infection of chicken dendritic cells (DC) induces a cytokine deregulation which may contribute to their highly pathogenic nature. Infection of DC with LPAI H7N1 and H5N2 resulted in viral RNA and NP expression without increase in time, in contrast to HPAI H7N1 and H5N2 mRNA expression. No increase in IFN mRNA was detected after infection with LPAI but after LPAI H5N2, and not LPAI H7N1, infection the level of bioactive IFN alpha/beta significantly increased. After HPAI H7N1 and H5N2 infection, significant increases in IL-8, IFN-alpha, IFN-gamma mRNA expression and in TLR1, 3, and 21 mRNA were observed. This enhanced activation of DC after HPAI infection may trigger deregulation of the immune response as seen during HPAI infection in chickens. (C) 2012 Elsevier Ltd. All rights reserved.
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