Article
Nutrition & Dietetics
Min Fu, Yuanpeng Gao, Wenxing Guo, Qi Meng, Qi Jin, Rui Yang, Ying Yang, Yaqi Zhang, Wanqi Zhang
Summary: This research investigates the compensation mechanism of iodine deficiency and excess in the mammary gland during lactation. The study found that milk iodine concentration is positively correlated with iodine intake, and the regulation of glycosylation and degradation of NIS by DPAGT1 and VCP in the mammary gland plays a role in regulating milk iodine level. However, the mammary gland has limited ability to compensate for iodine deficiency and excess.
Article
Agriculture, Dairy & Animal Science
Jinbo Wu, Shiming He, Zhonghua Yu, Daoliang Lan, Xianrong Xiong, Zhu Li
Summary: In this study, RNA-seq was used to analyze the mammary gland transcriptomes of high-yielding and low-yielding yaks during lactation. The results showed that 144 differential genes were identified, which were involved in various biological processes such as carbohydrate metabolism. This study provides new insights into the molecular mechanism of yak mammary gland tissue and potential strategies for improving milk production in yaks.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rong Xuan, Jianmin Wang, Qing Li, Yanyan Wang, Shanfeng Du, Qingling Duan, Yanfei Guo, Peipei He, Zhibin Ji, Tianle Chao
Summary: This study conducted transcriptome sequencing of goat-mammary-gland tissue at different developmental stages to reveal the expression characteristics and molecular functions of circRNAs during mammary involution. A total of 11,756 circRNAs were identified, with 2528 circRNAs expressed in all three stages. Gene ontology analysis showed functional diversity of circRNAs' source genes. Furthermore, differentially expressed circRNAs and circRNA-miRNA-mRNA ceRNA regulatory networks were identified, providing insights into the regulatory role of circRNAs in mammary cell involution and remodeling.
Article
Agriculture, Dairy & Animal Science
Wei Xia, Yili Liu, Juan J. Loor, Massimo Bionaz, Mingfeng Jiang
Summary: This study evaluated the transcriptome of mammary tissue in four yaks throughout the lactation cycle. The analysis identified over 6000 differentially expressed genes, with a large number of genes showing differential expression at the onset and end of lactation. The functions affected by transcriptomic adaptation to lactation in yak mammary tissue were similar to those observed in dairy cows, including induction of lipid metabolism, amino acid metabolism, and glycan biosynthesis, as well as suppression of the cell cycle and immune response.
Article
Cell Biology
Ivan Luzardo-Ocampo, Jose L. Dena-Beltran, Xarubet Ruiz-Herrera, Ana Luisa Ocampo-Ruiz, Gonzalo Martinez de la Escalera, Carmen Clapp, Yazmin Macotela
Summary: Obesity is a modern pandemic that negatively impacts women's reproductive health. Women with obesity experience changes in their mammary glands which affect their ability to exclusively breastfeed. The hormone prolactin, which is responsible for lactation, has reduced activity in the mammary glands of obese lactating rodents, contributing to impaired lactation. Treatment with prolactin has shown to improve milk production in women with inadequate lactation. This review focuses on the effects of diet-induced obesity on lactating mammary glands and how obesity impairs the lactogenic action of prolactin. While the impact of obesity on lactation has been studied in both humans and rodents, most of the research has been conducted on rodents.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Immunology
Dilay Cansever, Ekaterina Petrova, Sinduya Krishnarajah, Caroline Mussak, Christina A. Welsh, Wiebke Mildenberger, Kevin Mulder, Victor Kreiner, Elsa Roussel, Sebastian A. Stifter, Myrto Andreadou, Pascale Zwicky, Nicole Puertas Jurado, Hubert Rehrauer, Ge Tan, Zhaoyuan Liu, Camille Bleriot, Francesca Ronchi, Andrew J. Macpherson, Florent Ginhoux, Giancarlo Natalucci, Burkhard Becher, Melanie Greter
Summary: Macrophages play a role in immune defense, organogenesis, and tissue homeostasis. During lactation, a unique population of macrophages called liMacs emerges in the mammary gland and milk, which is similar to macrophages found in human milk.
Article
Agriculture, Dairy & Animal Science
J. Y. Dourmad, J. J. Matte
Summary: During lactation, the mammary gland in sows adapts its metabolism quickly in response to short-term changes in nutrient availability, demonstrating a rapid ability to adjust nutrient uptake and modify metabolism according to the nutrients in the bloodstream.
Article
Biochemistry & Molecular Biology
Lilia Sanchez, Jessica Epps, Steven Wall, Cole McQueen, Scott J. Pearson, Kelly Scribner, Elizabeth A. Wellberg, Erin D. Giles, Monique Rijnkels, Weston W. Porter
Summary: The functionally differentiated mammary gland adapts to extreme levels of stress by activating specific protective mechanisms. The breast tumor suppressor gene SIM2s is identified as a novel regulator of mitophagy, a key component of this stress response.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Veterinary Sciences
Weihao Chen, Xinyu Gu, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Shanhe Wang, Wei Sun
Summary: This study used RNA-seq technology to analyze the expression of miRNAs and circRNAs in sheep mammary gland during different lactation periods and identified potential miRNAs and circRNAs related to sheep mammary gland development through bioinformatics analysis.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Genetics & Heredity
Elitsa Ivanova, Sandrine Le Guillou, Cathy Hue-Beauvais, Fabienne Le Provost
Summary: The mammary gland undergoes significant anatomical and physiological changes from embryogenesis through various stages, with epigenetic mechanisms playing a crucial role in these processes. Research has shown the importance of epigenetic marks in milk component biosynthesis and highlights the involvement of DNA methylation, histone modifications, polycomb protein activity, and non-coding RNA functions in regulating gene expression in the mammary gland.
Article
Agriculture, Dairy & Animal Science
Danielle Nicole Coleman, Mario Vailati-Riboni, Russell T. Pate, Ahmad Aboragah, Daniel Luchini, Felipe C. Cardoso, Juan J. Loor
Summary: Enhanced post-ruminal supply of methionine can affect mammary metabolism and immune response. Heat stress and rumen-protected methionine have been found to influence abundance and phosphorylation of signaling proteins in mammary gland. However, rumen-protected methionine supplementation does not attenuate the inflammatory response induced by lipopolysaccharide in vitro.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Endocrinology & Metabolism
Georgia Colleluori, Jessica Perugini, Giorgio Barbatelli, Saverio Cinti
Summary: The mammary gland is an exocrine gland responsible for milk production in female mammals, composed mainly of epithelial cells and adipocytes. It displays highly plastic properties during different stages of the lactation cycle and requires close association with adipocytes for proper development. The role of adipocytes in mammary gland development and diseases like obesity and breast cancer deserves further investigation.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Article
Immunology
Chervin Hassel, Blandine Gausseres, Laurence Guzylack-Piriou, Gilles Foucras
Summary: The mammary gland in female mammals undergoes development and remodeling during lactation. Macrophages dominate the immune cell repertoire and can be subdivided into ductal and stromal macrophages. Adaptive T and B lymphocytes are remarkably less numerous at this stage.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Xiaoyun Wu, Wondossen Ayalew, Min Chu, Jie Pei, Chunnian Liang, Pengjia Bao, Xian Guo, Ping Yan
Summary: In this study, the RNA editome of the yak mammary gland during the lactation period and dry period was characterized. The findings revealed RNA editing sites associated with mammary gland development-related pathways. This research provides novel insights into the RNA editing function in the mammary gland of yaks.
Article
Genetics & Heredity
Yaqi Fei, Yedan Gai, Qingchao Liao, Linxi Zhang, Zheng Li, Bojiang Li, Man Bai, Na Li, Liang Deng
Summary: In this study, mRNA-seq and miRNA-seq were performed to investigate the regulatory profile of miRNAs and mRNAs in lactation in donkeys. The results revealed differentially expressed miRNAs and mRNAs in lactating and nonlactating groups, and identified key miRNAs that target genes involved in immunity and milk component metabolism. These findings contribute to our understanding of the molecular mechanisms regulating bioactive milk component metabolism in donkeys and have potential implications for improving milk production.
Article
Genetics & Heredity
Julie A. Sharp, Christophe Lefevre, Ashalyn Watt, Kevin R. Nicholas
FUNCTIONAL & INTEGRATIVE GENOMICS
(2016)
Article
Endocrinology & Metabolism
Ashwantha Kumar Enjapoori, Christophe M. Lefevre, Kevin R. Nicholas, Julie A. Sharp
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2017)
Review
Endocrinology & Metabolism
Julie A. Sharp, Stephen Wanyonyi, Vengama Modepalli, Ashalyn Watt, Sanjana Kuruppath, Lyn A. Hinds, Amit Kumar, Helen E. Abud, Christophe Lefevre, Kevin R. Nicholas
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2017)
Article
Physics, Applied
B. Ponraj, Julie A. Sharp, Jagat R. Kanwar, Andrew J. Sinclair, Ladge Kviz, Kevin R. Nicholas, Xiujuan J. Dai
PLASMA PROCESSES AND POLYMERS
(2017)
Article
Nutrition & Dietetics
Ashwantha Kumar Enjapoori, Sonja Kukuljan, Karen M. Dwyer, Julie A. Sharp
Article
Biochemical Research Methods
Janet Newman, Julie A. Sharp, Ashwantha Kumar Enjapoori, John Bentley, Kevin R. Nicholas, Timothy E. Adams, Thomas S. Peat
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS
(2018)
Article
Biotechnology & Applied Microbiology
Vengamanaidu Modepalli, Amit Kumar, Julie A. Sharp, Norman R. Saunders, Kevin R. Nicholas, Christophe Lefevre
Article
Biochemistry & Molecular Biology
Alok Kumar, Sadiya Parveen, Isha Sharma, Himani Pathak, Mandar V. Deshmukh, Julie A. Sharp, Satish Kumar
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2019)
Article
Biochemical Research Methods
Manjusha Neerukonda, Sivapriya Pavuluri, Isha Sharma, Alok Kumar, Purnima Sailasree, Jyothi B. Lakshmi, Julie A. Sharp, Satish Kumar
TRANSGENIC RESEARCH
(2019)
Article
Materials Science, Biomaterials
Wanjie Xie, Fei Yang, Esfandiar Pakdel, Julie Sharp, Dan Liu, Xungai Wang, Shi Zhan, Lu Sun
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2020)
Article
Cell Biology
Ashalyn P. Watt, Christophe Lefevre, Cynthia S. Wong, Kevin R. Nicholas, Julie A. Sharp
Summary: The study revealed the crucial role of insulin in mammary acinar development, highlighting its importance in secretory differentiation and function. This suggests a potential decrease in lactational efficiency in women with obesity and gestational diabetes.
CELL AND TISSUE RESEARCH
(2021)
Article
Materials Science, Biomaterials
Ehsan Farabi, Julie A. Sharp, Alireza Vahid, Daniel M. Fabijanic, Matthew R. Barnett, Santiago Corujeira Gallo
Summary: A study on Zn-Al-Li alloys for potential bioresorbable implant applications revealed that the formation of secondary phases during hot-extrusion significantly influenced the dynamic recrystallization and grain refinement of the matrix, while the corrosion rate was affected by the formation of zinc oxide and phosphate layers.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Materials Science, Biomaterials
Ehsan Farabi, Julie Sharp, Alireza Vahid, Jiangting Wang, Daniel M. Fabijanic, Matthew R. Barnett, Santiago Corujeira Gallo
Summary: A series of quaternary Zn-Al-Cu-Li alloys with various intermetallic structures were developed, showing promising mechanical and corrosion properties for potential applications in bioresorbable implants.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Proceedings Paper
Nutrition & Dietetics
Kevin R. Nicholas, Vengama Modepalli, Ashalyn P. Watt, Lyn A. Hinds, Amit Kumar, Christophe Lefevre, Julie A. Sharp
HUMAN MILK: COMPOSITION, CLINICAL BENEFITS AND FUTURE OPPORTUNITIES
(2019)
Article
Cell Biology
Julie A. Sharp, Amelia J. Brennan, Galina Polekhina, David B. Ascher, Christophe Lefevre, Kevin R. Nicholas
CELLULAR SIGNALLING
(2017)
Article
Fisheries
Ratiporn Thongsoi, Siriluk Maskaew, Panumas Puechpon, Benjaporn Noppradit, Napassawan Inaek, Prapaporn Utarabhand, Phanthipha Runsaeng
Summary: In this study, a PPAE gene called FmPPAE1 was cloned and analyzed in banana shrimp. FmPPAE1 plays a vital role in regulating the proPO system, exhibits antibacterial properties, and contributes to the suppression of bacterial proliferation.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jishuang Tan, Paizelaiti Sahaer, Huan Li, Wei Han, Hongyan Sun
Summary: Circular RNAs (circRNA) are involved in gene expression and affect cellular processes such as transcription, splicing, and translation by interacting with microRNA and RNA binding proteins. A study identified circDNAJB6 as a circular RNA abundant in chicken macrophages after bacterial infection, and found that circDNAJB6 exacerbates cellular injury and interacts with multiple miRNAs and target genes, potentially impacting autophagy and MAPK signaling pathways.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Rodrigo Guabiraba, Damaris Ribeiro Rodrigues, Paul T. Manna, Melanie Chollot, Vincent Saint-Martin, Sascha Trapp, Marisa Oliveira, Clare E. Bryant, Brian J. Ferguson
Summary: The innate immune response relies on the ability of host cells to detect and respond to microbial nucleic acids. Toll-like receptors (TLRs) play a crucial role in this process by distinguishing self from non-self. This study focused on TLR21, an avian TLR that recognizes bacterial DNA motifs. The findings suggest that avian TLR21 shares similar activation mechanisms to mammalian TLR9, highlighting the conservation of nucleic acid sensing mechanisms across species.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Safieh Zeinali, Kate Sutton, Lonneke Vervelde
Summary: Chickens have a unique immune structure characterized by the absence of draining lymph nodes and the presence of well-developed mucosa-associated lymphoid tissue. The structure and development of chicken lymphoid tissues in the intestine, particularly Peyer's patches, have been poorly studied. However, the use of CSF1R-eGFP reporter transgenic chickens has allowed for the visualization and investigation of the development and distribution of these tissues. This research provides insights that could benefit mucosal vaccination strategies and the development of targeted vaccine delivery systems.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Retraction
Fisheries
G. -g. Li, Z. -z. Guo, X. -f. Ma, N. Cao, S. -n. Geng, Y. -q. Zheng, M. -j. Meng, H. -h. Lin, G. Han, G. -j. Du
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jinyue Yang, Peng Zhou, Wanrong Wu, Qingxiang Zhang, Dong Chen, Rui Luo
Summary: This study cloned and characterized the full-length sequence of duck MRE11 (duMRE11) for the first time, and found that this protein plays an important role in the innate immune response of ducks.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Mengjiao Guo, Jiaqi Zhang, Mingtao Li, Xiaorong Zhang, Yantao Wu
Summary: rNLRC3 negatively regulates the NF -KB signaling pathway induced by P. multocida in rabbits by inhibiting the activation of NF -KB, reducing the expression of inflammatory cytokines, and interacting with rTRAF4 and rTRAF6. The NACHT-LRR domain is the functional domain of rNLRC3. These findings provide insights into the important role of rNLRC3 in combating P. multocida infection.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Yinan Li, Xingye Lian, Wenwen Yang, Jinyuan Leng, Jiejie Sun, Yu Liu, Siqi Fan, Lingling Wang, Linsheng Song
Summary: The DM9-containing protein CgDM9CP-7 plays an important role in the innate immune response of molluscs. It is constitutively expressed in various tissues and is up-regulated in haemocytes after stimulation by Vibrio splendidus and lipopolysaccharide (LPS). CgDM9CP-7 binds to various pathogens and exhibits antimicrobial activity, while also regulating the expression of CgMyD88 and CgIL-17.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Xiuwen Bao, Haoran Song, Liying He, Yong Li, Shuqi Niu, Jinlin Guo
Summary: This study focuses on the interaction between Hepialus xiaojinensis larvae and Ophiocordyceps sinensis during the infection process. The results show that the infected third instar larvae enhance antioxidant defense ability, while the infected fourth instar larvae reduce this ability and allocate more energy to growth and development.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)