Review
Oncology
Anneloes van Duijn, Sjoerd H. Van der Burg, Ferenc A. Scheeren
Summary: This article focuses on the interactions between myeloid immune cells and anti-tumor immune responses in the tumor microenvironment. Blocking the CD47/SIRP alpha axis can enhance adaptive immune response. The potential therapeutic role of CD47/SIRP alpha axis is discussed in tumors with acquired resistance to classic immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Fisheries
Qinglin Yang, Xiaobo Yu, Chunying Du, Xin Ni, Wenyu Li, Weizhi Yao, Zhengli Wu
Summary: This study evaluated the effects of common pathogenic infections on immune function in the bivalve species Hyriopsis cumingii. The results showed that infection with different pathogens led to changes in antioxidant enzyme activities and histological alterations. Bacterial infection increased total haemocyte counts and especially the proportion of granulocytes in H. cumingii.
Article
Agriculture, Dairy & Animal Science
Morteza H. Ghaffari, Hassan Sadri, Julia Steinhoff-Wagner, Harald M. Hammon, Helga Sauerwein
Summary: The study suggests that feeding colostrum may improve immune responsiveness and epithelial barrier function in neonatal calves, as evidenced by the higher mRNA abundance of certain TLR genes and CLDN1 in most intestinal sections of the colostrum-fed calves.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Oncology
Matthew R. Woeste, Rejeena Shrestha, Anne E. Geller, Shu Li, Diego Montoya-Durango, Chuanlin Ding, Xiaoling Hu, Hong Li, Aaron Puckett, Robert A. Mitchell, Traci Hayat, Min Tan, Yan Li, Kelly M. McMasters, Robert C. G. Martin, Jun Yan
Summary: This study investigates the combination therapy of IRE and beta-glucan in the treatment of pancreatic cancer, and finds that this combination can enhance immune response, reduce tumor burden, and prolong survival in patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Immunology
Seika Hashimoto-Hill, Luisa Colapietro, Vivienne Woo, Simona Antonacci, Jordan Whitt, Laura Engleman, Theresa Alenghat
Summary: This study demonstrates that consuming rice bran can reduce the risk of intestinal infection, and the phytate component in it plays a role by promoting innate immune response in intestinal epithelial cells. This effect is dependent on the metabolism of phytate by commensal bacteria.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Carolina N. Ruera, Emanuel Miculan, Federico Perez, Geronimo Ducca, Paula Carasi, Fernando G. Chirdo
Summary: Intestinal epithelial cells have rapid turnover and are maintained by different forms of cell death mechanisms. In inflammation, p31-43 can activate multiple cell death pathways, including apoptosis, pyroptosis, and necroptosis.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Review
Cell Biology
Xuehua Xu, Miao Pan, Tian Jin
Summary: The discovery of how phagocytes effectively find and kill pathogens through chemotaxis and phagocytosis sheds light on the evolutionarily conserved mechanisms underlying these processes in mammals.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Edna Ayerim Mandujano-Tinoco, Eliya Sultan, Aner Ottolenghi, Orly Gershoni-Yahalom, Benyamin Rosental
Summary: The evolution of the immune system is aimed at protecting organisms from infections and providing regenerative capacities and tissue maintenance. Despite the diverse range of effector cells, common features and interesting convergent mechanisms can be observed across different animals. The review explores the evolution of phagocytic and cytotoxic immune lineages, highlighting the diverse function plasticity within evolved immune effector cells.
Article
Immunology
Vaibhvi Vaibhvi, Sven Kuenzel, Thomas Roeder
Summary: The immune organs of the fruit fly, Drosophila, namely the fat body and hemocytes, show distinct responses to systemic infection. The fat body exhibits improved peptide synthesis and export, while hemocytes display enhanced phagocytic signatures.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Kate Sutton, Tessa Nash, Samantha Sives, Dominika Borowska, Jordan Mitchell, Prerna Vohra, Mark P. Stevens, Lonneke Vervelde
Summary: This study investigated the host response to early stages of Salmonella infection in chicken enteroids. The findings indicate that Salmonella infection disrupts the epithelial barrier integrity and induces inflammatory responses. Additionally, the 3D model provides a more accurate representation of host responses.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Clinical Neurology
Che-Feng Chang, Brittany A. Goods, Michael H. Askenase, Hannah E. Beatty, Artem Osherov, Jonathan H. DeLong, Matthew D. Hammond, Jordan Massey, Margaret Landreneau, J. Christopher Love, Lauren H. Sansing
Summary: Our study shows that microglia and MDMs have distinct functional properties in the brain after ICH, with MDMs exhibiting higher phagocytic activity, erythrophagocytosis, and antigen-presenting capabilities compared to microglia. This suggests that the different origins of microglia and MDMs lead to divergent responses and functions in the inflamed brain following ICH.
Review
Gastroenterology & Hepatology
Ghada Tafesh-Edwards, Ioannis Eleftherianos
Summary: The gut epithelia of animals house complex microbial communities that play a crucial role in maintaining immune and cellular homeostasis. These microbial populations have adapted to the gut environment and regulate intestinal stem cells, promoting a healthy gut barrier and epithelial self-renewal. Disruption of these populations is associated with inflammatory disorders and cancerous lesions of the intestine, but the molecular mechanisms controlling gut-microbe interactions are still not fully understood.
Review
Agriculture, Dairy & Animal Science
Jie Peng, Yimei Tang, Yanhua Huang
Summary: The composition of the pig intestinal flora and the characteristics of intestinal mucosal immunity are closely related, with imbalances potentially leading to compromised health. Understanding the interaction between intestinal microorganisms and the mucosal immune system is crucial for maintaining overall well-being.
Article
Microbiology
Nelly Amenyogbe, Pedro Dimitriu, Kinga K. Smolen, Eric M. Brown, Casey P. Shannon, Scott J. Tebbutt, Phillip J. Cooper, Arnaud Marchant, Tessa Goetghebuer, Monika Esser, Brett B. Finlay, Tobias R. Kollmann, William W. Mohn
Summary: This study identified differences in immune responses correlating to gut microbiomes across biogeographically diverse settings and evaluated biological plausibility using a mouse model.
Article
Oncology
Yan Wang, Haiqing Ni, Shuaixiang Zhou, Kaijie He, Yarong Gao, Weiwei Wu, Min Wu, Zhihai Wu, Xuan Qiu, Ying Zhou, Bingliang Chen, Donghui Pan, Chenrong Huang, Mingzhu Li, Yicong Bian, Min Yang, Liyan Miao, Junjian Liu
Summary: The newly designed CD47/PD-L1 bispecific antibody, IBI322, effectively inhibits CD47-SIRP alpha signal, promotes tumor cell phagocytosis, accumulates in PD-L1-positive tumors, shows synergistic therapeutic effects, and has minimal impact on red blood cells, making it a promising option for cancer treatment.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Cell Biology
Diogo Paramos-de-Carvalho, Isaura Martins, Ana Margarida Cristovao, Ana Filipa Dias, Dalila Neves-Silva, Telmo Pereira, Diana Chapela, Ana Farinho, Antonio Jacinto, Leonor Saude
Summary: Persistent senescent cells play a role in aging-related chronic disorders but may also be central during tissue remodeling events like development or organ repair. Research has shown that different senescence profiles are induced in regenerative zebrafish compared to scarring mouse after spinal cord injury. Depletion of senescent cells in injured mice improves motor, sensory, and bladder functions, associated with enhanced myelin sparing, reduced fibrotic scars, and decreased inflammation. Targeting senescent cells could be a promising therapeutic strategy for spinal cord injuries and other non-regenerative organs.
Article
Cell Biology
Nuno-Valerio Silva, Diogo Carregosa, Catarina Goncalves, Otilia V. Vieira, Claudia Nunes dos Santos, Antonio Jacinto, Carolina Lage Crespo
Summary: Inflammatory bowel diseases with chronic immune cell infiltration in the gastrointestinal tract are common and challenging to treat. To address this, a dietary cholesterol-based in vivo assay using transgenic zebrafish models was developed for screening immune-modulatory therapeutics. This method is simple, cost-effective, and highly physiological, allowing for the identification of novel lead molecules with immune modulatory action on intestinal inflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Raquel Lourenco, Ana S. Brandao, Jorge Borbinha, Rita Gorgulho, Antonio Jacinto
Summary: This study demonstrates that Yap plays a crucial role in regulating Muller glia response to injury, promoting cell cycle reentry and progenitor cell formation, leading to the differentiation of new photoreceptors in zebrafish retina regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Urology & Nephrology
Silvia Coelho, Maria Guadalupe Cabral, Rute Salvador, Claudia Andrade, Ana Martins, Bruna Correia, Paulo Freitas, Josep Maria Cruzado, Antonio Jacinto
Summary: This study investigated the urinary immune cell phenotype in patients with acute kidney injury (AKI), and found that M2 macrophages may promote renal recovery while B cells may impede it.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Review
Biology
Diogo Paramos-de-Carvalho, Antonio Jacinto, Leonor Saude
Summary: Cellular senescence is a complex and programmed cellular state with diverse physiological and pathological roles across the lifespan of an organism. New tools have allowed researchers to uncover the functional impact of senescent cells in various contexts, although reconciling these effects can be challenging. Ongoing clinical research is exploring the targeting of senescent cells and its potential implications in this rapidly evolving field.
Article
Pharmacology & Pharmacy
Teresa Lopes Gomes, Virginia de Oliveira-Marques, Richard John Hampson, Antonio Jacinto, Luciana Vieira de Moraes, Rui Goncalo Martinho
Summary: Tight junctions are formed by proteins that seal the intercellular space and control the permeability of epithelia. This study focuses on finding compounds that reinforce the epithelial barrier and developed a screening platform to identify compounds that modulate the expression of Par-6, a protein involved in tight junction assembly. Six compounds were tested and two of them (myricetin and quercetin) were shortlisted for further development.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biology
Ana S. Brandao, Jorge Borbinha, Telmo Pereira, Patricia H. Brito, Raquel Lourenco, Anabela Bensimon-Brito, Antonio Jacinto
Summary: This study explores the role of glucose metabolism in fish bone regeneration. The results show that injury triggers a modulation in the metabolic profile, allowing mature bone cells to transition into pre-osteoblasts and induce cell proliferation. The study also finds that manipulation of the metabolic profile significantly reduces the number of pre-osteoblasts and completely inhibits blastema formation.
Article
Microbiology
Mariana Galvao Ferrarini, Elisa Dell'Aglio, Agnes Vallier, Severine Balmand, Carole Vincent-Monegat, Sandrine Hughes, Benjamin Gillet, Nicolas Parisot, Anna Zaidman-Remy, Cristina Vieira, Abdelaziz Heddi, Rita Rebollo
Summary: This study reveals the active involvement of the bacteriome in the innate immune response of insects, showing the induction of antimicrobial peptides upon immune challenge. Surprisingly, the endosymbionts do not undergo any changes in their gene expression, indicating that they are protected from immune effectors mainly through confinement within the bacteriome. The physical separation between the host immune response and the endosymbionts ensures their survival during immune challenges.
Article
Multidisciplinary Sciences
Joao Cardeira-da-Silva, Anabela Bensimon-Brito, Marco Tarasco, Ana S. Brandao, Joana T. Rosa, Jorge Borbinha, Paulo J. Almeida, Antonio Jacinto, M. Leonor Cancela, Paulo J. Gavaia, Didier Y. R. Stainier, Vincent Laize
Summary: By studying the bone patterning during zebrafish fin ray regeneration, it was discovered that the fin rays form through two mineralization fronts and bifurcation is not a simple splitting process. Osteolytic tubules play a key role in defining the position of the branchpoint.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Physiology
Mariana Galvao Ferrarini, Agnes Vallier, Elisa Dell'Aglio, Severine Balmand, Carole Vincent-Monegat, Meriem Debbache, Justin Maire, Nicolas Parisot, Anna Zaidman-Remy, Abdelaziz Heddi, Rita Rebollo
Summary: Insects establish long-term relationships with intracellular symbiotic bacteria, which provide them with essential nutrients. The endosymbionts are confined within specialized host cells called bacteriocytes, which form the bacteriome organ. In the cereal weevil Sitophilus oryzae, bacteriomes are present at specific locations in larvae and adults. While the midgut bacteriomes experience proliferation and elimination, the ovarian bacteriomes are maintained throughout the weevil's lifetime. Ovarian endosymbionts are thought to be transmitted through the female germline, but the exact mode of transmission is not fully understood.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cell Biology
Jennifer C. Regan, Yu-Xuan Lu, Enric Urena, Ralf L. Meilenbrock, James H. Catterson, Disna Kissler, Jenny Froehlich, Emilie Funk, Linda Partridge
Summary: Pharmacological attenuation of mTOR presents a promising route for delay of age-related disease. In this study, the researchers found that the mTOR inhibitor rapamycin extends lifespan in female Drosophila by slowing down age-related gut pathology through increased autophagy. The study also reveals sexual dimorphism in enterocyte autophagy and response to rapamycin, which is conserved in mice.
Article
Cell Biology
Paula Juricic, Yu-Xuan Lu, Thomas Leech, Lisa F. Drews, Jonathan Paulitz, Jiongming Lu, Tobias Nespital, Sina Azami, Jennifer C. Regan, Emilie Funk, Jenny Frohlich, Sebastian Gronke, Linda Partridge
Summary: One challenge in repurposing the drug rapamycin for prolonging lifespan is to avoid side effects. The study shows that a brief early administration of rapamycin can have long-lasting beneficial effects in model organisms similar to lifelong treatment. This suggests that rapamycin has potential for geroprotection if side effects from continuous dosing can be avoided.
Article
Fisheries
Ratiporn Thongsoi, Siriluk Maskaew, Panumas Puechpon, Benjaporn Noppradit, Napassawan Inaek, Prapaporn Utarabhand, Phanthipha Runsaeng
Summary: In this study, a PPAE gene called FmPPAE1 was cloned and analyzed in banana shrimp. FmPPAE1 plays a vital role in regulating the proPO system, exhibits antibacterial properties, and contributes to the suppression of bacterial proliferation.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jishuang Tan, Paizelaiti Sahaer, Huan Li, Wei Han, Hongyan Sun
Summary: Circular RNAs (circRNA) are involved in gene expression and affect cellular processes such as transcription, splicing, and translation by interacting with microRNA and RNA binding proteins. A study identified circDNAJB6 as a circular RNA abundant in chicken macrophages after bacterial infection, and found that circDNAJB6 exacerbates cellular injury and interacts with multiple miRNAs and target genes, potentially impacting autophagy and MAPK signaling pathways.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Rodrigo Guabiraba, Damaris Ribeiro Rodrigues, Paul T. Manna, Melanie Chollot, Vincent Saint-Martin, Sascha Trapp, Marisa Oliveira, Clare E. Bryant, Brian J. Ferguson
Summary: The innate immune response relies on the ability of host cells to detect and respond to microbial nucleic acids. Toll-like receptors (TLRs) play a crucial role in this process by distinguishing self from non-self. This study focused on TLR21, an avian TLR that recognizes bacterial DNA motifs. The findings suggest that avian TLR21 shares similar activation mechanisms to mammalian TLR9, highlighting the conservation of nucleic acid sensing mechanisms across species.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Safieh Zeinali, Kate Sutton, Lonneke Vervelde
Summary: Chickens have a unique immune structure characterized by the absence of draining lymph nodes and the presence of well-developed mucosa-associated lymphoid tissue. The structure and development of chicken lymphoid tissues in the intestine, particularly Peyer's patches, have been poorly studied. However, the use of CSF1R-eGFP reporter transgenic chickens has allowed for the visualization and investigation of the development and distribution of these tissues. This research provides insights that could benefit mucosal vaccination strategies and the development of targeted vaccine delivery systems.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Retraction
Fisheries
G. -g. Li, Z. -z. Guo, X. -f. Ma, N. Cao, S. -n. Geng, Y. -q. Zheng, M. -j. Meng, H. -h. Lin, G. Han, G. -j. Du
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jinyue Yang, Peng Zhou, Wanrong Wu, Qingxiang Zhang, Dong Chen, Rui Luo
Summary: This study cloned and characterized the full-length sequence of duck MRE11 (duMRE11) for the first time, and found that this protein plays an important role in the innate immune response of ducks.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Mengjiao Guo, Jiaqi Zhang, Mingtao Li, Xiaorong Zhang, Yantao Wu
Summary: rNLRC3 negatively regulates the NF -KB signaling pathway induced by P. multocida in rabbits by inhibiting the activation of NF -KB, reducing the expression of inflammatory cytokines, and interacting with rTRAF4 and rTRAF6. The NACHT-LRR domain is the functional domain of rNLRC3. These findings provide insights into the important role of rNLRC3 in combating P. multocida infection.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Yinan Li, Xingye Lian, Wenwen Yang, Jinyuan Leng, Jiejie Sun, Yu Liu, Siqi Fan, Lingling Wang, Linsheng Song
Summary: The DM9-containing protein CgDM9CP-7 plays an important role in the innate immune response of molluscs. It is constitutively expressed in various tissues and is up-regulated in haemocytes after stimulation by Vibrio splendidus and lipopolysaccharide (LPS). CgDM9CP-7 binds to various pathogens and exhibits antimicrobial activity, while also regulating the expression of CgMyD88 and CgIL-17.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Xiuwen Bao, Haoran Song, Liying He, Yong Li, Shuqi Niu, Jinlin Guo
Summary: This study focuses on the interaction between Hepialus xiaojinensis larvae and Ophiocordyceps sinensis during the infection process. The results show that the infected third instar larvae enhance antioxidant defense ability, while the infected fourth instar larvae reduce this ability and allocate more energy to growth and development.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)