期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 36, 期 2, 页码 433-441出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2011.08.010
关键词
TRIM; Rainbow trout; FinTRIM; Ubiquitination; Deep sequencing; Antiviral immunity
资金
- Institut National Recherche Agronomique
- Wageningen University
TRIM proteins have recently emerged as novel players in antiviral defense. TRIM proteins contain a tripartite motif, composed of a RING zinc finger, one or two B-boxes and a coiled-coil domain. Many members of this large protein family of E3 ubiquitin ligases catalyze the attachment of ubiquitin to a substrate protein, an activity dependent on the RING domain. We earlier made a full description of the TRIM gene family in zebrafish and pufferfish and identified three multigene TRIM subsets, a feature unique to fish. To determine their biological role, we further characterized members of the finTRIM subset. FinTRIM gene expression was studied during development and in multiple tissues in adult rainbow trout. Upregulation of a large number of finTRIM upon viral stimulation suggests they are involved in antiviral immunity. We also demonstrate that two finTRIM members display E3 ubiquitin ligase activity, indicating that finTRIMs could regulate antiviral signaling through ubiquitination. (C) 2011 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据