Article
Multidisciplinary Sciences
Zhongshun Liu, Congwei Jiang, Zhangmengxue Lei, Sihan Dong, Linlin Kuang, Chenxu Huang, Ying Gao, Mu Liu, Hui Xiao, Patrick Legembre, Jae U. Jung, Huaping Liang, Xiaozhen Liang
Summary: Type I interferons (IFNs) are the first line of defense against invading pathogens. This study identified a previously unknown protein, PINLYP, that interacts with TBK1 to induce the production of type I IFN. Loss of PINLYP impaired the activation of IRF3 and the production of IFN induced by various viruses and Toll-like receptor ligands. Mice lacking PINLYP were more susceptible to lethal virus infection, highlighting the importance of PINLYP in the host defense against viral infections.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Juan Felipe Valdes-Lopez, Geysson J. Fernandez, Silvio Urcuqui-Inchima
Summary: The study revealed that CHIKV-infected MDMs activate the IL27 pathway in an IFN-independent manner, leading to the activation of JAK-STAT signaling and induction of an anti-inflammatory and antiviral response, helping control CHIKV replication.
CELLULAR IMMUNOLOGY
(2021)
Article
Fisheries
Ge Qin, Xiang Yu, Yuanjie Zhao, Xiaoping Li, Beibei Yu, Hui Peng, Diqi Yang
Summary: The expression of NLRP9 was examined in piglets and IPECJ2 cells, and it was found that NLRP9 had high levels of mRNA and protein expression in the intestine of piglets and IPEC-J2 cells. Furthermore, it was demonstrated that NLRP9 acts in combination with VIM to participate in porcine intestinal antiviral innate immunity. These findings provide preliminary insights into the molecular mechanisms involved in the regulation of mucosal immunity in the porcine intestine by NLRP9.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Virology
Matthias Neulinger-Munoz, Dominik Schaack, Svetlana P. Grekova, Andrea S. Bauer, Thomas Giese, Gabriel A. Salg, Elisa Espinet, Barbara Leuchs, Anette Heller, Juerg P. F. Nueesch, Miriam Schenk, Michael Volkmar, Nathalia A. Giese
Summary: Despite entering clinical trials, predicting the therapeutic success of oncolytic parvovirus H-1PV remains challenging. Research found that in pancreatic cancer cell lines, H-1PV caused a late global shutdown of innate immunity by co-regulatively inhibiting human endogenous retroviruses (HERVs) and interferon-stimulated genes (ISGs). The growth-inhibitory effect of H-1PV did not correlate with absolute ISG levels but with the power of suppression.
Review
Virology
Laurie-Anne Lamotte, Lionel Tafforeau
Summary: The review discusses how the NS1 protein of influenza A virus inhibits the host's antiviral response by disturbing ubiquitination.
Review
Immunology
Michelle Felicia Lee, Guan Zhong Voon, Hui Xuan Lim, Mun Lok Chua, Chit Laa Poh
Summary: Dengue is a mosquito-borne disease that poses significant public health concerns in tropical and subtropical countries. The dengue virus has evolved various strategies to manipulate the host's immune responses, and miRNAs and DENV non-structural proteins (NS) are promising targets for anti-dengue therapeutics.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Fisheries
Yankai Liu, Jun Xiao, Guoxia Qiao, Qun Wang, Xiao Yang, Xingjian Xu, Jun Li, Jie Zhang, Mingxian Chang, Hao Feng
Summary: In this study, the negative regulatory role of black carp DDX19 (bcDDX19) in the innate immune response was investigated. It was found that bcDDX19 restricts the entry of IRF3 into the nucleus, thereby negatively regulating the RLR/IRF3-mediated type I IFN signaling pathway.
Review
Immunology
Zahra Telikani, Ebony A. Monson, Markus J. Hofer, Karla J. Helbig
Summary: The central nervous system (CNS) is composed of various cell types and protected by anatomical barriers. The different cell types distributed in different brain regions are the main targets of several neurotropic viruses. It has been found that viral susceptibility within the CNS is not absolute and different cell types initiate specific antiviral responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Pengfei Chen, Junrui Zhu, Jiarong Yu, Ruilin Liu, Mengqin Lao, Lingxue Yu, Fei Gao, Yifeng Jiang, Changlong Liu, Wu Tong, Huili Liu, Guangzhi Tong, Yanjun Zhou
Summary: This study found that PEDV infection activates the host innate immune response, leading to the production of abundant type I/III interferons and interferon-stimulated genes. In the late stage of infection, the JAK-STAT signaling pathway is activated and promotes interferon expression. Silencing of the RLRs and TLRs signaling pathways resulted in a significant decrease in type I/III interferons and interferon-stimulated genes.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Virology
Raegan M. Skelton, Victor C. Huber
Summary: This article reviews the known information about the host-pathogen interactions that limit the disease caused by influenza D virus (IDV). It focuses on the early immune interactions between the virus and infected host cells in IDV pathogenesis. This work establishes a foundation for further research on IDV infection and immunity in mammalian hosts.
Article
Virology
Chuan Kok Lim, Bang Manh Tran, Dustin Flanagan, Erin Mccartney, Edmund Tse, Elizabeth Vincan
Summary: This study evaluated the application of intrahepatic cholangiocyte organoids (ICOs) model in hepatitis B virus (HBV) infection and cellular responses. The results showed that human ICOs can support HBV infection and replication, but did not upregulate interferon-stimulated genes (ISGs). These findings are important for the development of personalized antiviral drugs.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Virology
Joe McKellar, Antoine Rebendenne, Melanie Wencker, Olivier Moncorge, Caroline Goujon
Summary: Host cells have developed a multi-modular system to detect and combat influenza viruses, including interferon response and intrinsic immunity. These mechanisms activate a wide array of antiviral effectors that inhibit virus replication at various stages, providing important insights for the development of new influenza treatments.
Article
Biochemistry & Molecular Biology
Yanchao Gu, Jingjing Tang, Fuhua Zhang, Yichen Qu, Min Zhao, Mengyuan Li, Zhen Xie, Xiao Wang, Li Song, Zhengfan Jiang, Yao Wang, Xihui Shen, Lei Xu
Summary: Divalent metal ions such as Mn2+ and Zn2+ have immunostimulatory effects and can enhance the expression of genes involved in innate immune responses induced by lipopolysaccharide. The enhancement of gene expression by Mn2+ is dose-dependent and partially relies on the cGAS-STING pathway independent of TLR4. Mn2+ has the potential to be a therapeutic target for preventing excessive immune responses.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Virology
Qingsen Wang, Wenliang Pan, Song Wang, Chen Pan, Hongya Ning, Shile Huang, Shih-Hsin Chiu, Ji-Long Chen
Summary: The study demonstrates that influenza A virus (IAV) suppresses antiviral innate immunity by activating EGFR/ERK signaling and induces activation of protein tyrosine phosphatase SHP2, which modulates EGFR-mediated ERK activity and antiviral effectiveness. SHP2 acts as a key signal transducer between EGFR and ERK during IAV infection, playing a crucial role in suppressing host innate immunity.
JOURNAL OF VIROLOGY
(2021)
Article
Genetics & Heredity
Xiaoyong Chen, Tongling Shan, Dage Sun, Huanjie Zhai, Sujie Dong, Ning Kong, Hao Zheng, Wu Tong, Guangzhi Tong
Summary: Porcine ZCCHC3 plays an inhibitory role in the proliferation of pseudorabies virus (PRV) by regulating cellular innate immune responses. Overexpression of ZCCHC3 inhibits viral titers and protein levels, while knockdown of ZCCHC3 promotes viral growth. ZCCHC3 overexpression upregulates IFN-beta expression to suppress viral replication. PRV infection reduces endogenous expression of ZCCHC3, and PRV-encoded UL13 and UL24 proteins inhibit ZCCHC3 expression, antagonizing its antiviral effect.
Article
Multidisciplinary Sciences
Emilie Crouchet, Simonetta Bandiera, Naoto Fujiwara, Shen Li, Hussein El Saghire, Mirian Fernandez-Vaquero, Tobias Riedl, Xiaochen Sun, Hadassa Hirschfield, Frank Juhling, Shijia Zhu, Natascha Roehlen, Clara Ponsolles, Laura Heydmann, Antonio Saviano, Tongqi Qian, Anu Venkatesh, Joachim Lupberger, Eloi R. Verrier, Mozhdeh Sojoodi, Marine A. Oudot, Francois H. T. Duong, Ricard Masia, Lan Wei, Christine Thumann, Sarah C. Durand, Victor Gonzalez-Motos, Danijela Heide, Jenny Hetzer, Shigeki Nakagawa, Atsushi Ono, Won-Min Song, Takaaki Higashi, Roberto Sanchez, Rosa S. Kim, C. Billie Bian, Karun Kiani, Tom Croonenborghs, Aravind Subramanian, Raymond T. Chung, Beate K. Straub, Detlef Schuppan, Maliki Ankavay, Laurence Cocquerel, Evelyne Schaeffer, Nicolas Goossens, Anna P. Koh, Milind Mahajan, Venugopalan D. Nair, Ganesh Gunasekaran, Myron E. Schwartz, Nabeel Bardeesy, Alex K. Shalek, Orit Rozenblatt-Rosen, Aviv Regev, Emanuele Felli, Patrick Pessaux, Kenneth K. Tanabe, Mathias Heikenwaelder, Catherine Schuster, Nathalie Pochet, Mirjam B. Zeisel, Bryan C. Fuchs, Yujin Hoshida, Thomas F. Baumert
Summary: The lack of suitable models for clinical translation hampers drug and target discovery for advanced liver disease. The authors present a human liver cell-based system modeling a clinical prognostic signature, proposing nizatidine for treatment of advanced liver fibrosis and hepatocellular carcinoma prevention. This research identifies urgently needed targets and therapeutics for treatment of advanced liver disease and cancer prevention.
NATURE COMMUNICATIONS
(2021)
Article
Virology
Gaetan Ligat, Eloi R. Verrier, Michael Nassal, Thomas F. Baumert
Summary: Chronic HBV infection is difficult to cure, but targeting host factors to intervene in the viral life cycle may achieve a cure. Current treatments often require long-term use, with risks of drug resistance and side effects, but interferon therapy has a potential for cure.
CURRENT OPINION IN VIROLOGY
(2021)
Article
Pharmacology & Pharmacy
Eloi R. Verrier, Anna Salvetti, Caroline Pons, Maud Michelet, Michel Rivoire, Thomas F. Baumert, David Durantel, Julie Lucifora
Summary: Chronic hepatitis D is the most severe form of chronic viral hepatitis, and there are limited therapeutic approaches for hepatitis D virus. This study found that the farnesyl transferase inhibitor Lonafarnib, currently being tested in clinical trials, has side effects on virus replication. Treatment with Lonafarnib led to an accumulation of intracellular HDV RNAs and an increase in the levels of edited RNAs, while decreasing the infectivity of the viral particles produced.
ANTIVIRAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Zakaria Boulahtouf, Alessia Virzi, Thomas F. Baumert, Eloi R. Verrier, Joachim Lupberger
Summary: Chronic viral hepatitis is a major cause of liver disease and hepatocellular carcinoma. Despite being caused by different viruses, hepatitis B, C, and D have striking similarities in pathological impact. The advancements in omics and bioinformatics have revealed the important role of signaling networks in viral pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Valerio Taverniti, Gaetan Ligat, Yannick Debing, Dieudonne Buh Kum, Thomas F. Baumert, Eloi R. Verrier
Summary: Despite the availability of a preventive vaccine, over 250 million people are still affected by chronic hepatitis B virus (HBV) infection, which is a major cause of liver disease and hepatocellular carcinoma. The core protein of HBV plays a crucial role in the virus's life cycle and represents a promising target for the development of new antiviral therapies. Capsid assembly modulators (CAM) have shown potent antiviral activity in cell-based and in vivo models, and several CAMs are currently being developed for clinical use.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Gastroenterology & Hepatology
Julie Lucifora, Eloi R. Verrier, Thomas F. Baumert
JOURNAL OF HEPATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Charlotte Bach, Julie Lucifora, Marion Delphin, Laura Heydmann, Margaux J. Heuschkel, Caroline Pons, Kaku Goto, Els Scheers, Catherine Schuster, David Durantel, Frederik Pauwels, Thomas F. Baumert, Eloi R. Verrier
Summary: Chronic hepatitis D, caused by super-infection of hepatitis B virus (HBV)-infected hepatocytes with hepatitis D virus (HDV), is the most aggressive form of chronic viral hepatitis. Further improvement in therapy is needed to address the unmet medical need, which requires a more detailed characterization of virus-host interactions for the identification of novel therapeutic targets.
ANTIVIRAL RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Eloi R. Verrier, Gaetan Ligat, Laura Heydmann, Katharina Doernbrack, Julija Miller, Anne Maglott-Roth, Frank Juehling, Houssein El Saghire, Margaux J. Heuschkel, Naoto Fujiwara, Sen-Yung Hsieh, Yujin Hoshida, David E. Root, Emanuele Felli, Patrick Pessaux, Atish Mukherji, Laurent Mailly, Catherine Schuster, Laurent Brino, Michael Nassal, Thomas F. Baumert
Summary: Chronic hepatitis B virus (HBV) infection is a major cause of liver disease and hepatocellular carcinoma. The covalently closed circular (ccc) DNA, which is not targeted by current treatments, is crucial for viral cure. This study established a cell-based HBV cccDNA reporter assay and identified Y box binding protein 1 (YBX1) as an important host factor in the early steps of HBV life cycle. The expression of YBX1 in patients also correlates with HBV load and liver disease progression.
Article
Gastroenterology & Hepatology
Julie Lucifora, Dulce Alfaiate, Caroline Pons, Maud Michelet, Ricardo Ramirez, Floriane Fusil, Fouzia Amirache, Axel Rossi, Anne-Flore Legrand, Emilie Charles, Serena Vegna, Rayan Farhat, Michel Rivoire, Guillaume Passot, Nicolas Gadot, Barbara Testoni, Charlotte Bach, Thomas F. Baumert, Anastasia Hyrina, Rudolf K. Beran, Fabien Zoulim, Andre Boonstra, Hildegard Buening, Eloi R. Verrier, Francois-Loic Cosset, Simon P. Fletcher, Anna Salvetti, David Durantel
Summary: This study elucidates the molecular mechanisms underlying how HDV interferes with HBV in patients with chronic coinfection. The researchers found that HDV induces the expression of interferon-stimulated genes (ISGs), and these genes are upregulated in HDV/HBV-coinfected patients. Inhibiting the hepatocyte's response to interferon partially restores the levels of HBV.
JOURNAL OF HEPATOLOGY
(2023)
News Item
Medicine, Research & Experimental
Eloi R. Verrier
M S-MEDECINE SCIENCES
(2022)
Article
Cell Biology
Etienne Lelievre, Charlotte Bureau, Yann Bordat, Maxence Fretaud, Christelle Langevin, Chris Jopling, Karima Kissa
Summary: In this study, the zebrafish endoglin locus was characterized and it was found that deficiency of endoglin leads to heart failure and hypochromic anemia. This study also establishes the zebrafish as a valuable model for studying hereditary hemorrhagic telangiectasia (HHT).
DISEASE MODELS & MECHANISMS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Yannick Debing, Hannah Vanrusselt, Dieudonne Buh Kum, Abel Acosta Sanchez, Valerio Taverniti, Eloi R. Verrier, Thomas F. Baumert, Cheng Liu, Jerome Deval, Leonid N. Beigelman, Lawrence M. Blatt, Julian A. Symons, Pierre Raboisson, Andreas Jekle, Sandrine Vendeville
Meeting Abstract
Gastroenterology & Hepatology
Dieudonne Buh Kum, Hannah Vanrusselt, Abel Acosta Sanchez, Valerio Taverniti, Eloi R. Verrier, Thomas F. Baumert, Cheng Liu, Jerome Deval, Leonid N. Beigelman, Lawrence M. Blatt, Julian A. Symons, Pierre Raboisson, Sandrine Vendeville, Andreas Jekle, Yannick Debing
Meeting Abstract
Gastroenterology & Hepatology
Eloi Verrier, Anna Salvetti, Caroline Pons, Michelet Maud, Thomas Baumert, David Durantel, Julie Lucifora
JOURNAL OF HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Alessia Virzi, Zakaria Boulahtouf, Sarah Durand, Emanuele Felli, Patrick Pessaux, Oliver Popp, Evelyn Ramberger, Philipp Mertins, Eloi Verrier, Catherine Schuster, Thomas Baumert, Joachim Lupberger
JOURNAL OF HEPATOLOGY
(2022)
Article
Fisheries
Ratiporn Thongsoi, Siriluk Maskaew, Panumas Puechpon, Benjaporn Noppradit, Napassawan Inaek, Prapaporn Utarabhand, Phanthipha Runsaeng
Summary: In this study, a PPAE gene called FmPPAE1 was cloned and analyzed in banana shrimp. FmPPAE1 plays a vital role in regulating the proPO system, exhibits antibacterial properties, and contributes to the suppression of bacterial proliferation.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jishuang Tan, Paizelaiti Sahaer, Huan Li, Wei Han, Hongyan Sun
Summary: Circular RNAs (circRNA) are involved in gene expression and affect cellular processes such as transcription, splicing, and translation by interacting with microRNA and RNA binding proteins. A study identified circDNAJB6 as a circular RNA abundant in chicken macrophages after bacterial infection, and found that circDNAJB6 exacerbates cellular injury and interacts with multiple miRNAs and target genes, potentially impacting autophagy and MAPK signaling pathways.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Rodrigo Guabiraba, Damaris Ribeiro Rodrigues, Paul T. Manna, Melanie Chollot, Vincent Saint-Martin, Sascha Trapp, Marisa Oliveira, Clare E. Bryant, Brian J. Ferguson
Summary: The innate immune response relies on the ability of host cells to detect and respond to microbial nucleic acids. Toll-like receptors (TLRs) play a crucial role in this process by distinguishing self from non-self. This study focused on TLR21, an avian TLR that recognizes bacterial DNA motifs. The findings suggest that avian TLR21 shares similar activation mechanisms to mammalian TLR9, highlighting the conservation of nucleic acid sensing mechanisms across species.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Safieh Zeinali, Kate Sutton, Lonneke Vervelde
Summary: Chickens have a unique immune structure characterized by the absence of draining lymph nodes and the presence of well-developed mucosa-associated lymphoid tissue. The structure and development of chicken lymphoid tissues in the intestine, particularly Peyer's patches, have been poorly studied. However, the use of CSF1R-eGFP reporter transgenic chickens has allowed for the visualization and investigation of the development and distribution of these tissues. This research provides insights that could benefit mucosal vaccination strategies and the development of targeted vaccine delivery systems.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Retraction
Fisheries
G. -g. Li, Z. -z. Guo, X. -f. Ma, N. Cao, S. -n. Geng, Y. -q. Zheng, M. -j. Meng, H. -h. Lin, G. Han, G. -j. Du
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jinyue Yang, Peng Zhou, Wanrong Wu, Qingxiang Zhang, Dong Chen, Rui Luo
Summary: This study cloned and characterized the full-length sequence of duck MRE11 (duMRE11) for the first time, and found that this protein plays an important role in the innate immune response of ducks.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Mengjiao Guo, Jiaqi Zhang, Mingtao Li, Xiaorong Zhang, Yantao Wu
Summary: rNLRC3 negatively regulates the NF -KB signaling pathway induced by P. multocida in rabbits by inhibiting the activation of NF -KB, reducing the expression of inflammatory cytokines, and interacting with rTRAF4 and rTRAF6. The NACHT-LRR domain is the functional domain of rNLRC3. These findings provide insights into the important role of rNLRC3 in combating P. multocida infection.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Yinan Li, Xingye Lian, Wenwen Yang, Jinyuan Leng, Jiejie Sun, Yu Liu, Siqi Fan, Lingling Wang, Linsheng Song
Summary: The DM9-containing protein CgDM9CP-7 plays an important role in the innate immune response of molluscs. It is constitutively expressed in various tissues and is up-regulated in haemocytes after stimulation by Vibrio splendidus and lipopolysaccharide (LPS). CgDM9CP-7 binds to various pathogens and exhibits antimicrobial activity, while also regulating the expression of CgMyD88 and CgIL-17.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Xiuwen Bao, Haoran Song, Liying He, Yong Li, Shuqi Niu, Jinlin Guo
Summary: This study focuses on the interaction between Hepialus xiaojinensis larvae and Ophiocordyceps sinensis during the infection process. The results show that the infected third instar larvae enhance antioxidant defense ability, while the infected fourth instar larvae reduce this ability and allocate more energy to growth and development.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
