Article
Immunology
Kamila R. Santos, Fernando N. Souza, Eduardo M. Ramos-Sanchez, Camila F. Batista, Luiza C. Reis, Wesley F. Fotoran, Marcos B. Heinemann, Hiro Goto, Magnus Gidlund, Adriano F. Cunha, Angelica Rosa Faria, Helida M. Andrade, Andrey P. Lage, Monica M. O. P. Cerqueira, Alice M. M. P. Della Libera
Summary: Immunization with Staphylococcus aureus recombinant proteins in mice generated memory cells and led to an increase in IL-17A(+) cells, while combined with GM-CSF DNA vaccine. This approach fostered type 3 immunity, suggesting the development of a protective immune response against S. aureus.
Review
Nutrition & Dietetics
Muhammad Akhtar, Syed Umair-Ali-Shah Naqvi, Qiyao Liu, Hong Pan, Ziyu Ma, Na Kong, Yan Chen, Deshi Shi, Muhammad Fakhar-E-Alam Kulyar, Jawaria Ali Khan, Huazhen Liu
Summary: Mastitis is an emerging health concern with increasing incidence in dairy cows worldwide. Staphylococcus aureus (S. aureus) is the most common bacteria causing mastitis and it has developed resistance to most antibiotics, including methicillin. Finding alternative treatments has become a pressing need, and short chain fatty acids (SCFAs) are being explored as potential therapeutic agents against mastitis.
Article
Veterinary Sciences
Shauna D. Drumm, Paul Cormican, Rebecca A. Owens, Jennifer Mitchell, Orla M. Keane
Summary: CC97 and CC151 are common lineages of Staphylococcus aureus associated with bovine intramammary infection. The genotype of the infecting strain affects virulence and disease progression. Proteins produced by these strains can provide insights into their pathogenesis and contribute to the development of targeted treatments, vaccines, and diagnostics. The identification and evaluation of cell wall-anchored (CWA) proteins in strains MOK023 (CC97) and MOK124 (CC151) showed differences in protein repertoire. Variations in the humoral response to these proteins were observed among infected cows. Immunogenic proteins were identified, including ClfB, SdrE/Bbp, and IsdA, suggesting their potential as vaccine targets. The strain-specific antigens detected indicate the need to consider strain variation when designing control strategies.
VETERINARY RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Fernando N. Souza, Kamila R. Santos, Jose A. Ferronatto, Eduardo M. Ramos Sanchez, Bruno Toledo-Silva, Marcos B. Heinemann, Sarne De Vliegher, Alice M. M. P. Della Libera
Summary: This study investigated whether different staphylococcal and mammaliicoccal species and strains can induce B and T lymphocyte proliferation and production of interleukin-17A (IL-17A) and interferon-gamma (IFN-gamma) in peripheral blood mononuclear cells (PBMCs) of nulliparous, primiparous, and multiparous dairy cows. Flow cytometry was used to measure lymphocyte proliferation, specific antibodies were used to identify different lymphocyte populations, and the PBMC culture supernatant was used to measure IL-17A and IFN-gamma production. The results showed that certain strains of Staphylococcus aureus and Staphylococcus chromogenes triggered T lymphocyte proliferation and increased IL-17A and IFN-gamma production. Conversely, Mammaliicoccus fleurettii and other strains had no effect on lymphocyte proliferation. Multiparous cows had higher B lymphocyte proliferation and cytokine production compared to primiparous and nulliparous cows. Phytohemagglutinin M-form specifically stimulated T cell proliferation.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Medicine, Research & Experimental
Lihua Zhao, Lei Jin, Bin Yang
Summary: The study found that diosmetin suppressed Staphylococcus aureus-induced mastitis by attenuating inflammation and ferroptosis.
Article
Agriculture, Multidisciplinary
Zhi Chen, Kun Wang, Jiahe Guo, Jingpeng Zhou, Juan J. Loor, Zhangping Yang, Yi Yang
Summary: This study demonstrates the therapeutic effect of melatonin against Staphylococcus aureus by regulating the expression of miR-16b/YAP1, inhibiting inflammation. It provides a new strategy for the prevention of bovine mastitis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Agriculture, Dairy & Animal Science
John D. Lippolis, Ellie J. Putz, Timothy A. Reinhardt, Eduardo Casas, Wanda J. Weber, Brian A. Crooker
Summary: Selective breeding of US dairy cows has led to increased milk yield but also increased health issues. Comparing genetically static, unselected Holsteins (UH) with contemporary Holsteins (CH), it was found that UH cows produce less milk and have fewer health concerns. This study aimed to investigate the effects of Holstein genotype on innate immune response in an experimental intramammary Escherichia coli challenge model. The results showed that UH cows exhibited more effective control of E. coli in the mammary gland, indicating that selective breeding practices have resulted in CH cows with a less effective immune system.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Immunology
Kangjun Liu, Xi Zhou, Li Fang, Junsheng Dong, Luying Cui, Jun Li, Xia Meng, Guoqiang Zhu, Jianji Li, Heng Wang
Summary: Staphylococcus aureus (S. aureus) has the ability to invade mammalian cells and protect itself from clearance by the immune system. The role of mitophagy in S. aureus-associated bovine mastitis has been unclear. This study found that S. aureus infection induces mitophagy and enhances inflammation, contributing to S. aureus survival.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Carolina Engler, Maria S. Renna, Camila Beccaria, Paula Silvestrini, Silvana I. Pirola, Elizabet A. L. Pereyra, Celina Baravalle, Cecilia M. Camussone, Stefan Monecke, Luis F. Calvinho, Bibiana E. Dallard
Summary: This study evaluated and compared the ability of two S. aureus strains with different adaptation genotypes to establish an intramammary infection and induce immune responses in lactating cows. The results showed that the strains with different genotypes and adaptability influenced the course and severity of the infection and the local immune response in the bovine mammary gland.
MICROBIAL PATHOGENESIS
(2022)
Article
Chemistry, Multidisciplinary
Shuting Jiang, Yueqi Ni, Fanyu Zhang, Yiling Duan, Haoning Qi, Wenting Mo, Qinchao Tang, Richard J. Miron, Yufeng Zhang
Summary: Zirconium implants are favored by clinicians for their superior mechanical properties, although they have poorer early osseointegration compared to titanium implants. The mechanism for the higher inflammation caused by zirconia implants is currently unknown. This study demonstrates that zirconium oxide triggers complement activation, leading to differences in inflammation compared to titanium oxide. The results provide new insights for implant design and optimization.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Veterinary Sciences
Zhuo-Ma Luoreng, Jian Yang, Xing-Ping Wang, Da-Wei Wei, Lin-Sen Zan
Summary: Staphylococcus aureus infection causes mastitis in dairy cows, affecting milk quality and economic benefits. The study identified differentially expressed miRNAs that may regulate inflammation processes, with specific miRNAs showing significant expression changes on days 5 and 7, potentially playing important biological roles in mastitis and guiding research into molecular therapy technologies.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Pablo Gomes Noleto, Florence B. B. Gilbert, Christelle Rossignol, Patricia Cunha, Pierre Germon, Pascal Rainard, Rodrigo Prado Martins
Summary: In this study, an ex vivo model using punch-excised teat tissue was used to investigate the immune mechanisms of the mammary gland in the early stages of infection. The results showed that the teat tissue responded to TLR agonists and bacteria, simulating the inflammatory response caused by infection. The study also demonstrated that this ex vivo model can be applied to frozen-stored tissue explants.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Immunology
Yuanyang Yi, Hanqing Wang, Lingling Su, Hao Wang, Baojiang Zhang, Yan Su
Summary: Staphylococcus aureus is a major cause of bovine mastitis, with the ESS secretion system being considered a key virulence factor. EsxA and EsxB, proteins secreted by ESS, are associated with T-cell antigens. EsxB can enhance EsxA-specific antibody levels and increase CD8+ T cell proliferation.
MICROBIAL PATHOGENESIS
(2021)
Article
Immunology
Elisa Petruccioli, Linda Petrone, Teresa Chiacchio, Chiara Farroni, Gilda Cuzzi, Assunta Navarra, Valentina Vanini, Umberto Massafra, Marianna Lo Pizzo, Giuliana Guggino, Nadia Caccamo, Fabrizio Cantini, Fabrizio Palmieri, Delia Goletti
Summary: Patients with immune-mediated inflammatory diseases (IMID), such as rheumatoid arthritis (RA), have a higher risk of developing active tuberculosis (TB) compared to the general population. Studying the M. tuberculosis (Mtb) specific T-cell response may help identify immune biomarkers of Mtb burden or clearance in different TB statuses and risk groups.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Mackenzie Zendt, Fausto A. Bustos Carrillo, Sophie Kelly, Taylor Saturday, Maureen Degrange, Anita Ginigeme, Lurline Wu, Viviane Callier, Ana Ortega-Villa, Mondreakest Faust, Emma Chang-Rabley, Kara Bugal, Heather Kenney, Pavel Khil, Jung-Ho Youn, Gloria Osei, Pravesh Regmi, Victoria Anderson, Marita Bosticardo, Janine Daub, Thomas Dimaggio, Samantha Kreuzburg, Francesca Pala, Justina Pfister, Jennifer Treat, Jean Ulrick, Maria Karkanitsa, Heather Kalish, Douglas B. Kuhns, Debra L. Priel, Danielle L. Fink, John S. Tsang, Rachel Sparks, Gulbu Uzel, Meryl A. Waldman, Christa S. Zerbe, Ottavia M. Delmonte, Jenna R. E. Bergerson, Sanchita Das, Alexandra F. Freeman, Michail S. Lionakis, Kaitlyn Sadtler, Neeltje van Doremalen, Vincent Munster, Luigi D. Notarangelo, Steven M. Holland, Emily E. Ricotta
Summary: Research on coronavirus disease 2019 vaccination in immune-deficient/disordered people has primarily focused on cancer and organ transplantation populations. Three doses of the vaccine induced antispike IgG in most immune-deficient/disordered individuals, but additional doses are required for increased protection. The reduced IgG response to the Omicron BA.1 variant highlights the need for studying the efficacy of additional vaccinations, including bivalent vaccines, in this population.
Article
Fisheries
Ratiporn Thongsoi, Siriluk Maskaew, Panumas Puechpon, Benjaporn Noppradit, Napassawan Inaek, Prapaporn Utarabhand, Phanthipha Runsaeng
Summary: In this study, a PPAE gene called FmPPAE1 was cloned and analyzed in banana shrimp. FmPPAE1 plays a vital role in regulating the proPO system, exhibits antibacterial properties, and contributes to the suppression of bacterial proliferation.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jishuang Tan, Paizelaiti Sahaer, Huan Li, Wei Han, Hongyan Sun
Summary: Circular RNAs (circRNA) are involved in gene expression and affect cellular processes such as transcription, splicing, and translation by interacting with microRNA and RNA binding proteins. A study identified circDNAJB6 as a circular RNA abundant in chicken macrophages after bacterial infection, and found that circDNAJB6 exacerbates cellular injury and interacts with multiple miRNAs and target genes, potentially impacting autophagy and MAPK signaling pathways.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Rodrigo Guabiraba, Damaris Ribeiro Rodrigues, Paul T. Manna, Melanie Chollot, Vincent Saint-Martin, Sascha Trapp, Marisa Oliveira, Clare E. Bryant, Brian J. Ferguson
Summary: The innate immune response relies on the ability of host cells to detect and respond to microbial nucleic acids. Toll-like receptors (TLRs) play a crucial role in this process by distinguishing self from non-self. This study focused on TLR21, an avian TLR that recognizes bacterial DNA motifs. The findings suggest that avian TLR21 shares similar activation mechanisms to mammalian TLR9, highlighting the conservation of nucleic acid sensing mechanisms across species.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Safieh Zeinali, Kate Sutton, Lonneke Vervelde
Summary: Chickens have a unique immune structure characterized by the absence of draining lymph nodes and the presence of well-developed mucosa-associated lymphoid tissue. The structure and development of chicken lymphoid tissues in the intestine, particularly Peyer's patches, have been poorly studied. However, the use of CSF1R-eGFP reporter transgenic chickens has allowed for the visualization and investigation of the development and distribution of these tissues. This research provides insights that could benefit mucosal vaccination strategies and the development of targeted vaccine delivery systems.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Retraction
Fisheries
G. -g. Li, Z. -z. Guo, X. -f. Ma, N. Cao, S. -n. Geng, Y. -q. Zheng, M. -j. Meng, H. -h. Lin, G. Han, G. -j. Du
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jinyue Yang, Peng Zhou, Wanrong Wu, Qingxiang Zhang, Dong Chen, Rui Luo
Summary: This study cloned and characterized the full-length sequence of duck MRE11 (duMRE11) for the first time, and found that this protein plays an important role in the innate immune response of ducks.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Mengjiao Guo, Jiaqi Zhang, Mingtao Li, Xiaorong Zhang, Yantao Wu
Summary: rNLRC3 negatively regulates the NF -KB signaling pathway induced by P. multocida in rabbits by inhibiting the activation of NF -KB, reducing the expression of inflammatory cytokines, and interacting with rTRAF4 and rTRAF6. The NACHT-LRR domain is the functional domain of rNLRC3. These findings provide insights into the important role of rNLRC3 in combating P. multocida infection.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Yinan Li, Xingye Lian, Wenwen Yang, Jinyuan Leng, Jiejie Sun, Yu Liu, Siqi Fan, Lingling Wang, Linsheng Song
Summary: The DM9-containing protein CgDM9CP-7 plays an important role in the innate immune response of molluscs. It is constitutively expressed in various tissues and is up-regulated in haemocytes after stimulation by Vibrio splendidus and lipopolysaccharide (LPS). CgDM9CP-7 binds to various pathogens and exhibits antimicrobial activity, while also regulating the expression of CgMyD88 and CgIL-17.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Xiuwen Bao, Haoran Song, Liying He, Yong Li, Shuqi Niu, Jinlin Guo
Summary: This study focuses on the interaction between Hepialus xiaojinensis larvae and Ophiocordyceps sinensis during the infection process. The results show that the infected third instar larvae enhance antioxidant defense ability, while the infected fourth instar larvae reduce this ability and allocate more energy to growth and development.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)