期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 34, 期 6, 页码 648-658出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2010.01.009
关键词
Ovary; Viral hemorrhagic septicemia virus (VHSV); Infectious pancreatic necrosis virus (IPNV); Chemokines; Immune response
资金
- Ministerio de Ciencia e Innovacion [AGL2008-03519-004-02]
- EPIZONE European Netwok
Viral hemorrhagic septicemia virus (VHSV) and infectious pancreatic necrosis virus (IPNV) are two rainbow trout (Oncorhynchus mykiss) pathogens. While IPNV is known to be vertically transmitted to the next generation through the oocyte. VHSV is known to replicate in the ovary and be transmitted horizontally through the ovarian fluid. In this work, we wanted to study whether these differences had an effect on the immune response triggered in the ovary, with a focus on the chemokine response. We have studied the kinetics of viral gene expression and the sites of replication, confirming that great differences exist between the replication of the two viruses in the gonad. Next, we studied the levels of expression of several CXC and CC chemokines in the ovary and found that while VHSV strongly triggered chemokine transcription, IPNV had almost no effect. This lack of immune response might be an advantage that permits its vertical transmission. (C) 2010 Elsevier Ltd. All rights reserved.
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