Article
Chemistry, Multidisciplinary
Shanchong Chen, Chi Zhang, Lihan Zhang
Summary: This study provides a global atlas of bacterial aromatic polyketides based on large-scale analysis of type II polyketide synthases. The chain length factor protein is identified as a marker that can predict the chemical class and molecular uniqueness of the biosynthetic product. The results serve as a compass for exploiting the entire type II polyketide synthase-derived aromatic polyketides in bacteria.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Plant Sciences
Terezie Mandakova, Martin A. Lysak
Summary: This study presents the progress in understanding the genome of camelina, revealing the molecular evolutionary history of the polyploid complex. By studying the tetraploid camelina genome in detail, researchers have identified a high collinearity with two maternally inherited subgenomes of the hexaploid camelina.
Article
Genetics & Heredity
Yanping Li, Yunyun Lv, Chao Bian, Xinxin You, Qiong Shi
Summary: The study conducted a comprehensive examination of MTNRs in vertebrates through comparative genome mining. The potential expansions of mtnr1a and mtnr1b in zebrafish were also identified in other Cyprinifomes. This expansion was observed to cluster into a primitive position of the Actinopterygii, resulting from teleost-specific genome duplication.
Article
Agronomy
Juanyu Zhang, Yanyan Tang, Xi Pu, Xuebing Qiu, Jinhui Wang, Tao Li, Zhao Yang, Yao Zhou, Yuxiao Chang, Junjun Liang, Haili Zhang, Guangbing Deng, Hai Long
Summary: This study characterized a wheat mutant and identified a novel qualitative locus WPS1 related to wheat spike development. Transcriptomic analysis indicated that WPS1 is associated with auxin-related pathways. This study laid the foundation for further validation of the causal gene of WPS1 and explored its regulatory mechanism in wheat spike development.
THEORETICAL AND APPLIED GENETICS
(2022)
Article
Chemistry, Physical
Li Liu, Yingchun He, Dong-Dong Ma, Xin-Tao Wu, Qi-Long Zhu
Summary: Anodic oxidation assisted hydrogen production under mild conditions powered by renewable electricity represents a sustainable approach to energy conversion systems. Here, we fabricated a versatile and universal self-supported nanoarray platform that can be intelligently edited to achieve adaptive electrocatalysis for alcohol oxidation reactions and hydrogen evolution reaction (HER). The obtained self-supported nanoarray electrocatalysts exhibit excellent catalytic activity due to the integration of multiple merits of rich nanointerface-reconstruction and self-supported hierarchical structures.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Xiaoyang Wu, Jun Chen, Xibao Wang, Yongquan Shang, Qinguo Wei, Honghai Zhang
Summary: This study investigated the evolution of PRR genes in 43 Carnivora species, providing insights into the molecular mechanisms of carnivorous adaptation to complex habitats. The results showed that PRRs were relatively conserved, but different gene families showed different evolutionary patterns. Different ecological niches may have driven the evolution of PRR genes.
Article
Biotechnology & Applied Microbiology
Ehren J. Bentz, Alexander G. Ophir
Summary: The Southern giant pouched rat is a large rodent with the ability to detect landmines using its impressive sense of smell. It has powerful chemosensory abilities and shows unique reproductive physiology, possibly mediated by pheromonal mechanisms. The chromosome-scale genomic sequence of the pouched rat reveals genetic expansions related to olfactory specialization. This reference-quality genomic sequence will be useful for future molecular research on the pouched rat.
Article
Computer Science, Artificial Intelligence
Kumie Gedamu, Yanli Ji, LingLing Gao, Yang Yang, Heng Tao Shen
Summary: This paper proposes a skeleton-based human action recognition method using a Relation-mining Self-Attention Network (RSA-Net) to model spatiotemporal global dependencies and dynamics of body joints. The RSA-Net contains pairwise self-attention, unary self-attention, and position embedding attention modules. Extensive evaluations show that the proposed RSA-Net outperforms existing transformer-based approaches and achieves comparable results with state-of-the-art graph ConvNet methods.
PATTERN RECOGNITION
(2023)
Article
Multidisciplinary Sciences
Claire A. de March, Hiroaki Matsunami, Masashi Abe, Matthew Cobb, Kara C. Hoover
Summary: Humans, Neanderthals, and Denisovans have independently adapted to diverse geographic environments and associated food odors. By studying the ancient DNA sequences, we discovered variations in odorant receptor genes in our genus Homo. These variations in protein sequence and structure might have influenced our odor detection and perception abilities. Different variants had minimal impact on specificity but had more noticeable effects on functional sensitivity. The Neanderthal variants caused disruptions in function, while Denisovan variants led to an increased sensitivity to sweet and sulfur odors. This suggests that geographic adaptations have resulted in greater functional variation in our lineage, expanding our olfactory repertoire and adaptive capacity. Our exploration of olfactory genes and odorant receptors indicates a shared genetic repertoire within our genus, potentially associated with local ecological adaptations.
Article
Environmental Sciences
Chenyu Wang, Fu Liao, Guangcai Wang, Shen Qu, Hairu Mao, Yunfei Bai
Summary: This study investigates the hydrogeochemical evolution of groundwater in a multi-aquifer system in the Fengfeng Mining Area using machine learning and isotopic analysis. The results show that long-term mining activities have different impacts on the hydrogeochemical characteristics of different aquifers, and pyrite oxidation, gypsum dissolution, and carbonate dissolution are the main controlling factors.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Multidisciplinary
Bryce da Camara, Connor Z. Woods, Komal Sharma, Hoi-Ting Wu, Naira S. Farooqi, Changwei Chen, Ryan R. Julian, Douglas A. Vander Griend, Richard J. Hooley
Summary: Spacious M4L6 tetrahedra can act as catalytic inhibitors for base-mediated reactions by increasing the acidity of the reaction solvent, resulting in a reduced conversion rate of the conjugate addition reaction.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Multidisciplinary Sciences
Arang Rhie, Shane A. McCarthy, Olivier Fedrigo, Joana Damas, Giulio Formenti, Sergey Koren, Marcela Uliano-Silva, William Chow, Arkarachai Fungtammasan, Juwan Kim, Chul Lee, Byung June Ko, Mark Chaisson, Gregory L. Gedman, Lindsey J. Cantin, Francoise Thibaud-Nissen, Leanne Haggerty, Iliana Bista, Michelle Smith, Bettina Haase, Jacquelyn Mountcastle, Sylke Winkler, Sadye Paez, Jason Howard, Sonja C. Vernes, Tanya M. Lama, Frank Grutzner, Wesley C. Warren, Christopher N. Balakrishnan, Dave Burt, Julia M. George, Matthew T. Biegler, David Iorns, Andrew Digby, Daryl Eason, Bruce Robertson, Taylor Edwards, Mark Wilkinson, George Turner, Axel Meyer, Andreas F. Kautt, Paolo Franchini, H. William Detrich, Hannes Svardal, Maximilian Wagner, Gavin J. P. Naylor, Martin Pippel, Milan Malinsky, Mark Mooney, Maria Simbirsky, Brett T. Hannigan, Trevor Pesout, Marlys Houck, Ann Misuraca, Sarah B. Kingan, Richard Hall, Zev Kronenberg, Ivan Sovi, Christopher Dunn, Zemin Ning, Alex Hastie, Joyce Lee, Siddarth Selvaraj, Richard E. Green, Nicholas H. Putnam, Ivo Gut, Jay Ghurye, Erik Garrison, Ying Sims, Joanna Collins, Sarah Pelan, James Torrance, Alan Tracey, Jonathan Wood, Robel E. Dagnew, Dengfeng Guan, Sarah E. London, David F. Clayton, Claudio Mello, Samantha R. Friedrich, Peter Lovell, Ekaterina Osipova, Farooq O. Al-Ajli, Simona Secomandi, Heebal Kim, Constantina Theofanopoulou, Michael Hiller, Yang Zhou, Robert S. Harris, Kateryna D. Makova, Paul Medvedev, Jinna Hoffman, Patrick Masterson, Karen Clark, Fergal Martin, Kevin Howe, Paul Flicek, Brian P. Walenz, Woori Kwak, Hiram Clawson, Mark Diekhans, Luis Nassar, Benedict Paten, Robert H. S. Kraus, Andrew J. Crawford, M. Thomas P. Gilbert, Guojie Zhang, Byrappa Venkatesh, Robert W. Murphy, Klaus-Peter Koepfli, Beth Shapiro, Warren E. Johnson, Federica Di Palma, Tomas Marques-Bonet, Emma C. Teeling, Tandy Warnow, Jennifer Marshall Graves, Oliver A. Ryder, David Haussler, Stephen J. O'Brien, Jonas Korlach, Harris A. Lewin, Kerstin Howe, Eugene W. Myers, Richard Durbin, Adam M. Phillippy, Erich D. Jarvis
Summary: The Vertebrate Genome Project and the international Genome 10K consortium have collaborated to generate high-quality genome assemblies for 16 species representing six major vertebrate lineages, leading to new biological discoveries. Long-read sequencing technologies are essential for maximizing genome quality, and addressing complex repeats and haplotype heterozygosity are crucial for reducing assembly errors and improving completeness of reference genomes. The lessons learned from this project have paved the way for the Vertebrate Genomes Project (VGP), an international effort to generate high-quality, complete reference genomes for all known vertebrate species.
Article
Biochemistry & Molecular Biology
Qiang He, Dan Ma, Wei Li, Longsheng Xing, Hongyu Zhang, Yu Wang, Cailian Du, Xuanzhao Li, Zheng Jia, Xiuxiu Li, Jianan Liu, Ze Liu, Yuqing Miao, Rui Feng, Yang Lv, Meijia Wang, Hongwei Lu, Xiaochen Li, Yao Xiao, Ruyu Wang, Hanfei Liang, Qinghong Zhou, Lijun Zhang, Chengzhi Liang, Huilong Du
Summary: We report the high-quality genome assembly of common buckwheat and compare it with Tartary buckwheat. The analysis reveals the insertion of repetitive sequences and chromosomal rearrangements in common buckwheat after divergence from Tartary buckwheat. Additionally, gene families involved in stress tolerance and flavonoid biosynthesis show significant expansion in buckwheat, especially common buckwheat. Integrated multi-omics analysis identifies different gene expression patterns related to flavonoid biosynthesis and self-incompatibility between the two buckwheat species. This study provides important resources for future research on flavonoid biosynthesis and self-incompatibility in buckwheat.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2023)
Article
Engineering, Biomedical
Wei Chen, Lihui Feng, Jihua Lu, Bian Wu
Summary: This study proposes an end-to-end neural network architecture called Myoformer, based on multi-channel self-attention mechanism, which automatically detects and repairs aberrant signals, enables global signal filtering, and improves gesture recognition accuracy.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Chemistry, Multidisciplinary
Hyunsung Nam, Joon Soo An, Jaepil Lee, Yonghwan Yun, Hyunbin Lee, Hyungou Park, Yousung Jung, Ki-Bong Oh, Dong-Chan Oh, Seokhee Kim
Summary: This study demonstrates the ability of cytochrome P450 enzymes to generate diverse biaryl linkages, expanding the chemical diversity of macrocyclic peptides. Using genome mining and NMR structure determination, the study identified three unprecedented or rare biaryl linkages. The findings are significant for exploring the chemical structures of biaryl-containing peptides encoded in bacterial genomes.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Anna S. Smagina, Sergey Kulemzin, Gaukhar M. Yusubalieva, Anna G. Kedrova, Andrey E. Sanzharov, Yurii Ivanov, Darya A. Matvienko, Vladimir A. Kalsin, Andrey A. Gorchakov, Vladimir P. Baklaushev, Aleksandr Taranin
Summary: Immunotherapy with genetically engineered T- and NK-cells has shown high efficacy in certain B-cell malignancies, with NK cells as carriers of CARs showing promise for reducing treatment costs and reaching more patients. Derivative YT-VAV1 cells with enhanced cytotoxicity outperform parental YT cells in vitro.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Arianna Lopez, Carolyn Shoen, Michael Cynamon, Dionysia Dimitrakopoulou, Matthieu Paiola, Martin S. Pavelka, Jacques Robert
Summary: The study demonstrated the use of Xenopus laevis tadpoles as a complementary model for investigating persistent Mab infection and pathogenesis. Both S and R Mab morphotypes were able to disseminate in tadpole tissues for up to 40 days, with the R morphotype showing higher bacterial load. Intracardiac injection of S Mab led to significantly higher mortality compared to injection of the R Mab form.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Toxicology
Connor C. McGuire, B. Paige Lawrence, Jacques Robert
Summary: Research shows that exposure to a mixture of EDCs can impact thymocyte development, especially during the perinatal stage. The mixture of chemicals is more potent in disrupting thymocyte development compared to individual chemicals. Genes and cells related to thymocyte development show significant alterations after exposure to the mixture.
TOXICOLOGICAL SCIENCES
(2021)
Article
Virology
Yun Tian, Francisco De Jesus Andino, Collins N. Khwatenge, Jiuyi Li, Jacques Robert, Yongming Sang
Summary: This study conducted a comprehensive genome-wide viral transcriptome profiling during FV3 infection across multiple amphibian host tissues. The findings suggest that Ranaviruses like FV3 have acquired previously unknown molecular mimics, interfering with host interferon signaling during evolution. Extensive analysis validated the expression of almost all of the 98 annotated ORFs and profiled their differential expression in a tissue-, virus-, and temporal class-dependent manner.
Article
Cell Biology
Andrey A. Gorchakov, Sergey V. Kulemzin, Sergey V. Guselnikov, Konstantin O. Baranov, Tatyana N. Belovezhets, Ludmila V. Mechetina, Olga Yu. Volkova, Alexander M. Najakshin, Nikolai A. Chikaev, Anton N. Chikaev, Pavel P. Solodkov, Victor F. Larichev, Marina A. Gulyaeva, Alexander G. Markhaev, Yulia V. Kononova, Alexander Yu. Alekseyev, Alexander M. Shestopalov, Gaukhar M. Yusubalieva, Tatiana V. Klypa, Alexander V. Ivanov, Vladimir T. Valuev-Elliston, Vladimir P. Baklaushev, Alexander V. Taranin
Summary: In the absence of approved small-molecule drugs targeting the virus, broadening the repertoire of potent SARS-CoV-2-neutralizing antibodies is crucial. This study isolated 23 RBD-specific human monoclonal antibodies with strong virus-neutralizing activity, including four categorized as ultrapotent. These antibodies retain activity against various SARS-CoV-2 variants and could effectively prevent viral replication and lung pathology.
Review
Health Care Sciences & Services
Sergey Kulemzin, Igor Evsyukov, Tatiana Belovezhets, Alexander Taranin, Andrey Gorchakov
Summary: The adoptive transfer of allogeneic CAR NK cells shows great promise in anticancer therapy due to the ease of manufacturing and genetic modification of NK cells, making it more affordable. However, compared to CAR T cell therapy, the evaluation of antitumor properties of CAR NK cells still lags behind. Understanding the biological features of NK cells and comparing T cells and NK cells through single-cell transcriptomic analysis are crucial in defining the therapeutic potential of CAR NK cells.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mariya B. Borgoyakova, Larisa I. Karpenko, Andrey P. Rudometov, Ekaterina A. Volosnikova, Iuliia A. Merkuleva, Ekaterina V. Starostina, Alexey M. Zadorozhny, Anastasiya A. Isaeva, Valentina S. Nesmeyanova, Daniil V. Shanshin, Konstantin O. Baranov, Natalya V. Volkova, Boris N. Zaitsev, Lyubov A. Orlova, Anna V. Zaykovskaya, Oleg V. Pyankov, Elena D. Danilenko, Sergei I. Bazhan, Dmitry N. Shcherbakov, Alexander V. Taranin, Alexander A. Ilyichev
Summary: This study developed a self-assembled vaccine particle that combines recombinant protein and DNA vaccine approaches. The results demonstrated that the combined vaccine effectively induced a higher level of antigen-specific IgG, neutralizing activity, and cellular immune response in mice compared to DNA or protein vaccines alone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Maria G. Byazrova, Sergey V. Kulemzin, Ekaterina A. Astakhova, Tatyana N. Belovezhets, Grigory A. Efimov, Anton N. Chikaev, Ilya O. Kolotygin, Andrey A. Gorchakov, Alexander V. Taranin, Alexander V. Filatov
Summary: The development of effective vaccines against SARS-CoV-2 is crucial. The study found that Sputnik V vaccination can result in robust B cell immunity, which is influenced by the individuals' history of SARS-CoV-2 infection. The research shows that B memory cell responses to Sputnik V play a significant role in neutralizing the virus and may provide insights into future responses against emerging variants.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Health Care Sciences & Services
Sergey Kulemzin, Maria Sergeeva, Konstantin O. Baranov, Andrey A. Gorchakov, Sergey Guselnikov, Tatyana N. Belovezhets, Olga Yu Volkova, Alexander M. Najakshin, Nikolai A. Chikaev, Daria M. Danilenko, Alexander Taranin
Summary: The immune evasion of SARS-CoV-2 undermines current strategies to counteract the pandemic, especially affecting the efficacy of virus-neutralizing antibodies. In this study, two previously identified human cross-neutralizing antibodies were tested for their ability to neutralize the Omicron variant. While both antibodies showed binding affinity to the Omicron RBD, they displayed different functional features. One antibody's neutralizing activity was reduced, while the other showed an unexpected increase, making it a potential candidate for COVID-19 therapy and prophylaxis.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cell Biology
Ekaterina A. Astakhova, Maria G. Byazrova, Gaukhar M. Yusubalieva, Sergey Kulemzin, Natalia A. Kruglova, Alexey G. Prilipov, Vladimir P. Baklaushev, Andrey A. Gorchakov, Alexander Taranin, Alexander Filatov
Summary: The study found that the B-cell response in COVID-19 convalescent patients was stronger compared to those who received the Gam-COVID-Vac vaccination. The levels of neutralizing antibodies in convalescent patients were significantly higher than those in vaccinated individuals. These results suggest that natural immunity is superior to Gam-COVID-Vac-induced immunity six months after recovery/vaccination.
Article
Immunology
Matthieu Paiola, Siyuan Ma, Jacques Robert
Summary: The fms-related tyrosine kinase 3 (Flt3) and its ligand (Flt3lg) play important roles in hematopoiesis and dendritic cell homeostasis. They show differences among species and duplicated genes in Xenopus laevis. The homoeologs of Flt3 and Flt3lg exhibit conformational divergence and different expression patterns in tadpoles and adult frogs. Flt3lg and Flt3 are involved in XL cell homeostasis and XL cells have hematopoietic origin. In addition, macrophage/monocyte marker Csf1r.S is expressed on XL cells, indicating a common evolutionary origin of vertebrate DCs.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Fisheries
Matthieu Paiola, Dionysia Dimitrakopoulou, Martin S. Pavelka Jr, Jacques Robert
Summary: Mycobacterial infections are a major concern for both humans and vertebrates in aquatic and terrestrial environments. There are common features in the interactions between non-tuberculous mycobacteria and endo-and ectothermic animals, similar to those observed in Mycobacterium tuberculosis infections. The detection of non-tuberculous mycobacteria in amphibians is not only economically damaging but also poses a growing threat to human health.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Fisheries
Connor C. McGuire, Jacques R. Robert
Summary: Immunity can be reprogrammed by environmental chemicals and endocrine signals. Thyroid disrupting chemicals (TDCs) have the potential to affect T cell immunity, but the mechanisms are not well understood. This review discusses the influence of thyroid hormones on T cell development and emerging TDCs that may affect both thyroid hormone physiology and immune outcomes. Using the amphibian Xenopus laevis is recommended for studying the impact of TDCs on immune toxicological endpoints.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Review
Biology
Vania Lopez Ruiz, Jacques Robert
Summary: Amphibians play a crucial role in bridging the evolutionary gap between mammals and ancient vertebrates. Understanding their immune system, which is similar to that of mammals, is important for disease research. The African clawed frog, Xenopus laevis, is a good model for studying the immune system, particularly during early development stages. This review summarizes the knowledge about the innate and adaptive immune system of X. laevis and compares it with other amphibians. It also discusses the response of amphibians to viral, bacterial, and fungal infections.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Editorial Material
Biology
Vania Regina Assis, Jacques Robert, Stefanny Christie Monteiro Titon
Summary: Amphibian populations are declining worldwide due to global climate changes and infectious diseases, such as ranavirosis and chytridiomycosis. The immune mechanisms underlying amphibian disease resistance and host-pathogen interactions are still not well understood. Understanding the stress, disease, and ecoimmunology contexts is crucial for better understanding amphibian immunity and developing effective conservation strategies.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Fisheries
Ratiporn Thongsoi, Siriluk Maskaew, Panumas Puechpon, Benjaporn Noppradit, Napassawan Inaek, Prapaporn Utarabhand, Phanthipha Runsaeng
Summary: In this study, a PPAE gene called FmPPAE1 was cloned and analyzed in banana shrimp. FmPPAE1 plays a vital role in regulating the proPO system, exhibits antibacterial properties, and contributes to the suppression of bacterial proliferation.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jishuang Tan, Paizelaiti Sahaer, Huan Li, Wei Han, Hongyan Sun
Summary: Circular RNAs (circRNA) are involved in gene expression and affect cellular processes such as transcription, splicing, and translation by interacting with microRNA and RNA binding proteins. A study identified circDNAJB6 as a circular RNA abundant in chicken macrophages after bacterial infection, and found that circDNAJB6 exacerbates cellular injury and interacts with multiple miRNAs and target genes, potentially impacting autophagy and MAPK signaling pathways.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Rodrigo Guabiraba, Damaris Ribeiro Rodrigues, Paul T. Manna, Melanie Chollot, Vincent Saint-Martin, Sascha Trapp, Marisa Oliveira, Clare E. Bryant, Brian J. Ferguson
Summary: The innate immune response relies on the ability of host cells to detect and respond to microbial nucleic acids. Toll-like receptors (TLRs) play a crucial role in this process by distinguishing self from non-self. This study focused on TLR21, an avian TLR that recognizes bacterial DNA motifs. The findings suggest that avian TLR21 shares similar activation mechanisms to mammalian TLR9, highlighting the conservation of nucleic acid sensing mechanisms across species.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Safieh Zeinali, Kate Sutton, Lonneke Vervelde
Summary: Chickens have a unique immune structure characterized by the absence of draining lymph nodes and the presence of well-developed mucosa-associated lymphoid tissue. The structure and development of chicken lymphoid tissues in the intestine, particularly Peyer's patches, have been poorly studied. However, the use of CSF1R-eGFP reporter transgenic chickens has allowed for the visualization and investigation of the development and distribution of these tissues. This research provides insights that could benefit mucosal vaccination strategies and the development of targeted vaccine delivery systems.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Retraction
Fisheries
G. -g. Li, Z. -z. Guo, X. -f. Ma, N. Cao, S. -n. Geng, Y. -q. Zheng, M. -j. Meng, H. -h. Lin, G. Han, G. -j. Du
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jinyue Yang, Peng Zhou, Wanrong Wu, Qingxiang Zhang, Dong Chen, Rui Luo
Summary: This study cloned and characterized the full-length sequence of duck MRE11 (duMRE11) for the first time, and found that this protein plays an important role in the innate immune response of ducks.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Mengjiao Guo, Jiaqi Zhang, Mingtao Li, Xiaorong Zhang, Yantao Wu
Summary: rNLRC3 negatively regulates the NF -KB signaling pathway induced by P. multocida in rabbits by inhibiting the activation of NF -KB, reducing the expression of inflammatory cytokines, and interacting with rTRAF4 and rTRAF6. The NACHT-LRR domain is the functional domain of rNLRC3. These findings provide insights into the important role of rNLRC3 in combating P. multocida infection.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Yinan Li, Xingye Lian, Wenwen Yang, Jinyuan Leng, Jiejie Sun, Yu Liu, Siqi Fan, Lingling Wang, Linsheng Song
Summary: The DM9-containing protein CgDM9CP-7 plays an important role in the innate immune response of molluscs. It is constitutively expressed in various tissues and is up-regulated in haemocytes after stimulation by Vibrio splendidus and lipopolysaccharide (LPS). CgDM9CP-7 binds to various pathogens and exhibits antimicrobial activity, while also regulating the expression of CgMyD88 and CgIL-17.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Xiuwen Bao, Haoran Song, Liying He, Yong Li, Shuqi Niu, Jinlin Guo
Summary: This study focuses on the interaction between Hepialus xiaojinensis larvae and Ophiocordyceps sinensis during the infection process. The results show that the infected third instar larvae enhance antioxidant defense ability, while the infected fourth instar larvae reduce this ability and allocate more energy to growth and development.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
