Article
Biochemistry & Molecular Biology
Magda Lewandowska, Ton Sharoni, Yael Admoni, Reuven Aharoni, Yehu Moran
Summary: The study characterized the antiviral immune response of the cnidarian Nematostella vectensis and showed that its RLR paralogs exhibit features distinctive for both vertebrate and invertebrate systems. The functional evidence provided supports the conserved role of RLRs in initiating immune response to dsRNA before the cnidarian-bilaterian split, laying a foundation for further research on the evolution of immune responses to RNA viruses.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Fisheries
Isis Rojas, Claudia Carcamo, Felipe Stambuk, Luis Mercado, Rodrigo Rojas, Paulina Schmitt, Katherina Brokordt
Summary: The study investigated the expression patterns of immune system genes during early development of scallop larvae. Results indicated a maturation of the immune system towards late developmental stages and a possible parental transfer of immune-related protein ApBD1.
Article
Fisheries
Chen-Yang Lin, Yan-Mei Zhang, Wen-Bin Xu, Miao-An Shu, Wei-Ren Dong
Summary: In this study, two subtypes of ERO1 involved in regulating disulfide bond formation and maintaining endoplasmic reticulum homeostasis were identified and characterized in Scylla paramamosain. The expression of these ERO1 subtypes exhibited distinct patterns in response to bacterial and viral challenges. Silencing of ERO1 expression resulted in downregulation of immune factors in the crabs. These findings provide initial insights into the role of ERO1 in the innate immunity of invertebrates.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Huan Zhang, Maocang Yan, Yaohua Wang, Hui Gao, Lihua Hu, Dewei Ji, Min Zhang
Summary: In this study, a C-type lectin homolog (PvCTL2) was identified and characterized in Penaeus vannamei. PvCTL2 was found to be highly expressed in various tissues and its expression level could be upregulated by Vibrio parahaemolyticus challenge. The recombinant PvCTL2 protein showed Ca2+-dependent agglutination activity against different types of bacteria and fungi. Silencing of the PvCTL2 gene resulted in higher mortality rate and shorter median lethal time in shrimp challenged with Vibrio parahaemolyticus, indicating its important role in the immune response against bacterial challenge.
AQUACULTURE INTERNATIONAL
(2023)
Review
Fisheries
Lage Cerenius, Kenneth Soderhall
Summary: Melanin production by different types of phenoloxidases provides immunity to a variety of pathogens, while proPO in arthropods exhibits multiple activities such as cytokine and microbiocidal activities. Pathogens influence proPO activation and the types of immune effects produced.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Apple Cortez Vollmers, Sergio Covarrubias, Daisy Kuang, Aaron Shulkin, Justin Iwuagwu, Sol Katzman, Ran Song, Kasthuribai Viswanathan, Christopher Vollmers, Edward Wakeland, Susan Carpenter
Summary: Recent studies have identified a previously unknown function for the lncRNA GAPLINC, which acts as a negative regulator of inflammation in the context of innate immunity, macrophages, and LPS-induced endotoxic shock. Transcriptome analysis in human and mouse macrophages showed that GAPLINC is highly expressed following macrophage differentiation, but rapidly down-regulated upon inflammatory activation. Depletion of GAPLINC leads to enhanced expression of inflammatory genes, while overexpression suppresses this response, ultimately modulating endotoxic shock and multiorgan failure.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Ho Am Jang, Bharat Bhusan Patnaik, Maryam Ali Mohammadie Kojour, Bo Bae Kim, Young Min Bae, Ki Beom Park, Yong Seok Lee, Yong Hun Jo, Yeon Soo Han
Summary: TmSpz-like, a cystine knot protein in T. molitor, plays a critical role in the innate immune response against E. coli infection by positively regulating AMP production and the expression of NF-κB-encoding genes. Its knockdown leads to downregulation of AMP-encoding genes and NF-κB expression, impacting the viability of infected larvae.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Food Science & Technology
Cristina Valeria Bulgaru, Daniela Eliza Marin, Gina Cecilia Pistol, Ionelia Taranu
Summary: ZEA is an estrogenic fusariotoxin that affects reproductive health and immune response. It can cause reproductive disorders and impact immune response, with studies showing effects on different types of immune cells and immune organs. Despite the increasing research on the mechanisms of ZEA in modulating immune response, data are currently insufficient and further investigation is needed.
Article
Fisheries
Dan Qiao, Yanjing Zhao, Chao Pei, Xianliang Zhao, Xinyu Jiang, Lei Zhu, Jie Zhang, Li Li, Xianghui Kong
Summary: In this study, two CCL19b genes (CcCCL19b_a and CcCCL19b_b) were cloned from Yellow River carp. The expression of CcCCL19bs was found to be high in gill and intestine of healthy fish, and up-regulated after infection and stimulation. Furthermore, CcCCL19bs were found to have chemotactic and antibacterial activity, attracting leukocytes and promoting their proliferation, as well as exhibiting antibacterial activity against certain pathogens.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Ming Guo, Yankai Wang, Xianmu Fu, Wenjun Tao, Chenghua Li
Summary: This study discovered a circRNA, circ1149, which is closely related to skin ulcer syndrome in sea cucumber. It was found that circ1149 plays a significant role in pathogen-induced cell apoptosis in sea cucumbers. The study also identified miR-92a as a promoter of cell apoptosis through targeting Bax. Furthermore, circ1149 acts as a competing endogenous RNA by competing for miR-92a to suppress pathogen-induced cell apoptosis.
Review
Nanoscience & Nanotechnology
Xiaodong Zhang, Xiaokai Chen, Yanli Zhao
Summary: Artificial nanosystems have the ability to modulate immune responses and can be used in vaccine development and treatment of bacterial infections and diseases. This review discusses the recent advances of nanosystems in vaccine development and immune activation, as well as the application of immune-suppressive nanosystems.
ACS APPLIED NANO MATERIALS
(2022)
Review
Immunology
Jia-Rui Zheng, Zi-Long Wang, Bo Feng
Summary: Hepatitis B virus infection causes indirect damage to hepatocytes through the immune system. The exhaustion of virus-specific immune cells and immune suppression by virus antigens contribute to the chronicity of the infection. Functional cure can be achieved by restoring the specific immune function, providing a theoretical basis for complete cure of hepatitis B.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Assunta Liberti, Carla Pollastro, Gabriella Pinto, Anna Illiano, Rita Marino, Angela Amoresano, Antonietta Spagnuolo, Paolo Sordino
Summary: This study investigated the inflammatory response induced by bacterial and fungal stimuli in Ciona juveniles at stage 4 of metamorphosis using transcriptional and proteomic approaches. It was found that specific inflammatory mechanisms were triggered by bacterial stimuli (Pam2CSK4 and zymosan), while bacterial LPS did not induce a significant response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Veterinary Sciences
Ying Huang, Qian Ren
Summary: The Hippo homologue MnHippo with three isoforms was identified for the first time from the freshwater prawn Macrobrachium nipponense. Phylogenetic analysis showed MnHippo was closely related to STPK4 and Hippo of Penaeus vannamei, and the expression of MnHippo was found to be upregulated in prawns challenged with Vibrio parahaemolyticus and Staphylococcus aureus. Knockdown of MnHippo resulted in decreased expression of antimicrobial peptides and weakened clearance of bacteria in prawns, suggesting a role for MnHippo in antibacterial immune defense in M. nipponense.
VETERINARY RESEARCH
(2021)
Article
Fisheries
Shiying Xin, Xing Lv, Linchao Wang, Wei Wei Zheng, Tianjun Xu, Yuena Sun
Summary: With the in-depth study of circRNA, its important role in mammals, such as cell proliferation, apoptosis, invasion, development, and disease state, has been demonstrated. However, the regulatory mechanism of circRNA in lower vertebrates remains unclear. In this study, a new circRNA named circRara was identified and its positive regulatory effect on the antiviral and antibacterial response, cell proliferation, and activity in miiuy croaker was confirmed.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Obstetrics & Gynecology
Christopher J. Robinson, Carol L. Wagner, Bruce W. Hollis, John E. Baatz, Donna D. Johnson
AMERICAN JOURNAL OF PERINATOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Stephan W. Glasser, Melissa D. Maxfield, Teah L. Ruetschilling, Henry T. Akinbi, John E. Baatz, Joseph A. Kitzmiller, Kristen Page, Yan Xu, Erik L. Bao, Thomas R. Korfhagen
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2013)
Article
Biotechnology & Applied Microbiology
Annalaura Mancia, John T. Elliott, Michael Halter, Kiran Bhadriraju, Alessandro Tona, Tighe A. Spurlin, Bobby L. Middlebrooks, John E. Baatz, Gregory W. Warr, Anne L. Plant
BIOTECHNOLOGY PROGRESS
(2012)
Meeting Abstract
Oncology
Demetri D. Spyropoulos, Chadrick E. Denlinger, Ellen C. Riemer, Danforth A. Newton, E. Ellen Jones, Richard R. Drake, John E. Baatz
Article
Biochemistry & Molecular Biology
Annalaura Mancia, Demetri D. Spyropoulos, Wayne E. McFee, Danforth A. Newton, John E. Baatz
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2012)
Article
Obstetrics & Gynecology
E. R. Unal, T. Lynn, J. Neidich, D. Salazar, L. Goetzl, J. E. Baatz, T. C. Hulsey, R. Van Dolah, L. J. Guillette, R. Newman
JOURNAL OF PERINATOLOGY
(2012)
Article
Respiratory System
Stephan W. Glasser, Albert P. Senft, Melissa D. Maxfield, Teah L. Ruetschilling, John E. Baatz, Kristen Page, Thomas R. Korfhagen
RESPIRATORY RESEARCH
(2013)
Review
Pediatrics
Hilal Yildiz Atar, John E. Baatz, Rita M. Ryan
Summary: The association between infants of diabetic mothers (IDMs) and respiratory distress syndrome (RDS) has been well recognized, with increased obesity and diabetes prevalence leading to more pregnant women being overweight and diabetic. Challenges in glycemic control during pregnancy may impact surfactant synthesis and contribute to respiratory distress in newborns.
Article
Nutrition & Dietetics
Katherine E. Chetta, Joseph L. Alcorn, John E. Baatz, Carol L. Wagner
Summary: Frozen storage is crucial for preserving human milk for critically ill and very preterm infants, while milk pasteurization is essential for donor milk given to this population. Nutrient changes occur in milk due to storage and processing conditions, potentially leading to the presence of bioactive complexes like HAMLET, which may have unknown clinical implications. HAMLET, a protein-lipid complex found in human milk, has specific toxicity to certain cells and can trigger inflammatory pathways with unclear consequences, particularly in immature intestinal tissues. Addressing HAMLET's presence and bioactive role in human milk is important in neonatal research.
Article
Pediatrics
Siamak M. Yazdi, Ekta U. Patel, Colby D. Richardson, K. Thomas Hardy, John E. Baatz, Jennifer K. Mulligan, Rita M. Ryan
Summary: This study demonstrates that dexamethasone treatment significantly reduces the severity of bronchopulmonary dysplasia (BPD) in preterm infants by decreasing respiratory severity score (RSS), CD4+IL-6+ cells, CD8+IL-6+ cells, CXCR3+IL-6+ cells, and CXCR3+IL-2+ cells, as well as total IFN-gamma in TA. Additionally, the study found a significant correlation between RSS and CD4+IL-6+ cells in TA.
Article
Nutrition & Dietetics
Danforth A. Newton, John E. Baatz, Katherine E. Chetta, Preston W. Walker, Renee O. Washington, Judy R. Shary, Carol L. Wagner
Summary: The sufficiency of vitamin D in breastfeeding mothers may have different physiological effects compared to the sufficiency of vitamin D in infants. Maternal vitamin D status showed an inverse correlation with infant plasma TNF concentration. The immune response of infants seemed to be more closely related to maternal vitamin D sufficiency, while IL-10 and IL-12 responses were more correlated to infant vitamin D status.
Article
Biochemistry & Molecular Biology
Melinda A. Engevik, Leah K. Stripe, John E. Baatz, Carol L. Wagner, Katherine E. Chetta
Summary: The intestinal microbiota plays a crucial role in the health of preterm neonates. This study aimed to analyze the growth patterns of different bacterial strains in the human intestine in response to formula and human milk. The findings suggest that formula supports the growth of specific pathogenic strains, while both formula and human milk support the growth of commensal bacteria.
Article
Respiratory System
Danforth A. Newton, Robyn G. Lottes, Rita M. Ryan, Demetri D. Spyropoulos, John E. Baatz
Summary: Studies suggest that altered lactate metabolism in AEC2 may play a key role in the development and progression of IPF, making it a potential novel therapeutic target.
RESPIRATORY RESEARCH
(2021)
Meeting Abstract
Critical Care Medicine
A. P. Senft, D. Mitzel, J. T. Hunzeker, T. Witt, M. G. Wathelet, K. S. Harrod, J. E. Baatz
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2011)
Meeting Abstract
Critical Care Medicine
D. A. Newton, D. D. Spyropoulos, J. E. Baatz
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2011)
Article
Fisheries
Ratiporn Thongsoi, Siriluk Maskaew, Panumas Puechpon, Benjaporn Noppradit, Napassawan Inaek, Prapaporn Utarabhand, Phanthipha Runsaeng
Summary: In this study, a PPAE gene called FmPPAE1 was cloned and analyzed in banana shrimp. FmPPAE1 plays a vital role in regulating the proPO system, exhibits antibacterial properties, and contributes to the suppression of bacterial proliferation.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jishuang Tan, Paizelaiti Sahaer, Huan Li, Wei Han, Hongyan Sun
Summary: Circular RNAs (circRNA) are involved in gene expression and affect cellular processes such as transcription, splicing, and translation by interacting with microRNA and RNA binding proteins. A study identified circDNAJB6 as a circular RNA abundant in chicken macrophages after bacterial infection, and found that circDNAJB6 exacerbates cellular injury and interacts with multiple miRNAs and target genes, potentially impacting autophagy and MAPK signaling pathways.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Rodrigo Guabiraba, Damaris Ribeiro Rodrigues, Paul T. Manna, Melanie Chollot, Vincent Saint-Martin, Sascha Trapp, Marisa Oliveira, Clare E. Bryant, Brian J. Ferguson
Summary: The innate immune response relies on the ability of host cells to detect and respond to microbial nucleic acids. Toll-like receptors (TLRs) play a crucial role in this process by distinguishing self from non-self. This study focused on TLR21, an avian TLR that recognizes bacterial DNA motifs. The findings suggest that avian TLR21 shares similar activation mechanisms to mammalian TLR9, highlighting the conservation of nucleic acid sensing mechanisms across species.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Safieh Zeinali, Kate Sutton, Lonneke Vervelde
Summary: Chickens have a unique immune structure characterized by the absence of draining lymph nodes and the presence of well-developed mucosa-associated lymphoid tissue. The structure and development of chicken lymphoid tissues in the intestine, particularly Peyer's patches, have been poorly studied. However, the use of CSF1R-eGFP reporter transgenic chickens has allowed for the visualization and investigation of the development and distribution of these tissues. This research provides insights that could benefit mucosal vaccination strategies and the development of targeted vaccine delivery systems.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Retraction
Fisheries
G. -g. Li, Z. -z. Guo, X. -f. Ma, N. Cao, S. -n. Geng, Y. -q. Zheng, M. -j. Meng, H. -h. Lin, G. Han, G. -j. Du
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jinyue Yang, Peng Zhou, Wanrong Wu, Qingxiang Zhang, Dong Chen, Rui Luo
Summary: This study cloned and characterized the full-length sequence of duck MRE11 (duMRE11) for the first time, and found that this protein plays an important role in the innate immune response of ducks.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Mengjiao Guo, Jiaqi Zhang, Mingtao Li, Xiaorong Zhang, Yantao Wu
Summary: rNLRC3 negatively regulates the NF -KB signaling pathway induced by P. multocida in rabbits by inhibiting the activation of NF -KB, reducing the expression of inflammatory cytokines, and interacting with rTRAF4 and rTRAF6. The NACHT-LRR domain is the functional domain of rNLRC3. These findings provide insights into the important role of rNLRC3 in combating P. multocida infection.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Yinan Li, Xingye Lian, Wenwen Yang, Jinyuan Leng, Jiejie Sun, Yu Liu, Siqi Fan, Lingling Wang, Linsheng Song
Summary: The DM9-containing protein CgDM9CP-7 plays an important role in the innate immune response of molluscs. It is constitutively expressed in various tissues and is up-regulated in haemocytes after stimulation by Vibrio splendidus and lipopolysaccharide (LPS). CgDM9CP-7 binds to various pathogens and exhibits antimicrobial activity, while also regulating the expression of CgMyD88 and CgIL-17.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Xiuwen Bao, Haoran Song, Liying He, Yong Li, Shuqi Niu, Jinlin Guo
Summary: This study focuses on the interaction between Hepialus xiaojinensis larvae and Ophiocordyceps sinensis during the infection process. The results show that the infected third instar larvae enhance antioxidant defense ability, while the infected fourth instar larvae reduce this ability and allocate more energy to growth and development.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
