Article
Biotechnology & Applied Microbiology
Trisha R. Barnard, Breanna N. Landry, Alex B. Wang, Selena M. Sagan
Summary: Initiation of viral RNA replication is a major target of antiviral responses to positive-sense RNA viruses. This study reveals that both the ZIKV NS3 and NS5 proteins as well as host factors contribute to the dsRNA accumulation phenotype, which correlates with viral negative-strand RNA accumulation. The differences in RNA accumulation precede the induction of the innate antiviral response to ZIKV infection, suggesting the involvement of RNA sensing pathways or intrinsic restriction factors.
JOURNAL OF GENERAL VIROLOGY
(2023)
Article
Immunology
Rocio Seoane, Yessica Y. Llamas-Gonzalez, Santiago Vidal, Ahmed El Motiam, Yanis Hichem Bouzaher, Danae Fonseca, Rosa Farras, Adolfo Garcia-Sastre, Jose Gonzalez-Santamaria, Carmen Rivas
Summary: Active hypusine-modified eIF5A plays a critical role in cell proliferation, differentiation, and immune response. Virus infection and double-stranded RNA viral mimic stimulation induce hypusination of eIF5A. Activation of eIF5A is crucial for the replication of various RNA viruses. Inhibiting hypusination of eIF5A may induce upregulation of endoplasmic reticulum stress marker proteins and interferon, leading to broad-spectrum antiviral activity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Zixuan Wang, Jing Xu, Jianhua Feng, Kaizheng Wu, Kangyong Chen, Zhao Jia, Xiaozhen Zhu, Wenji Huang, Xin Zhao, Qin Liu, Bangjie Wang, Xinhua Chen, Junya Wang, Jun Zou
Summary: This study reveals the interaction mechanism between fish type I interferons and receptors by solving the crystal structure of grass carp IFNa. The results show that fish type I interferons may interact with receptors in a different way compared to their mammalian homologs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Veterinary Sciences
Towseef Akram, Irfan Gul, Mahrukh Parveez Zia, Amreena Hassan, Amina Khatun, Riaz Ahmad Shah, Syed Mudasir Ahmad, Nazir Ahmad Ganai, Naveed Anjum Chikan, Won-Il Kim, Nadeem Shabir
Summary: This study explores the effect of different antivirals on the replication of a specific virus and investigates the mechanisms behind the most effective anti-viral drug. The results show that ribavirin has the least cytotoxicity and significantly inhibits the replication of the virus. Ribavirin primarily inhibits the virus through IMPDH-mediated depletion of the Guanosine Triphosphate pool of cells, rather than through mutagenesis.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Cell Biology
Ermela Paparisto, Nina R. Hunt, Daniel S. Labach, Macon D. Coleman, Eric J. Di Gravio, Mackenzie J. Dodge, Nicole J. Friesen, Marceline Cote, Andreas Muller, Thomas Hoenen, Stephen D. Barr
Summary: Survival after Ebola virus infection is closely linked to an early and robust interferon response. Research has identified that the IFN-induced HERC5 protein can inhibit EBOV replication by depleting viral mRNAs, and also shows an antagonist relationship with the virus glycoprotein during early infection, potentially leading to the development of novel antiviral therapeutics.
Article
Fisheries
Sarah K. W. Au, Iliana V. Portelli, Stephanie J. DeWitte-Orr
Summary: This study provides evidence in fish that sequence specific long dsRNA induces potent gene expression silencing and antiviral responses in vitro via an RNAi-like mechanism instead of an IFN-dependent response.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Microbiology
Steven B. Tillis, Camille Holt, Spencer Havens, Tracey D. Logan, Justin G. Julander, Robert J. Ossiboff
Summary: This study provides the first characterization of the in vitro properties of growth, stability, host range, and inactivation for ophidian serpentoviruses. The results offer insights for mitigating the spread of serpentoviruses and identifying treatment options for ophidian serpentoviral infections.
Article
Biology
Grace S. Gleason, Katherine Starr, Thomas J. Sanger, Alex R. Gunderson
Summary: Adaptive thermal tolerance plasticity can reduce the negative effects of warming. In this study, we tested the capacity for heat hardening in lizard embryos and found that hardened embryos had greater survival after lethal heat exposure. However, heat pre-treatment led to an increase in embryo heart rates, indicating an energetic cost. These results support the existence of adaptive thermal tolerance plasticity in embryos and emphasize the associated costs. The findings highlight the importance of considering thermal tolerance plasticity as a mechanism for embryo response to warming.
Article
Multidisciplinary Sciences
Yongzhi Chen, Xuqiu Lei, Zhaozhao Jiang, Katherine A. Fitzgerald
Summary: CNBP plays a crucial role in the production of type I interferons in response to RNA virus infection. It controls the recruitment of IRF3 and IRF7 to IFN promoters and directly binds to the promoter of IFNb in the nucleus. This provides an additional layer of control for the antiviral innate immune response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Linyong Zhi, Wenji Wang, Jiaying Zheng, Shanxing Liu, Sheng Zhou, Qiwei Qin, Youhua Huang, Xiaohong Huang
Summary: Fish TRIM23 plays a critical role in host defense against virus infections by interacting with multiple host proteins to regulate immune responses, increase the expression of interferon-related signaling molecules and pro-inflammatory cytokines, and activate the promoter activities of IFN and NF-kappa B.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Alisha Chitrakar, Kristina Solorio-Kirpichyan, Eliza Prangley, Sneha Rath, Jin Du, Alexei Korennykh
Summary: Research has found that phosphorothioate DNAs (PS DNAs) can trigger the production of endogenous dsRNA, activating endo-dsRNA responses. These responses are activated by intronic and intergenic inverted retroelements (IIIR), distinct from antiviral defense programs, and do not activate traditional IFN signaling pathways.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Fisheries
Shuang-Shuang Sun, Shi-Wei Ma, Jun Li, Qin Zhang, Guang-Zhou Zhou
Summary: Fish rhabdoviruses are harmful viruses that cause significant economic losses in aquaculture. This review examines over 50 organic compounds that have shown effectiveness in preventing and treating rhabdovirus infection in fish. These compounds have various mechanisms of action and lay the foundation for future development of new strategies against fish rhabdoviruses.
Article
Virology
Min Fu, Hui Zhang, Mengxue Yin, Zhenhao Han, Qing Bai, Yuhong Peng, Karim Shafik, Lifeng Zhai, Ni Hong, Wenxing Xu, Guoping Wang, Ioly Kotta-Loizou
Summary: A novel +ssRNA mycovirus, CfRV1, isolated from Colletotrichum fructicola in China, is phylogenetically related to Hadaka virus 1 and polymycoviruses, expanding our understanding of virus diversity and evolution.
JOURNAL OF VIROLOGY
(2022)
Article
Microbiology
Chiara Medaglia, Arnaud Charles-Antoine Zwygart, Paulo Jacob Silva, Samuel Constant, Song Huang, Francesco Stellacci, Caroline Tapparel
Summary: Influenza viruses have high genetic variability and can quickly develop resistance mutations. Combination therapy with two drugs can reduce the risk of resistance emergence. Combining interferon lambda with oseltamivir can delay the emergence of drug-resistant influenza virus variants.
Article
Biochemistry & Molecular Biology
Viktoriya O. Samarskaya, Nadezhda Spechenkova, Irina Ilina, Tatiana P. Suprunova, Natalia O. Kalinina, Andrew J. Love, Michael E. Taliansky
Summary: The external application of dsRNA has emerged as a non-transgenic approach for crop protection. However, it has been found that externally administered dsRNA generates a non-canonical pool of sRNAs, which have different characteristics from the naturally occurring RNAi mechanism. These findings have significant implications for the application of dsRNA in crop protection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Ru Li, Sisi Zhou, Yongbing Li, Xiaorui Shen, Zhiqiang Wang, Baoshan Chen
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Haiqiong Luo, Wei Lan, Qingfeng Chen, Zhiqiang Wang, Zhixian Liu, Xiaofeng Yue, Lingzhi Zhu
News Item
Plant Sciences
J. R. Meng, P. P. Liu, C. W. Zou, Z. Q. Wang, Y. M. Liao, J. H. Cai, B. X. Qin, B. S. Chen
Article
Reproductive Biology
Chan Luo, Fenghua Lu, Xiaoli Wang, Zhiqiang Wang, Xiangping Li, Fangqiang Gong, Jianrong Jiang, Qingyou Liu, Deshun Shi
Article
Reproductive Biology
Qiang Fu, Limei Pan, Delun Huang, Zhiqiang Wang, Zhen Hou, Ming Zhang
Article
Microbiology
Guining Zhu, Yizhen Deng, Enping Cai, Meixin Yan, Guobing Cui, Zhiqiang Wang, Chengwu Zou, Bin Zhang, Pinggen Xi, Changqing Chang, Baoshan Chen, Zide Jiang
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Genetics & Heredity
Zhipeng Li, Suyu Lu, Kuiqing Cui, Laiba Shafique, Saif Ur Rehman, Chan Luo, Zhiqiang Wang, Jue Ruan, Qian Qian, Qingyou Liu
Article
Multidisciplinary Sciences
Xier Luo, Yu Zhou, Bing Zhang, Yi Zhang, Xiaobo Wang, Tong Feng, Zhipeng Li, Kuiqing Cui, Zhiqiang Wang, Chan Luo, Hui Li, Yanfei Deng, Fenghua Lu, Jianlin Han, Yongwang Miao, Huaming Mao, Xiaoyan Yi, Cheng Ai, Shigang Wu, Alun Li, Zhichao Wu, Zijun Zhuo, Do Da Giang, Bikash Mitra, Mohammad Farhad Vahidi, Shahid Mansoor, Sahar Ahmed Al-Bayatti, Eka Meutia Sari, Neena Amatya Gorkhali, Sigit Prastowo, Laiba Shafique, Guoyou Ye, Qian Qian, Baoshan Chen, Deshun Shi, Jue Ruan, Qingyou Liu
NATIONAL SCIENCE REVIEW
(2020)
Article
Multidisciplinary Sciences
Shan Yang, Kai Zeng, Ling Luo, Wang Qian, Zhiqiang Wang, Jaroslav Dolezel, Muqing Zhang, Xiangxiong Gao, Zuhu Deng
SCIENTIFIC REPORTS
(2020)
Article
Infectious Diseases
Xier Luo, Kuiqing Cui, Zhiqiang Wang, Zhipeng Li, Zhengjiao Wu, Weiyi Huang, Xing-Quan Zhu, Jue Ruan, Weiyu Zhang, Qingyou Liu
Summary: Fascioliasis is a neglected zoonotic tropical disease that imposes a significant economic burden. The Pacbio assembly of the reference genome for F. gigantica reported in the study significantly improved assembly and gene annotation quality, and revealed evidence of transposon-mediated evolution.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Plant Sciences
Cheng-Wu Zou, Jiao-Rong Meng, Zi-Ting Yao, Lei Zhang, Zhi-Qiang Wang, Ben-Hui Wei, Bao-Shan Chen
PHYTOPATHOLOGY RESEARCH
(2020)
Article
Mathematical & Computational Biology
Qingfeng Chen, Zhao Zhe, Wei Lan, Ruchang Zhang, Zhiqiang Wang, Cheng Luo, Yi-Ping Pheobe Chen
QUANTITATIVE BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Qiang Fu, Yulin Huang, Zhiqiang Wang, Fumei Chen, Delun Huang, Yangqing Lu, Xianwei Liang, Ming Zhang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2016)
Article
Fisheries
Ratiporn Thongsoi, Siriluk Maskaew, Panumas Puechpon, Benjaporn Noppradit, Napassawan Inaek, Prapaporn Utarabhand, Phanthipha Runsaeng
Summary: In this study, a PPAE gene called FmPPAE1 was cloned and analyzed in banana shrimp. FmPPAE1 plays a vital role in regulating the proPO system, exhibits antibacterial properties, and contributes to the suppression of bacterial proliferation.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jishuang Tan, Paizelaiti Sahaer, Huan Li, Wei Han, Hongyan Sun
Summary: Circular RNAs (circRNA) are involved in gene expression and affect cellular processes such as transcription, splicing, and translation by interacting with microRNA and RNA binding proteins. A study identified circDNAJB6 as a circular RNA abundant in chicken macrophages after bacterial infection, and found that circDNAJB6 exacerbates cellular injury and interacts with multiple miRNAs and target genes, potentially impacting autophagy and MAPK signaling pathways.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Rodrigo Guabiraba, Damaris Ribeiro Rodrigues, Paul T. Manna, Melanie Chollot, Vincent Saint-Martin, Sascha Trapp, Marisa Oliveira, Clare E. Bryant, Brian J. Ferguson
Summary: The innate immune response relies on the ability of host cells to detect and respond to microbial nucleic acids. Toll-like receptors (TLRs) play a crucial role in this process by distinguishing self from non-self. This study focused on TLR21, an avian TLR that recognizes bacterial DNA motifs. The findings suggest that avian TLR21 shares similar activation mechanisms to mammalian TLR9, highlighting the conservation of nucleic acid sensing mechanisms across species.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Safieh Zeinali, Kate Sutton, Lonneke Vervelde
Summary: Chickens have a unique immune structure characterized by the absence of draining lymph nodes and the presence of well-developed mucosa-associated lymphoid tissue. The structure and development of chicken lymphoid tissues in the intestine, particularly Peyer's patches, have been poorly studied. However, the use of CSF1R-eGFP reporter transgenic chickens has allowed for the visualization and investigation of the development and distribution of these tissues. This research provides insights that could benefit mucosal vaccination strategies and the development of targeted vaccine delivery systems.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Retraction
Fisheries
G. -g. Li, Z. -z. Guo, X. -f. Ma, N. Cao, S. -n. Geng, Y. -q. Zheng, M. -j. Meng, H. -h. Lin, G. Han, G. -j. Du
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jinyue Yang, Peng Zhou, Wanrong Wu, Qingxiang Zhang, Dong Chen, Rui Luo
Summary: This study cloned and characterized the full-length sequence of duck MRE11 (duMRE11) for the first time, and found that this protein plays an important role in the innate immune response of ducks.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Mengjiao Guo, Jiaqi Zhang, Mingtao Li, Xiaorong Zhang, Yantao Wu
Summary: rNLRC3 negatively regulates the NF -KB signaling pathway induced by P. multocida in rabbits by inhibiting the activation of NF -KB, reducing the expression of inflammatory cytokines, and interacting with rTRAF4 and rTRAF6. The NACHT-LRR domain is the functional domain of rNLRC3. These findings provide insights into the important role of rNLRC3 in combating P. multocida infection.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Yinan Li, Xingye Lian, Wenwen Yang, Jinyuan Leng, Jiejie Sun, Yu Liu, Siqi Fan, Lingling Wang, Linsheng Song
Summary: The DM9-containing protein CgDM9CP-7 plays an important role in the innate immune response of molluscs. It is constitutively expressed in various tissues and is up-regulated in haemocytes after stimulation by Vibrio splendidus and lipopolysaccharide (LPS). CgDM9CP-7 binds to various pathogens and exhibits antimicrobial activity, while also regulating the expression of CgMyD88 and CgIL-17.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Xiuwen Bao, Haoran Song, Liying He, Yong Li, Shuqi Niu, Jinlin Guo
Summary: This study focuses on the interaction between Hepialus xiaojinensis larvae and Ophiocordyceps sinensis during the infection process. The results show that the infected third instar larvae enhance antioxidant defense ability, while the infected fourth instar larvae reduce this ability and allocate more energy to growth and development.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)