Article
Immunology
Carlos Munoz, Josue Gonzalez-Lorca, Mick Parra, Sarita Soto, Natalia Valdes, Ana Maria Sandino, Rodrigo Vargas, Alex Gonzalez, Mario Tello
Summary: The study explored the use of Lactococcus lactis as a type I interferon expression system in Atlantic salmon to stimulate the antiviral immune response, showing that oral administration of L. lactis producing interferon I induces systemic effects, reduces IPNV viral load, and increases Mx and PKR expression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Simon Chioma Weli, Lisa-Victoria Bernhardt, Lars Qviller, Ole Bendik Dale, Atle Lillehaug
Summary: Transmission of infectious salmon anemia virus (ISAV) in seawater can be detected through analysis of ISAV RNA, with viral shedding peaking before fish mortality. The combination of an electronegatively charged filter with lysis buffer shows significantly higher detection of ISAV RNA in seawater samples.
Article
Immunology
Jun Shu, Xiao Ma, Yang Zhang, Jingyi Zou, Zhenghong Yuan, Zhigang Yi
Summary: Flaviviruses, including Zika virus, have the ability to antagonize host interferon signaling, leading to suppression of host de novo protein synthesis and degradation of specific proteins. Understanding these mechanisms may provide insights for developing novel antiviral approaches.
EMERGING MICROBES & INFECTIONS
(2021)
Review
Fisheries
Yulema Valero, Alberto Cuesta
Summary: Aquaculture is responsible for over half of the fish consumed by humans worldwide, but infectious diseases caused by viruses are a major problem. The coexistence of different virus strains in the same area allows for natural reassortment, which is a recombination process where different viruses exchange their genetic material. This has been facilitated by the transportation of fish eggs and larvae between facilities globally.
REVIEWS IN AQUACULTURE
(2023)
Article
Fisheries
Magnus Vikan Rosaeg, Ragnar Thorarinsson, Arnfinn Aunsmo
Summary: This study evaluated three PD vaccines' effects on growth and mortality in salmon farming using controlled field designs. Results showed only one vaccine significantly improved harvest weight and reduced mortality compared to controls. The data demonstrated differences in the efficacy of PD vaccines in farmed Atlantic salmon.
JOURNAL OF FISH DISEASES
(2021)
Article
Gastroenterology & Hepatology
Mircea Teodor Chiriac, Zsuzsanna Hracsko, Claudia Guenther, Miguel Gonzalez-Acera, Raja Atreya, Iris Stolzer, Leonie Wittner, Anja Dressel, Laura Schickedanz, Reyes Gamez-Belmonte, Lena Erkert, Gheorghe Hundorfean, Sebastian Zundler, Timo Rath, Stefania Vetrano, Silvio Danese, Gregor Sturm, Zlatko Trajanoski, Anja A. Kuehl, Britta Siegmund, Arndt Hartmann, Stefan Wirtz, Jurgen Siebler, Susetta Finotto, Christoph Becker, Markus F. Neurath
Summary: This study aimed to investigate the role of interleukin (IL)-20 in inflammatory bowel disease (IBD) and experimental colitis. The results showed that IL-20 controls colitis and mucosal healing by interfering with the IFN/STAT2 death signalling pathway in intestinal epithelial cells (IECs). These findings provide new directions for suppressing gut inflammation by modulating IL-20-controlled STAT2 signals.
Article
Biotechnology & Applied Microbiology
Ophelie Gervais, Athina Papadopoulou, Remi Gratacap, Borghild Hillestad, Alan E. Tinch, Samuel A. M. Martin, Ross D. Houston, Diego Robledo
Summary: This study investigates the transcriptomic responses of ISAV-infected salmon with contrasting levels of resistance, revealing that the responses to ISAV are organ-specific with a strong immune response observed in the head kidney. Other biological processes such as ubiquitination and ribosomal processing also play a role during early infection.
Article
Virology
Debes Hammershaimb Christiansen, Petra Elisabeth Petersen, Maria Marjunardottir Dahl, Nicolina Vest, Maria Aamelfot, Anja Brathen Kristoffersen, Mona Dverdal Jansen, Iveta Matejusova, Michael D. Gallagher, Gisli Jonsson, Eduardo Rodriguez, Johanna Hol Fosse, Knut Falk
Summary: The nonvirulent infectious salmon anaemia virus (ISAV-HPR0) causes prevalent and transient infections in all three production stages of Atlantic salmon in the Faroe Islands. Different HPR0 subgroups dominate in different stages of production, and vertical transmission of HPR0 from broodfish to progeny is uncommon.
Article
Fisheries
Lisa-Victoria Bernhardt, Atle Lillehaug, Lars Qviller, Simon Chioma Weli, Estelle Gronneberg, Hanne Nilsen, Mette Myrmel
Summary: The traditional method of monitoring salmonid alphavirus (SAV) infection in Norwegian fish farms is costly and time-consuming. However, a water filtration method was found to detect SAV in seawater earlier than traditional methods, showing potential for earlier detection of SAV in Atlantic salmon farms.
DISEASES OF AQUATIC ORGANISMS
(2021)
Article
Immunology
Wenlong Cai, Surendra Kumar, Umasuthan Navaneethaiyer, Albert Caballero-Solares, Laura A. Carvalho, Shona K. Whyte, Sara L. Purcell, Nellie Gagne, Tiago S. Hori, Melissa Allen, Richard G. Taylor, Rachel Balder, Christopher C. Parrish, Matthew L. Rise, Mark D. Fast
Summary: This study investigated the impact of four experimental functional feeds on Atlantic salmon during a single infection with sea lice and a co-infection with sea lice and infectious salmon anemia virus (ISAv). Transcriptomic analysis revealed different gene expression responses in the skin tissues of fish with different experimental diets. The co-infection group showed lower survival rates and up-regulated genes associated with glycolysis and immune response pathways. Understanding the effects of experimental functional feeds on the host response and co-infection trajectory is crucial for developing effective intervention strategies in open cage culture.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mohamed Emam, Khalil Eslamloo, Albert Caballero-Solares, Evandro Kleber Lorenz, Xi Xue, Navaneethaiyer Umasuthan, Hajarooba Gnanagobal, Javier Santander, Richard G. Taylor, Rachel Balder, Christopher C. Parrish, Matthew L. Rise
Summary: This study investigates the immunomodulatory effects of different levels of dietary omega-6/omega-3 fatty acids on Atlantic salmon. The results show that the dietary fatty acid profile can affect the salmon's antibacterial response to pathogens, and different dietary regimens may have an impact on the expression of immune-related genes. This research provides a new direction for studying the immune response of fish to pathogens using high omega-6/high omega-3 diets.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Fisheries
Lisa-Victoria Bernhardt, Mette Myrmel, Atle Lillehaug, Lars Qviller, Simon Chioma Weli
Summary: This study developed and optimized a method for detecting SAV3 in water, showing the potential for serving as an alternative surveillance method for SAV in Norwegian Atlantic salmon farms. The method was tested through a cohabitant challenge trial and demonstrated a significant positive correlation between SAV3 in tank water concentrates and fish organ tissue samples.
DISEASES OF AQUATIC ORGANISMS
(2021)
Article
Allergy
Florian Gothe, Jarmila Stremenova Spegarova, Catherine F. Hatton, Helen Griffin, Thomas Sargent, Sally A. Cowley, William James, Anna Roppelt, Anna Shcherbina, Fabian Hauck, Hugh T. Reyburn, Christopher J. A. Duncan, Sophie Hambleton
Summary: This study investigated the abnormality of IFN-I signaling in patients with STAT2 and IRF9 deficiency and found that it may contribute to inflammatory responses. IFN-alpha receptor signaling in cells lacking STAT2 or IRF9 was prolonged, and the transcriptional response resembled that of IFN-gamma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Microbiology
Joseph P. Nowlan, Scott R. Britney, John S. Lumsden, Spencer Russell
Summary: There is limited understanding of the pathogenesis of tenacibaculosis in Atlantic salmon and few reproducible exposure models for comparison. Different species of Tenacibaculum were used to expose Atlantic salmon, showing varied mortality rates and clinical signs. This experimental infection model will be helpful for further research on the pathogenesis, treatment, and immunity of tenacibaculosis.
Article
Medicine, Research & Experimental
Giorgia Bucciol, Leen Moens, Masato Ogishi, Darawan Rinchai, Daniela Matuozzo, Mana Momenilandi, Nacim Kerrouche, Catherine M. Cale, Elsa R. Treffeisen, Mohammad Al Salamah, Bandar K. Al-Saud, Alain Lachaux, Remi Duclaux-Loras, Marie Meignien, Aziz Bousfiha, Ibtihal Benhsaien, Anna Shcherbina, Anna Roppelt, C. O. V. I. D. Human Genetic Effort COVID Human Genetic Effort, Florian Gothe, Nadhira Houhou-Fidouh, Scott J. Hackett, Lisa M. Bartnikas, Michelle C. Maciag, Mohammed F. Alosaimi, Janet Chou, Reem W. Mohammed, Bishara J. Freij, Emmanuelle Jouanguy, Shen-Ping Zhang, Stephanie Boisson-Dupuis, Vivien Beziat, Qian Zhang, Christopher J. A. Duncan, Sophie Hambleton, Jean-Laurent Casanova, Isabelle Meyts
Summary: This study reports 23 patients with loss-of-function variants of STAT2, which may be associated with unresolved viral infection after viral infection or vaccination. Lack of STAT2CD8+ memory T cells may contribute to inflammation. Some patients died from viral infection or heart failure, indicating that complete STAT2 deficiency underlies severe viral diseases and significantly impacts survival.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Fisheries
Bertrand Collet, Catherine Collins, Katherine Lester
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2018)
Article
Fisheries
Simon Muncaster, Kirsty Kraakman, Olivia Gibbons, Koen Mensink, Maria Forlenza, Gregory Jacobson, Steve Bird
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2018)
Article
Sport Sciences
Shannon O'Donnell, Steve Bird, Gregory Jacobson, Matthew Driller
EUROPEAN JOURNAL OF SPORT SCIENCE
(2018)
Article
Fisheries
L. Malcolm Hall, Catherine Collins, Bertrand Collet
FISH & SHELLFISH IMMUNOLOGY
(2019)
Article
Fisheries
Catherine Collins, Niels Lorenzen, Bertrand Collet
FISH & SHELLFISH IMMUNOLOGY
(2019)
Article
Fisheries
Dagoberto Sepulveda, Ellen Lorenzen, Jesper Skou Rasmussen, Katja Einer-Jensen, Bertrand Collet, C. J. Secombes, Niels Lorenzen
FISH & SHELLFISH IMMUNOLOGY
(2019)
Article
Immunology
Beatriz Abos, Steve Bird, Aitor G. Granja, Esther Morel, Juan A. More Bayona, Daniel R. Barreda, Carolina Tafalla
JOURNAL OF IMMUNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Stephen O. Evans, Gregory M. Jacobson, Hugh J. B. Goodman, Steve Bird, Michael B. Jameson
BIOLOGICAL TRACE ELEMENT RESEARCH
(2019)
Article
Environmental Sciences
Guilherme F. de Oliveira, Edoardo Bertone, Rodney A. Stewart, John Awad, Aleicia Holland, Kelvin O'Halloran, Steve Bird
Review
Virology
Christelle Langevin, Pierre Boudinot, Bertrand Collet
Article
Biotechnology & Applied Microbiology
Gregory M. Jacobson, Logan J. Voss, Anica Klockars, Steve Bird, Ivo Dimitrov, William A. Denny, Pawel K. Olszewski, James W. Sleigh, Martyn G. Harvey
Article
Biochemistry & Molecular Biology
Stephen O. Evans, Gregory M. Jacobson, Hugh J. B. Goodman, Steve Bird, Michael B. Jameson
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2020)
Article
Fisheries
Pierre Boudinot, Steve Bird, Louis Du Pasquier, Bertrand Collet
Summary: The STAT gene family diversified during early vertebrate evolution through two rounds of whole genome duplication. While main types of STAT factors can be found from bony fish to mammals in Agnathan genomes, a typical STAT1-6 repertoire is only observed in jawed vertebrates. Whole genome duplications did not lead to a uniform expansion of stat genes, as seen in fish including polyploid species.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Immunology
Pedro Perdiguero, Maria C. Gomez-Esparza, Diana Martin, Steve Bird, Irene Soleto, Esther Morel, Patricia Diaz-Rosales, Carolina Tafalla
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Fisheries
Gregory Jacobson, Simon Muncaster, Koen Mensink, Maria Forlenza, Nick Elliot, Grant Broomfield, Beth Signal, Steve Bird
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2017)
Article
Fisheries
Ratiporn Thongsoi, Siriluk Maskaew, Panumas Puechpon, Benjaporn Noppradit, Napassawan Inaek, Prapaporn Utarabhand, Phanthipha Runsaeng
Summary: In this study, a PPAE gene called FmPPAE1 was cloned and analyzed in banana shrimp. FmPPAE1 plays a vital role in regulating the proPO system, exhibits antibacterial properties, and contributes to the suppression of bacterial proliferation.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jishuang Tan, Paizelaiti Sahaer, Huan Li, Wei Han, Hongyan Sun
Summary: Circular RNAs (circRNA) are involved in gene expression and affect cellular processes such as transcription, splicing, and translation by interacting with microRNA and RNA binding proteins. A study identified circDNAJB6 as a circular RNA abundant in chicken macrophages after bacterial infection, and found that circDNAJB6 exacerbates cellular injury and interacts with multiple miRNAs and target genes, potentially impacting autophagy and MAPK signaling pathways.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Rodrigo Guabiraba, Damaris Ribeiro Rodrigues, Paul T. Manna, Melanie Chollot, Vincent Saint-Martin, Sascha Trapp, Marisa Oliveira, Clare E. Bryant, Brian J. Ferguson
Summary: The innate immune response relies on the ability of host cells to detect and respond to microbial nucleic acids. Toll-like receptors (TLRs) play a crucial role in this process by distinguishing self from non-self. This study focused on TLR21, an avian TLR that recognizes bacterial DNA motifs. The findings suggest that avian TLR21 shares similar activation mechanisms to mammalian TLR9, highlighting the conservation of nucleic acid sensing mechanisms across species.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Safieh Zeinali, Kate Sutton, Lonneke Vervelde
Summary: Chickens have a unique immune structure characterized by the absence of draining lymph nodes and the presence of well-developed mucosa-associated lymphoid tissue. The structure and development of chicken lymphoid tissues in the intestine, particularly Peyer's patches, have been poorly studied. However, the use of CSF1R-eGFP reporter transgenic chickens has allowed for the visualization and investigation of the development and distribution of these tissues. This research provides insights that could benefit mucosal vaccination strategies and the development of targeted vaccine delivery systems.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Retraction
Fisheries
G. -g. Li, Z. -z. Guo, X. -f. Ma, N. Cao, S. -n. Geng, Y. -q. Zheng, M. -j. Meng, H. -h. Lin, G. Han, G. -j. Du
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jinyue Yang, Peng Zhou, Wanrong Wu, Qingxiang Zhang, Dong Chen, Rui Luo
Summary: This study cloned and characterized the full-length sequence of duck MRE11 (duMRE11) for the first time, and found that this protein plays an important role in the innate immune response of ducks.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Mengjiao Guo, Jiaqi Zhang, Mingtao Li, Xiaorong Zhang, Yantao Wu
Summary: rNLRC3 negatively regulates the NF -KB signaling pathway induced by P. multocida in rabbits by inhibiting the activation of NF -KB, reducing the expression of inflammatory cytokines, and interacting with rTRAF4 and rTRAF6. The NACHT-LRR domain is the functional domain of rNLRC3. These findings provide insights into the important role of rNLRC3 in combating P. multocida infection.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Yinan Li, Xingye Lian, Wenwen Yang, Jinyuan Leng, Jiejie Sun, Yu Liu, Siqi Fan, Lingling Wang, Linsheng Song
Summary: The DM9-containing protein CgDM9CP-7 plays an important role in the innate immune response of molluscs. It is constitutively expressed in various tissues and is up-regulated in haemocytes after stimulation by Vibrio splendidus and lipopolysaccharide (LPS). CgDM9CP-7 binds to various pathogens and exhibits antimicrobial activity, while also regulating the expression of CgMyD88 and CgIL-17.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Xiuwen Bao, Haoran Song, Liying He, Yong Li, Shuqi Niu, Jinlin Guo
Summary: This study focuses on the interaction between Hepialus xiaojinensis larvae and Ophiocordyceps sinensis during the infection process. The results show that the infected third instar larvae enhance antioxidant defense ability, while the infected fourth instar larvae reduce this ability and allocate more energy to growth and development.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
