Review
Pharmacology & Pharmacy
Marie-Cecile Ploy, Antoine Andremont, Bruno Valtier, Claire Le Jeunne, Catherine Dumartin, Didier Guillemot, Alain Bousquet-Melou, Christian Brun-Buisson, Bruno Coignard, Didier Concordet, William Couet, Joanie Del Bano, Romain Guilhaumou, Cyril Guyard, Evelyne Jouvin-Marche, Solen Kerneis, Mohamed Khelifa, Michael Mourez, Marie-Clemence Verdier
Review
Biochemistry & Molecular Biology
Julie Bonnefoy, Stephanie Ghislin, Jerome Beyrend, Florence Coste, Gaetano Calcagno, Isabelle Lartaud, Guillemette Gauquelin-Koch, Sylvain Poussier, Jean-Pol Frippiat
Summary: The use of rotors to expose animals to hypergravity levels helps understand the effects of altered gravity on physiological functions and animal development. The GEPAM platform, part of ESA's ground-based facilities, studies the impact of altered gravity on aquatic animal models and mice, with rotors for hypergravity exposure and models for simulating microgravity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Tuong Thi Le, Armelle Ropars, Arnaud Aymes, Jean-Pol Frippiat, Romain Kapel
Summary: This study aimed to extract phenolic compounds from liquid effluent of the sunflower protein isolate process using XAD7 resin. Multicriteria optimization showed that the optimal conditions led to production of a fraction containing 76.05% chlorogenic acid with high antioxidant capacity. In vitro assays demonstrated that this fraction was non-toxic to cells and could reduce the production of inflammatory factors, highlighting its potential anti-inflammatory properties.
Article
Microbiology
Maurin D'agostino, Nicolas Tesse, Rose Anne Lavergne, Patrice Le Pape, Jean Pol Frippiat, Marie Machouart, Anne Debourgogne
Summary: CIN-102 has shown potential as a new class of antifungal drug that is effective against resistant filamentous fungi and inhibits biofilm formation. The study demonstrated the antifungal activity of CIN-102 and its lack of induced resistance in strains, making it a promising candidate for treating invasive fungal infections, especially in cases of resistance.
JOURNAL OF MEDICAL MICROBIOLOGY
(2021)
Article
Immunology
Arindam K. Dey, Adrien Nougarede, Flora Clement, Carole Fournier, Evelyne Jouvin-Marche, Marie Escude, Dorothee Jary, Fabrice P. Navarro, Patrice N. Marche
Summary: The study investigates the impact of cationic lipid nanoparticles on the physiology of macrophages or dendritic cells, revealing that the cationic nanocarrier has a substantial effect on macrophages depending on the positive surface charge. By fine-tuning the load of nucleic acid cargo, the primary adverse effects can be prevented, providing rationale for calibrating the nucleic acid load of cationic lipid nanocarriers based on the desired immunostimulation in therapeutic applications such as gene delivery or mRNA vaccines.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Jordan Chamarande, Lisiane Cunat, Celine Caillet, Laurence Mathieu, Jerome F. L. Duval, Alain Lozniewski, Jean-Pol Frippiat, Corentine Alauzet, Catherine Cailliez-Grimal
Summary: The gut microbiota is a complex ecosystem crucial for host's well-being, where stress-induced molecules significantly impact the adhesion and biofilm formation capacities of Parabacteroides distasonis. The study provides insights on inter-strain variability and paves the way for further research on stress-molecules' involvement in maintaining P. distasonis within gut microbiota.
Article
Biochemistry & Molecular Biology
Tuong Thi Le, Xavier Framboisier, Arnaud Aymes, Armelle Ropars, Jean-Pol Frippiat, Romain Kapel
Summary: This study identified phenolic compounds in an aqueous protein by-product from rapeseed meal, with sinapine being the main compound. XAD16 resin showed the highest adsorption capacity for phenolic compounds, and ethanol at specific concentrations was effective for their desorption. Antioxidant tests indicated that these compounds can serve as natural antioxidants in the food industry.
Article
Immunology
Nicolas Schall, Laura Talamini, Maud Wilhelm, Evelyne Jouvin-Marche, Sylviane Muller
Summary: In systemic lupus erythematosus, T cells display multiple abnormalities. P140, a synthetic peptide, can deplete these abnormal cells and restore normal immune homeostasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Pierre Vermeulen, Arnaud Gruez, Anne-Lyse Babin, Jean-Pol Frippiat, Marie Machouart, Anne Debourgogne
Summary: This study investigated the potential relationship between azole susceptibility and mutations in CYP51 protein sequences in the Fusarium solani species complex (FSSC). The results showed point mutations in FSSC similar to those described in azole-resistant strains. Protein sequence alignments of CYP51 revealed different patterns, and a link between voriconazole susceptibility and protein sequences was observed.
Article
Biochemistry & Molecular Biology
Gaetano Calcagno, Nassima Ouzren, Sandra Kaminski, Stephanie Ghislin, Jean-Pol Frippiat
Summary: Gravity changes during spaceflight affect the immune system and TCR beta repertoire. This study investigates the role of histone modifications in this process, finding that downregulation of H3K27me3 contributes to the regulation of V beta germline transcript expression. The study also suggests the involvement of EZH2 in the regulation of TCR beta locus chromatin structure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Gaetano Calcagno, Jeremy Jeandel, Jean-Pol Frippiat, Sandra Kaminski
Summary: Different forms of stress in spaceflights impact the immune system and specifically dendritic cells. Hypergravity induces a less mature phenotype in dendritic cells, while simulated microgravity reduces their activation and pro-inflammatory cytokine production. Microgravity also impairs dendritic cells' ability to induce a proper immune response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marwa Roumani, Armelle Ropars, Christophe Robin, Raphael E. Duval, Jean-Pol Frippiat, Michel Boisbrun, Romain Larbat
Summary: Resistance to conventional treatments calls for the discovery of new therapeutic molecules. Plant specialized metabolites like phenolamides in tomato plants have potential antioxidant, antimicrobial, and anti-inflammatory properties. This study investigated whether three major phenolamides found in Tuta absoluta-infested tomato leaves have antimicrobial, cytotoxic, and/or anti-inflammatory properties. The results showed that these phenolamides exhibited varying degrees of antibacterial activity and were able to counteract the pro-inflammatory effect on cells. Extracts from healthy tomato leaves could also reduce inflammation. These findings suggest that phenolamides from tomato leaves could serve as alternatives to conventional drugs.
Article
Microbiology
Maurine D'Agostino, Anne-Lyse Babin, Marie Zaffino, Jean-Pol Frippiat, Marie Machouart, Anne Debourgogne
Summary: This study investigated the physiological changes of Fusarium solani species complex under simulated microgravity. The results showed increased growth, spore production, and germination, while biofilm production was reduced under microgravity. These findings highlight the importance of further studying this fungus as microgravity may weaken astronauts' immune system.
Article
Biochemistry & Molecular Biology
Rosella Spina, Armelle Ropars, Sihem Bouazzi, Safa Dadi, Pascal Lemiere, Francois Dupire, Afra Khiralla, Sakina Yagi, Jean-Pol Frippiat, Dominique Laurain-Mattar
Summary: Endophytic fungi are a promising research area for the treatment of inflammatory chronic diseases, as they have the potential to possess anti-inflammatory properties. Compounds extracted from endophytic fungi can counteract inflammation and induce an anti-inflammatory state, suggesting their potential as alternatives to conventional anti-inflammatory drugs.
Review
Multidisciplinary Sciences
Pauline Jacob, Christian Oertlin, Bjorn Baselet, Lisa S. Westerberg, Jean-Pol Frippiat, Sarah Baatout
Summary: Despite more than 50 years of sending humans into space, there are still crucial unanswered questions regarding the immune response in space conditions. The complex interactions between the immune system and other physiological systems in the human body make it challenging to study the long-term effects of space stressors such as radiation and microgravity. Exposure to microgravity and cosmic radiation can lead to changes in the immune system at the cellular and molecular levels, as well as in the major physiological systems of the body. Future long-term space missions may face serious health consequences due to abnormal immune responses induced in the space environment, including reduced ability to respond to injuries, infections, and vaccines, and increased risk of chronic diseases.
Article
Fisheries
Ratiporn Thongsoi, Siriluk Maskaew, Panumas Puechpon, Benjaporn Noppradit, Napassawan Inaek, Prapaporn Utarabhand, Phanthipha Runsaeng
Summary: In this study, a PPAE gene called FmPPAE1 was cloned and analyzed in banana shrimp. FmPPAE1 plays a vital role in regulating the proPO system, exhibits antibacterial properties, and contributes to the suppression of bacterial proliferation.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jishuang Tan, Paizelaiti Sahaer, Huan Li, Wei Han, Hongyan Sun
Summary: Circular RNAs (circRNA) are involved in gene expression and affect cellular processes such as transcription, splicing, and translation by interacting with microRNA and RNA binding proteins. A study identified circDNAJB6 as a circular RNA abundant in chicken macrophages after bacterial infection, and found that circDNAJB6 exacerbates cellular injury and interacts with multiple miRNAs and target genes, potentially impacting autophagy and MAPK signaling pathways.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Rodrigo Guabiraba, Damaris Ribeiro Rodrigues, Paul T. Manna, Melanie Chollot, Vincent Saint-Martin, Sascha Trapp, Marisa Oliveira, Clare E. Bryant, Brian J. Ferguson
Summary: The innate immune response relies on the ability of host cells to detect and respond to microbial nucleic acids. Toll-like receptors (TLRs) play a crucial role in this process by distinguishing self from non-self. This study focused on TLR21, an avian TLR that recognizes bacterial DNA motifs. The findings suggest that avian TLR21 shares similar activation mechanisms to mammalian TLR9, highlighting the conservation of nucleic acid sensing mechanisms across species.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Safieh Zeinali, Kate Sutton, Lonneke Vervelde
Summary: Chickens have a unique immune structure characterized by the absence of draining lymph nodes and the presence of well-developed mucosa-associated lymphoid tissue. The structure and development of chicken lymphoid tissues in the intestine, particularly Peyer's patches, have been poorly studied. However, the use of CSF1R-eGFP reporter transgenic chickens has allowed for the visualization and investigation of the development and distribution of these tissues. This research provides insights that could benefit mucosal vaccination strategies and the development of targeted vaccine delivery systems.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Retraction
Fisheries
G. -g. Li, Z. -z. Guo, X. -f. Ma, N. Cao, S. -n. Geng, Y. -q. Zheng, M. -j. Meng, H. -h. Lin, G. Han, G. -j. Du
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jinyue Yang, Peng Zhou, Wanrong Wu, Qingxiang Zhang, Dong Chen, Rui Luo
Summary: This study cloned and characterized the full-length sequence of duck MRE11 (duMRE11) for the first time, and found that this protein plays an important role in the innate immune response of ducks.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Mengjiao Guo, Jiaqi Zhang, Mingtao Li, Xiaorong Zhang, Yantao Wu
Summary: rNLRC3 negatively regulates the NF -KB signaling pathway induced by P. multocida in rabbits by inhibiting the activation of NF -KB, reducing the expression of inflammatory cytokines, and interacting with rTRAF4 and rTRAF6. The NACHT-LRR domain is the functional domain of rNLRC3. These findings provide insights into the important role of rNLRC3 in combating P. multocida infection.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Yinan Li, Xingye Lian, Wenwen Yang, Jinyuan Leng, Jiejie Sun, Yu Liu, Siqi Fan, Lingling Wang, Linsheng Song
Summary: The DM9-containing protein CgDM9CP-7 plays an important role in the innate immune response of molluscs. It is constitutively expressed in various tissues and is up-regulated in haemocytes after stimulation by Vibrio splendidus and lipopolysaccharide (LPS). CgDM9CP-7 binds to various pathogens and exhibits antimicrobial activity, while also regulating the expression of CgMyD88 and CgIL-17.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Xiuwen Bao, Haoran Song, Liying He, Yong Li, Shuqi Niu, Jinlin Guo
Summary: This study focuses on the interaction between Hepialus xiaojinensis larvae and Ophiocordyceps sinensis during the infection process. The results show that the infected third instar larvae enhance antioxidant defense ability, while the infected fourth instar larvae reduce this ability and allocate more energy to growth and development.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
