Article
Reproductive Biology
Wen-Jie Jiang, Ming-Hong Sun, Xiao-Han Li, Song-Hee Lee, Geun Heo, Dongjie Zhou, Xiang-Shun Cui
Summary: In mammals, E2F4 is an important cell cycle regulator and has been extensively studied for its role in multiple functions, such as cell cycle regulation and apoptosis. However, its role during embryonic development remains poorly understood.
Review
Cell & Tissue Engineering
Sonam Raj, Sushil K. Jaiswal, Melvin L. DePamphilis
Summary: This review article addresses the enigmatic role of the p53 transcription factor and tumor suppressor in programmed cell death during embryonic development. Contradictory results regarding the dependence of pluripotent embryonic stem cells on p53 for cell death are reconciled based on experimental conditions. The review concludes that p53 is not required for mouse embryonic development, but can accelerate programmed cell death in certain conditions. Additionally, DNA damage in differentiated cells induces p53-dependent cell cycle arrest and senescence.
Article
Oncology
Christina Voelkel-Johnson
Summary: The aberrant biology of polyploid giant cancer cells (PGCC) involves dysregulation of the cell cycle, induction of stress responses, and dedifferentiation. Sphingolipids, as an important class of membrane lipids, play crucial roles in polyploidy and the generation of offspring with stem-like properties. This review explores the functions of sphingolipids in embryonic development, cell cycle regulation, and stem cells, aiming to highlight the parallels to polyploidy.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Ceren Canse, Ecem Yildirim, Aylin Yaba
Summary: Cell-cell junctions play crucial roles in maintaining cell integrity, polarity, cell fate specification, and morphogenesis during embryonic development. By orchestrating mechanotransduction, morphokinetics, and signaling networks, these junctions, along with cell adhesion molecules and cytoskeletal elements, regulate the development of early embryos. This review focuses on the structure, organization, function, and expression pattern of cell-cell junction complexes during early embryonic development. Understanding the importance of dynamic junction formation and maturation processes will provide insights into the molecular mechanisms underlying developmental abnormalities in early embryos.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Khalil Joron, Juliane Oliveira Viegas, Liam Haas-Neill, Sariel Bier, Paz Drori, Shani Dvir, Patrick Siang Lin Lim, Sarah Rauscher, Eran Meshorer, Eitan Lerner
Summary: The authors developed a method to report high local densities and used it to show that the density distribution of heterochromatin in mouse embryonic stem cells is not in a liquid phase. They demonstrated the use of this method to distinguish between homogeneous and heterogeneous local densities within bio-condensates by measuring fluorescence lifetimes of common monomeric fluorescent proteins.
NATURE COMMUNICATIONS
(2023)
Review
Biology
Boyang Liu, Han Zhao, Keliang Wu, Joerg Grosshans
Summary: Embryonic cells are able to sense temporal gradients of regulatory signals to determine the timing of cell cycle progression or remodeling, accurately linking the cell cycle with the developmental program. The mid-blastula transition serves as a paradigm for timing in early embryogenesis in various animals, with recent studies indicating multiple independent signals contribute to the timing of different processes. In Drosophila, cell cycle remodeling relies on gradual changes of signals over time, linked to Cdk1 activity through readout mechanisms involving thresholds.
Review
Biophysics
Stefano Di Talia, Massimo Vergassola
Summary: This article reviews the importance of signaling waves in embryonic development, presents a range of theoretical models, and links them to molecular mechanisms, providing a concise and comprehensive guiding reference for theoretical frameworks in embryonic development.
ANNUAL REVIEW OF BIOPHYSICS
(2022)
Article
Cell Biology
Stephanie Chrysanthou, Julio C. Flores, Meelad M. Dawlaty
Summary: Tet1 plays a non-catalytic role in regulating cell cycle progression and proliferation in mouse embryonic stem cells, mainly by suppressing p21 to ensure a rapid G1-to-S progression.
Article
Genetics & Heredity
Guojia Xie, Ji-Eun Lee, Anna D. Senft, Young-Kwon Park, Younghoon Jang, Shreeta Chakraborty, Joyce J. J. Thompson, Kaitlin McKernan, Chengyu Liu, Todd S. S. Macfarlan, Pedro P. P. Rocha, Weiqun Peng, Kai Ge
Summary: The enzymatic activities of MLL3 and MLL4 are critical for embryonic development and embryonic stem cell differentiation.
Article
Multidisciplinary Sciences
Yu-Rong Cheng, Ching-Yi Lin, Jr-Kai Yu
Summary: This study describes the embryonic development and larval stages of the parasitic copepod Ive ptychoderae, providing insights into the classification and developmental mechanisms of parasitic copepods. Comparative analysis of morphological features suggests that the Ive-group is more closely related to the Cyclopoida, resolving the problematic phylogenetic position based on 18S rDNA sequences.
Article
Biochemistry & Molecular Biology
Luke Hayden, Woonyung Hur, Massimo Vergassola, Stefano Di Talia
Summary: This study demonstrates that sweep waves are the dominant mechanism in Drosophila embryogenesis and identifies genetic and temperature factors that can induce the transition from sweep to trigger waves.
Review
Cell Biology
Feng Li, Ying Ye, Xiaohua Lei, Wensheng Zhang
Summary: With the development of science and technology, mankind's exploration of outer space has increased tremendously. Settling in outer space or on other planets could help solve the Earth's resource crisis, but such settlement will first face the problem of reproduction. There are considerable differences between outer space and the Earth's environment, with the effects of gravity being one of the most significant. Studying the possible effects and underlying mechanisms of microgravity on embryonic stem cell (ESC) differentiation and embryonic development could help provide solutions to healthy living and reproduction in deep space. This article summarizes recent research progress on the effects of microgravity on ESCs and early embryonic development and proposes hypotheses regarding the potential mechanisms. In addition, we discuss the controversies and key questions in the field and indicate directions for future research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Physics, Multidisciplinary
Shuchun Huan, Shihao Zhang, Zhicheng Jiang, Hao Su, Hongyuan Wang, Xin Zhang, Yichen Yang, Zhengtai Liu, Xia Wang, Na Yu, Zhiqiang Zou, Dawei Shen, Jianpeng Liu, Yanfeng Guo
Summary: In this study, we reveal that MnSb4Te7 is a magnetic topological system with versatile topological phases that can be manipulated by both carrier doping and magnetic field. This introduces a new magnetic topological material with different topological phases that are highly tunable by carrier doping or magnetic field.
PHYSICAL REVIEW LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Bingbing Zhao, Miaoyi Zhou, Wen Ren, Hanshuai Li, Qian Zhang, Guangming He, Ya Liu, Haohua He
Summary: This study demonstrates that ZmCYCB1-1 plays a critical role in regulating embryo growth and seed size in maize. Overexpression of ZmCYCB1-1 accelerates embryo growth and increases seed size, while knocking out ZmCYCB1-1 results in slow plant growth. Transcriptome analysis reveals that ZmCYCB1-1 overexpression affects multiple metabolic pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Joey J. Ghersi, Gabriel Baldissera, Jared Hintzen, Stephanie A. Luff, Siyuan Cheng, Ivan Fan Xia, Christopher M. Sturgeon, Stefania Nicoli
Summary: Ghersi et al. have found that the diversity of haematopoietic stem and progenitor cells is established at the haemogenic endothelium level and is regulated by microRNA-128-mediated modulation of Wnt and Notch signalling. Haematopoietic stem and progenitor cells (HSPCs) generate different lineages and are produced in the embryo through the transformation of haemogenic endothelial cells in the aorta-gonad-mesonephros (AGM). The researchers discovered that loss of microRNA-128 leads to an expansion of HSPCs in the AGM with different cell cycle states and a bias towards erythroid and lymphoid progenitors.
NATURE CELL BIOLOGY
(2023)
Article
Developmental Biology
Tiago Faial, Andreia S. Bernardo, Sasha Mendjan, Evangelia Diamanti, Daniel Ortmann, George E. Gentsch, Victoria L. Mascetti, Matthew W. B. Trotter, James C. Smith, Roger A. Pedersen
Article
Multidisciplinary Sciences
Matteo Villa, Stefania Crotta, Kevin S. Dingwell, Elizabeth M. A. Hirst, Manolis Gialitakis, Helena Ahlfors, James C. Smith, Brigitta Stockinger, Andreas Wack
NATURE COMMUNICATIONS
(2016)
Article
Cell Biology
Timothy D. Cummins, Kevin Z. L. Wu, Polyxeni Bozatzi, Kevin S. Dingwell, Thomas J. Macartney, Nicola T. Wood, Joby Varghese, Robert Gourlay, David G. Campbell, Alan Prescott, Eric Griffis, James C. Smith, Gopal P. Sapkota
JOURNAL OF CELL SCIENCE
(2018)
Correction
Multidisciplinary Sciences
Elsie S. Place, James C. Smith
Article
Cell Biology
George E. Gentsch, Thomas Spruce, Rita S. Monteiro, Nick D. L. Owens, Stephen R. Martin, James C. Smith
DEVELOPMENTAL CELL
(2018)
Article
Biochemistry & Molecular Biology
Polyxeni Bozatzi, Kevin S. Dingwell, Kevin Z. L. Wu, Fay Cooper, Timothy D. Cummins, Luke D. Hutchinson, Janis Vogt, Nicola T. Wood, Thomas J. Macartney, Joby Varghese, Robert Gourlay, David G. Campbell, James C. Smith, Gopal P. Sapkota
Article
Cell Biology
Christo P. Christov, Kevin S. Dingwell, Mark Skehel, Helen S. Wilkes, Julian E. Sale, James C. Smith, Torsten Krude
Article
Multidisciplinary Sciences
Vicente Perez-Garcia, Elena Fineberg, Robert Wilson, Alexander Murray, Cecilia Icoresi Mazzeo, Catherine Tudor, Arnold Sienerth, Jacqueline K. White, Elizabeth Tuck, Edward J. Ryder, Diane Gleeson, Emma Siragher, Hannah Wardle-Jones, Nicole Staudt, Neha Wali, John Collins, Stefan Geyer, Elisabeth M. Busch-Nentwich, Antonella Galli, James C. Smith, Elizabeth Robertson, David J. Adams, Wolfgang J. Weninger, Timothy Mohun, Myriam Hemberger
Article
Multidisciplinary Sciences
Alexander M. J. Eve, Elsie S. Place, James C. Smith
Article
Multidisciplinary Sciences
Elsie S. Place, James C. Smith
Article
Multidisciplinary Sciences
George E. Gentsch, Thomas Spruce, Nick D. L. Owens, James C. Smith
NATURE COMMUNICATIONS
(2019)
Article
Biology
Karen Dunbar, Rebecca A. Jones, Kevin Dingwell, Thomas J. Macartney, James C. Smith, Gopal P. Sapkota
Summary: FAM83F protein interacts with CK1 alpha at the plasma membrane to activate Wnt signaling, leading to axis duplication in Xenopus embryos, and its effects on Wnt signaling are mediated through farnesylation at the plasma membrane.
LIFE SCIENCE ALLIANCE
(2021)
Biographical-Item
Developmental Biology
J. C. Smith
Article
Biology
J. C. Smith, David W. Goodhew
Summary: The conduct of research has changed during the COVID-19 pandemic, with discoveries in discovery science benefiting efforts against the virus. However, the scientific advice provided to schools has often been flawed or inconsistent, leading to larger impacts on disadvantaged children.
Article
Cell Biology
Clara Collart, James C. Smith, Philip Zegerman
DEVELOPMENTAL CELL
(2017)