期刊
DEVELOPMENT
卷 141, 期 10, 页码 2139-2149出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.107029
关键词
Diphtheria; Leydig; Male fertility; Peritubular myoid; Sertoli; Testis; Mouse
资金
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/J015105/1, BB/JO1446X/1]
- Medical Research Council (MRC) [G1100354/1]
- Swiss National Science Foundation [3100A 135227]
- Departement de l'Instruction Publique of the Canton de Geneve
- Biotechnology and Biological Sciences Research Council [BB/J015105/1, BB/J016209/1, BBS/E/D/20211552] Funding Source: researchfish
- Medical Research Council [G1100354, G1002033] Funding Source: researchfish
- BBSRC [BBS/E/D/20211552, BB/J016209/1, BB/J015105/1] Funding Source: UKRI
- MRC [G1100354, G1002033] Funding Source: UKRI
Sertoli cells (SCs) regulate testicular fate in the differentiating gonad and are the main regulators of spermatogenesis in the adult testis; however, their role during the intervening period of testis development, in particular during adult Leydig cell (ALC) differentiation and function, remains largely unknown. To examine SC function during fetal and prepubertal development we generated two transgenic mouse models that permit controlled, cell-specific ablation of SCs in pre- and postnatal life. Results show that SCs are required: (1) to maintain the differentiated phenotype of peritubular myoid cells (PTMCs) in prepubertal life; (2) to maintain the ALC progenitor population in the postnatal testis; and (3) for development of normal ALC numbers. Furthermore, our data show that fetal LCs function independently from SC, germ cell or PTMC support in the prepubertal testis. Together, these findings reveal that SCs remain essential regulators of testis development long after the period of sex determination. These findings have significant implications for our understanding of male reproductive disorders and wider androgen-related conditions affecting male health.
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