Article
Reproductive Biology
Xin-Yuan Li, Jie-Xue Pan, Hong Zhu, Guo-Lian Ding, He-Feng Huang
Summary: In recent years, there has been an increasing recognition of the developmental origins of diseases. It is suggested that many chronic diseases in adulthood, including diabetes, obesity, cardiovascular disease, and tumors, may develop early on. Germ cells play a crucial role in inheritance, and external influences during their differentiation and development can lead to damage and increase the risk of chronic disease development. This article further explores the concept of gamete and embryo origins of adult diseases, focusing on environmental insults on germ cells.
BIOLOGY OF REPRODUCTION
(2022)
Review
Biochemistry & Molecular Biology
Meenu Ghai, Farzeen Kader
Summary: Epigenetics aims to regulate DNA inheritance, with studies showing transgenerational inheritance in animal models but controversial evidence in humans. Male and female germline development in humans follow separate paths of epigenetic events, with oocytes and sperm possessing unique epigenomes. While DNA methylation alterations are reset during reprogramming, non-coding RNAs in human sperm are reliable carriers for transgenerational inheritance.
BIOCHEMICAL GENETICS
(2022)
Review
Geriatrics & Gerontology
Mark T. Mc Auley
Summary: In the last decade, epigenetics has become a central discipline in the field of biogerontology, as age-associated epigenetic changes are linked to various pathologies and epigenetic clocks can correlate biological age with chronological age. Recent empirical observations also suggest that inherited epigenetic effects could influence lifespan/longevity in different organisms. This review critically evaluates these effects from an evolutionary perspective, aiming to integrate the evidence with the main evolutionary theories of ageing.
EXPERIMENTAL GERONTOLOGY
(2023)
Review
Endocrinology & Metabolism
Nicole Mohajer, Erika M. Joloya, Jeongbin Seo, Toshi Shioda, Bruce Blumberg
Summary: Obesity and metabolic disorders are global pandemics, potentially linked to exposure to endocrine disrupting chemicals known as obesogens. Transgenerational inheritance of phenotypic traits and diseases, such as obesity, may be mediated by epigenetic mechanisms, highlighting the complexity of inherited susceptibility to environmental exposures.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Plant Sciences
Narendra Singh Yadav, Viktor Titov, Ivie Ayemere, Boseon Byeon, Yaroslav Ilnytskyy, Igor Kovalchuk
Summary: Plants can adapt to environmental stress not only through physiological changes but also through genetic and epigenetic alterations. The study on multigenerational heat stress in Arabidopsis thaliana revealed that the stressed progeny exhibited higher heat tolerance, genetic mutations, and epigenetic changes, highlighting the importance of adaptation mechanisms over generations.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Cell Biology
Titas Sengupta, Rachel Kaletsky, Coleen T. Murphy
Summary: Organisms have evolved mechanisms to adapt to changing environments, and environmental memories can be passed down through generations. Understanding the molecular mechanisms and logic underlying the inheritance and transmission of environmental memories is fundamental to understanding how organisms acquire and respond to ancestral conditions.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Nicholas O. Burton, Eric L. Greer
Summary: Inherited epigenetic information regulates complex organismal phenotypes and plays an important role in inheritance. The molecular mediators of non-genetic transmission of information are just starting to be understood. This study provides an intellectual framework for interpreting and understanding these findings, and defines the different mechanisms that mediate epigenetic inheritance.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Review
Food Science & Technology
Shuai Han, Yi Luo, Bo Liu, Tianyi Guo, Dandan Qin, Feijun Luo
Summary: Epigenetics plays a crucial role in exploring the etiology and treatment of diabetes, and reversing epigenetic alterations may reduce the burden of the disease. Dietary flavonoids as natural epigenetic modulators can serve as biomarkers for diabetes prevention and the development of alternative therapies. Further research is needed to explore the potential anti-diabetic effects of different flavonoids with various epigenetic regulation mechanisms through clinical trials.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Cell Biology
Richa Pant, Priyanka Firmal, Vibhuti Kumar Shah, Aftab Alam, Samit Chattopadhyay
Summary: Obesity is a major public health concern characterized by an increase in adipose tissue mass, which can lead to impaired metabolic health and even influence cancer progression. Dysfunction in adipocyte function is influenced by genetics and environmental factors, affecting gene expression and onset of obesity. Understanding the complexities of adipogenesis is crucial for recognizing disease conditions and identifying therapeutic interventions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Plant Sciences
Kaoru Tonosaki, Ryo Fujimoto, Elizabeth S. S. Dennis, Victor Raboy, Kenji Osabe
Summary: It has been shown that both DNA sequence diversity and epigenetic diversity can contribute to increased phenotypic diversity. Epigenetics bring new perspectives for crop improvement, such as the use of epigenetic variation or epigenome editing in breeding, leading to successful outcomes.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Genetics & Heredity
Ling Zeng, Mei Wang, Jinzhao Zhou, Xiaofei Wang, Yanwei Zhang, Ping Su
Summary: The interaction between gametic epigenetic marks and retrotransposons plays a crucial role in the transmission of parental acquired traits during early embryonic development.
Article
Environmental Sciences
Louis Legoff, Shereen Cynthia D'Cruz, Morgane Lebosq, Aurore Gely-Pernot, Katia Bouchekhchoukha, Christine Monfort, Pierre-Yves Kernanec, Sergei Tevosian, Luc Multigner, Fatima Smagulova
Summary: The study investigated the transgenerational effects of chlordecone on murine prostate tissue. Results showed the presence of prostatic intraepithelial neoplasia in male offspring exposed to CD, with differential gene expressions in prostates of different generations linked to tumor-related biological processes. CD exposure led to increased expression of Hox genes in the prostate, significant upregulation of genes involved in testosterone synthesis, and epigenetic changes.
ENVIRONMENT INTERNATIONAL
(2021)
Review
Genetics & Heredity
Jamie O. Lo, Rahul J. D'Mello, Lester Watch, Danny J. Schust, Susan K. Murphy
Summary: The rate of substance use is increasing, especially among reproductive-age individuals. Paternal pre-conception and maternal prenatal substance use may alter offspring epigenetic regulation and outcomes later in life. More research is needed in this area to provide public health warnings and healthcare provider counseling for individuals or couples in the pre-conception and prenatal periods to mitigate long-term offspring morbidity and mortality.
Article
Biology
Pedro Robles, Anisa Turner, Giusy Zuco, Sally Adams, Panagiota Paganopolou, Michael Winton, Beth Hill, Vikas Kache, Christine Bateson, Andre Pires-daSilva
Summary: Environmental stimuli experienced by the parental generation can influence the phenotype of subsequent generations through the germline. Metabolic sensors regulate phenotypic plasticity by modulating the subcellular localization of their effectors, leading to changes in chromatin acetylation and epigenetic status of the germline.
Article
Biochemistry & Molecular Biology
Jose Maria Costa-Junior, Sandra Mara Ferreira, Mirian Ayumi Kurauti, Diana L. Bernstein, Elena G. Ruano, Vasumathi Kameswaran, Jonathan Schug, Ricardo Freitas-Dias, Claudio C. Zoppi, Antonio C. Boschero, Camila A. M. de Oliveira, Gustavo J. Santos, Everardo M. Carneiro, Klaus H. Kaestner
Summary: Paternal exercise has a positive impact on the metabolic health of offspring, which can be achieved through transgenerational inheritance. The study showed that paternal exercise improves glucose tolerance and insulin sensitivity in the offspring, and this effect may be achieved by influencing the epigenetic mechanisms of transgenerational inheritance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Nidhi Khatri, Bommaraju Sumadhura, Sandeep Kumar, Ravinder Kumar Kaundal, Sunil Sharma, Ashok Kumar Datusalia
Summary: Traumatic brain injury is a major cause of death and disability, with patients facing issues like mood changes, impulsivity, social judgment problems, and memory deficits. The consequences of TBI differ between open and closed head injuries. Despite significant research, many individuals may still suffer from lifelong disability.
CURRENT NEUROPHARMACOLOGY
(2021)
Article
Immunology
M. Elizabeth Deerhake, Keiko Danzaki, Makoto Inoue, Emre D. Cardakli, Toshiaki Nonaka, Nupur Aggarwal, William E. Barclay, Ru-Rong Ji, Mari L. Shinohara
Summary: This study revealed that Dectin-1 limits experimental autoimmune encephalomyelitis (EAE) by inducing the gene expression of the neuroprotective molecule Osm through a Card9-independent pathway. The Osm receptor functions in astrocytes to reduce EAE severity. The study introduces a mechanism of beneficial myeloid cell-astrocyte crosstalk regulated by a Dectin-1 pathway.
Article
Pharmacology & Pharmacy
Rajvir Singh, Ravinder K. Kaundal, Baoyin Zhao, Rihab Bouchareb, Djamel Lebeche
Summary: This study reveals the role of resistin in cardiac fibrosis, promoting fibroblast-to-myofibroblast differentiation through JAK/STAT3 and JNK/c-Jun pathways, independent of TGF beta 1. Resistin-null mice showed improvements in cardiac function and reduction in tissue fibrosis, indicating the potential stimulation of cardiac fibrosis by resistin.
PHARMACOLOGICAL RESEARCH
(2021)
Correction
Multidisciplinary Sciences
Yongqin Li, Yuxin Chen, Shaoshuai Mao, Ravinder Kaundal, Zhengyu Jing, Qin Chen, Xinxin Wang, Jing Xia, Dahai Liu, Jianlong Sun, Haopeng Wang, Tian Chi
NATURE COMMUNICATIONS
(2021)
Article
Immunology
M. Elizabeth Deerhake, Estefany Y. Reyes, Shengjie Xu-Vanpala, Mari L. Shinohara
Summary: Neutrophils play a critical role in acute pulmonary cryptococcosis by forming two distinct subsets during infection: Ox-PMN with oxidative stress signature and Cyt-PMN with enhanced cytokine gene expression. Ox-PMNs interact with the fungus to generate ROS, while Cyt-PMNs modulate cell-cell communication with dendritic cells and alveolar macrophages in response to Cn-derived ligands and cytokines. This suggests a division of labor in activated neutrophils during in vivo fungal infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Ravinder K. Kaundal, Anil K. Kalvala, Ashutosh Kumar
Summary: COVID-19, caused by SARS-CoV-2, has been declared a pandemic by WHO, with no definitive treatment strategy identified yet. The main challenges lie in identifying viral strain heterogeneity and mechanisms of viral infection to human tissues. Understanding the basic processes of clinical manifestations is crucial for designing effective therapies.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Immunology
M. Elizabeth Deerhake, Mari L. Shinohara
Summary: Dectin-1, a C-type lectin receptor expressed on myeloid cells, recognizes beta-glucans and induces antifungal proinflammatory immune responses. Apart from its known role in fungal infections, Dectin-1 has been found to promote tolerance, anti-inflammatory, and neuroprotective responses in certain contexts. Studies in neuroimmunology suggest potential new therapeutic approaches for modifying innate immune responses in neurological disorders.
TRENDS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Ravinder K. Kaundal, Ashok Kumar Datusalia, Shyam S. Sharma
Summary: The nuclear factor erythroid-derived 2-related factor 2 (NFE2L2/Nrf2) is a crucial regulator of cytoprotective responses and miRNAs play a role in AD pathogenesis by targeting Nrf2 expression.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Cell Biology
Nupur Aggarwal, M. Elizabeth Deerhake, Devon DiPalma, Shailesh K. Shahi, Margaret R. Gaggioli, Ashutosh K. Mangalam, Mari L. Shinohara
Summary: This study demonstrates that OPN generated by CD4(+) T cells helps control aGVHD by limiting gastrointestinal pathology and modulating gut microbiota. Secreted OPN (sOPN) is solely responsible for the protective role of OPN.
Article
Medicine, Research & Experimental
William E. Barclay, Nupur Aggarwal, M. Elizabeth Deerhake, Makoto Inoue, Toshiaki Nonaka, Kengo Nozaki, Nathan A. Luzum, Edward A. Miao, Mari L. Shinohara
Summary: Inflammasomes are immune signaling platforms that activate in response to cellular damage and pathogens. They promote inflammation and enhance immunity against pathogens. This study investigates the role of inflammasomes in the central nervous system during experimental autoimmune encephalomyelitis (EAE), a disease associated with inflammation. The researchers found increased inflammasome activation in astrocytes during EAE, but no significant cell death.
Article
Biochemistry & Molecular Biology
Bo Liu, Zhengyu Jing, Xiaoming Zhang, Yuxin Chen, Shaoshuai Mao, Ravinder Kaundal, Yan Zou, Ge Wei, Ying Zang, Xinxin Wang, Wenyang Lin, Minghui Di, Yiwen Sun, Qin Chen, Yongqin Li, Jing Xia, Jianlong Sun, Chao-Po Lin, Xingxu Huang, Tian Chi
Summary: Here, we report the development of a transgenic platform called iMAP, which allows for simultaneous targeting of multiple genes throughout the mouse body, enabling high-throughput gene perturbation. Using this platform, we have successfully mapped a miniature Perturb-Atlas that provides valuable insights into gene functions.
Article
Cell Biology
M. Elizabeth Deerhake, Emre D. Cardakli, Mari L. Shinohara
Summary: Dectin-1 signaling in neutrophils promotes a cellular phenotype with T cell-suppressive properties.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Editorial Material
Clinical Neurology
M. Elizabeth Deerhake, James Giarraputo, Megha Gupta, Christopher Eckstein
Review
Pharmacology & Pharmacy
Chandan Chauhan, Ravinder Kumar Kaundal
Summary: Stroke is a debilitating condition with limited treatment options. Understanding the pathophysiology of stroke is crucial for developing more effective therapies. The cGAS-STING signaling pathway plays a central role in the poststroke immune response, regulating important processes such as immune cell activation, cytokine production, and tissue regeneration. Modulating this pathway shows potential in improving stroke outcomes, but challenges like specificity and off-target effects need to be addressed.
DRUG DISCOVERY TODAY
(2023)
Review
Immunology
Shobhit Gairola, Antarip Sinha, Ravinder K. Kaundal
Summary: Pulmonary fibrosis is a devastating disorder characterized by inflammation and matrix accumulation. Activation of NLRP3 is directly correlated with the development of pulmonary fibrosis. IL-1β, by affecting the activity of various transcription factors including TGF-β, promotes myofibroblast activation and lung fibrosis.
INFLAMMOPHARMACOLOGY
(2023)