期刊
DEVELOPMENT
卷 138, 期 24, 页码 5311-5320出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.070946
关键词
Temporal genes; COUP-TFI/II; Cell specification; Lineage progression; Drosophila
资金
- Swedish Research Council
- Swedish Strategic Research Foundation
- Knut and Alice Wallenberg foundation
- Swedish Brain Foundation
- Swedish Cancer Foundation
- Swedish Royal Academy of Sciences
- Spanish Ministerio de Ciencia e Innovacion [BFU-2008-04683-C02-02]
Drosophila embryonic neuroblasts generate different cell types at different time points. This is controlled by a temporal cascade of Hb -> Kr -> Pdm -> Cas -> Grh, which acts to dictate distinct competence windows sequentially. In addition, Seven up (Svp), a member of the nuclear hormone receptor family, acts early in the temporal cascade, to ensure the transition from Hb to Kr, and has been referred to as a 'switching factor'. However, Svp is also expressed in a second wave within the developing CNS, but here, the possible role of Svp has not been previously addressed. In a genetic screen for mutants affecting the last-born cell in the embryonic NB5-6T lineage, the Ap4/FMRFamide neuron, we have isolated a novel allele of svp. Expression analysis shows that Svp is expressed in two distinct pulses in NB5-6T, and mutant analysis reveals that svp plays two distinct roles. In the first pulse, svp acts to ensure proper downregulation of Hb. In the second pulse, which occurs in a Cas/Grh double-positive window, svp acts to ensure proper sub-division of this window. These studies show that a temporal factor may play dual roles, acting at two different stages during the development of one neural lineage.
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