期刊
DEVELOPMENT
卷 138, 期 22, 页码 5039-5048出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.072454
关键词
TTG1; GL3; Nuclear trapping
资金
- Deutsche Forschungsgemeinschaf [SFB 572]
- International Graduate School in Genetic and Functional Genomics (IGS-GFG), University of Cologne
Trichome patterning on Arabidopsis leaves is one of the best-studied model systems for two-dimensional de novo patterning. In addition to an activator-inhibitor-related mechanism, we previously proposed a depletion mechanism to operate during this process such that GLABRA3 (GL3) traps the trichome-promoting factor TRANSPARENT TESTA GLABRA1 (TTG1) in trichomes that, in turn, results in a depletion of TTG1 in trichome neighbouring cells. In this manuscript we analyze the molecular basis underlying this trapping mechanism. We demonstrate the ability of GL3 to regulate TTG1 mobility by expressing TTG1 and GL3 in different tissue layers in different combinations. We further show that TTG1 trapping by GL3 is based on direct interaction between both proteins and recruitment in the nucleus.
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