Review
Cell Biology
Rebecca Cusseddu, Amelie Robert, Jean-Francois Cote
Summary: The tight coordination of diverse cytoskeleton elements is crucial for dynamic cellular processes involved in development and tissue homeostasis. Spectraplakin proteins, such as MACF1, play a key role in connecting different cytoskeleton components and orchestrating precise cytoskeletal dynamic events. Understanding the roles of MACF1 in developmental and cancer processes is essential, although technical challenges remain in studying such a large protein.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xabier Morales, Rafael Pelaez, Saray Garasa, Carlos Ortiz de Solorzano, Ana Rouzaut
Summary: CRMP2 is an adaptor protein involved in cytoskeleton molding and has been found to play a crucial role in cancer progression. Phosphorylation of CRMP2 affects cancer cell migration, leading to impaired tumor growth in related mutants.
Review
Biochemistry & Molecular Biology
Eleonora Sarantelli, Apostolis Mourkakis, Lefteris C. Zacharia, Andreas Stylianou, Vasiliki Gkretsi
Summary: As metastasis is a major cause of cancer-related deaths, understanding the cellular and molecular events involved in cancer cell migration and invasion is crucial for developing novel anti-metastatic therapies. Fascin-1, an actin-bundling protein, plays a fundamental role in cell migration processes. It is significantly elevated in most cancers and its high expression is associated with aggressive disease and poor prognosis. Recent studies show that Fascin-1 is critically involved in metastasis and suggest it as a promising target for anti-metastatic treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Soontorn Tuntithavornwat, Daniel J. Shea, Bin Sheng Wong, Talia Guardia, Se Jong Lee, Christopher L. Yankaskas, Lei Zheng, Aikaterini Kontrogianni-Konstantopoulos, Konstantinos Konstantopoulos
Summary: Obscurins, encoded by the OBSCN gene, play a critical role in pancreatic cancer progression and metastasis by regulating cytoskeletal remodeling through RhoA activity. Decreased levels of giant obscurins in pancreatic ductal adenocarcinomas lead to faster cell migration, tumor growth, and metastasis development.
Article
Chemistry, Physical
Binbin Chu, Xuan Qin, Qianqian Zhu, Houyu Wang, Zhen Wen, Xuhui Sun, Yao He, Shuit-Tong Lee
Summary: This study presents a novel electrotherapeutic strategy using triboelectric nanogenerators (TENG) to suppress cancer cell migration in vitro and alleviate early tumor metastasis in vivo. The TENG stimulation with an output current of 150 μA can effectively destroy the cellular cytoskeleton and inhibit cancer cell migration. In mouse models, TENG-based treatments with the current of 150 μA prevent cancer cell spreading to other body sites without apparent toxicity to normal organs and tissues.
Article
Multidisciplinary Sciences
Amir Vahabikashi, Suganya Sivagurunathan, Fiona Ann Sadsad Nicdao, Yu Long Han, Chan Young Park, Mark Kittisopikul, Xianrong Wong, Joseph R. Tran, Gregg G. Gundersen, Karen L. Reddy, G. W. Gant Luxton, Ming Guo, Jeffrey J. Fredberg, Yixian Zheng, Stephen A. Adam, Robert D. Goldman
Summary: The interactions between the nucleus and cytoskeleton play a crucial role in regulating cellular mechanics. A-type lamins engage with F-actin and vimentin intermediate filaments to modulate cortical stiffness and contractility, while B-type lamins predominantly interact with vimentin intermediate filaments to regulate cytoplasmic stiffness and contractility. The loss of each lamin isoform affects nucleocytoskeletal interactions and cellular mechanics.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Laura Bozal-Basterra, Maria Gonzalez-Santamarta, Veronica Muratore, Natalia Martin-Martin, Amaia Ercilla, Jose A. Rodriguez, Arkaitz Carracedo, James D. Sutherland, Rosa Barrio
Summary: LUZP1 exhibits frequent genomic aberrations in cancer, particularly gene deletions, and its loss promotes cell migration, invasion, apoptosis, and alterations in cell morphology. Additionally, LUZP1 plays regulatory roles beyond actin filament bundling, affecting actin polymerization through changes in ACTR3 and phospho-cofilin ratios. These findings suggest a novel role for LUZP1 in cancer regulation through actin cytoskeleton control.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Materials Science, Biomaterials
Adrian A. Shimpi, Erik D. Williams, Lu Ling, Tigist Tamir, Forest M. White, Claudia Fischbach
Summary: This study investigates tumor cell migration on fibrotic ECM using a cell-derived matrix (CDM) model and phosphotyrosine phosphoproteomics. The results demonstrate that tumor cells cultured on CDMs migrate faster and in a more directional manner, which correlates with decreased cell spreading and increased cell elongation. The study also suggests that LYN may be differentially regulated and involved in regulating tumor cell migration on CDMs.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Pharmacology & Pharmacy
Frederic Larbret, Pierric Biber, Nicholas Dubois, Stoyan Ivanov, Laurence Lafanechere, Sophie Tartare-Deckert, Marcel Deckert
Summary: In this study, the Actin CytoFRET method was used to screen PTM-interfering compounds, and small molecule inhibitors of DUBs were found to induce actin polymerization and block cell migration. Further mechanistic investigation revealed that ROS-dependent cofilin modulation plays a key role in the regulation of actin dynamics.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shohreh Azadi, Ehsan Mohammadi, Mohammad Tafazzoli-Shadpour, Mohammad Tabatabaei
Summary: The development of cancer involves changes in cell structure and physical state. This study shows that there is a synergy between the physical and biological behaviors of cancer cells, with the physical behaviors being affected by targeting proteins involved in biological behaviors. By targeting EGRF, the researchers were able to alter the physical behaviors of breast cancer cells, leading to a decrease in cell invasion and viability. The findings suggest that the synergy between physical and chemical pathways can enhance the efficacy of anti-cancer drugs.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Wen Lu, Margot Lakonishok, Vladimir Gelfand
Summary: The study demonstrates that the Drosophila Shot protein controls the flow direction from nurse cells to the oocyte, and its loss changes transport direction resulting in halted oocyte growth. Shot is localized at the asymmetrical actin baskets on the ring canals, regulating microtubule polarity to facilitate transport driven by the minus-end-directed motor cytoplasmic dynein.
Article
Multidisciplinary Sciences
Ryota Sakamoto, Ziane Izri, Yuta Shimamoto, Makito Miyazaki, Yusuke T. Maeda
Summary: Cell migration in confined environments is crucial for various biological processes. This study investigates the physical determinants of actomyosin-based migration in confined environments using an in vitro migratory cell model. The results reveal the importance of the physical interaction between actomyosin networks and the cell membrane in generating a propulsive force for cell movement.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Lyndsay Avery, Tanner F. Robertson, Christine F. Wu, Nathan H. Roy, Samuel D. Chauvin, Eric Perkey, Ashley Vanderbeck, Ivan Maillard, Janis K. Burkhardt
Summary: X-MAID is a primary immunodeficiency disease characterized by severe lymphopenia and recurrent infections. Using a mouse model, researchers found that the disease is caused by a mutation in the protein moesin. This model provides valuable insights into the complexity of immunodeficiency and the role of the actin cortex in lymphocyte function.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
D. Nashchekin, L. Busby, M. Jakobs, I Squires, D. St Johnston
Summary: By recruiting Patronin to the fusome and stabilizing more MTs, a polarized MT network is formed, along which Dynein transports oocyte determinants into the presumptive oocyte, breaking symmetry and selecting the oocyte.
Article
Biochemistry & Molecular Biology
Simona Mareike Luttgenau, Christin Emming, Thomas Wagner, Julia Harms, Justine Guske, Katrin Weber, Ute Neugebauer, Rita Schroeter, Olga Panichkina, Zoltan Petho, Florian Weber, Albrecht Schwab, Anja Kathrin Wege, Pavel Nedvetsky, Michael P. Krahn
Summary: Pals1 is frequently downregulated in colorectal cancer and plays a key role in preventing cancer cell metastasis by controlling Rac1-dependent cell migration through inhibition of Arf6. This new function of Pals1 is independent of its role in tight junction formation and apical-basal polarity.
Article
Developmental Biology
Sophie Quintin, Shahoe Wang, Julien Pontabry, Ambre Bender, Francois Robin, Vincent Hyenne, Frederic Landmann, Christelle Gally, Karen Oegema, Michel Labouesse
Article
Biology
Shaohe Wang, Di Wu, Sophie Quintin, Rebecca A. Green, Dhanya K. Cheerambathur, Stacy D. Ochoa, Arshad Desai, Karen Oegema
Article
Biophysics
Camille Paoletti, Sophie Quintin, Audrey Matifas, Gilles Charvin
BIOPHYSICAL JOURNAL
(2016)
Review
Developmental Biology
Sophie Quintin, Christelle Gally, Michel Labouesse
Article
Developmental Biology
Christelle Gally, Frederic Wissler, Hala Zahreddine, Sophie Quintin, Frederic Landmann, Michel Labouesse
Review
Genetics & Heredity
Sophie Quintin, Christelle Gally, Michel Labouesse
TRENDS IN GENETICS
(2008)
Article
Developmental Biology
Shashi Kumar Suman, Csaba Daday, Teresa Ferraro, Thanh Vuong-Brender, Saurabh Tak, Sophie Quintin, Francois Robin, Frauke Graeter, Michel Labouesse
Article
Developmental Biology
Marie Diogon, Frédéric Wissler, Sophie Quintin, Yasuko Nagamatsu, Satis Sookhareea, Frédéric Landmann, Harald Hutter, Nicolas Vitale, Michel Labouesse
Article
Biochemistry & Molecular Biology
Anne-Lore Schlaitz, Martin Srayko, Alexander Dammermann, Sohie Quintin, Natalie Wielsch, Ian MacLeod, Quentin de Robillard, Andrea Zinke, John R. Yates, Thomas Mueller-Reichert, Andrei Shevchenko, Karen Oegema, Anthony A. Hyman
Article
Developmental Biology
F Landmann, S Quintin, M Labouesse
DEVELOPMENTAL BIOLOGY
(2004)
Article
Biochemistry & Molecular Biology
M Srayko, S Quintin, A Schwager, AA Hyman
Article
Developmental Biology
S Quintin, G Michaux, L McMahon, A Gansmuller, M Labouesse
DEVELOPMENTAL BIOLOGY
(2001)
Article
Biochemistry & Molecular Biology
JC Dantonel, S Quintin, L Lakatos, M Labouesse, L Tora
Article
Biochemistry & Molecular Biology
S Quintin, PE Mains, A Zinke, AA Hyman