期刊
DEVELOPMENT
卷 138, 期 3, 页码 465-474出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.061234
关键词
Tbx2; Pronephric nephron; Xenopus; BMP; Gremlin; Hey1
资金
- Pure Basic Research Group of the KRF [070-2005-C00115]
- Brain Korea (BK) 21 Project
- National Research Foundation of Korea (NRF) [2009-0081320]
- National Research Foundation of Korea [2009-0081320] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Despite extensive study of the development of the nephron, which is the functional unit of the kidney, the molecular mechanisms underlying the determination of nephron size remain largely unknown. Using the Xenopus pronephros, we demonstrate here that Tbx2, a T-box transcriptional repressor, functions to demarcate the territory of the pronephric nephron. Tbx2 is specifically expressed around three distinct components of the pronephric nephron: the tubule, duct and glomus. Gain of function of Tbx2 inhibits nephric mesoderm formation. Conversely, Tbx2 loss of function expands the boundary of each component of the pronephric nephron, resulting in an enlarged pronephros. BMP signals induce Tbx2 in the non-nephric mesoderm, which inhibits the expression of the nephric markers Hey1 and Gremlin. Importantly, these pronephric molecules repress Tbx2 expression by antagonizing BMP signals in the nephric mesoderm. These results suggest that the negative regulatory loops between BMP/Tbx2 and Gremlin or Hey1 are responsible for defining the territory of the pronephric nephron.
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