期刊
DEVELOPMENT
卷 138, 期 21, 页码 4649-4660出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.071951
关键词
Morphogenesis; hox; ras; C. elegans; Vulva
资金
- University of Melbourne
- Dr Sue Newton Research Award
- Australia Research Council
- National Health and Medical Research Council Parasitology Research Network
- Australian Academy of Science
- Forschungskredit of the University of Zurich
- Swiss National Science Foundation
Morphogenesis represents a phase of development during which cell fates are executed. The conserved hox genes are key cell fate determinants during metazoan development, but their role in controlling organ morphogenesis is less understood. Here, we show that the C. elegans hox gene lin-39 regulates epidermal morphogenesis via its novel target, the essential zinc finger protein VAB-23. During the development of the vulva, the egg-laying organ of the hermaphrodite, the EGFR/RAS/MAPK signaling pathway activates, together with LIN-39 HOX, the expression of VAB-23 in the primary cell lineage to control the formation of the seven vulval toroids. VAB-23 regulates the formation of homotypic contacts between contralateral pairs of cells with the same sub-fates at the vulval midline by inducing smp-1 (semaphorin) transcription. In addition, VAB-23 prevents ectopic vulval cell fusions by negatively regulating expression of the fusogen eff-1. Thus, LIN-39 and the EGFR/RAS/MAPK signaling pathway, which specify cell fates earlier during vulval induction, continue to act during the subsequent phase of cell fate execution by regulating various aspects of epidermal morphogenesis. Vulval cell fate specification and execution are, therefore, tightly coupled processes.
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