期刊
DEVELOPMENT
卷 137, 期 14, 页码 2265-2278出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.044826
关键词
Yan; Mathematical modeling; Multistable switch; Photoreceptor development; Signaling network
资金
- NIH
- International Human Frontier Science Program Organization (HFSP)
A major goal of developmental biology is to understand the molecular mechanisms whereby genetic signaling networks establish and maintain distinct cell types within multicellular organisms. Here, we review cell-fate decisions in the developing eye of Drosophila melanogaster and the experimental results that have revealed the topology of the underlying signaling circuitries. We then propose that switch-like network motifs based on positive feedback play a central role in cell-fate choice, and discuss how mathematical modeling can be used to understand and predict the bistable or multistable behavior of such networks.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据