期刊
DEVELOPMENT
卷 137, 期 11, 页码 1777-1785出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.040055
关键词
Epibranchial; Inner ear; Neurogenesis; Placode; Signalling
资金
- RIKEN Center for Developmental Biology
- JSPS
- RIKEN FPR
- BBSRC
- OUP
- Biotechnology and Biological Sciences Research Council [BB/G011524/1] Funding Source: researchfish
- BBSRC [BB/G011524/1] Funding Source: UKRI
The inner ear and the epibranchial ganglia constitute much of the sensory system in the caudal vertebrate head. The inner ear consists of mechanosensory hair cells, their neurons, and structures necessary for sound and balance sensation. The epibranchial ganglia are knots of neurons that innervate and relay sensory signals from several visceral organs and the taste buds. Their development was once thought to be independent, in line with their independent functions. However, recent studies indicate that both systems arise from a morphologically distinct common precursor domain: the posterior placodal area. This review summarises recent studies into the induction, morphogenesis and innervation of these systems and discusses lineage restriction and cell specification in the context of their common origin.
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