Article
Oncology
Sara J. Hamis, Yury Kapelyukh, Aileen McLaren, Colin J. Henderson, C. Roland Wolf, Mark A. J. Chaplain
Summary: The study developed a mechanistic mathematical model to describe the synergistic action of dabrafenib and trametinib on ERK activity in BRAFV600E-mutant melanoma cells, elucidating the molecular mechanism underlying vertical inhibition of the BRAF-MEK-ERK cascade.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Axelle Wilmerding, Lauranne Bouteille, Nathalie Caruso, Ghislain Bidaut, Heather C. Etchevers, Yacine Graba, Marie-Claire Delfini
Summary: The MAPK/ERK pathway plays a crucial role in regulating cell functions and is abnormally activated in many types of human cancers. By using a chicken embryo model, researchers have found that overactivation of ERK1/2 leads to significant changes in the transcriptional signature of developing spinal cord cells, potentially uncovering mechanisms involved in tumor initiation and malignancy.
Article
Biochemistry & Molecular Biology
Wen-Yang Hu, Parivash Afradiasbagharani, Ranli Lu, Lifeng Liu, Lynn A. Birch, Gail S. Prins
Summary: The MEK/ERK and Rho/Rho kinase signaling pathways play crucial roles in prostate growth and branching during development, with MLCK-regulated MLC-P potentially serving as a central downstream target of both pathways in regulating prostate morphogenesis. Experiments demonstrated that inhibiting these pathways significantly inhibited prostate growth and blocked branching morphogenesis, highlighting their importance in prostate development.
Article
Immunology
Wenyue Zhao, Lu Liu, Xuehao Li, Shun Xu
Summary: EphA10 is overexpressed in LUAD tissues, with higher expression in tissues at advanced tumor stages and positively correlated with EGFR. Knockdown of EphA10 suppresses proliferation, migration, invasion, and epithelial-mesenchymal transition of LUAD cells, reduces PD-L1 expression, and enhances NK cell-mediated anti-tumor effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Virology
Tuchakorn Lertwanakarn, Matepiya Khemthong, Puntanut Tattiyapong, Win Surachetpong
Summary: This study investigated the involvement of the MAPK/ERK pathway in the early stages of TiLV infection and found that TiLV infection led to distinct patterns of ERK phosphorylation in two different fish cell lines. The infected E-11 cells showed a substantial decrease in p-ERK levels and exhibited cytopathic effects, while the infected TiB cells had constant p-ERK levels and no cytopathic effects. Suppressing p-ERK significantly reduced TiLV load and gene expression levels in TiB cells. These findings provide new insights into the cellular mechanisms of TiLV infection and may contribute to the development of strategies to control this virus.
Article
Multidisciplinary Sciences
Ethan J. Brock, Ryan M. Jackson, Julie L. Boerner, Quanwen Li, Meredith A. Tennis, Bonnie F. Sloane, Raymond R. Mattingly
Summary: Research on breast ductal carcinoma in situ (DCIS) suggests that Sprouty4 plays a crucial role in controlling ERK/MAPK signaling, thereby limiting the progression of these lesions towards invasive ductal carcinoma (IDC).
Article
Cell Biology
Chang Xie, Shaun R. Abrams, Vicente Herranz-Perez, Jose Manuel Garcia-Verdugo, Jeremy F. Reiter
Summary: Removing centrioles in the mouse endoderm did not affect intestinal growth but blocked lung branching. Acentriolar lung cells apoptosed due to p53 activation, while ERK activity in the endoderm influenced the developmental consequences of centriolar defects and p53 activation.
DEVELOPMENTAL CELL
(2021)
Article
Biochemistry & Molecular Biology
Hsin-Yu Ho, Ping-Ju Chen, Yi-Ching Chuang, Yu-Sheng Lo, Chia-Chieh Lin, Ming-Ju Hsieh, Mu-Kuan Chen
Summary: Picrasidine I exerts anticancer effects in nasopharyngeal carcinoma by modulating HO-1 via the ERK and Akt signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Yue Zhao, Qingqing Jiang, Limin Guo, Daming Fan, Mingfu Wang, Yueliang Zhao
Summary: Glycidol is a food contaminant found in refined edible oils and various thermally processed foods, which induces cell cycle arrest, apoptosis, and autophagy in HUVECs. The toxicity effects of glycidol are mediated through activation of the ERK/JNK/p38 signaling pathways, and these effects can be attenuated by apigenin-7 (API-C8) through inhibition of the same pathways.
CURRENT RESEARCH IN FOOD SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Jieya Liu, Ting Shao, Jin Zhang, Qianyi Liu, Hui Hua, Hongying Zhang, Jiao Wang, Ting Luo, Yuenian Eric Shi, Yangfu Jiang
Summary: This study demonstrates the role of SNCG in promoting TGF-β-MKK3/6-p38MAPK signaling, with p38MAPK playing a critical role in SNCG-induced cancer metastasis. The findings suggest that p38MAPK inhibitors may have therapeutic potential for SNCG-overexpressed cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Ruei-Ci Lin, Yu-Ying Chao, Wei-Chih Lien, Huei-Cih Chang, Shih-Wei Tsai, Chia-Yih Wang
Summary: Adrenocortical carcinoma (ACC) is a rare but malignant tumor. Surgical removal, radiotherapy and combined chemotherapy are commonly used to treat ACC. However, the mortality rate of ACC remains high after treatments. Therefore, identifying a novel therapeutic molecule is important. This study found that BI2536 inhibited ACC cell proliferation, blocked cell cycle progression and induced cell apoptosis. It also induced centrosome amplification, leading to aberrant mitosis.
Article
Biochemistry & Molecular Biology
Laura Scheffler, Samantha Feicht, Tea Babushku, Laura B. Kuhn, Stefanie Ehrenberg, Samantha Frankenberger, Frank M. Lehmann, Elias Hobeika, Berit Jungnickel, Manuela Baccarini, Georg W. Bornkamm, Lothar J. Strobl, Ursula Zimber-Strobl
Summary: Members of the RAF family of serine-threonine kinases play vital roles in controlling key differentiation processes in B cells. Raf-1 and B-Raf act together in positive selection of specific B cell populations and plasma cell differentiation. ERK phosphorylation significantly increases during the transition from activated B cells to pre-plasmablasts, with Raf-1 and B-Raf being essential for this process.
Article
Biology
Kristen Kurtzeborn, Hyuk Nam Kwon, Vladislav Iaroshenko, Imrul Faisal, Martin Ambroz, Xing Jin, Talha Qureshi, Jussi Kupari, Anneliis Ihermann-Hella, Juho Vaananen, Henna Tyynismaa, Iva Bousova, Sunghyouk Park, Satu Kuure
Summary: Through RNA sequencing and tissue-specific MAPK/ERK inactivation experiments, we found that MAPK/ERK signaling maintains ureteric bud tip cells, potentially playing a regulatory role in collecting duct progenitors. Additionally, we provide new mechanistic insights on how MAPK/ERK signaling regulates progenitor maintenance through its effects on chromatin accessibility and energy metabolism.
Article
Biochemistry & Molecular Biology
Hui Dang, Mengjun Sui, Qingyuan He, Jingyi Xie, Yan Liu, Peng Hou, Meiju Ji
Summary: This study shows that Pin1 inhibitor API-1 has strong antitumor activity against thyroid cancer and improves the sensitivity of BRAF-mutant thyroid cancer cells to BRAF inhibitor PLX4032. The combination therapy of API-1 and PLX4032 offers an alternative therapeutic strategy for BRAF-mutant thyroid cancers.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Natalia A. Muraleva, Nataliya G. Kolosova, Natalia A. Stefanova
Summary: SkQ1 alleviates AD pathology by suppressing MEK1/2-ERK1/2 signaling pathway activity in the OXYS rat hippocampus, making it a promising candidate drug for human AD treatment.
Article
Cell Biology
Mohamad Bouhamdan, Christian Bauerfeld, Jaya Talreja, Laurent Beuret, Jean Charron, Lobelia Samavati
CELLULAR SIGNALLING
(2015)
Article
Anatomy & Morphology
Olivier Boucherat, Kim Landry-Truchon, Rifdat Aoidi, Nicolas Houde, Valerie Nadeau, Jean Charron, Lucie Jeannotte
DEVELOPMENTAL DYNAMICS
(2017)
Article
Immunology
Matthew E. Long, William E. Eddy, Ke-Qin Gong, Lara L. Lovelace-Macon, Ryan S. McMahan, Jean Charron, W. Conrad Liles, Anne M. Manicone
JOURNAL OF IMMUNOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Rifdat Aoidi, Annie Maltais, Jean Charron
Article
Biochemistry & Molecular Biology
Rifdat Aoidi, Annie Maltais, Jean Charron
Article
Multidisciplinary Sciences
Jiho Choi, Aaron J. Huebner, Kendell Clement, Ryan M. Walsh, Andrej Savol, Kaixuan Lin, Hongcang Gu, Bruno Di Stefano, Justin Brumbaugh, Sang-Yong Kim, Jafar Sharif, Christopher M. Rose, Arman Mohammad, Junko Odajima, Jean Charron, Toshi Shioda, Andreas Gnirke, Steven Gygi, Haruhiko Koseki, Ruslan I. S. Adreyev, Andrew Xiao, Alexander Meissner, Konrad Hochedlinger
Article
Cell Biology
Rifdat Aoidi, Nicolas Houde, Kim Landry-Truchon, Michael Holter, Kevin Jacquet, Louis Charron, Suguna Rani Krishnaswami, Benjamin D. Yu, Katherine A. Rauen, Nicolas Bisson, Jason Newbern, Jean Charron
DISEASE MODELS & MECHANISMS
(2018)
Article
Immunology
Harvinder Talwar, Mohamad Bouhamdan, Christian Bauerfeld, T. Jaya Talreja, Rifdat Aoidi, Nicolas Houde, Jean Charron, Lobelia Samavati
JOURNAL OF IMMUNOLOGY
(2019)
Article
Oncology
Hongguang Wu, Dan He, Soma Biswas, Md Shafiquzzaman, Xin Zhou, Jean Charron, Yibin Wang, Bijaya K. Nayak, Samy L. Habib, Huijuan Liu, Baojie Li
Summary: Activation of the mTOR signaling pathway combined with inactivation of the p38MAPK-p53/p16 axis initiates the development of RCC from renal proximal tubules, uncovering previously unidentified mechanisms and potential therapeutic targets for RCC treatment.
Article
Endocrinology & Metabolism
Yoshiko Matsumoto Ikushima, Motoharu Awazawa, Naoki Kobayashi, Sho Osonoi, Seiichi Takemiya, Hiroshi Kobayashi, Hirotsugu Suwanai, Yuichi Morimoto, Kotaro Soeda, Jun Adachi, Masafumi Muratani, Jean Charron, Hiroki Mizukami, Noriko Takahashi, Kohjiro Ueki
Summary: Research has shown that decreased phosphorylation of ERK1/2 in diabetes pathology leads to beta-cell dysfunction and hyperglycemia. Abrogation of ERK signaling in pancreatic beta-cells through deletion of Mek1 and Mek2 results in insufficient insulin production, reduced beta-cell proliferation, and decreased insulin exocytosis events in individual beta-cells.
Article
Cell Biology
Ke Li, Hongguang Wu, Ao Wang, Jean Charron, Yuji Mishina, Samy L. Habib, Huijuan Liu, Baojie Li
Summary: The activation of mTOR can promote proliferation and inhibit differentiation of gastric epithelial progenitors. Through regulating MEK1-ERKs and BMP-Smad1 pathways, mTOR signaling controls the homeostasis and cancerization of Lgr5(+) GEPs in gastric tissues.
Article
Cell Biology
Laurent Beuret, Simon-Pierre Fortier-Beaulieu, Vincent Rondeau, Sophie Roy, Nicolas Houde, Karl Balabanian, Marion Espeli, Jean Charron
Summary: Studies have highlighted the crucial role of Mek genes in hematopoietic cell proliferation and differentiation, with functional ablation leading to anemia and other hematopoietic abnormalities. However, mice retaining one functional Mek gene allele did not exhibit significant defects in erythropoiesis, suggesting a certain level of redundancy among Mek genes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ke-Qin Gong, Carmen Mikacenic, Matthew E. Long, Charles W. Frevert, Timothy P. Birkland, Jean Charron, Sina A. Gharib, Anne M. Manicone
Summary: Inhibition of MAP2K2 can improve acute lung injury (ALI) and deficiency of MAP2K2 can accelerate the resolution of ALI. Genetic variants in MAP2K2 are associated with mortality from acute respiratory distress syndrome (ARDS). MAP2K2 plays an important role in promoting and sustaining proinflammatory pathway activation in ALI.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Cell Biology
Nicolas Houde, Laurent Beuret, Amelie Bonaud, Simon-Pierre Fortier-Beaulieu, Kim Truchon-Landry, Rifdat Aoidi, Emilie Pic, Nagham Alouche, Vincent Rondeau, Geraldine Schlecht-Louf, Karl Balabanian, Marion Espeli, Jean Charron
Summary: This study reveals the critical role of fine-tuning the ERK/MAPK pathway in immune cell activation and function. It also demonstrates that MEK1 and MEK2 isoforms play distinct roles in lymphocyte activation and disease development.
Article
Medicine, Research & Experimental
Matthew E. Long, Ke-Qin Gong, William E. Eddy, Joseph S. Volk, Eric D. Morrell, Carmen Mikacenic, T. Eoin West, Shawn J. Skerrett, Jean Charron, W. Conrad Liles, Anne M. Manicone