Review
Endocrinology & Metabolism
Yimin Zou
Summary: Most spinal cord injury cases are anatomically incomplete, with potential for functional restoration through new axon growth and synaptic connections. Rehabilitation can partially restore function, but limitations and uncertainties still exist.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Multidisciplinary Sciences
Mary Jo Cantoria, Elaheh Alizadeh, Janani Ravi, Reeba P. Varghese, Nawat Bunnag, Kelvin W. Pond, Arminja N. Kettenbach, Yashi Ahmed, Andrew L. Paek, John J. Tyson, Konstantin Doubrovinski, Ethan Lee, Curtis A. Thorne
Summary: In this study, it was found that the cellular response to Wnt ligands is proportional to their concentration. Positive feedback between the scaffold protein Axin and the kinase GSK3 resulted in bistable behavior of the destruction complex. Experimental evidence showed that the cellular concentration of beta-catenin exhibited an all-or-none response with sustained memory.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Nikolaos Koutras, Vasileios Morfos, Kyriakos Konnaris, Adamantia Kouvela, Athanasios-Nasir Shaukat, Constantinos Stathopoulos, Vassiliki Stamatopoulou, Konstantina Nika
Summary: This study reveals the ectopic function of SFKs in B cells and compares it to the predominant B cell SFK, Lyn. Our findings show substrate promiscuity displayed by these two SFKs, which is regulated by different mechanisms. Moreover, we demonstrate that signals generated by Lck and Lyn are sufficient to induce transcriptome alterations in B cells, resembling B cell activation. Additionally, we uncover a previously unknown role of SFKs in tipping the balance of cellular stress responses in B lymphocytes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Hyun-Taek Kim, Paolo Panza, Khrievono Kikhi, Yuko Nakamichi, Ann Atzberger, Stefan Guenther, Clemens Ruppert, Andreas Guenther, Didier Y. R. Stainier
Summary: This study reveals that WNT/RYK signaling plays a regulatory role in lung diseases and highlights the anti-inflammatory modulation of RYK signaling in lung development and homeostasis. These findings provide an animal model for further investigation of the etiology and therapeutic approaches to inflammatory lung diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Elisa Ventura, Antonino Belfiore, Renato V. Iozzo, Antonio Giordano, Andrea Morrione
Summary: Progranulin, a growth factor, regulates cell migration, invasion, adhesion, and tumor formation in mesothelioma by modulating a complex signaling network involving multiple receptor tyrosine kinases. The study reveals the molecular mechanism of how progranulin interacts with RYK and EGFR, and how it regulates the stability and trafficking of RYK in mesothelioma cells.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Dermatology
Amy L. Harding, Helen E. Colley, Inmaculada Barragan Vazquez, Simon Danby, Md Zobaer Hasan, Hirofumi Nakanishi, Tetsuo Furuno, Craig Murdoch
Summary: Skin irritancy is a significant problem that affects millions of people worldwide. New testing methods using human skin equivalents have found evidence of specific activation of c-Src kinase in response to chemical irritants, suggesting the development of rapid screening methods for potential irritants.
EXPERIMENTAL DERMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Christina A. Daly, Eric T. Hall, Stacey K. Ogden
Summary: Cells communicate with their neighbors during development and tissue homeostasis to ensure coordinated responses to signals. One way this communication occurs is through specialized extensions called cytonemes. However, the molecular mechanisms of cytoneme initiation, growth, and signal delivery are still not fully understood.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
David E. Heppner
Summary: The activity of SFKs kinases is regulated by protein phosphorylation, and the oxidation state of their redox-active cysteine residues is influenced by the local structural environment. Conserved and non-conserved cysteine residues exhibit differences in oxidation activity and structural environments.
Article
Otorhinolaryngology
Anh Thu Vu, Lara Akingunsade, Konstantin Hoffer, Cordula Petersen, Christian Stephan Betz, Kai Rothkamm, Thorsten Rieckmann, Lara Bussmann, Malte Kriegs
Summary: The study demonstrates the potential benefits of SFK inhibition in HNSCC, but highlights the challenges due to non-specific effects of different drugs.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Anesthesiology
Attila Keresztes, Keith Olson, Paul Nguyen, Marissa A. Lopez-Pier, Ryan Hecksel, Natalie K. Barker, Zekun Liu, Victor Hruby, John Konhilas, Paul R. Langlais, John M. Streicher
Summary: This study reveals a new function of opioid receptors as a negative feedback brake on opioid-induced analgesia. By using a selective antagonist for the mu and delta opioid receptors (MDOR), the researchers found that the antagonist could enhance the analgesic effect of oxymorphone in mice, suggesting a role for MDOR in regulating pain. Additionally, the study found that the enhancement effect was selective to MDOR and occurred through the repression of Src and CaMKII signal transduction. These findings suggest that MDOR antagonism could be a potential approach to improve clinical opioid therapy.
Review
Oncology
Takashi Matozaki, Takenori Kotani, Yoji Murata, Yasuyuki Saito
Summary: The turnover of intestinal epithelial cells is regulated by various signaling pathways, including Wnt-beta-catenin and receptor protein tyrosine kinases. These pathways not only promote cell proliferation but also affect cell differentiation, showing cross-regulatory relationships with each other.
Article
Biochemistry & Molecular Biology
Oriane Guillermin, Nikolaos Angelis, Clara M. Sidor, Rachel Ridgway, Anna Baulies, Anna Kucharska, Pedro Antas, Melissa R. Rose, Julia Cordero, Owen Sansom, Vivian S. W. Li, Barry J. Thompson
Summary: Wnt signaling induces gradient proliferation of stem/progenitor cells along the intestinal axis, with YAP-TEAD acting as a key downstream effector. YAP regulates the sensitivity of crypt stem cells to apoptosis and cell proliferation during regeneration, and its nuclear localization is influenced by Src family kinase. The interaction between Wnt and Src-YAP signals plays a crucial role in driving intestinal regeneration.
Article
Cell Biology
Xue-Hua Du, Shao-Bo Ke, Xin-Yi Liang, Jie Gao, Xiao-Xiao Xie, Lin-Zhi Qi, Xue-Yi Liu, Guo-Yuan Xu, Xiao-Dong Zhang, Run-Lei Du, Shang-Ze Li
Summary: Our study demonstrates that USP14 functions as a deubiquitinase that interacts and stabilizes JNK, promoting MAPK/JNK signaling and colorectal carcinogenesis. Increased expression of USP14 is associated with elevated levels of JNK protein and downstream gene expression in colorectal cancer patients. Inhibition of USP14 reduces cancer cell proliferation and tumorigenesis by downregulating the activation of the MAPK/JNK pathway.
CELL DEATH & DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Aziz M. Rangwala, Victoria R. Mingione, George Georghiou, Markus A. Seeliger
Summary: Phosphorylation plays a vital role in regulating biological processes, and protein kinases have been extensively studied for their involvement in human health and disease. Some kinases possess additional catalytic functions in addition to phosphotransferase activity, while others have lost their catalytic activity completely. In this study, we analyzed the UniProtKB database for bifunctional protein kinases and focused on those crucial for bacterial and human cellular homeostasis. These kinases have diverse functional roles in environmental sensing, metabolic regulation, immune-host defense, and cell cycle control. This article explores their dual catalytic activities and their contributions to disease pathogenesis.
Review
Cell Biology
Horacio Maldonado, Lisette Leyton
Summary: Cancer progression and metastasis are controlled by the integrin receptor family and their interaction with Src family kinases (SFKs). The non-receptor tyrosine kinase CSK suppresses SFK activity and may play a crucial role in inhibiting SFK oncogenic effects in cancer. CSK can localize near focal adhesions and interact with focal adhesion components, suggesting a role in regulating focal adhesion dynamics and structure. The specific role of CSK and its crosstalk with integrins in cancer progression, particularly in mechanosensing, remains unclear.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Microbiology
C. E. Melia, H. M. van der Schaar, A. W. M. de Jong, H. R. Lyoo, E. J. Snijder, A. J. Koster, F. J. M. van Kuppeveld, M. Barcena
Article
Biochemistry & Molecular Biology
Iveta M. Petrova, Liza L. Lahaye, Tania Martianez, Anja W. M. de Jong, Martijn J. Malessy, Joost Verhaagen, Jasprina N. Noordermeer, Lee G. Fradkin
MOLECULAR AND CELLULAR BIOLOGY
(2013)
Article
Multidisciplinary Sciences
Liza L. Lahaye, Rene R. Wouda, Anja W. M. de Jong, Lee G. Fradkin, Jasprina N. Noordermeer
Article
Virology
Adriaan H. de Wilde, A. Linda Boomaars-van Der Zanden, Anja W. M. de Jong, Montserrat Barcena, Eric J. Snijder, Clara C. Posthuma
JOURNAL OF VIROLOGY
(2019)
Article
Microbiology
Charlotte E. Melia, Christopher J. Peddie, Anja W. M. de Jong, Eric J. Snijder, Lucy M. Collinson, Abraham J. Koster, Hilde M. van der Schaar, Frank J. M. van Kuppeveld, Montserrat Barcena
Article
Multidisciplinary Sciences
Georg Wolff, Ronald W. A. L. Limpens, Jessika C. Zevenhoven-Dobbe, Ulrike Laugks, Shawn Zheng, Anja W. M. de Jong, Roman Koning, David A. Agard, Kay Grunewald, Abraham J. Koster, Eric J. Snijder, Montserrat Barcena
Article
Developmental Biology
Mariska C. van der Plas, Gonneke S. K. Pilgram, Anja W. M. de Jong, Monique R. K. S. Bansraj, Lee G. Fradkin, Jasprina N. Noordermeer
MECHANISMS OF DEVELOPMENT
(2007)
Article
Neurosciences
MC van der Plas, GSK Pilgram, JJ Plomp, A de Jong, LG Fradkin, JN Noordermeer
JOURNAL OF NEUROSCIENCE
(2006)
Article
Developmental Biology
LG Fradkin, M van Schie, RR Wouda, A de Jong, JT Kamphorst, M Radjkoemar-Bansraj, JN Noordermeer
DEVELOPMENTAL BIOLOGY
(2004)
Article
Genetics & Heredity
MM Gorski, RJ Romeijn, JCJ Eeken, AWM de Jong, BL van Veen, K Szuhai, LH Mullenders, W Ferro, A Pastink
Article
Genetics & Heredity
MM Gorski, JCJ Eeken, AWM de Jong, I Klink, M Loos, RJ Romeijn, BL van Veen, LH Mullenders, W Ferro, A Pastink
Article
Biotechnology & Applied Microbiology
JCJ Eeken, RJ Romeijn, AWM de Jong, A Pastink, PHM Lohman
MUTATION RESEARCH-DNA REPAIR
(2001)