Article
Cell Biology
Chunxiao Niu, Jijun Yu, Tao Zou, Yuchen Lu, Lijiao Deng, Hongfang Yun, Chuan-Yimu Si, Xian Wu, Hui Jiang, Tingting Guo, Mengyao Wu, Tongtong Kan, Jiannan Feng, Chao Yuan, Xiqin Yang, Qianqian Cheng, Jie Dong, Qingyang Wang, Jiyan Zhang
Summary: The steady-state meninges of adult mice contain hematopoietic stem cells (HSCs) that have the ability to self-renew and reconstitute multiple lineages. These HSCs reside in the meninges after birth and are locally maintained using pro-hematopoietic niche factors. They can provide the central nervous system with a constant supply of leukocytes that are better adapted to the local microenvironment, replenishing from the blood only when necessary.
Review
Biochemistry & Molecular Biology
Lucas Lange, Michael Morgan, Axel Schambach
Summary: The in vitro generation of hematopoietic cells, especially HSCs, from human pluripotent stem cells has great potential for regenerative medicine, but still faces challenges due to insufficient functionality and quantity of the produced HSCs. Further understanding of the complex processes involved in this conversion is needed to achieve the goal of generating therapeutically applicable PSC-derived HSCs in vitro.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell & Tissue Engineering
Emmanuelle Julien, Katia Biasch, Reine El Omar, Jean-Noel Freund, Christian Gachet, Francois Lanza, Manuela Tavian
Summary: The study found that angiotensin-converting enzyme is expressed in hematopoietic progenitors in developing mouse embryos and various elements of the renin-angiotensin system are present in specific regions of human and mouse embryos. Experimentally, angiotensin II signaling is crucial for the generation of hematopoietic cells, with the peptide stimulating hematopoiesis in culture.
Article
Hematology
Anthony D. Pomicter, Phillip M. Clair, Dongqing Yan, William L. Heaton, Anna M. Eiring, Michael B. Anderson, Stephen M. Richards, Jeremy Gililland, Thomas O'Hare, Michael W. Deininger
Summary: This study explored the use of femoral heads as a cost-effective source of normal bone marrow cells, successfully obtaining high-quality marrow cells from 21 patients and demonstrating comparable results to standard bone marrow aspirates.
ACTA HAEMATOLOGICA
(2021)
Article
Cell Biology
Ilker A. Deniz, Jana Karbanova, Manja Wobus, Martin Bornhaeuser, Pauline Wimberger, Jan Dominik Kuhlmann, Denis Corbeil
Summary: In this study, it is found that MSCs isolated from bone marrow can generate migrasomes, a newly discovered organelle involved in intercellular communication. Migrasomes have the ability to attract both leukemic cells and hematopoietic progenitors, possibly through the SDF-1 signaling pathway.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Cell Biology
Lucia de Miguel-Gomez, Sara Lopez-Martinez, Emilio Frances-Herrero, Adolfo Rodriguez-Eguren, Antonio Pellicer, Irene Cervello
Summary: Various types of endogenous stem cells have been identified in the endometrium, with potential involvement of exogenous stem cells from bone marrow. These findings are driving the development of stem cell therapies for endometrial pathologies, as well as proposing promising therapeutic alternatives based on bioengineering.
Article
Cell Biology
Yi Zhang, Kathleen E. McGrath, Edward Ayoub, Paul D. Kingsley, Hongbo Yu, Kate Fegan, Kelly A. McGlynn, Sarah Rudzinskas, James Palis, Archibald S. Perkins
Summary: The research revealed that HSC-derived erythroid, myeloid, and lymphoid progeny significantly expand in the liver and blood stream between E14.5 and E16.5, highlighting the importance of HSC contribution.
Article
Multidisciplinary Sciences
Zhigang Li, Xuemei Fu, Weiru Wu, Zhilong Liu, Zhe Chen, Chengfang Zhou, Yuanyuan Liu, Mei Kuang, Fangfang Sun, Feifei Xiao, Yongxiu Huang, Xiaojun Zhang, Shijun Fan, Xingqin Huang, Guangling Zheng, Jieping Chen, Yu Hou
Summary: Zfp521 is a critical regulator of quiescence and self-renewal of HSC in adult hematopoiesis, mediating its effects partly through controlling Rela expression, especially under regenerative stress conditions.
Article
Multidisciplinary Sciences
Yan Sun, Xiaolin Lin, Bangdong Liu, Yaxuan Zhang, Wei Li, Sheng Zhang, Falian He, Han Tian, Xun Zhu, Ximeng Liu, Jueheng Wu, Junchao Cai, Mengfeng Li
Summary: ATF4 deficiency leads to severe HSC defects with aging-like phenotype, affecting HSC function by regulating HIF1α and p16(Ink4a), and delaying leukemogenesis.
Review
Oncology
Isabella Maria Mayer, Andrea Hoelbl-Kovacic, Veronika Sexl, Eszter Doma
Summary: Transplantation of adult hematopoietic stem cells is crucial for treating hematological disorders, while leukemic stem cells play a significant role in disease initiation and relapse. Understanding methods to maintain and expand hematopoietic cells, as well as isolate and enrich hematopoietic stem cells and leukemic stem cells, is essential for developing therapeutic strategies.
Article
Pediatrics
Tomasz Jarmolinski, Monika Rosa, Blanka Rybka, Renata Ryczan-Krawczyk, Kornelia Gajek, Katarzyna Bogunia-Kubik, Maja Klaudel-Dreszler, Piotr Czubkowski, Piotr Kalicinski, Joanna Teisseyre, Marek Stefanowicz, Ewa Gorczynska, Krzysztof Kalwak, Marek Ussowicz
Summary: A child with Fanconi anemia underwent orthotopic liver transplantation (OLT) after hematopoietic stem cell transplantation (HSCT) complicated by acute graft versus host disease (GVHD). The liver can serve as a clinically significant source of hematopoietic stem cells. Close monitoring of hematopoietic chimerism after OLT is necessary in patients at risk for complications such as GVHD.
FRONTIERS IN PEDIATRICS
(2022)
Article
Hematology
Sarah Warsi, Maria Dahl, Emma M. K. Smith, Anna Rydstrom, Els Mansell, Valgardur Sigurdsson, Julia Sjoberg, Shamit Soneji, Emma Rorby, Kavitha Siva, Tan H. M. Grahn, Yang Liu, Ulrika Blank, Goran Karlsson, Stefan Karlsson
Summary: This study identifies Slfn2 as a novel and critical regulator of adult hematopoietic stem cells (HSC) and HSC quiescence. Mutations in Slfn2 lead to functional deficiency of primitive hematopoietic cells and increased HSC proliferation.
Article
Cell Biology
Pallavi Budgude, Anuradha Vaidya, Vaijayanti Kale
Summary: Hematopoiesis is a complex process regulated by intrinsic and extrinsic factors. Understanding the dominant intrinsic factors governing the activation and quiescence of hematopoietic stem cells can provide insights for novel therapeutic approaches. This review focuses on recent research on adult HSCs and their associated intrinsic factors.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Engineering, Environmental
Yunhua Chang, Yaqin Gao, Yiqun Lu, Liping Qiao, Yaqiong Kuang, Kai Cheng, Yuhang Wu, Shengrong Lou, Shengao Jing, Hongli Wang, Cheng Huang
Summary: The study conducted measurements of gaseous amines emitted from the ceiling duct in Shanghai, showing strong pulses of C2- and C3-amines emissions driven by human activity. Direct source-determined emission ratios of amines to ammonia were found to vary significantly with amine species and differ systematically from previous assumptions in models.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2021)
Article
Cell & Tissue Engineering
Rebecca L. Murdaugh, Kevin A. Hoegenauer, Ayumi Kitano, Matthew Holt, Matthew C. Hill, Xiangguo Shi, Jonathan F. Tiessen, Richard Chapple, Tianyuan Hu, Yu-Jung Tseng, Angelique Lin, James F. Martin, Nicolas L. Young, Daisuke Nakada
Summary: Histone variant H3.3 is incorporated into genic elements independent of DNA replication by its chaperone HIRA, which is required for the self-renewal of adult hematopoietic stem cells (HSCs) and to restrain erythroid differentiation. Depletion of HSCs after Hira deletion is accompanied by increased expression of bivalent and erythroid genes, highlighting the role of HIRA-dependent H3.3 incorporation in defining repressive chromatin that represses erythroid differentiation of HSCs.
