期刊
JOURNAL OF ORAL PATHOLOGY & MEDICINE
卷 44, 期 9, 页码 649-655出版社
WILEY
DOI: 10.1111/jop.12306
关键词
cancer; epithelial-to-mesenchymal transition; heterogeneity; mesenchymal-to-epithelial transition; plasticity
资金
- National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs)
- BAOMS/Saving Faces - FSRF
- Barts and The London Charity
- National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) [NC/K500495/1, NC/L00061X/1, G0900799/1] Funding Source: researchfish
It is increasingly recognised that phenotypic plasticity, apparently driven by epigenetic mechanisms, plays a key role in tumour behaviour and markedly influences the important processes of therapeutic survival and metastasis. An important source of plasticity in malignancy is epithelial-to-mesenchymal transition (EMT), a common epigenetically controlled event that results in transition of malignant cells between different phenotypic states that confer motility and enhance survival. In this review, we discuss the importance of phenotypic plasticity and its contribution to cellular heterogeneity in oral squamous cell carcinoma with emphasis on aspects of drug resistance and EMT.
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