Article
Food Science & Technology
Amruta Kulkarni, Ai Zhao, Baoru Yang, Yumei Zhang, Kaisa M. Linderborg
Summary: The intake of fatty acids affects the composition of lipids in the body. In this study, rats were fed a peanut-oil-based diet for 33 days after weaning to investigate the effects of mild (n-3) deficiency on the lipid composition of various organs and feces. Results showed a lower level of docosahexaenoic acid (DHA) in the (n-3) deficient group compared to the control group, but no difference in DHA content was observed in the eyes and feces. This study highlights the importance of adequate maternal nutrition for a healthy fatty acid balance in rats.
Article
Agriculture, Dairy & Animal Science
Paulo H. de Mello, Bruno C. Araujo, Victor H. Marques, Giovana S. Branco, Renato M. Honji, Renata G. Moreira, Artur N. Rombenso, Maria C. Portella
Summary: This study investigated the effects of different lipid classes on the physiological and morphological responses of dusky groupers. The results showed that including different lipid classes in the diet can improve fish fillet quality. Additionally, the study found that DHA and EPA have an impact on the morphophysiology of dusky grouper juveniles, providing valuable insights for establishing this fish species as a produced species worldwide.
Article
Nutrition & Dietetics
Timo Drobner, Theresa S. Braun, Michael Kiehntopf, Peter Schlattmann, Stefan Lorkowski, Christine Dawczynski
Summary: This study aimed to investigate the impact of various factors on the conversion of ALA obtained from linseed oil into its long-chain metabolites and its effect on cardiovascular risk markers. The results showed that ALA, C-20:4n3, and EPA concentrations increased in erythrocytes in all groups, while DHA and n-3 index decreased in the HLA, LLA, and control groups. Only the MF and control groups showed an increase in C-22:5n3. Additionally, an increase in LA was found in the HLA, LLA, and control groups, while C-20:3n6, arachidonic acid, C-22:4n6, and C-22:5n6 decreased. Conversion into EPA was higher in men and in subjects with low EPA status. ALA supplementation did not have clear effects on blood lipids and glucose metabolism parameters, consistent with the literature.
Article
Nutrition & Dietetics
Maria Dolores Mesa, Fernando Gil, Pablo Olmedo, Angel Gil
Summary: This study aims to estimate the amount of n-3 LC-PUFA provided by commonly consumed fishes, shrimps, and mollusks, to conduct a risk-benefit analysis of fish consumption. Consuming 2-3 servings of a variety of fishery products per week can help meet recommended n-3 LC-PUFA levels while maintaining a balance to avoid potential risks from contaminants.
Article
Biochemistry & Molecular Biology
C. J. Urso, Heping Zhou
Summary: Obesity and metabolic syndrome are associated with cognitive decline and dementia, and palmitic acid (PA) has been found to have lipotoxic effects on BV2 microglia cells, while unsaturated fatty acids could protect cells from lipotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Fisheries
Chang Liu, Wanxiu Rao, Zhengyi Cui, Peng Chen, Keke Lei, Kangsen Mai, Wenbing Zhang
Summary: In this study, the effects of different levels of dietary docosahexaenoic acid (DHA) on growth performance, fatty acid profile, and lipid metabolism in abalone were compared. The optimal dietary DHA content for large and small abalone was estimated to be 1.32% and 0.88%, respectively, based on weight gain rate (WGR). DHA supplementation increased digestive enzymes' activity, polyunsaturated fatty acids content, and n-3/n-6 PUFA ratio in abalone.
Article
Oncology
Mara De Martino, Camille Daviaud, Hanna E. Minns, Artur Lazarian, Anja Wacker, Ana Paula Costa, Nabeel Attarwala, Qiuying Chen, Seung-Won Choi, Rail Rabadan, Laura Beth J. McIntire, Robyn D. Gartrell, James M. Kelly, Evagelia C. Laiakis, Claire Vanpouille-Box
Summary: Radiation therapy (RT) is crucial for glioblastoma (GBM) management, but it often leads to relapse within the treated region. It is unclear whether resistance to RT is due to metabolic adaptation. This study shows that irradiated GBM tumors switch their metabolic program to accumulate lipids, which protects against endoplasmic reticulum stress. Inhibiting fatty acid synthase (FASN) reduces lipid accumulation, impairs mitochondrial function, and increases apoptosis in irradiated GBM cells. Combining FASN inhibition with RT improves the survival of GBM-bearing mice and targeting lipid metabolism could lead to more effective anti-GBM strategies.
Article
Cell Biology
Ying Yang, Jiaxing He, Bo Zhang, Zhansheng Zhang, Guozhan Jia, Shiqi Liu, Tao Wu, Xianli He, Nan Wang
Summary: SLC25A1 is significantly upregulated in CRC, associated with poor survival in patients, and reprograms energy metabolism through two mechanisms to promote CRC growth. It serves as a potential diagnostic marker and therapeutic target in CRC.
CELL DEATH & DISEASE
(2021)
Article
Food Science & Technology
Muhammad Suhaib Shahid, Shengyu Zhou, Wei Nie, Liang Wang, Huiyuan Lv, Jianmin Yuan
Summary: The study found that adding vitamin E, polyphenol, chlorogenic acid, and lutein can increase egg weight and hen day egg production, reduce oxidation, and maintain fatty acid content, positively impacting egg quality maintenance.
Article
Nutrition & Dietetics
Marie C. Conway, Emeir M. McSorley, Maria S. Mulhern, Toni Spence, Edwin van Wijngaarden, Gene E. Watson, Karin Wahlberg, Daniela Pineda, Karin Broberg, Barry W. Hyland, Diego F. Cobice, J. J. Strain, Alison J. Yeates
Summary: The study found that consuming two portions of fish per week significantly increased concentrations of EPA, DHA, and total n-3 PUFA in women of childbearing age, with a lower n-6:n-3 ratio compared to those consuming no fish or one portion per week. However, fish consumption did not have a significant effect on biomarkers of oxidative stress, inflammation, and lipid profile in the current study.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Yi-Chan Liu, Samwel Mchele Limbu, Jin-Gang Wang, Mai Wang, Li-Qiao Chen, Fang Qiao, Yuan Luo, Mei-Ling Zhang, Zhen-Yu Du
Summary: This study investigated the role of dietary docosahexaenoic acid (DHA) in improving liver health in Nile tilapia. The results showed that tilapia fed on DHA diets had lower lipid content in the liver and serum, as well as decreased triglyceride concentrations. Furthermore, DHA supplementation also downregulated the expression of genes related to liver damage.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Guangyuan Zhao, Yuying Tan, Horacio Cardenas, David Vayngart, Yinu Wang, Hao Huang, Russell Keathley, Jian-Jun Wei, Christina R. Ferreira, Sandra Orsulic, Ji-Xin Cheng, Daniela Matei
Summary: Fatty acids are an important energy source and component of cell membranes. This study investigates the impact of the balance between saturated fatty acids (SFAs) and unsaturated fatty acids (UFAs), regulated by stearoyl Co-A desaturase (SCD), on ovarian cancer cell survival and tumor progression. Depletion or inhibition of SCD leads to lower levels of UFAs, triggering endoplasmic reticulum (ER) stress response and cell death. However, supplementation with UFAs and reequilibration of SFA/UFA levels rescues stress and apoptosis. This research highlights the importance of targeting lipid balance in the treatment of ovarian cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biotechnology & Applied Microbiology
Tao Wu, Lihua Yu, Yu Zhang, Jin Liu
Summary: This study elucidated the pathways of C18 FA desaturations and comprehensive profiles of polar membrane lipids in Chromochloris zofingiensis for the first time, shedding light on the collaboration of CzFADs for the synthesis and enrichment of C18 UFAs in triacylglycerol.
BIOTECHNOLOGY FOR BIOFUELS
(2021)
Article
Biochemistry & Molecular Biology
Ruxandra D. Rotarescu, Kimia Rezaei, David M. Mutch, Adam H. Metherel
Summary: Dietary feeding and stable isotope studies in rodents have shown that 24-carbon omega-3 polyunsaturated fatty acids, specifically tetracosapentaenoic acid (TPAn-3) and tetracosahexaenoic acid (THA), serve as immediate precursors to docosahexaenoic acid (DHA). This study assessed changes in TPAn-3 and THA levels in humans following omega-3 PUFA supplementation, finding that EPA supplementation significantly increased TPAn-3 and THA levels in plasma. Women generally had higher levels of TPAn-3 and THA compared to men, and EPA supplementation had a greater impact on their levels. The study suggests that THA accumulates before conversion to DHA in the n-3 PUFA synthesis pathway.
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2022)
Article
Biochemistry & Molecular Biology
Wangkuk Son, Katie Brown, Aaron Persinger, Ashley Pryke, Jason Lin, Zereque Powell, Noah Wallace, Marie van der Merwe, Melissa Puppa
Summary: The aim of this study was to examine whether the fat composition resulting from a high-fat diet affects glucocorticoid-induced changes in lipid metabolism in the liver and skeletal muscle. The results demonstrated that a high omega-3 polyunsaturated fatty acid (PUFA) diet attenuated fatty accumulation and prevented glucocorticoid-induced increases in liver lipid metabolism markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Liping Chen, Fumiaki Beppu, Kazuo Miyashita, Masashi Hosokawa
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
(2020)
Article
Fisheries
Fumiaki Beppu, Yusuke Aida, Masahiro Kaneko, Satoshi Kasatani, Yoshinori Aoki, Naohiro Gotoh
Article
Food Science & Technology
Kazuyoshi Teramukai, Shusuke Kakui, Fumiaki Beppu, Masashi Hosokawa, Kazuo Miyashita
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2020)
Article
Biochemistry & Molecular Biology
Naoki Takatani, Yuka Kono, Fumiaki Beppu, Yuko Okamatsu-Ogura, Yumiko Yamano, Kazuo Miyashita, Masashi Hosokawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Kazuo Miyashita, Fumiaki Beppu, Masashi Hosokawa, Xiaoyong Liu, Shuzhou Wang
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2020)
Article
Food Science & Technology
Naoki Takatani, Daisuke Taya, Ami Katsuki, Fumiaki Beppu, Yumiko Yamano, Akimori Wada, Kazuo Miyashita, Masashi Hosokawa
Summary: Fucoxanthin is metabolized into fucoxanthinol and amarouciaxanthin A in mice, with further metabolism of apocarotenoids remaining unclear. In vivo studies show that certain fucoxanthin-derived apocarotenoids with allenic bond and epoxide residue exhibit anti-inflammatory effects against activated macrophages and adipocytes.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Agriculture, Multidisciplinary
Kazuaki Yoshinaga, Haruna Ishikawa, Fumiaki Beppu, Naohiro Gotoh
Summary: The study found that dietary polyunsaturated fatty acids can pass through the blood-brain barrier and reach the brain, but most of them are stored in the brain instead of being converted into other forms.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Fisheries
Liping Chen, Fumiaki Beppu, Naoki Takatani, Kazuo Miyashita, Masashi Hosokawa
Summary: n-3 PUFA-PG exhibited potent anti-inflammatory effects on RAW264.7 cells stimulated by LPS through Nrf2 activation by altering cellular fatty acids.
Review
Plant Sciences
Fumiaki Beppu, Naohiro Gotoh
Summary: Fruits and seeds are naturally rich in antioxidants, with vitamin E being a typical antioxidant that plays a crucial role in preventing oxidation and supporting the biological functions of organisms. Recent studies have identified minor homologues like tocomonoenol and tocodienol, which have attracted research interest due to their unique structural characteristics and potential nutritional functionality.
JOURNAL OF BERRY RESEARCH
(2021)
Article
Chemistry, Medicinal
Kodai Nagata, Naoki Takatani, Fumiaki Beppu, Aya Abe, Etsuko Tominaga, Tomohisa Fukuhara, Makoto Ozeki, Masashi Hosokawa
Summary: Fucoxanthin, a marine carotenoid found in brown seaweeds and microalgae, has health benefits such as anti-obesity and anti-diabetic effects. This study investigated the combined feeding of fucoxanthin-containing seaweed oil (SO) and monocaprin to improve the bioavailability of fucoxanthin. The results showed that the combination diet increased the accumulation of fucoxanthinol in the liver, small intestine, and serum.
Article
Chemistry, Multidisciplinary
Naoki Takatani, Fumiaki Beppu, Yumiko Yamano, Takashi Maoka, Kazuo Miyashita, Masashi Hosokawa
Summary: It is discovered that apocarotenoids, derived from astaxanthin through chemical oxidation, have anti-inflammatory effects and can inhibit inflammatory reactions in macrophages and adipocytes. These findings suggest the potential of apocarotenoids in regulating adipose tissue inflammation caused by obesity.
Article
Chemistry, Applied
Koji Nagao, Junya Ueno, Kazuaki Yoshinaga, Toshiharu Nagai, Hoyo Mizobe, Akihiko Yoshida, Fumiaki Beppu, Seiya Tanaka, Naohiro Gotoh
Summary: This study investigated the effects of different trans-octadecenoic acid (t-18:1) isomers on lipid profiles in golden Syrian hamsters. The results showed that t5-18:1 did not significantly alter the lipid profiles compared to natural oleic acid (OA). This suggests that lipid metabolism in animals is influenced by the structure of trans-fatty acids (TFA).
JOURNAL OF OLEO SCIENCE
(2022)
Article
Chemistry, Applied
Naoki Takatani, Fumiaki Beppu, Yumiko Yamano, Takashi Maoka, Masashi Hosokawa
Summary: beta-Apocarotenoids, cleavage products of beta-carotene, were prepared through chemical oxidation and investigated for their anti-inflammatory effects against activated macrophages. The seco-beta-apo-8'-carotenal showed significant anti-inflammatory activity compared to beta-apo-8'-carotenal, possibly due to its opened beta-ring structure. The results suggest that seco-beta-apo-8'-carotenal has high potential for preventing inflammation-related diseases.
JOURNAL OF OLEO SCIENCE
(2021)
Article
Chemistry, Applied
Fumiaki Beppu, Aimi Sakuma, Satoshi Kasatani, Yoshinori Aoki, Naohiro Gotoh
Summary: Research has identified minor homologs of vitamin E, Ti and T2, which can be generated from tocotrienol through partial hydrogenation. Feeding the hydrogenated product can ameliorate hyperglycemia and improve lipid metabolism abnormalities.
JOURNAL OF OLEO SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Kazuo Miyashita, Fumiaki Beppu, Masashi Hosokawa, Xiaoyong Liu, Shuzhou Wang
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
(2020)