Review
Medicine, General & Internal
Puneet Agarwal, Snehal Balvant Lunge, Nandini Sundar Shetty, Priyanka Karagaiah, Steven Daveluy, Alex G. Ortega-Loayza, Thrasyvoulos Tzellos, Jacek C. Szepietowski, Christos C. Zouboulis, Stephan Grabbe, Mohamad Goldust
Summary: Hidradenitis suppurativa/acne inversa (HS) is a chronic inflammatory disease that causes painful, inflammatory nodules, abscesses, and tunnels in the apocrine gland-bearing areas of the skin. Pain and drainage are the main symptoms that affect the quality of life in HS patients. Itch, which is often overlooked in quality of life studies, is also an important symptom and is associated with reduced quality of life, depression, and impairment of social life. Mast cells and mTor signaling are elevated in both lesional and perilesional skin. Brodalumab, a monoclonal antibody against IL-17A receptor, has shown significant improvements in itch, pain, quality of life, and depression in patients with moderate to severe HS. Statins have shown some reduction in itch intensity score. Further studies are needed to better understand the etiopathogenesis and optimal therapeutic modalities for itch in HS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Allergy
Kelsey R. van Straalen, Errol P. Prens, Johann E. Gudjonsson
Summary: Hidradenitis suppurativa is a chronic, inflammatory skin disorder that affects around 1% of the population and significantly impacts patients' quality of life. It is characterized by inflammatory lesions such as nodules, abscesses, and sinus tracts in areas like the armpits, groin, and buttocks, typically appearing during or after puberty. The development and maintenance of the disease involve a complex interplay of genetic predisposition, hormonal factors, obesity, and smoking. It is believed to stem from a defect in the hair follicle, leading to follicular plugging, cyst formation, and subsequent acute inflammation. Over time, acute lesions progress to a chronic condition with draining sinus tracts and extensive fibrosis. Hidradenitis suppurativa is associated with other immune-mediated inflammatory diseases, metabolic and cardiovascular disorders, and psychiatric comorbidities.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
John W. Frew, N. Singh, C. S. Jiang, R. Vaughan, J. G. Krueger
Summary: The study showed that elevated BMI in Hidradenitis Suppurativa is associated with decreased response to Adalimumab therapy. The findings suggest that BMI is a significant covariate in the setting of lower baseline disease activity, supporting the concept of disease heterogeneity and differential therapeutic response to Adalimumab. However, it remains unresolved whether a threshold BMI exists above which increased dosages may provide clinical benefit.
FRONTIERS IN MEDICINE
(2021)
Article
Nutrition & Dietetics
Luigi Barrea, Giovanna Muscogiuri, Gabriella Pugliese, Giulia de Alteriis, Maria Maisto, Marianna Donnarumma, Gian Carlo Tenore, Annamaria Colao, Gabriella Fabbrocini, Silvia Savastano
Summary: In this study, circulating TMAO levels were higher and adherence to the Mediterranean diet was lower in HS patients, with HS patients of higher severity showing higher BMI, waist circumference, and energy intake but lower PhA and MD adherence. Circulating TMAO levels were positively correlated with HS severity, and both circulating TMAO levels and PhA were main predictors of HS clinical severity.
Article
Dermatology
L. M. Prens, K. Bouwman, P. Aarts, S. Arends, K. R. van Straalen, K. Dudink, B. Horvath, E. P. Prens
Summary: This study evaluated the drug survival of antitumour necrosis factor biologics for patients with hidradenitis suppurativa in daily practice. Survival rates for adalimumab and infliximab were similar at 12 months, mainly determined by ineffectiveness. Age, disease duration (adalimumab), and surgery (infliximab) were identified as predictors for longer drug survival.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chiara Moltrasio, Paola Maura Tricarico, Maurizio Romagnuolo, Angelo Valerio Marzano, Sergio Crovella
Summary: This article provides an overview of the contribution of various genetic studies in the field of Hidradenitis Suppurativa (HS) and discusses the role of genetics in HS, as well as the application of next-generation sequencing technologies.
Article
Dermatology
Siobhan McCarthy, Maurice Barrett, Shivashini Kirthi, Paola Pellanda, Klara Vlckova, Anne-Marie Tobin, Michelle Murphy, Fergus Shanahan, Paul W. O'Toole
Summary: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by nodules, abscesses, and fistulae. This study found that individuals with HS had lower microbial diversity in fecal, skin, and nasal samples, and certain bacteria were more abundant. Finegoldia magna was overabundant in HS skin samples, potentially contributing to local inflammation. These findings suggest that the microbiome alterations in both the gut and skin of HS patients deserve further investigation.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Zuzanna Swierczewska, Milosz Lewandowski, Agnieszka Surowiecka, Wioletta Baranska-Rybak
Summary: Interest in the microbiome of cutaneous diseases, especially the gut-brain-skin axis, has increased recently. The link between the commensals and the host in the pathogenesis of hidradenitis suppurativa is yet to be established. Studies consistently show increased abundance of specific bacterial species and a loss of commensal species in HS lesions. The role of gut and blood microbiome in HS is not fully understood, but there is a link to an increased risk of developing Crohn's disease and ulcerative colitis. Lifestyle, dietary approaches, and probiotics show promise as adjuvant therapy for HS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Dermatology
Aswatha Rabindranathnambi, Balasubramanian Jeevankumar
Summary: Hidradenitis suppurativa is a chronic, inflammatory, recurrent disease with limited evidence supporting the efficacy of dapsone as a treatment. More well-designed randomized controlled trials are needed to support its usage.
DERMATOLOGY AND THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Zuzanna Swierczewska, Milosz Lewandowski, Agnieszka Surowiecka, Wioletta Baranska-Rybak
Summary: Hidradenitis suppurativa, also known as acne inversa, is a debilitating skin disease characterized by severe inflammation and the formation of painful nodules, abscesses, and fistulas. Current treatment options are limited and ineffective, leading to the search for new biologics and target treatments. This article discusses the current and future targets for acne inversa treatment and provides insights into the molecular pathomechanisms of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Jing-Wun Lu, Yu-Wen Huang, Tai-Li Chen
Summary: The study found that weekly administration of adalimumab was associated with better clinical response achievement, improved disease severity, and quality of life in patients with moderate-to-severe HS, while bi-weekly administration showed improvement only in disease severity.
Article
Dermatology
Verena Gerlinde Frings, Boris Bauer, Roswitha Schuster, Matthias Goebeler, Dagmar Presser, Andreas Kerstan
Summary: In this study, the duration of complete secondary wound healing after surgical intervention for hidradenitis suppurativa/acne inversa was assessed. The anogenital/inguinal region showed significantly faster wound healing compared to the axillary region, possibly due to differences in pilosebaceous unit density and hair follicle progenitor cells as reflected by CK15 and CD200 expression.
EUROPEAN JOURNAL OF DERMATOLOGY
(2021)
Review
Dermatology
Gautham Vellaichamy, Peter Dimitrion, Li Zhou, David Ozog, Henry W. Lim, Wilson Liao, Iltefat H. Hamzavi, Qing-Sheng Mi
Summary: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with significant heritability and racial predisposition. The pathogenesis of HS is complex, with some patients associated with mutations in gamma-secretase, which may be a pathway underlying HS.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Dermatology
Uppala Radhakrishna, Uppala Ratnamala, Devendrasinh D. Jhala, Lavanya V. Uppala, Aaren Vedangi, Nazia Saiyed, Maulikkumar Patel, Nikita Vadsaria, Sushma R. Shah, Rakesh M. Rawal, Santo R. Mercuri, Dennis McGonagle, Gregor B. E. Jemec, Giovanni Damiani
Summary: This study investigates the potential use of TRG methylomes as biomarkers in HS and identifies differentially methylated CpG sites associated with HS. It also suggests that the disruption of TRGs leads to telomere shortening and is associated with HS progression and increased risk of various diseases.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hakim Ben Abdallah, Anne Bregnhoj, Lars Iversen, Claus Johansen
Summary: Hidradenitis suppurativa is a chronic inflammatory skin disease with limited treatment options. This study used transcriptomic approaches to investigate the underlying inflammatory pathways and cell types in hidradenitis suppurativa, revealing the activation of multiple inflammatory processes and the involvement of lymphoid and myeloid cells. The study also found increased expression of TH1/2/17 signatures in hidradenitis suppurativa. These findings provide molecular insights into the pathomechanisms of hidradenitis suppurativa and suggest potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
