Article
Multidisciplinary Sciences
Kie Mizumaki, Motoki Horii, Miyu Kano, Akito Komuro, Takashi Matsushita
Summary: This study found that increased regulatory B cells in mice can suppress IL-23-mediated psoriasis-like inflammation by expanding regulatory T cells and inhibiting Th17 cell differentiation, making them a potential strategy for treating psoriasis.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Renyi Ding, Anjun Jiao, Baojun Zhang
Summary: This article summarizes the prospects and role of therapeutic methods targeting T cells in patients with hematologic malignancies. Studies have found that Toll-like receptors (TLRs) play an important role in T cell-mediated anti-tumor immunity. The article discusses the potential of combining TLR agonists with other treatment methods.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Hiroyuki Nakashima, Manabu Kinoshita
Summary: The liver plays a crucial role in systemic immunity and defends against the spread of tumor cells. It contains a higher percentage of innate immune lymphocytes, such as NK and NKT cells, which eliminate malignant cells with their strong cytotoxic ability. These lymphocytes also initiate immune responses by adaptive immune cells, making them important contributors to systemic antitumor immunity. Understanding the mechanisms of these immune cells provides insight for tumor immunity research and potential clinical applications for cancer therapies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Natasa Kustrimovic, Daniela Gallo, Eliana Piantanida, Luigi Bartalena, Adriana Lai, Nicola Zerbinati, Maria Laura Tanda, Lorenzo Mortara
Summary: Maintaining the delicate balance between immune response and tolerance is crucial for health. T regulatory cells play a pivotal role in preserving self-tolerance and suppressing inflammation. In Graves' disease, these cells are likely impaired or reduced in frequency. Understanding the role of Tregs in Graves' disease is important for developing new treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Khalid W. Kalim, Jun-Qi Yang, Mark Wunderlich, Vishnu Modur, Phuong Nguyen, Yuan Li, Ting Wen, Ashley Kuenzi Davis, Ravinder Verma, Qing Richard Lu, Anil G. Jegga, Yi Zheng, Fukun Guo
Summary: Targeting Cdc42 in Treg cells has shown promising therapeutic potential in cancer immunotherapy, by enhancing antitumor T-cell immunity without triggering autoimmune reactions. This approach involves inducing Treg cell instability through Cdc42 targeting, leading to improved immune responses against tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Immunology
Payal Grover, Peeyush N. Goel, Mark I. Greene
Summary: T regulatory cells employ various immunosuppressive mechanisms to limit immune responses, including secretion of cytokines, cell cytolysis, metabolic perturbation, guiding antigen-presenting cell function, etc.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Yejin Cao, Yueru Hou, Longhao Zhao, Yijin Huang, Guangwei Liu
Summary: Tfr cells are a unique subset of Treg cells located in germinal centers, expressing transcription profiles of both Tfh and Treg cells and negatively regulating GC reactions. They have specific characteristics in different local immune microenvironments.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Yu Yu, Wenjing Yang, Tianming Yu, Xiaojing Zhao, Zheng Zhou, Yanbo Yu, Lifeng Xiong, Hui Yang, Anthony J. Bilotta, Suxia Yao, George Golovko, Agustin Plasencia, Francisco J. Quintana, Liang Zhou, Yanqing Li, Yingzi Cong
Summary: Glucose promotes intestinal inflammation at high concentrations, but suppresses colitis at moderate doses by increasing the proportion of intestinal regulatory T cells. This effect is mediated by activation of the aryl hydrocarbon receptor (AhR) to induce T cell polarization.
Review
Immunology
Jaehwan Kim, Ariana Moreno, James G. G. Krueger
Summary: Psoriasis vulgaris is a common inflammatory disease affecting 7.5 million adults in the US, with immunopathogenesis paradigms rapidly evolving due to advancements in technology. Single-cell RNA sequencing technology is now being applied to clinical trials of biologics to test the expansion of regulatory immune cell subsets involved in skin homeostasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Weiwei Wang, Jing Zhao, Changlong Hao, Shudong Hu, Chen Chen, Yi Cao, Zhengyu Xu, Jun Guo, Liguang Xu, Maozhong Sun, Chuanlai Xu, Hua Kuang
Summary: This study discovers the potential of chiral nanomaterials as immunoadjuvants for the prevention and treatment of cancer. Chiral nanoparticles enhance immune response and inhibit tumor growth through the stimulation of specific cell types, showing better therapeutic effects compared to achiral nanoparticles.
ADVANCED MATERIALS
(2022)
Article
Immunology
Rui Dai, Xiaopei Huang, Yiping Yang
Summary: This study demonstrates the critical role of gamma delta T cells in promoting the CD8(+) T cell response to VV infection. Gamma delta T cells are able to present viral antigens and activate CD8(+) T cells, with MyD88 signaling playing a key role in this process. Understanding the regulation of adaptive T cell response by gamma delta T cells may provide insight for the development of more effective vaccine strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Selen Dogan, Ender Terzioglu, Selda Ucar
Summary: Cervical carcinoma is significantly associated with the human papillomavirus (HPV), with persistent infection with high-risk HPV being necessary but not sufficient for its development. Immune mechanisms play a crucial role in HPV persistence, with gamma 8 T cells potentially playing a key role in persistent HPV infection and cervical carcinogenesis in the early phase. Further research into the role of gamma 8 T cells could lead to potential therapeutic strategies against HPV in infected patients.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Immunology
Yime Zhang, Luni Hu, Guanqun Ren, Yanyu Zeng, Xingyu Zhao, Chao Zhong
Summary: This study compared the transcriptomes of innate lymphoid cells (ILCs) and CD4+ T helper (Th) cells using bulk RNA-sequencing data and identified gene sets that distinguish ILCs from Th cells and different immune responses. Chromatin accessibility analysis revealed that ILCs rely more on specific transcriptional regulation at promoter regions compared to Th cells. Additionally, ILCs and Th cells are under differential transcriptional regulation, with ILCs being regulated by multiple transcription factors such as ROR alpha, GATA3, and NF-kappa B, while Th cells are regulated by AP-1. These findings highlight the substantial distinctions in regulatory machineries between ILCs and Th cells, providing a comprehensive understanding of their unique roles during immune responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Yingyuan Yu, Zeyu Chen, Yu Wang, Ying Li, Jiajing Lu, Lian Cui, Zengyang Yu, Yangfeng Ding, Chunyuan Guo, Xilin Zhang, Yuling Shi
Summary: The study investigated the expression of co-inhibitory receptors (CIRs) on circulating T lymphocytes of psoriasis patients before and after anti-tumor necrosis factor-alpha (TNF-alpha) therapy. The results showed that anti-TNF-alpha therapy increased the frequency of Tregs and TIGIT, LAG-3, CTLA-4 expression but reduced PROCR expression on circulating CD4+ T cells in psoriasis patients. The baseline proportion of Tregs and the expression level of TIGIT on circulating CD4+ T cells might serve as predictive markers for the degree of disease remission benefited from infliximab treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Wenyong Huang, Dongmei Ye, Wenjing He, Xiaoshun He, Xiaomin Shi, Yifang Gao
Summary: The study found that MAIT cells in patients with HCC had lower levels in both peripheral blood and liver compared to healthy controls, with reduced IFN-γ production. While peripheral MAIT cells showed upregulation of HLA-DR and PD-1, intrasinusoidal MAIT cells did not exhibit significant differences. Additionally, MAIT cells were significantly enriched in the livers of HCC patients, showing high levels of activation and exhaustion markers.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Dermatology
Alfredo Rossi, Maria Caterina Fortuna, Giulia Pranteda, Valentina Garelli, Donato Di Nunno, Elena Mari, Stefano Calvieri, Marta Carlesimo
Review
Dermatology
A. Rossi, A. Iorio, D. Di Nunno, L. Priolo, M. C. Fortuna, V. Garelli, M. Carlesimo, S. Calvieri, E. Mari
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2015)
Letter
Dermatology
A. Diociaiuti, G. Zambruno, S. Giancristoforo, V. Proto, R. Boldrini, D. Castiglia, M. El Hachem
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2016)
Article
Biotechnology & Applied Microbiology
A. Curioni-Fontecedro, R. Pitocco, N. L. Schoenewolf, D. Holzmann, D. Soldini, R. Dummer, S. Calvieri, H. Moch, D. Mihic-Probst, A. Fitsche
BIOMED RESEARCH INTERNATIONAL
(2015)
Article
Genetics & Heredity
Andrea Diociaiuti, May El Hachem, Elisa Pisaneschi, Simona Giancristoforo, Silvia Genovese, Pietro Sirleto, Renata Boldrini, Adriano Angioni
ORPHANET JOURNAL OF RARE DISEASES
(2016)
Article
Ophthalmology
Solmaz Abdolrahimzadeh, Lorenzo Felli, Rocco Plateroti, Andrea Maria Plateroti, Sandra Giustini, Stefano Calvieri, Santi Maria Recupero
BRITISH JOURNAL OF OPHTHALMOLOGY
(2015)
Article
Dermatology
Fabio Ayala, Julien Lambert
JOURNAL OF DERMATOLOGICAL TREATMENT
(2015)
Article
Dermatology
B. Visconti, G. Paolino, S. Carotti, A. L. Pendolino, S. Morini, A. G. Richetta, S. Calvieri
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2015)
Letter
Dermatology
C. Longo, L. Neri, G. Argenziano, S. Calvieri, P. G. Calzavara-Pinton, C. Cantisani, C. Catricala, K. Peris, A. Peserico, N. Pimpinelli, G. Pellacani
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2016)
Article
Oncology
Giovanni Paolino, Elisa Moliterni, Dario Didona, Valentina Garelli, Paola Corsetti, Teresa Lopez, Antonio Giovanni Richetta, Carmen Cantisani, Ugo Bottoni, Stefano Calvieri
Letter
Dermatology
Sara D'Epiro, Monica Salvi, Carlo Mattozzi, Simona Giancristoforo, Valentina Faina, Laura Macaluso, Cecilia Luci, Teresa Grieco, Stefano Calvieri, Antonio G. Richetta
INTERNATIONAL WOUND JOURNAL
(2015)
Review
Dermatology
Roberta Rotunno, Federica Marenco, Simone Ribero, Stefano Calvieri, Paolo Amerio, Pietro Curatolo, Pietro Quaglino
GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
(2016)
Letter
Dermatology
Emanuele Miraglia, Stefano Calvieri, Sandra Giustini
ACTA DERMATOVENEROLOGICA CROATICA
(2015)
Article
Pharmacology & Pharmacy
U. Bottoni, G. Paolino, D. Didona, P. Corsetti, R. Clerico, C. Cantisani, A. G. Richetta, V. Arcidiacono, E. Scali, G. Pranteda, S. Calvieri
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2015)
Article
Pharmacology & Pharmacy
C. Cantisani, G. Paolino, P. Corsetti, U. Bottoni, D. Didona, S. Calvieri
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2015)