Article
Pharmacology & Pharmacy
Joanna Bartosinska, Paulina Szczepanik-Kulak, Dorota Raczkiewicz, Marta Niewiedziol, Agnieszka Gerkowicz, Dorota Kowalczuk, Miroslaw Kwasny, Dorota Krasowska
Summary: The study evaluated the efficacy and cosmetic outcome of different photosensitizers in AK patients, indicating that ALA-P may have better effects and lower pain intensity compared to ALA-HCl and MAL-HCl.
Article
Dermatology
Soledad Saenz-Guirado, Carlos Cuenca-Barrales, Jorge Vega-Castillo, Laura Linares-Gonzalez, Teresa Rodenas-Herranz, Alejandro Molina-Leyva, Ricardo Ruiz-Villaverde
Summary: The study demonstrates that combined PDT (daylight PDT followed by conventional PDT) for the treatment of actinic keratosis is as effective as conventional PDT in reducing lesions, but shows superior results in reducing pain and local skin reactions. The primary endpoint results show no significant difference between the two treatments in reducing actinic keratosis.
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Montserrat Fernandez Guarino, Diego Fernandez-Nieto, Laura Vila Montes, Dario de Perosanz Lobo
Summary: This study compares the effectiveness of lower doses of red light conventional PDT (h-PDT) with methyl aminolaevulinic acid (MAL) and aminolaevulinic acid (ALA) in the treatment of multiple actinic keratosis (AK). The results show that there were no significant differences in the outcomes of both treatments at 12 months, although ALA exhibited slightly better results at 3 months. Neither pain nor adverse events showed any differences.
Article
Medicine, General & Internal
Norbert Kiss, Klara Farkas, Giulio Tosti, Federico De Gado, Beata Bergler-Czop, Gilda Fazia, Antonella Tammaro, Carmen Cantisani
Summary: Photodynamic therapy (PDT) using 5-aminolevulinic acid (5-ALA) patch is an effective and well-tolerated treatment option for actinic keratosis (AK), as demonstrated in this case series study.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Maria Paulina Romero, Veronica Posso, Valeria Urena, Natalia Inada, Vanderlei Bagnato, Franklin Cabrera
Summary: This study compared the efficacy and side effects of Photodynamic Therapy (MALA-PDT) and 5-fluorouracil (5-FU) treatments for actinic keratosis (AK). The results showed that MALA-PDT was less aggressive than 5-FU but had the same clinical response. MALA-PDT-based treatment for AK is a practical, inexpensive, and easy-to-use technique.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Dermatology
Jiandan Li, Yunfeng Zhang, Guolong Zhang, Linglin Zhang, Zhongxia Zhou, Peiru Wang, Xiuli Wang
Summary: The study aimed to explore the efficacy and pain tolerance of the modified painless PDT (M-PDT) in facial multiple actinic keratosis. The results showed that M-PDT is comparable to conventional PDT (C-PDT) in efficacy for treating facial multiple AK, with significantly lower pain scores reported by patients undergoing M-PDT.
LASERS IN SURGERY AND MEDICINE
(2023)
Article
Dermatology
Daniel B. Eisen, Maryam M. Asgari, Daniel D. Bennett, Suzanne M. Connolly, Robert P. Dellavalle, Esther E. Freeman, Gary Goldenberg, David J. Leffell, Sue Peschin, James E. Sligh, Peggy A. Wu, Lindsy Frazer-Green, Sameer Malik, Todd E. Schlesinger
Summary: This analysis reviewed the literature related to the management of AK to provide evidence-based recommendations for treatment. Strong recommendations were made for using ultraviolet protection, topical medications, and cryosurgery to treat AK. Conditional recommendations were made for photodynamic therapy and diclofenac for the treatment of AK.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Polymer Science
Teocrito Carlesi, Tatiane Cristina Dotta, Tania Vanessa Pierfelice, Emira D'Amico, Stefania Lepore, Domenico Tripodi, Adriano Piattelli, Simonetta D'Ercole, Morena Petrini
Summary: In this ex vivo study, the effects of ALAD and red light on Enterococcus faecalis in infected root canals were evaluated. The results showed that 2.5% sodium hypochlorite had a good bactericidal effect on E. faecalis, while 1% sodium hypochlorite had no significant bactericidal effect. The combination of ALAD and red light had a significant bactericidal effect on E. faecalis.
Article
Biochemistry & Molecular Biology
Elena Campione, Monia Di Prete, Cosimo Di Raimondo, Gaetana Costanza, Vincenzo Palumbo, Virginia Garofalo, Sara Mazzilli, Chiara Franceschini, Emi Dika, Luca Bianchi, Augusto Orlandi
Summary: This study evaluated the clinical efficacy of three different therapeutic modalities for actinic keratosis and assessed the expression of matrix metalloproteinases through histopathological examination and immunohistochemistry. The results showed a gradual decrease in actinic keratosis assessment scores at the end of treatments and a reduction in matrix metalloproteinase expression in treated skin lesions compared to baseline.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Dermatology
T. Steeb, E. A. T. Koch, A. Wessely, L. G. Wiest, L. Schmitz, C. Berking, M. Heppt
Summary: Chemical peelings for AK have varying efficacy and risks, and more high-quality studies are needed to determine their value in treatment.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Dermatology
Miguel Fernando Garcia-Gil, Tamara Gracia-Cazana, Paulina Cerro-Munoz, Laura Bernal-Masferrer, Alba Navarro-Bielsa, Yolanda Gilaberte
Summary: This study evaluates the effectiveness and safety of methyl aminolevulinate daylight photodynamic therapy (MAL DL-PDT) performed at home. The results show that MAL DL-PDT is highly effective for the long-term treatment of nonhyperkeratotic actinic keratosis (AK), with a high level of patient satisfaction.
DERMATOLOGIC THERAPY
(2022)
Article
Dermatology
Jon Chim Bai-Habelski, Annette Ko, Christoph Ortland, Marcus Stocker, Andrea Ebeling, Uwe Reinhold
Summary: Photodynamic therapy with 5-aminolevulinic acid hydrochloride is an established method for treating actinic keratosis (AK). Occlusion during ALA incubation can improve the clinical outcome of PDT for AK on hands and arms. Two PD P 506 A-PDT sessions 1-2 weeks apart are an efficacious treatment for AK on hands and arms.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Chemistry, Medicinal
Yiman Chen, Huihui Deng, Liya Yang, Ling Guo, Min Feng
Summary: Hypertrophic scar is a common problem after skin burns or trauma, causing physical, psychological, and cosmetic issues for patients. Photodynamic therapy with 5-aminolevulinic acid (5-ALA) shows promise in treating hypertrophic scar. However, limitations in the clinical application of 5-ALA due to low permeability and rapid binding of protoporphyrin IX (PpIX) with iron ions have been observed. In this study, a mixture of 5-ALA and DFO (a special iron chelator) was used for hypertrophic scar treatment. The combination effectively blocked the biotransformation of PpIX, leading to increased accumulation of the photosensitizer and subsequent destruction of hypertrophic scar fibroblasts.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Oncology
Katarina Silic, Michael Kammer, Paul-Gunther Sator, Adrian Tanew, Sonja Radakovic
Summary: This study compared the efficacy of two different cooling methods, cold air blower (CAB) and standard fan (FAN), in relieving pain during photodynamic therapy (PDT) for actinic keratosis (AK) of the head region. The results showed that cooling with CAB had a greater analgesic effect and led to lower pain intensity and skin temperature compared to cooling with FAN. However, there was no significant difference in the severity of phototoxic skin reaction and the clearance rate of AK between the two cooling methods.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Oncology
Lauren E. Heusinkveld, Taylor A. Bullock, Jeffrey Negrey, Christine B. Warren, Edward V. Maytin
Summary: This study aimed to compare the efficacy of photodynamic therapy (PDT) with or without sandpaper curettage for the treatment of actinic keratosis (AK). The results showed that patients who received sandpaper curettage before PDT treatment had a significantly higher scalp AK clearance rate compared to those who did not receive curettage, after controlling for sex, age, time to follow-up, and baseline AK count.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Review
Dermatology
Christine Fink, Alexander Enk, Patrick Gholam
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2015)
Article
Dermatology
P. Gholam, C. Fink, I. Bosselmann, A. H. Enk
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2016)
Article
Medicine, General & Internal
Patrick Gholam, Christine Fink, Lorenz Uhlmann, Alexander Enkl
Letter
Dermatology
Christine Fink, Ferdinand Toberer, Alexander Enk, Patrick Gholam
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2016)
Article
Dermatology
C. Fink, L. Uhlmann, A. Enk, P. Gholam
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2017)
Article
Dermatology
Patrick Gholam, Ina Bosselmann, Alexander Enk, Christine Fink
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2018)
Letter
Dermatology
Mona Bidier, Carolin Zschoche, Patrick Gholam, Alexander H. Enk, Eva N. Hadaschik
ACTA DERMATO-VENEREOLOGICA
(2012)
Letter
Dermatology
E. Streit, P. Gholam, E. Hadaschik, W. Hartschuh
BRITISH JOURNAL OF DERMATOLOGY
(2014)
Article
Dermatology
Patrick Gholam, Verena Kroehl, Alexander H. Enk
Article
Dermatology
T. Weberschock, I. Hausser, P. Gholam, M. Hartmann
Article
Dermatology
Patrick Gholam, Ina Bosselmann, Alexander H. Enk, Julika Dick
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2019)
Letter
Dermatology
Lukas Freund, Stephanie Oehrl, Galina Graebe, Patrick Gholam, Thomas Plum, Knut Schaekel
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2020)
Editorial Material
Allergy
Julia Hartmann, Alexander H. Enk, Patrick Gholam
CONTACT DERMATITIS
(2020)
Article
Dermatology
Aric Keller, Julia Hartmann, Alexander Enk, Patrick Gholam
Summary: Low-irradiance PDT is an effective method to reduce pain and the risk of post-interventional hypertension in photodynamic therapy, which is particularly important for older patients with cardiovascular diseases.
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2022)
Article
Dermatology
J. Hartmann, A. Keller, A. Enk, P. Gholam
Summary: This study observed the effects of conventional photodynamic therapy (c-PDT) and daylight photodynamic therapy (dl-PDT) on different hemodynamic parameters. The results showed that c-PDT caused more pain and hypertension, while dl-PDT was almost painless and did not lead to any changes in hemodynamic parameters. Both treatments had a similar lesion response rate after one month. Therefore, dl-PDT may be a more favorable treatment option.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)