Review
Biochemistry & Molecular Biology
Fumi Miyagawa, Hideo Asada
Summary: For severe cutaneous adverse reactions (SCARs) like Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) and drug-induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS), analyzing distinct chemokine profiles can aid in their diagnosis and treatment. It is crucial to identify new therapeutic targets for SCARs, with chemokines playing a key role in the pathogenesis and adjuvant diagnosis of these conditions. Additionally, the association between human herpesvirus 6 (HHV-6) and DIHS/DRESS, as well as the possible roles of chemokine/chemokine receptor homologs encoded by HHV-6 in the pathogenesis, are areas of increasing interest.
Review
Medicine, General & Internal
Shang-Chen Yang, Chun-Bing Chen, Mao-Ying Lin, Zhi-Yang Zhang, Xiao-Yan Jia, Ming Huang, Ya-Fen Zou, Wen-Hung Chung
Summary: In recent years, significant progress has been made in the research of SCARs, including SJS/TEN, particularly in the genetic factors. The identification of genetic alleles associated with drugs related SCARs has been an important breakthrough for the prevention of these severe skin reactions.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Alyce Mei-Shiuan Kuo, Stephanie Gu, Joseph Stoll, Andrea P. Moy, Stephen W. Dusza, Allison Gordon, Elena C. Haliasos, Yelena Janjigian, Lukas Kraehenbuehl, Elizabeth A. Quigley, Paul Chapman, Mario E. Lacouture, Alina Markova
Summary: Immune checkpoint inhibitors (ICI) can effectively target cancer cells, but they may also cause immune-related cutaneous adverse events (ircAEs) in a significant number of patients. This study examined the use of dupilumab for treating ICI-associated ircAEs and found that 87% of patients responded to the treatment, with 44.1% achieving complete resolution of the adverse events.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Dermatology
Georgi Bogdanov, Ivan Bogdanov, Jana Kazandjieva, Nikolai Tsankov
Summary: Vaccines have played a crucial role in improving global health, especially during the COVID-19 pandemic. Different types of COVID-19 vaccines are widely used, with most adverse reactions being mild.
CLINICS IN DERMATOLOGY
(2021)
Article
Dermatology
Henry T. Quach, Douglas B. Johnson, Nicole R. LeBoeuf, Jeffrey P. Zwerner, Anna K. Dewan
Summary: ICIs can lead to a variety of cutaneous adverse events, ranging from common eczematous and morbilliform dermatoses to less common psoriasiform dermatoses and bullous disorders. The immunologic mechanism of ICIs may also cause rheumatologic adverse reactions with cutaneous manifestations, which can typically be managed with steroids. As ICIs become more widely prescribed, dermatologists will play a crucial role in accurately diagnosing and treating these toxicities to ensure favorable outcomes for patients.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Food Science & Technology
Greta Mucignat, Irene Bassan, Mery Giantin, Marianna Pauletto, Anisa Bardhi, Silvia Iori, Rosa Maria Lopparelli, Andrea Barbarossa, Anna Zaghini, Enrico Novelli, Mauro Dacasto
Summary: This study investigated the toxicity and transcriptional changes of bentonite (BEN) and aflatoxin B1 (AFB1) in Caco-2 cells. The results showed that BEN did not affect cell viability and permeability at lower concentrations, but reduced AFB1 cytotoxicity. However, at higher concentrations, BEN exhibited cytotoxicity.
Review
Medicine, General & Internal
Francesco Bellinato, Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
Summary: This review summarizes the cutaneous adverse reactions associated with SARS-CoV-2 vaccines, categorizing them into new onset reactions and flares of preexisting dermatoses. Injection site reactions are the most common, affecting 30-70% of cases and generally mild or moderate.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Icia Santos-Zas, Jeremie Lemarie, Ivana Zlatanova, Marine Cachanado, Jean-Christophe Seghezzi, Hakim Benamer, Pascal Goube, Marie Vandestienne, Raphael Cohen, Maya Ezzo, Vincent Duval, Yujiao Zhang, Jin-Bo Su, Alain Bize, Lucien Sambin, Philippe Bonnin, Maxime Branchereau, Christophe Heymes, Corinne Tanchot, Jose Vilar, Clement Delacroix, Jean-Sebastien Hulot, Clement Cochain, Patrick Bruneval, Nicolas Danchin, Alain Tedgui, Ziad Mallat, Tabassome Simon, Bijan Ghaleh, Jean-Sebastien Silvestre, Hafid Ait-Oufella
Summary: This study reveals the detrimental role of CD8(+) T lymphocytes following acute myocardial infarction, showing that they release Granzyme B in the ischemic heart tissue leading to cardiomyocyte apoptosis, adverse ventricular remodeling, and deterioration of myocardial function. Depletion of CD8(+) T lymphocytes leads to reduced apoptosis, inhibited inflammatory response, limited myocardial injury, and improved heart function. Elevated circulating levels of GRANZYME B in AMI patients may predict increased risk of death at 1-year follow-up. Targeting pathogenic CD8(+) T lymphocytes could be a potential therapeutic strategy in the setting of acute myocardial infarction.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Mauro Bavetta, Dionisio Silvaggio, Elena Campione, Pietro Sollena, Vincenzo Formica, Deborah Coletta, Grazia Graziani, Maria Concetta Pucci Romano, Mario Roselli, Ketty Peris, Luca Bianchi
Summary: Polydatin, a topical product containing glycosylated polyphenol, has been shown to be effective in preventing and treating skin papulopustular rash in EGFRi-treated patients, leading to significant improvement in patients' quality of life. Additionally, no cutaneous adverse events related to the use of polydatin were reported in the study, suggesting its safety and efficacy in managing skin manifestations in cancer patients undergoing EGFRi treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Vasiliki Nikolaou, Antonis Tsimpidakis, Alexander Stratigos
Summary: Immune checkpoint blockers (ICBs) have been widely used for the treatment of melanoma, but they can also cause autoimmune toxicities, especially in the skin. The role of dermatologists is important in detecting and treating these adverse events. Common cutaneous toxicities include rash, psoriasis-like and lichenoid dermatoses, and bullous pemphigoid. Rare toxicities such as sarcoidosis, dermatomyositis, and subacute lupus have also been reported. This review provides a summary of ICB-induced cutaneous toxicities in melanoma patients and discusses management and treatment options.
Review
Biochemistry & Molecular Biology
Silvia Attardo, Olimpia Musumeci, Daniele Velardo, Antonio Toscano
Summary: Statins, commonly prescribed for high-risk patients with cerebrovascular or cardiovascular diseases, may cause neuromuscular side effects and potentially lead to neuromuscular damage. Clinical follow-up of patients can help identify early side effects and improve treatment approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Environmental Sciences
Kunle Okaiyeto, Oluwafemi O. Oguntibeju
Summary: The African continent is rich in plant resources, especially in the field of traditional herbal medicine with great potential, but the research on these medicinal plants is still lacking, with issues of safety and scientific support.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Dermatology
Gero Vorwerk, Sabine Zahn, Thomas Bieber, Joerg Wenzel
Summary: The study indicates that NKG2D is highly expressed in CDLE and SCLE skin lesions, and may be associated with cytotoxicity in IFN-driven skin lesions in CLE. It suggests a potential role of NKG2D in CLE inflammation induced by stressed keratinocytes.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Dongxuan Li, Jinghui Gou, Jun Zhu, Tongyan Zhang, Feng Liu, Daojun Zhang, Liyang Dai, Wenjun Li, Qinglong Liu, Chunmeng Qin, Qian Du, Songqing Liu
Summary: This study provides a comprehensive landscape of culprit-drugs for severe cutaneous adverse reactions (SCARs) by analyzing reports from the FDA Adverse Event Reporting System database. It reveals the risk characteristics of different drugs and may help optimize patient management.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Dermatology
Sabha Mushtaq, Erdinc Terzi, Sebastiano Recalcati, Julio C. Salas-Alanis, Sanober Amin, Nafis Faizi
Summary: This study investigated dermatoses induced by the use of protective measures against COVID-19 among healthcare workers and the general population. Prolonged use of personal protective equipment was significantly associated with multiple symptoms. Contact dermatitis was the most common adverse effect noted, with soap and water being the most common culprit material.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2021)
Article
Cell Biology
Rei Watanabe, Ahmed Gehad, Chao Yang, Laura L. Scott, Jessica E. Teague, Christoph Schlapbach, Christopher P. Elco, Victor Huang, Tiago R. Matos, Thomas S. Kupper, Rachael A. Clark
SCIENCE TRANSLATIONAL MEDICINE
(2015)
Article
Dermatology
Brooke Rothstein, Deep Joshipura, Ami Saraiya, Rana Abdat, Huda Ashkar, Yana Turkowski, Vaneeta Sheth, Victor Huang, Shiu Chung Au, Courtney Kachuk, Nicole Dumont, Alice B. Gottlieb, David Rosmarin
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2017)
Letter
Dermatology
Monique Gupta, Victor Huang, Gerry Linette, Lynn Cornelius
ARCHIVES OF DERMATOLOGY
(2012)
Article
Dermatology
Victor Huang, Donna Hepper, Milan Anadkat, Lynn Cornelius
ARCHIVES OF DERMATOLOGY
(2012)
Article
Dermatology
Mitra Dowlatshahi, Victor Huang, Ahmed E. Gehad, Ying Jiang, Adam Calarese, Jessica E. Teague, Andrew A. Dorosario, Jingwei Cheng, Paul Nghiem, Carl F. Schanbacher, Manisha Thakuria, Chrysalyne D. Schmults, Linda C. Wang, Rachael A. Clark
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2013)
Article
Dermatology
Fan Di Xia, Bart S. Ferket, Victor Huang, Robert S. Stern, Peggy A. Wu
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2019)
Article
Dermatology
Herbert C. Chiang, Victor Huang, Lynn A. Cornelius
SEMINARS IN CUTANEOUS MEDICINE AND SURGERY
(2011)
Article
Dermatology
Peggy A. Wu, Robert S. Stern, Victor Huang, Kevin X. Liu, Chen (Amy) Chen, Dimitrios Tzachanis, Robin M. Joyce, Roger B. Davis, Vincent T. Ho
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2019)
Editorial Material
Dermatology
Allison M. Han, Elaine J. Lin, Victor Huang, Maxwell A. Fung, Smita Awasthi
PEDIATRIC DERMATOLOGY
(2019)
Letter
Dermatology
P. Mobasher, R. Guerra, S. J. Li, J. Frangos, A. K. Ganesan, V. Huang
BRITISH JOURNAL OF DERMATOLOGY
(2020)
Review
Dermatology
Penelope Kim-Lim, Ebba Wennberg, Megan Van Noord, Lauren W. Hastings, Sydney D. Sullivan, Victor Huang, Peggy A. A. Wu
Summary: This systematic review examined the effects of systemic corticosteroid therapy on patch test reactions. The results showed that different doses of corticosteroids can reduce the intensity of inflammatory skin reactions.
Article
Hematology
Ahmed Gehad, Jessica E. Teague, Tiago R. Matos, Victor Huang, Chao Yang, Rei Watanabe, John T. O'Malley, Cornelia L. Trimble, Thomas S. Kupper, Rachael A. Clark
