Article
Chemistry, Multidisciplinary
Shutao Zhang, Xinhua Qu, Haozheng Tang, You Wang, Hongtao Yang, Weien Yuan, Bing Yue
Summary: The study shows that high-dose diclofenac inhibits the growth of MRSA without inducing drug-resistant mutations easily, while low-dose diclofenac can resensitize bacteria to beta-lactams and inhibit biofilm formation. Transcriptomic and proteomic analyses indicate that diclofenac reduces the expression of genes and proteins associated with antibiotic resistance and biofilm formation. Murine implant infection models suggest that diclofenac combined with beta-lactams can substantially alleviate MRSA infections in vivo, offering promising applications for preventing perioperative infections.
Review
Infectious Diseases
Elham Zarenezhad, Hussein T. Abdulabbas, Mahrokh Marzi, Esraa Ghazy, Mohammad Ekrahi, Babak Pezeshki, Abdolmajid Ghasemian, Amira A. Moawad
Summary: Methicillin-resistant Staphylococcus aureus (MRSA) has developed extensive antibiotic resistance and contains virulence factors for severe infections. Nickel nanoparticles (NiNPs) have shown potential as a cheap prognostic and therapeutic agent, exerting antibacterial effects through disrupting cell membranes, deforming proteins, and inhibiting DNA replication.
Article
Microbiology
Jiun-Liang Chen, Tsung-Yu Huang, Wei-Bin Hsu, Chiang-Wen Lee, Yao-Chang Chiang, Pey-Jium Chang, Kuo-Ti Peng
Summary: This study investigated the genotypic and phenotypic characteristics of MRSA clones isolated from PJI patients in a hospital in Taiwan. The findings showed that ST239 MRSA isolates were highly resistant to multiple antibiotics, had a high biofilm formation ability, and infected patients typically exhibited fever and inflammation. Additionally, knee infections were mainly attributed to ST59 MRSA, and there was an increasing trend of infections caused by ST8 and other MRSA genotypes in PJI patients.
Article
Engineering, Biomedical
Shutao Zhang, Xinhua Qu, Juyang Jiao, Haozheng Tang, Minqi Wang, You Wang, Hongtao Yang, Weien Yuan, Bing Yue
Summary: Felodipine has antibacterial effects against MRSA, biofilm, and persisters. It can inhibit the expression of proteins associated with aminoglycoside resistance, eradicate formed biofilms and kill persisters. Felodipine also reduces MRSA virulence and modulates bacterial metabolism. It inhibits the growth of persisters by binding to a protease. In a mouse infection model, felodipine in combination with gentamicin alleviates bacterial burden and inflammation.
BIOACTIVE MATERIALS
(2022)
Article
Microbiology
Yuwen Lu, Yifei Lu, Baobao Li, Jiazhen Liu, Lixin Wang, Lianyang Zhang, Yang Li, Qiu Zhong
Summary: StAP1 phage is a MRSA phage isolated from a Chinese hospital, exhibiting broad-spectrum characteristics and strong lytic effects on various MRSA strains, indicating its potential application in MRSA infection treatment.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Kuan-Yi Lu, Nikki J. Wagner, Amanda Z. Velez, Agathe Ceppe, Brian P. Conlon, Marianne S. Muhlebach
Summary: MRSA infections are common and chronic in cystic fibrosis patients but are often resistant to antibiotic therapy. This study investigated whether bacterial phenotypes could predict the clinical outcomes of MRSA infections. The results showed no associations between these phenotypes and MRSA clearance, suggesting that additional factors may be relevant for predicting the clearance of MRSA.
MICROBIOLOGY SPECTRUM
(2023)
Article
Orthopedics
Itay Ashkenazi, Jeremiah Thomas, Kyle W. Lawrence, Joshua C. Rozell, Claudette M. Lajam, Ran Schwarzkopf
Summary: This study aimed to evaluate the impact of preoperative nasal colonization with MRSA on TJA outcomes. The results showed that MRSA+ patients had longer hospital stays, lower discharge rates, higher readmission rates, and higher rates of septic and aseptic revisions. Surgeons should consider preoperative MRSA colonization status when counseling patients on the risks of TJA.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Chemistry, Multidisciplinary
Haozheng Tang, Xinhua Qu, Wenkai Zhang, Xuan Chen, Shutao Zhang, Yang Xu, Hongtao Yang, You Wang, Jianping Yang, Wei-en Yuan, Bing Yue
Summary: In this study, an ultra-micro photosensitizer, AgB nanodots, were used to efficiently clear multidrug-resistant bacteria MRSA through photothermal therapy, photodynamic therapy, and Ag+ ion sterilization. The AgB nanodots were found to enhance host immunogenicity and establish immunological memory in a murine model, providing a novel platform for the effective treatment of postoperative infection and a systematic immunotherapeutic strategy to combat persistent infections, thereby reducing the incidence of recurrence.
ADVANCED MATERIALS
(2022)
Article
Dermatology
Torstein Gronseth, Kirill Ovchinnikov, Harald Carlsen, Jurate Saltyte Benth, Dzung B. Diep, Magnus von Unge, Juha T. Silvola
Summary: This study evaluated the antibacterial efficacy of Lugol's solution and Gentian violet against MRSA biofilm in vivo, and found that these two agents effectively eradicated MRSA biofilm, suggesting their potential as alternatives or adjuncts to topical antibiotics.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Rong Huang, Guang-Qing Cai, Jian Li, Xi-Sheng Li, Hai-Ting Liu, Xue-Ling Shang, Jian-Dang Zhou, Xin-Min Nie, Rong Gui
Summary: A novel nano-drug delivery system, PLT@Ag-MOF-Vanc, was constructed for the treatment of MRSA infections, showing good antibacterial activity, biocompatibility, and targeting capabilities. It killed MRSA through multiple approaches and demonstrated superior anti-infective effects in a mouse MRSA pneumonia model compared to free vancomycin.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mengli Jin, Shuyue Zhu, Yating Tang, Xiangri Kong, Xingye Wang, Yufen Li, Shuang Jiang, Lin Wei, Chunjie Hu, Bingmei Wang, Wu Song
Summary: Antimicrobial resistance (AMR) is a global health threat, and there is a need for new anti-infective agents. Ayanin, a flavonoid extracted from Callicarpa nudiflora, was found to be an inhibitor of MRSA ClpP, suggesting its potential therapeutic effect against MRSA infections.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Materials Science, Multidisciplinary
Shreya Kanth, Akshatha Nagaraja, Yashoda Malgar Puttaiahgowda
Summary: The current global death rate is threatened by deadly unknown infections and the emergence of multidrug-resistant bacteria. Combatting drug-resistant bacteria, such as MRSA, has become a daunting challenge globally, with polymer synthesis being explored as a significant approach in preventing the spread of infections.
JOURNAL OF MATERIALS SCIENCE
(2021)
Article
Cell Biology
Zhimin Bai, Min Chen, Qiaofa Lin, Ying Ye, Hongmei Fan, Kaizhen Wen, Jianxing Zeng, Donghong Huang, Wenfei Mo, Ying Lei, Zhijun Liao
Summary: By extracting feature vectors from protein sequences and using classification tools, MRSA and MSSA were successfully distinguished. MRSA showed high resistance to penicillin and high pathogenic risk. Cross-infection between different types of MRSA was found in Quanzhou, and MRSA in traditional hospitals exhibited increasingly blurred molecular characteristics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Silvia Ravera, Gabriele Tancreda, Luigi Vezzulli, Anna Maria Schito, Isabella Panfoli
Summary: Polyphenols such as cisiliol and quercetin have been found to inhibit ATP synthase and decrease intracellular ATP levels in methicillin-resistant bacteria. These compounds may serve as potential additions to antibiotics due to their ability to target ATP synthase, against which bacteria cannot develop resistance.
Article
Infectious Diseases
Joshua T. Smith, Elissa M. Eckhardt, Nicole B. Hansel, Tahmineh Rahmani Eliato, Isabella W. Martin, Cheryl P. Andam
Summary: The study revealed that the S. aureus population in New Hampshire was mainly shaped by the clonal expansion, recombination, and co-dominance of two major MRSA clones over the last five decades. These results have important implications for the development of effective strategies for intervention, control, and treatment of life-threatening bloodstream infections.
BMC INFECTIOUS DISEASES
(2021)